2,5-Dimethyl-4-ethoxy-3(2H)-furanone

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  • Identifiers

    CAS number
    65330-49-6

    Molecular formula
    C8H12O3

    SMILES
    CCOC1=C(OC(C1=O)C)C

  • Odor profile

    Fragrance
    Fruity 91.32%
    Caramellic 86.29%
    Sweet 84.14%
    Burnt 61.14%
    Roasted 51.66%
    Nutty 51.62%
    Strawberry 49.97%
    Buttery 47.14%
    Berry 43.21%
    Coffee 42.05%

     

    Flavor
    Fruity 90.34%
    Caramel 61.45%
    Sweet 53.03%
    Grape 41.64%
    Sugar 32.34%
    Maple 31.92%
    Berry 30.86%
    Tropical 29.49%
    Mushroom 26.09%
    Mildew 25.94%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    6.99 (neutral)

    Molecular weight
    156.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    202°C

    Flash point

    • 79.46 ˚C est.

    Solubility expt.

    • Practically insoluble or insoluble
    • Soluble (in ethanol)

  • Synonyms

    • 65330-49-6
    • 2,5-Dimethyl-4-ethoxy-3(2H)-furanone
    • FRAISION ETHYL ETHER
    • 4-Ethoxy-2,5-dimethylfuran-3(2H)-one
    • 4-ethoxy-2,5-dimethylfuran-3-one
    • XQ599P1UOI
    • EINECS 265-701-8
    • UNII-XQ599P1UOI
    • 3(2H)-Furanone, 4-ethoxy-2,5-dimethyl-
    • FEMA NO. 4104
    • DTXSID20867137
    • 4-ethoxy-2,5-dimethyl-2,3-dihydrofuran-3-one
    • STRAWBERRY ETHYL ETHER NATURAL
    • (+/-)-2,5-DIMETHYL-4-ETHOXY-3(2H)-FURANONE
    • 2,5-DIMETHYL-4-ETHOXY-3(2H)-FURANONE [FHFI]
    • 2,5-DIMETHYL-4-ETHOXY-3(2H)-FURANONE, (+/-)-
    • ADMF
    • SCHEMBL3505102
    • DTXCID10815344
    • CHEBI:169451
    • 4-ethoxy-2,5-dimethyluran-3-one
    • AKOS006290724
    • 2,3-Dihydro-2,5-dimethyl-3-furanone
    • 2,5-Dimethyl-4-ethoxy-3(2H)furanone
    • 4-Ethoxy-2,5-Dimethyl-3(2H)-Furanon
    • DB-302470
    • NS00056177
    • G84796
    • Q21546959
    • 265-701-8

  • Applications

    2,5-Dimethyl-4-ethoxy-3(2H)-furanone (CAS 65330-49-6) is a furanone lactone that may serve as a fragrance component and synthesis precursor across several industrial applications: it may be used as an aroma ingredient in perfumery and cosmetics; it can be evaluated as a flavoring ingredient in food-related applications; it may be employed in household and cleaning products to impart fragrance; it can be used in coatings and inks as a fragrance additive; and it acts as an intermediate in the manufacture of specialty fragrance chemicals and other chemical precursors.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 541.63
    methanol 1082.44
    isopropanol 338.48
    water 39.88
    ethyl acetate 612.61
    n-propanol 431.44
    acetone 803.29
    n-butanol 352.29
    acetonitrile 1103.1
    DMF 1129.22
    toluene 334.82
    isobutanol 308.7
    1,4-dioxane 933.56
    methyl acetate 701.74
    THF 765.35
    2-butanone 534.99
    n-pentanol 316.17
    sec-butanol 325.61
    n-hexane 52.04
    ethylene glycol 403.67
    NMP 787.32
    cyclohexane 116.79
    DMSO 1005.25
    n-butyl acetate 355.99
    n-octanol 226.73
    chloroform 2458.85
    n-propyl acetate 377.71
    acetic acid 807.16
    dichloromethane 3276.61
    cyclohexanone 723.72
    propylene glycol 233.45
    isopropyl acetate 332.14
    DMAc 749.97
    2-ethoxyethanol 760.36
    isopentanol 279.33
    n-heptane 51.85
    ethyl formate 740.24
    1,2-dichloroethane 1499.36
    n-hexanol 270.92
    2-methoxyethanol 1054.07
    isobutyl acetate 205.23
    tetrachloromethane 534.02
    n-pentyl acetate 276.45
    transcutol 770.65
    n-heptanol 171.88
    ethylbenzene 252.3
    MIBK 251.35
    2-propoxyethanol 565.86
    tert-butanol 367.33
    MTBE 282.51
    2-butoxyethanol 346.4
    propionic acid 491.08
    o-xylene 277.63
    formic acid 595.55
    diethyl ether 394.6
    m-xylene 235.74
    p-xylene 357.39
    chlorobenzene 735.93
    dimethyl carbonate 401.9
    n-octane 35.97
    formamide 761.22
    cyclopentanone 740.02
    2-pentanone 409.07
    anisole 511.18
    cyclopentyl methyl ether 360.05
    gamma-butyrolactone 1091.79
    1-methoxy-2-propanol 558.89
    pyridine 957.05
    3-pentanone 394.09
    furfural 1412.1
    n-dodecane 36.4
    diethylene glycol 590.99
    diisopropyl ether 127.85
    tert-amyl alcohol 316.81
    acetylacetone 610.55
    n-hexadecane 41.78
    acetophenone 498.31
    methyl propionate 551.14
    isopentyl acetate 284.32
    trichloroethylene 2635.58
    n-nonanol 190.06
    cyclohexanol 362.46
    benzyl alcohol 513.83
    2-ethylhexanol 182.41
    isooctanol 142.62
    dipropyl ether 195.55
    1,2-dichlorobenzene 730.85
    ethyl lactate 284.85
    propylene carbonate 693.58
    n-methylformamide 938.54
    2-pentanol 215.88
    n-pentane 57.56
    1-propoxy-2-propanol 314.41
    1-methoxy-2-propyl acetate 335.66
    2-(2-methoxypropoxy) propanol 278.34
    mesitylene 181.97
    ε-caprolactone 680.4
    p-cymene 175.05
    epichlorohydrin 1337.92
    1,1,1-trichloroethane 1184.6
    2-aminoethanol 447.88
    morpholine-4-carbaldehyde 1022.7
    sulfolane 1079.1
    2,2,4-trimethylpentane 40.37
    2-methyltetrahydrofuran 490.04
    n-hexyl acetate 391.12
    isooctane 26.9
    2-(2-butoxyethoxy)ethanol 355.03
    sec-butyl acetate 229.08
    tert-butyl acetate 299.21
    decalin 75.7
    glycerin 384.42
    diglyme 852.02
    acrylic acid 571.94
    isopropyl myristate 164.15
    n-butyric acid 551.7
    acetyl acetate 521.55
    di(2-ethylhexyl) phthalate 163.62
    ethyl propionate 404.86
    nitromethane 1411.99
    1,2-diethoxyethane 354.66
    benzonitrile 813.66
    trioctyl phosphate 124.06
    1-bromopropane 536.37
    gamma-valerolactone 1046.02
    n-decanol 141.37
    triethyl phosphate 214.76
    4-methyl-2-pentanol 134.6
    propionitrile 691.61
    vinylene carbonate 882.41
    1,1,2-trichlorotrifluoroethane 961.4
    DMS 402.8
    cumene 196.13
    2-octanol 147.3
    2-hexanone 309.51
    octyl acetate 213.44
    limonene 208.72
    1,2-dimethoxyethane 1049.0
    ethyl orthosilicate 179.4
    tributyl phosphate 148.39
    diacetone alcohol 310.26
    N,N-dimethylaniline 330.54
    acrylonitrile 1033.2
    aniline 446.72
    1,3-propanediol 508.78
    bromobenzene 817.07
    dibromomethane 1700.1
    1,1,2,2-tetrachloroethane 1626.65
    2-methyl-cyclohexyl acetate 243.98
    tetrabutyl urea 186.44
    diisobutyl methanol 115.28
    2-phenylethanol 359.06
    styrene 353.68
    dioctyl adipate 240.41
    dimethyl sulfate 557.32
    ethyl butyrate 352.49
    methyl lactate 329.25
    butyl lactate 203.09
    diethyl carbonate 317.69
    propanediol butyl ether 286.82
    triethyl orthoformate 246.64
    p-tert-butyltoluene 155.29
    methyl 4-tert-butylbenzoate 346.88
    morpholine 755.71
    tert-butylamine 253.97
    n-dodecanol 110.24
    dimethoxymethane 797.42
    ethylene carbonate 694.74
    cyrene 302.56
    2-ethoxyethyl acetate 347.78
    2-ethylhexyl acetate 237.84
    1,2,4-trichlorobenzene 797.53
    4-methylpyridine 860.77
    dibutyl ether 216.33
    2,6-dimethyl-4-heptanol 115.28
    DEF 564.58
    dimethyl isosorbide 443.2
    tetrachloroethylene 1359.97
    eugenol 378.82
    triacetin 396.11
    span 80 216.52
    1,4-butanediol 328.25
    1,1-dichloroethane 1170.28
    2-methyl-1-pentanol 260.38
    methyl formate 964.03
    2-methyl-1-butanol 285.24
    n-decane 53.65
    butyronitrile 618.34
    3,7-dimethyl-1-octanol 184.36
    1-chlorooctane 198.08
    1-chlorotetradecane 87.98
    n-nonane 53.18
    undecane 42.79
    tert-butylcyclohexane 61.09
    cyclooctane 50.82
    cyclopentanol 405.49
    tetrahydropyran 485.94
    tert-amyl methyl ether 237.71
    2,5,8-trioxanonane 493.57
    1-hexene 154.81
    2-isopropoxyethanol 437.28
    2,2,2-trifluoroethanol 446.02
    methyl butyrate 533.15

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction