2,5-Dimethyl-7-Hydroxychromone

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  • Identifiers

    CAS number
    38412-47-4

    Molecular formula
    C11H10O3

    SMILES
    CC1=CC(=CC2=C1C(=O)C=C(O2)C)O

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 50.61%
    Burnt 37.59%
    Fruity 32.31%
    Woody 31.9%
    Sweet 31.36%
    Nutty 28.86%
    Dry 26.93%
    Odorless 26.15%
    Spicy 26.04%
    Roasted 25.86%

     

    Flavor
    Bitter 63.5%
    Phenolic 26.17%
    Musty 24.76%
    Nutty 24.18%
    Flat 22.11%
    Eugenol 21.8%
    Indole 21.63%
    Shellfish 21.62%
    Very strong 21.58%
    Soybean 21.5%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    7.91 (neutral)

    Molecular weight
    190.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    441°C

    Melting point expt.

    • 258 - 260 °C

    Flash point

    • 159.97 ˚C est.

  • Synonyms

    • Altechromone A
    • 38412-47-4
    • 7-hydroxy-2,5-dimethylchromone
    • 7-hydroxy-2,5-dimethylchromen-4-one
    • 2,5-dimethyl-7-hydroxychromone
    • 68L85KAC8Q
    • DTXSID20415713
    • RefChem:908834
    • DTXCID50366562
    • 7-Hydroxy-2,5-dimethyl-4H-1-benzopyran-4-one
    • 2,5Dimethyl7hydroxy chromone
    • 4H-1-Benzopyran-4-one, 7-hydroxy-2,5-dimethyl-
    • 7-Hydroxy-2,5-dimethyl-4H-chromen-4-one
    • CHEMBL509319
    • orb1683173
    • SCHEMBL18096537
    • SCHEMBL29586871
    • 2,5-Dimethyl-7-hydroxychromenone
    • 2,5?Dimethyl?7?hydroxy chromone
    • CHEBI:173911
    • CRNGFKXWIYTEPH-UHFFFAOYSA-N
    • 7-Hydroxy-2,5-dimethyl-4H-chromone
    • AKOS022643238
    • 2,5-Dimethyl-7-oxidanyl-chromen-4-one
    • DA-60956
    • HY-134241
    • CS-0140509
    • 7-Hydroxy-2,5-dimethyl-4H-chromen-4-one #
    • H50848
    • Q4736228
    • 38412-47-4

  • Applications

    2,5-Dimethyl-7-Hydroxychromone (CAS 38412-47-4) is primarily used as an organic synthesis intermediate and building block for more complex chromone-based compounds; in industry it is explored as a chromophore-bearing starter for dye and pigment formulations and as a precursor for specialty polymers and plastics. It may play a role in coatings and inks as a colorant precursor or functional additive, and the chromone framework is investigated for optoelectronic materials and fluorescence-related applications. In research contexts it can serve as a stepping stone for the synthesis of pharmaceutical or agrochemical intermediates, subject to applicable regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 27.89
    methanol 44.25
    isopropanol 18.57
    water 0.44
    ethyl acetate 59.81
    n-propanol 23.98
    acetone 107.95
    n-butanol 22.69
    acetonitrile 76.19
    DMF 460.9
    toluene 9.5
    isobutanol 19.68
    1,4-dioxane 167.94
    methyl acetate 78.46
    THF 302.9
    2-butanone 51.08
    n-pentanol 23.09
    sec-butanol 14.8
    n-hexane 1.14
    ethylene glycol 15.42
    NMP 238.24
    cyclohexane 1.61
    DMSO 255.95
    n-butyl acetate 45.44
    n-octanol 23.42
    chloroform 29.14
    n-propyl acetate 58.47
    acetic acid 89.74
    dichloromethane 59.35
    cyclohexanone 109.79
    propylene glycol 16.02
    isopropyl acetate 30.1
    DMAc 172.26
    2-ethoxyethanol 72.32
    isopentanol 20.74
    n-heptane 2.17
    ethyl formate 78.94
    1,2-dichloroethane 41.77
    n-hexanol 27.35
    2-methoxyethanol 143.3
    isobutyl acetate 32.96
    tetrachloromethane 2.8
    n-pentyl acetate 33.0
    transcutol 202.31
    n-heptanol 15.77
    ethylbenzene 7.28
    MIBK 32.55
    2-propoxyethanol 104.12
    tert-butanol 27.03
    MTBE 16.21
    2-butoxyethanol 45.49
    propionic acid 43.16
    o-xylene 7.53
    formic acid 43.44
    diethyl ether 23.0
    m-xylene 9.97
    p-xylene 11.56
    chlorobenzene 19.57
    dimethyl carbonate 60.19
    n-octane 1.03
    formamide 89.02
    cyclopentanone 175.86
    2-pentanone 51.24
    anisole 34.01
    cyclopentyl methyl ether 71.98
    gamma-butyrolactone 262.15
    1-methoxy-2-propanol 94.18
    pyridine 62.65
    3-pentanone 30.99
    furfural 206.77
    n-dodecane 1.48
    diethylene glycol 95.81
    diisopropyl ether 6.56
    tert-amyl alcohol 17.88
    acetylacetone 100.92
    n-hexadecane 1.77
    acetophenone 41.28
    methyl propionate 67.06
    isopentyl acetate 33.1
    trichloroethylene 73.41
    n-nonanol 22.04
    cyclohexanol 26.18
    benzyl alcohol 36.51
    2-ethylhexanol 19.53
    isooctanol 13.69
    dipropyl ether 25.09
    1,2-dichlorobenzene 19.71
    ethyl lactate 36.93
    propylene carbonate 118.37
    n-methylformamide 161.33
    2-pentanol 12.52
    n-pentane 0.78
    1-propoxy-2-propanol 61.24
    1-methoxy-2-propyl acetate 61.03
    2-(2-methoxypropoxy) propanol 60.28
    mesitylene 6.17
    ε-caprolactone 102.1
    p-cymene 9.19
    epichlorohydrin 230.8
    1,1,1-trichloroethane 21.2
    2-aminoethanol 26.55
    morpholine-4-carbaldehyde 278.92
    sulfolane 236.99
    2,2,4-trimethylpentane 0.8
    2-methyltetrahydrofuran 105.34
    n-hexyl acetate 51.86
    isooctane 0.76
    2-(2-butoxyethoxy)ethanol 90.52
    sec-butyl acetate 26.27
    tert-butyl acetate 34.03
    decalin 1.83
    glycerin 38.54
    diglyme 159.39
    acrylic acid 51.91
    isopropyl myristate 20.83
    n-butyric acid 55.03
    acetyl acetate 47.81
    di(2-ethylhexyl) phthalate 25.02
    ethyl propionate 48.21
    nitromethane 284.02
    1,2-diethoxyethane 57.05
    benzonitrile 49.51
    trioctyl phosphate 19.31
    1-bromopropane 13.59
    gamma-valerolactone 292.4
    n-decanol 17.45
    triethyl phosphate 22.57
    4-methyl-2-pentanol 10.81
    propionitrile 41.15
    vinylene carbonate 117.66
    1,1,2-trichlorotrifluoroethane 97.59
    DMS 55.19
    cumene 6.85
    2-octanol 12.91
    2-hexanone 46.12
    octyl acetate 28.15
    limonene 12.53
    1,2-dimethoxyethane 180.38
    ethyl orthosilicate 20.07
    tributyl phosphate 24.11
    diacetone alcohol 56.8
    N,N-dimethylaniline 24.8
    acrylonitrile 74.0
    aniline 24.35
    1,3-propanediol 44.32
    bromobenzene 15.29
    dibromomethane 24.19
    1,1,2,2-tetrachloroethane 41.41
    2-methyl-cyclohexyl acetate 34.36
    tetrabutyl urea 34.55
    diisobutyl methanol 12.53
    2-phenylethanol 37.64
    styrene 7.92
    dioctyl adipate 36.9
    dimethyl sulfate 94.48
    ethyl butyrate 40.2
    methyl lactate 50.66
    butyl lactate 32.87
    diethyl carbonate 29.77
    propanediol butyl ether 50.39
    triethyl orthoformate 27.62
    p-tert-butyltoluene 8.18
    methyl 4-tert-butylbenzoate 42.2
    morpholine 154.29
    tert-butylamine 11.8
    n-dodecanol 13.3
    dimethoxymethane 201.0
    ethylene carbonate 91.99
    cyrene 72.84
    2-ethoxyethyl acetate 57.57
    2-ethylhexyl acetate 26.7
    1,2,4-trichlorobenzene 26.63
    4-methylpyridine 67.0
    dibutyl ether 27.15
    2,6-dimethyl-4-heptanol 12.53
    DEF 84.43
    dimethyl isosorbide 128.57
    tetrachloroethylene 21.27
    eugenol 53.38
    triacetin 54.18
    span 80 49.52
    1,4-butanediol 21.94
    1,1-dichloroethane 24.07
    2-methyl-1-pentanol 20.43
    methyl formate 188.17
    2-methyl-1-butanol 17.79
    n-decane 2.22
    butyronitrile 43.47
    3,7-dimethyl-1-octanol 21.75
    1-chlorooctane 11.66
    1-chlorotetradecane 5.24
    n-nonane 1.85
    undecane 1.81
    tert-butylcyclohexane 1.8
    cyclooctane 0.68
    cyclopentanol 42.94
    tetrahydropyran 74.33
    tert-amyl methyl ether 15.69
    2,5,8-trioxanonane 120.29
    1-hexene 6.18
    2-isopropoxyethanol 46.55
    2,2,2-trifluoroethanol 39.2
    methyl butyrate 70.04

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction