2,5-Dimethyl-3-propylpyrazine

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  • Identifiers

    CAS number
    18433-97-1

    Molecular formula
    C9H14N2

    SMILES
    CCCC1=NC(=CN=C1C)C

  • Odor profile

    Fragrance
    Nutty 70.41%
    Roasted 64.54%
    Earthy 57.0%
    Hazelnut 53.01%
    Cocoa 52.42%
    Burnt 51.41%
    Musty 49.68%
    Coffee 42.14%
    Chocolate 42.02%
    Potato 40.21%

     

    Flavor
    Nutty 62.93%
    Roasted 58.88%
    Earthy 55.2%
    Potato 50.58%
    Musty 46.87%
    Meaty 46.62%
    Hazelnut 44.96%
    Roast 43.46%
    Cocoa 42.19%
    Coffee 41.74%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    5.01 (weak acid)

    Molecular weight
    150.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    215°C

    Flash point

    • 78.43 ˚C est.

  • Synonyms

    • 2,5-Dimethyl-3-propylpyrazine
    • 18433-97-1
    • Pyrazine, 2,5-dimethyl-3-propyl-
    • 3,6-Dimethyl-2-propylpyrazine
    • 2-Propyl-3,6-dimethylpyrazine
    • 2,5-Dimethyl-3-pyropylpyrazine
    • DTXSID0066375
    • Pyrazine, 2,5-dimethyl-3-propyl- (8CI,9CI)
    • Pyrazine,2,5-dimethyl-3-propyl-
    • DTXCID2035859
    • SCHEMBL10307332
    • 2,5-Dimethyl-3-Propyl Pyrazine
    • CHEBI:192295
    • HS-3538
    • 2,5-DIMETHYL-3-PROPYL-PYRAZINE
    • DB-324388
    • NS00026049
    • 606-025-9

  • Applications

    2,5-Dimethyl-3-propylpyrazine (CAS 18433-97-1) is a pyrazine derivative primarily used as an odorant and flavor/aroma ingredient in commercial formulations. In perfumery, it contributes roasted and nutty notes, adding complexity to fragrance compositions. In flavor applications, it is evaluated or used as a flavor/aroma compound in certain foods and beverages. In cosmetics and personal care, it can serve as a fragrance ingredient in products such as cosmetics and body care items. In household products and cleaning formulations, it is used to impart scent in air fresheners, cleaners, and related products. In industrial manufacturing, it can act as an intermediate in the synthesis of other pyrazine derivatives for research and development. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 323.52
    methanol 331.06
    isopropanol 250.45
    water 1.29
    ethyl acetate 252.96
    n-propanol 307.16
    acetone 335.53
    n-butanol 285.95
    acetonitrile 238.93
    DMF 523.93
    toluene 295.82
    isobutanol 264.68
    1,4-dioxane 478.85
    methyl acetate 264.8
    THF 717.51
    2-butanone 329.3
    n-pentanol 248.38
    sec-butanol 289.76
    n-hexane 117.08
    ethylene glycol 78.58
    NMP 562.31
    cyclohexane 177.27
    DMSO 447.15
    n-butyl acetate 450.72
    n-octanol 231.34
    chloroform 1574.65
    n-propyl acetate 207.02
    acetic acid 264.7
    dichloromethane 1408.92
    cyclohexanone 605.04
    propylene glycol 112.0
    isopropyl acetate 171.5
    DMAc 460.88
    2-ethoxyethanol 222.96
    isopentanol 243.1
    n-heptane 125.08
    ethyl formate 274.41
    1,2-dichloroethane 653.99
    n-hexanol 396.27
    2-methoxyethanol 323.64
    isobutyl acetate 167.0
    tetrachloromethane 345.46
    n-pentyl acetate 254.5
    transcutol 477.91
    n-heptanol 214.33
    ethylbenzene 207.57
    MIBK 184.95
    2-propoxyethanol 358.11
    tert-butanol 261.64
    MTBE 275.4
    2-butoxyethanol 243.04
    propionic acid 252.68
    o-xylene 227.49
    formic acid 82.78
    diethyl ether 269.13
    m-xylene 223.66
    p-xylene 285.04
    chlorobenzene 487.33
    dimethyl carbonate 125.8
    n-octane 61.29
    formamide 92.25
    cyclopentanone 623.27
    2-pentanone 262.82
    anisole 244.9
    cyclopentyl methyl ether 378.29
    gamma-butyrolactone 635.9
    1-methoxy-2-propanol 252.57
    pyridine 528.47
    3-pentanone 245.23
    furfural 629.72
    n-dodecane 56.89
    diethylene glycol 217.43
    diisopropyl ether 109.41
    tert-amyl alcohol 278.79
    acetylacetone 264.07
    n-hexadecane 63.13
    acetophenone 252.39
    methyl propionate 238.05
    isopentyl acetate 357.85
    trichloroethylene 1210.8
    n-nonanol 187.92
    cyclohexanol 310.5
    benzyl alcohol 228.64
    2-ethylhexanol 290.6
    isooctanol 169.76
    dipropyl ether 282.9
    1,2-dichlorobenzene 472.38
    ethyl lactate 127.42
    propylene carbonate 458.36
    n-methylformamide 230.05
    2-pentanol 197.33
    n-pentane 101.63
    1-propoxy-2-propanol 292.98
    1-methoxy-2-propyl acetate 271.88
    2-(2-methoxypropoxy) propanol 213.18
    mesitylene 161.2
    ε-caprolactone 473.86
    p-cymene 209.11
    epichlorohydrin 657.47
    1,1,1-trichloroethane 714.42
    2-aminoethanol 144.92
    morpholine-4-carbaldehyde 467.37
    sulfolane 747.86
    2,2,4-trimethylpentane 70.41
    2-methyltetrahydrofuran 543.71
    n-hexyl acetate 345.56
    isooctane 45.59
    2-(2-butoxyethoxy)ethanol 253.07
    sec-butyl acetate 144.83
    tert-butyl acetate 182.37
    decalin 97.61
    glycerin 133.58
    diglyme 425.98
    acrylic acid 218.33
    isopropyl myristate 158.78
    n-butyric acid 340.65
    acetyl acetate 185.68
    di(2-ethylhexyl) phthalate 164.69
    ethyl propionate 188.98
    nitromethane 308.2
    1,2-diethoxyethane 276.8
    benzonitrile 404.16
    trioctyl phosphate 131.83
    1-bromopropane 497.41
    gamma-valerolactone 615.28
    n-decanol 149.42
    triethyl phosphate 149.16
    4-methyl-2-pentanol 124.3
    propionitrile 278.41
    vinylene carbonate 473.92
    1,1,2-trichlorotrifluoroethane 428.08
    DMS 236.56
    cumene 169.08
    2-octanol 171.13
    2-hexanone 246.0
    octyl acetate 207.17
    limonene 279.03
    1,2-dimethoxyethane 393.67
    ethyl orthosilicate 143.46
    tributyl phosphate 152.73
    diacetone alcohol 185.82
    N,N-dimethylaniline 222.27
    acrylonitrile 318.32
    aniline 272.41
    1,3-propanediol 199.18
    bromobenzene 585.22
    dibromomethane 1027.94
    1,1,2,2-tetrachloroethane 997.51
    2-methyl-cyclohexyl acetate 248.58
    tetrabutyl urea 194.39
    diisobutyl methanol 145.25
    2-phenylethanol 297.48
    styrene 238.15
    dioctyl adipate 215.89
    dimethyl sulfate 199.63
    ethyl butyrate 276.58
    methyl lactate 133.08
    butyl lactate 195.5
    diethyl carbonate 196.97
    propanediol butyl ether 224.92
    triethyl orthoformate 191.62
    p-tert-butyltoluene 184.09
    methyl 4-tert-butylbenzoate 244.21
    morpholine 458.33
    tert-butylamine 215.91
    n-dodecanol 127.76
    dimethoxymethane 319.28
    ethylene carbonate 367.67
    cyrene 212.11
    2-ethoxyethyl acetate 261.04
    2-ethylhexyl acetate 315.6
    1,2,4-trichlorobenzene 505.91
    4-methylpyridine 536.8
    dibutyl ether 274.95
    2,6-dimethyl-4-heptanol 145.25
    DEF 344.37
    dimethyl isosorbide 370.84
    tetrachloroethylene 711.35
    eugenol 235.83
    triacetin 245.7
    span 80 228.94
    1,4-butanediol 119.65
    1,1-dichloroethane 668.81
    2-methyl-1-pentanol 237.65
    methyl formate 230.92
    2-methyl-1-butanol 272.85
    n-decane 80.89
    butyronitrile 350.08
    3,7-dimethyl-1-octanol 203.56
    1-chlorooctane 233.83
    1-chlorotetradecane 111.78
    n-nonane 84.69
    undecane 65.78
    tert-butylcyclohexane 92.35
    cyclooctane 68.28
    cyclopentanol 342.65
    tetrahydropyran 531.82
    tert-amyl methyl ether 243.18
    2,5,8-trioxanonane 313.02
    1-hexene 253.33
    2-isopropoxyethanol 171.86
    2,2,2-trifluoroethanol 99.88
    methyl butyrate 272.22

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction