2,5-Dimethoxytetrahydrofuran

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  • Identifiers

    CAS number
    696-59-3

    Molecular formula
    C6H12O3

    SMILES
    COC1CCC(O1)OC

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Ethereal 67.39%
    Alcoholic 39.24%
    Fruity 37.37%
    Sweet 33.58%
    Fermented 29.61%
    Fresh 27.6%
    Green 27.01%
    Sharp 25.86%
    Solvent 25.55%
    Pungent 24.82%

     

    Flavor
    Sweet 56.31%
    Green 47.09%
    Vegetable 39.52%
    Bitter 35.56%
    Earthy 35.2%
    Musty 30.8%
    Nutty 30.74%
    Fatty 25.52%
    Caramel 25.34%
    Fruit 24.61%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    6.74 (neutral)

    Molecular weight
    132.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    163°C

    Flash point

    • 45.75 ˚C est.

  • Synonyms

    • 2,5-Dimethoxytetrahydrofuran
    • 696-59-3
    • Tetrahydro-2,5-dimethoxyfuran
    • 2,5-dimethoxyoxolane
    • Furan, tetrahydro-2,5-dimethoxy-
    • Dimethoxytetrahydrofuran
    • Protectol DMT
    • 2.5-dimethoxytetrahydrofuran
    • MFCD00005359
    • 2,5-Dimethoxytetrahydrofuran,c&t
    • NSC 7911
    • EINECS 211-797-1
    • 2,5-dimethoxy-tetrahydrofuran
    • AI3-61757
    • DTXSID10862378
    • EC 211-797-1
    • NSC-7911
    • cis,trans-2,5-Dimethoxytetrahydrofuran
    • 2,5-Bis(methyloxy)tetrahydrofuran; 2,5-Dimethoxytetrahydrofuran; Dimethoxytetrahydrofuran; NSC 7911
    • 2,5-dimethoxytetrahydrofurane
    • 2,5 dimethoxy tetrahydrofuran
    • 2,5-dimethoxy tetrahydrofuran
    • Dimethoxytetrahydrofuran (VAN)
    • Furan,5-dimethoxy-
    • DMTHF
    • 2,5-dimethoxytetrahyrofuran
    • 2,5 dimethoxytetrahydrofuran
    • J9CNJ39HZ2
    • SCHEMBL58448
    • 2.5-dimethoxytetrahydrofurane
    • 2,5-dimethoxytetra-hydrofuran
    • 2,5-dimethoxy-tetrahydrofurane
    • 2,5-dimethoxy tetrahydro furan
    • 2,5-dimethoxy-tetrahydro-furan
    • DTXCID60811154
    • NSC7911
    • 2,5-bis(methyloxy)tetrahydrofuran
    • STL194266
    • AKOS000119966
    • CS-W020517
    • FD00819
    • AC-15670
    • AS-11451
    • 2,5-Dimethoxytetrahydrofuran, cis + trans
    • D0986
    • NS00004785
    • EN300-19750
    • D77900
    • 2,5-Dimethoxytetrahydrofuran (cis- and trans- mixture)
    • F0001-1807
    • 2,5-Dimethoxytetrahydrofuran, mixture of (cis) and trans

  • Applications

    2,5-Dimethoxytetrahydrofuran (CAS 696-59-3) is considered a chemical intermediate in organic synthesis and a masked carbonyl form, commonly used as a protecting acetal in carbohydrate and aldehyde chemistry. It can also function as a solvent or co-solvent in specialized syntheses and serves as a building block for acetal derivatives used in polymers, coatings, and adhesives. The compound is evaluated as a precursor in fragrance and flavor chemistry as well as an intermediate in pharmaceutical synthesis, reflecting its utility in fine chemical production. Its use is subject to formulation requirements and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3402.57
    methanol 5111.62
    isopropanol 2138.27
    water 228.55
    ethyl acetate 1076.22
    n-propanol 2007.35
    acetone 1182.72
    n-butanol 1757.58
    acetonitrile 2469.29
    DMF 1705.27
    toluene 689.5
    isobutanol 1254.62
    1,4-dioxane 2061.23
    methyl acetate 1109.25
    THF 2143.93
    2-butanone 846.76
    n-pentanol 988.21
    sec-butanol 1565.4
    n-hexane 173.24
    ethylene glycol 1091.59
    NMP 1112.42
    cyclohexane 488.53
    DMSO 1469.89
    n-butyl acetate 432.66
    n-octanol 345.31
    chloroform 6650.16
    n-propyl acetate 521.03
    acetic acid 4461.31
    dichloromethane 5509.03
    cyclohexanone 1051.59
    propylene glycol 900.02
    isopropyl acetate 482.39
    DMAc 1229.48
    2-ethoxyethanol 1588.62
    isopentanol 1020.02
    n-heptane 165.13
    ethyl formate 1280.81
    1,2-dichloroethane 1680.64
    n-hexanol 705.26
    2-methoxyethanol 2972.64
    isobutyl acetate 275.9
    tetrachloromethane 1467.59
    n-pentyl acetate 282.17
    transcutol 1021.83
    n-heptanol 356.64
    ethylbenzene 257.77
    MIBK 317.93
    2-propoxyethanol 1096.97
    tert-butanol 1676.78
    MTBE 897.57
    2-butoxyethanol 612.05
    propionic acid 1658.24
    o-xylene 345.55
    formic acid 3035.72
    diethyl ether 1187.52
    m-xylene 325.52
    p-xylene 380.29
    chlorobenzene 794.46
    dimethyl carbonate 307.97
    n-octane 61.1
    formamide 2840.41
    cyclopentanone 1043.14
    2-pentanone 646.65
    anisole 482.3
    cyclopentyl methyl ether 875.62
    gamma-butyrolactone 1463.24
    1-methoxy-2-propanol 1460.01
    pyridine 2077.65
    3-pentanone 480.94
    furfural 1586.13
    n-dodecane 45.08
    diethylene glycol 926.16
    diisopropyl ether 232.96
    tert-amyl alcohol 1233.39
    acetylacetone 497.35
    n-hexadecane 49.64
    acetophenone 373.6
    methyl propionate 708.59
    isopentyl acetate 304.62
    trichloroethylene 3298.22
    n-nonanol 294.49
    cyclohexanol 1289.87
    benzyl alcohol 620.5
    2-ethylhexanol 359.52
    isooctanol 255.85
    dipropyl ether 463.41
    1,2-dichlorobenzene 575.8
    ethyl lactate 284.19
    propylene carbonate 786.84
    n-methylformamide 1869.69
    2-pentanol 869.9
    n-pentane 279.71
    1-propoxy-2-propanol 629.64
    1-methoxy-2-propyl acetate 309.83
    2-(2-methoxypropoxy) propanol 308.21
    mesitylene 189.78
    ε-caprolactone 965.44
    p-cymene 165.05
    epichlorohydrin 1766.62
    1,1,1-trichloroethane 1958.04
    2-aminoethanol 1754.25
    morpholine-4-carbaldehyde 1372.43
    sulfolane 1036.55
    2,2,4-trimethylpentane 99.23
    2-methyltetrahydrofuran 1715.81
    n-hexyl acetate 347.19
    isooctane 55.73
    2-(2-butoxyethoxy)ethanol 437.92
    sec-butyl acetate 310.96
    tert-butyl acetate 344.73
    decalin 113.82
    glycerin 1160.0
    diglyme 934.57
    acrylic acid 1535.7
    isopropyl myristate 137.84
    n-butyric acid 1960.59
    acetyl acetate 702.96
    di(2-ethylhexyl) phthalate 145.74
    ethyl propionate 456.75
    nitromethane 3095.91
    1,2-diethoxyethane 473.61
    benzonitrile 819.48
    trioctyl phosphate 106.89
    1-bromopropane 1329.47
    gamma-valerolactone 1421.3
    n-decanol 196.4
    triethyl phosphate 186.54
    4-methyl-2-pentanol 370.78
    propionitrile 1506.02
    vinylene carbonate 881.41
    1,1,2-trichlorotrifluoroethane 1795.38
    DMS 217.46
    cumene 163.14
    2-octanol 224.13
    2-hexanone 431.94
    octyl acetate 191.27
    limonene 252.94
    1,2-dimethoxyethane 1805.79
    ethyl orthosilicate 198.15
    tributyl phosphate 120.06
    diacetone alcohol 447.31
    N,N-dimethylaniline 323.17
    acrylonitrile 1787.07
    aniline 1066.1
    1,3-propanediol 2134.28
    bromobenzene 796.95
    dibromomethane 3308.43
    1,1,2,2-tetrachloroethane 2306.86
    2-methyl-cyclohexyl acetate 240.09
    tetrabutyl urea 155.95
    diisobutyl methanol 186.8
    2-phenylethanol 441.07
    styrene 357.67
    dioctyl adipate 200.92
    dimethyl sulfate 360.28
    ethyl butyrate 405.61
    methyl lactate 395.28
    butyl lactate 203.06
    diethyl carbonate 278.19
    propanediol butyl ether 371.01
    triethyl orthoformate 305.64
    p-tert-butyltoluene 158.41
    methyl 4-tert-butylbenzoate 285.23
    morpholine 2652.81
    tert-butylamine 1250.99
    n-dodecanol 147.77
    dimethoxymethane 1053.64
    ethylene carbonate 734.21
    cyrene 317.24
    2-ethoxyethyl acetate 307.18
    2-ethylhexyl acetate 241.04
    1,2,4-trichlorobenzene 714.34
    4-methylpyridine 1478.02
    dibutyl ether 310.01
    2,6-dimethyl-4-heptanol 186.8
    DEF 931.75
    dimethyl isosorbide 417.79
    tetrachloroethylene 1907.98
    eugenol 307.74
    triacetin 303.5
    span 80 293.93
    1,4-butanediol 783.63
    1,1-dichloroethane 2273.98
    2-methyl-1-pentanol 632.88
    methyl formate 1209.51
    2-methyl-1-butanol 1045.24
    n-decane 78.19
    butyronitrile 1686.77
    3,7-dimethyl-1-octanol 277.94
    1-chlorooctane 212.51
    1-chlorotetradecane 88.94
    n-nonane 80.03
    undecane 55.81
    tert-butylcyclohexane 94.61
    cyclooctane 130.67
    cyclopentanol 1423.3
    tetrahydropyran 1891.56
    tert-amyl methyl ether 609.5
    2,5,8-trioxanonane 561.97
    1-hexene 479.88
    2-isopropoxyethanol 807.31
    2,2,2-trifluoroethanol 1517.33
    methyl butyrate 652.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction