2,5-Dimethoxythiophenol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    1483-27-8

    Molecular formula
    C8H10O2S

    SMILES
    COC1=CC(=C(C=C1)OC)S

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 68.52%
    Phenolic 66.38%
    Smoky 60.27%
    Spicy 58.58%
    Vanilla 57.99%
    Meaty 56.86%
    Roasted 47.73%
    Burnt 45.77%
    Woody 37.39%
    Sulfurous 37.17%

     

    Flavor
    Phenolic 52.09%
    Sweet 48.42%
    Smoky 46.45%
    Spicy 42.93%
    Vanilla 41.74%
    Spice 40.67%
    Bitter 37.01%
    Woody 35.91%
    Bacon 35.47%
    Powdery 34.42%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    5.88 (weak acid)

    Molecular weight
    170.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    288°C

    Flash point

    • 100.68 ˚C est.

  • Synonyms

    • 2,5-Dimethoxythiophenol
    • 1483-27-8
    • DTXSID30333873
    • RefChem:82923
    • DTXCID40284963
    • 626-652-1
    • SESUUAOAUZDHHP-UHFFFAOYSA-N
    • 2,5-Dimethoxybenzenethiol
    • Benzenethiol, 2,5-dimethoxy-
    • 2,5-dimethoxybenzene-1-thiol
    • MFCD00052738
    • 2,5-Dimethoxybenzenethiol;
    • 3,6-dimethoxybenzenethiol
    • 2,5-Dimethoxybenzenethiol #
    • SCHEMBL440122
    • SCHEMBL1402441
    • 2,5-Dimethoxythiophenol, 98%
    • SCHEMBL29758335
    • SBB058944
    • AKOS009158941
    • CS-W017697
    • PS-5213
    • AC-11320
    • SY101154
    • DB-020111
    • ST50824977
    • E77003
    • EN300-104983
    • F791482
    • 1483-27-8

  • Applications

    2,5-Dimethoxythiophenol (CAS 1483-27-8) is used as a building block in the synthesis of thiophene-containing compounds for organic electronics and conductive polymers. It also serves as a precursor for dyes, pigments, and coating/ink formulations based on thiophene chemistry. Given the thiol group, it can function as an odorant precursor or fragrance intermediate in perfumery and related applications. It is commonly used as an intermediate in the synthesis of pharmaceutical and agrochemical compounds. In research and development, it is employed as a precursor for functional thiophene-based materials such as organic semiconductors and chemical sensors.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 84.03
    methanol 112.83
    isopropanol 60.69
    water 6.83
    ethyl acetate 192.89
    n-propanol 70.56
    acetone 226.05
    n-butanol 63.77
    acetonitrile 217.78
    DMF 286.64
    toluene 69.5
    isobutanol 52.55
    1,4-dioxane 473.04
    methyl acetate 232.93
    THF 413.95
    2-butanone 160.33
    n-pentanol 52.56
    sec-butanol 57.56
    n-hexane 11.55
    ethylene glycol 91.28
    NMP 332.28
    cyclohexane 25.37
    DMSO 302.16
    n-butyl acetate 89.65
    n-octanol 30.18
    chloroform 483.21
    n-propyl acetate 112.92
    acetic acid 271.07
    dichloromethane 494.83
    cyclohexanone 213.09
    propylene glycol 45.82
    isopropyl acetate 107.21
    DMAc 296.02
    2-ethoxyethanol 211.0
    isopentanol 61.48
    n-heptane 12.84
    ethyl formate 134.88
    1,2-dichloroethane 299.58
    n-hexanol 51.04
    2-methoxyethanol 334.83
    isobutyl acetate 75.25
    tetrachloromethane 109.6
    n-pentyl acetate 55.13
    transcutol 305.29
    n-heptanol 31.68
    ethylbenzene 42.72
    MIBK 74.45
    2-propoxyethanol 152.16
    tert-butanol 115.58
    MTBE 133.63
    2-butoxyethanol 86.68
    propionic acid 117.13
    o-xylene 57.52
    formic acid 166.32
    diethyl ether 156.01
    m-xylene 50.18
    p-xylene 56.08
    chlorobenzene 120.42
    dimethyl carbonate 123.31
    n-octane 6.06
    formamide 258.8
    cyclopentanone 286.91
    2-pentanone 112.98
    anisole 134.94
    cyclopentyl methyl ether 165.4
    gamma-butyrolactone 365.61
    1-methoxy-2-propanol 161.74
    pyridine 215.69
    3-pentanone 119.19
    furfural 373.43
    n-dodecane 5.78
    diethylene glycol 188.95
    diisopropyl ether 48.79
    tert-amyl alcohol 91.9
    acetylacetone 206.37
    n-hexadecane 6.57
    acetophenone 123.59
    methyl propionate 153.07
    isopentyl acetate 84.44
    trichloroethylene 563.96
    n-nonanol 31.36
    cyclohexanol 85.7
    benzyl alcohol 87.29
    2-ethylhexanol 42.32
    isooctanol 30.35
    dipropyl ether 67.52
    1,2-dichlorobenzene 129.25
    ethyl lactate 65.61
    propylene carbonate 187.25
    n-methylformamide 175.02
    2-pentanol 45.72
    n-pentane 12.39
    1-propoxy-2-propanol 84.02
    1-methoxy-2-propyl acetate 119.47
    2-(2-methoxypropoxy) propanol 93.0
    mesitylene 36.92
    ε-caprolactone 200.3
    p-cymene 34.64
    epichlorohydrin 432.31
    1,1,1-trichloroethane 309.45
    2-aminoethanol 89.07
    morpholine-4-carbaldehyde 392.44
    sulfolane 365.47
    2,2,4-trimethylpentane 10.53
    2-methyltetrahydrofuran 272.03
    n-hexyl acetate 72.64
    isooctane 6.95
    2-(2-butoxyethoxy)ethanol 113.32
    sec-butyl acetate 83.03
    tert-butyl acetate 130.11
    decalin 16.48
    glycerin 122.21
    diglyme 277.02
    acrylic acid 147.66
    isopropyl myristate 40.02
    n-butyric acid 120.39
    acetyl acetate 193.24
    di(2-ethylhexyl) phthalate 40.97
    ethyl propionate 111.69
    nitromethane 535.12
    1,2-diethoxyethane 118.48
    benzonitrile 107.19
    trioctyl phosphate 28.71
    1-bromopropane 111.42
    gamma-valerolactone 384.64
    n-decanol 25.12
    triethyl phosphate 65.93
    4-methyl-2-pentanol 33.1
    propionitrile 115.93
    vinylene carbonate 196.34
    1,1,2-trichlorotrifluoroethane 323.71
    DMS 119.18
    cumene 35.06
    2-octanol 22.37
    2-hexanone 89.27
    octyl acetate 45.84
    limonene 46.29
    1,2-dimethoxyethane 314.38
    ethyl orthosilicate 62.65
    tributyl phosphate 38.09
    diacetone alcohol 114.27
    N,N-dimethylaniline 88.2
    acrylonitrile 161.72
    aniline 102.07
    1,3-propanediol 120.51
    bromobenzene 118.63
    dibromomethane 264.93
    1,1,2,2-tetrachloroethane 385.46
    2-methyl-cyclohexyl acetate 81.31
    tetrabutyl urea 47.65
    diisobutyl methanol 31.96
    2-phenylethanol 78.96
    styrene 56.97
    dioctyl adipate 62.83
    dimethyl sulfate 198.52
    ethyl butyrate 91.26
    methyl lactate 88.98
    butyl lactate 42.44
    diethyl carbonate 83.25
    propanediol butyl ether 56.67
    triethyl orthoformate 73.69
    p-tert-butyltoluene 34.85
    methyl 4-tert-butylbenzoate 94.12
    morpholine 371.43
    tert-butylamine 69.64
    n-dodecanol 21.58
    dimethoxymethane 252.3
    ethylene carbonate 163.71
    cyrene 139.64
    2-ethoxyethyl acetate 102.96
    2-ethylhexyl acetate 73.71
    1,2,4-trichlorobenzene 164.0
    4-methylpyridine 166.84
    dibutyl ether 50.38
    2,6-dimethyl-4-heptanol 31.96
    DEF 160.37
    dimethyl isosorbide 188.9
    tetrachloroethylene 284.88
    eugenol 91.36
    triacetin 111.19
    span 80 65.96
    1,4-butanediol 53.97
    1,1-dichloroethane 226.0
    2-methyl-1-pentanol 54.88
    methyl formate 173.38
    2-methyl-1-butanol 58.91
    n-decane 8.65
    butyronitrile 93.1
    3,7-dimethyl-1-octanol 33.63
    1-chlorooctane 30.46
    1-chlorotetradecane 16.31
    n-nonane 7.97
    undecane 6.82
    tert-butylcyclohexane 13.76
    cyclooctane 9.94
    cyclopentanol 101.53
    tetrahydropyran 238.17
    tert-amyl methyl ether 102.33
    2,5,8-trioxanonane 192.74
    1-hexene 33.19
    2-isopropoxyethanol 131.56
    2,2,2-trifluoroethanol 181.02
    methyl butyrate 123.66

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction