2,5-Dimethoxytoluene

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    24599-58-4

    Molecular formula
    C9H12O2

    SMILES
    CC1=C(C=CC(=C1)OC)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 65.06%
    Sweet 62.85%
    Earthy 61.21%
    Spicy 57.68%
    Nutty 52.38%
    Smoky 45.43%
    Woody 44.55%
    Vanilla 43.97%
    Anisic 42.8%
    Medicinal 40.88%

     

    Flavor
    Phenolic 44.88%
    Musty 38.6%
    Earthy 37.67%
    Bitter 36.4%
    Spice 35.71%
    Sweet 35.51%
    Smoky 35.07%
    Vanilla 34.43%
    Spicy 34.13%
    Woody 33.78%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.7

    pKa est.
    6.47 (neutral)

    Molecular weight
    152.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    231°C

    Flash point

    • 84.83 ˚C est.

  • Synonyms

    • 2,5-Dimethoxytoluene
    • 24599-58-4
    • 1,4-Dimethoxy-2-methylbenzene
    • Benzene, 1,4-dimethoxy-2-methyl-
    • Toluene, 2,5-dimethoxy-
    • 2-Methylhydroquinone dimethyl ether
    • Methyl hydroquinone dimethyl ester
    • QK260AXY6T
    • EINECS 246-343-1
    • 2-Methyl-1,4-bis(methyloxy)benzene
    • MFCD00041901
    • UNII-QK260AXY6T
    • NSC 149950
    • NSC-149950
    • 2-methyl-1,4-dimethoxybenzene
    • DTXSID5067005
    • Methylhydroquinone, dimethyl ether
    • 1-METHYL-2,5-DIMETHOXYBENZENE
    • 1,4-Di(methoxy-d3)-2-methyl-benzene
    • METHYLHYDROQUINONE DIMETHYL ETHER
    • 2,5-dimethoxy toluene
    • SCHEMBL82486
    • 2,5-Dimethoxytoluene, 99%
    • Benzene,4-dimethoxy-2-methyl-
    • DTXCID5037105
    • NSC149950
    • AKOS015889856
    • AC-25934
    • AS-19103
    • DB-046500
    • CS-0153182
    • D2552
    • NS00027701
    • EN300-123757
    • F11429
    • 246-343-1

  • Applications

    2,5-Dimethoxytoluene (CAS 24599-58-4) is an electron-rich aromatic used mainly as a synthetic intermediate: a convenient building block to access diverse 2,5-dimethoxy–substituted benzene derivatives (e.g., converting the benzylic methyl into aldehydes, acids, or benzyl halides, performing ring halogenation/nitration/sulfonation, Friedel–Crafts reactions, or demethylation to the corresponding dihydroxy motif), enabling applications in pharmaceutical and agrochemical discovery, the preparation of dyes and organic electronic materials, and fragrance manufacture; its activated ring also makes it a common model substrate for assessing oxidation catalysts, electrophilic aromatic substitution and coupling reactions, and a useful protecting/directing unit for regiocontrol in laboratory and scale-up synthesis.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 369.19
    methanol 408.66
    isopropanol 314.33
    water 10.31
    ethyl acetate 776.38
    n-propanol 376.53
    acetone 531.57
    n-butanol 389.16
    acetonitrile 698.37
    DMF 556.53
    toluene 372.29
    isobutanol 312.13
    1,4-dioxane 1686.3
    methyl acetate 693.0
    THF 1244.05
    2-butanone 489.77
    n-pentanol 267.34
    sec-butanol 327.43
    n-hexane 121.05
    ethylene glycol 174.8
    NMP 585.0
    cyclohexane 244.25
    DMSO 523.18
    n-butyl acetate 325.43
    n-octanol 107.31
    chloroform 2205.1
    n-propyl acetate 372.39
    acetic acid 729.85
    dichloromethane 2150.12
    cyclohexanone 724.01
    propylene glycol 121.68
    isopropyl acetate 412.43
    DMAc 506.52
    2-ethoxyethanol 724.34
    isopentanol 344.24
    n-heptane 72.47
    ethyl formate 433.05
    1,2-dichloroethane 1333.49
    n-hexanol 252.52
    2-methoxyethanol 1009.95
    isobutyl acetate 236.56
    tetrachloromethane 625.04
    n-pentyl acetate 189.42
    transcutol 852.16
    n-heptanol 120.64
    ethylbenzene 205.47
    MIBK 282.09
    2-propoxyethanol 516.03
    tert-butanol 587.53
    MTBE 676.78
    2-butoxyethanol 262.68
    propionic acid 444.01
    o-xylene 232.67
    formic acid 329.26
    diethyl ether 946.49
    m-xylene 229.37
    p-xylene 251.77
    chlorobenzene 491.62
    dimethyl carbonate 307.76
    n-octane 31.78
    formamide 501.81
    cyclopentanone 693.98
    2-pentanone 407.96
    anisole 456.95
    cyclopentyl methyl ether 684.83
    gamma-butyrolactone 896.18
    1-methoxy-2-propanol 540.88
    pyridine 822.91
    3-pentanone 436.34
    furfural 847.52
    n-dodecane 23.08
    diethylene glycol 445.84
    diisopropyl ether 260.8
    tert-amyl alcohol 466.8
    acetylacetone 526.77
    n-hexadecane 26.4
    acetophenone 323.38
    methyl propionate 497.68
    isopentyl acetate 305.84
    trichloroethylene 2115.98
    n-nonanol 102.01
    cyclohexanol 442.09
    benzyl alcohol 270.31
    2-ethylhexanol 173.1
    isooctanol 107.33
    dipropyl ether 287.35
    1,2-dichlorobenzene 486.9
    ethyl lactate 164.72
    propylene carbonate 501.46
    n-methylformamide 400.68
    2-pentanol 270.41
    n-pentane 116.95
    1-propoxy-2-propanol 277.79
    1-methoxy-2-propyl acetate 353.73
    2-(2-methoxypropoxy) propanol 223.39
    mesitylene 169.18
    ε-caprolactone 661.7
    p-cymene 119.25
    epichlorohydrin 1284.02
    1,1,1-trichloroethane 1431.3
    2-aminoethanol 255.89
    morpholine-4-carbaldehyde 812.12
    sulfolane 849.72
    2,2,4-trimethylpentane 68.89
    2-methyltetrahydrofuran 970.56
    n-hexyl acetate 250.75
    isooctane 50.26
    2-(2-butoxyethoxy)ethanol 290.35
    sec-butyl acetate 274.03
    tert-butyl acetate 505.28
    decalin 96.23
    glycerin 252.14
    diglyme 707.7
    acrylic acid 444.53
    isopropyl myristate 119.45
    n-butyric acid 536.86
    acetyl acetate 618.63
    di(2-ethylhexyl) phthalate 108.95
    ethyl propionate 380.97
    nitromethane 1185.5
    1,2-diethoxyethane 425.82
    benzonitrile 339.0
    trioctyl phosphate 75.32
    1-bromopropane 646.66
    gamma-valerolactone 937.62
    n-decanol 75.13
    triethyl phosphate 190.07
    4-methyl-2-pentanol 162.89
    propionitrile 515.16
    vinylene carbonate 541.3
    1,1,2-trichlorotrifluoroethane 842.02
    DMS 313.13
    cumene 145.51
    2-octanol 82.96
    2-hexanone 298.5
    octyl acetate 135.17
    limonene 175.57
    1,2-dimethoxyethane 998.65
    ethyl orthosilicate 187.5
    tributyl phosphate 102.6
    diacetone alcohol 362.8
    N,N-dimethylaniline 279.07
    acrylonitrile 590.65
    aniline 411.56
    1,3-propanediol 433.28
    bromobenzene 547.43
    dibromomethane 1291.22
    1,1,2,2-tetrachloroethane 1566.44
    2-methyl-cyclohexyl acetate 248.34
    tetrabutyl urea 117.18
    diisobutyl methanol 118.16
    2-phenylethanol 235.6
    styrene 273.26
    dioctyl adipate 170.86
    dimethyl sulfate 395.48
    ethyl butyrate 290.31
    methyl lactate 210.34
    butyl lactate 120.03
    diethyl carbonate 242.98
    propanediol butyl ether 146.21
    triethyl orthoformate 230.03
    p-tert-butyltoluene 123.53
    methyl 4-tert-butylbenzoate 257.04
    morpholine 1359.8
    tert-butylamine 393.94
    n-dodecanol 61.8
    dimethoxymethane 704.28
    ethylene carbonate 496.39
    cyrene 286.0
    2-ethoxyethyl acetate 294.79
    2-ethylhexyl acetate 261.03
    1,2,4-trichlorobenzene 576.22
    4-methylpyridine 619.41
    dibutyl ether 194.73
    2,6-dimethyl-4-heptanol 118.16
    DEF 522.17
    dimethyl isosorbide 451.84
    tetrachloroethylene 1246.05
    eugenol 226.61
    triacetin 263.71
    span 80 169.71
    1,4-butanediol 161.29
    1,1-dichloroethane 1113.44
    2-methyl-1-pentanol 261.11
    methyl formate 373.84
    2-methyl-1-butanol 338.88
    n-decane 37.93
    butyronitrile 443.47
    3,7-dimethyl-1-octanol 117.96
    1-chlorooctane 120.6
    1-chlorotetradecane 55.84
    n-nonane 37.78
    undecane 28.49
    tert-butylcyclohexane 85.04
    cyclooctane 90.35
    cyclopentanol 414.1
    tetrahydropyran 1127.77
    tert-amyl methyl ether 495.45
    2,5,8-trioxanonane 446.17
    1-hexene 235.01
    2-isopropoxyethanol 446.46
    2,2,2-trifluoroethanol 434.13
    methyl butyrate 413.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Cascarilla 2 8007-06-5 Croton eluteria Bennett, fam. Euphorbiaceae 0.01%