2,5-Dimethoxybenzyl alcohol

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  • Identifiers

    CAS number
    33524-31-1

    Molecular formula
    C9H12O3

    SMILES
    COC1=CC(=C(C=C1)OC)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 80.68%
    Vanilla 74.1%
    Floral 51.24%
    Anisic 49.92%
    Fruity 46.09%
    Phenolic 45.32%
    Aromatic 45.18%
    Spicy 41.65%
    Balsamic 41.38%
    Powdery 41.2%

     

    Flavor
    Sweet 63.21%
    Vanilla 51.58%
    Bitter 49.2%
    Powdery 42.3%
    Floral 38.19%
    Creamy 36.67%
    Woody 35.97%
    Phenolic 35.63%
    Flower 35.44%
    Smoky 34.05%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    7.14 (neutral)

    Molecular weight
    168.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    294°C

    Flash point

    • 128.89 ˚C est.

  • Synonyms

    • 2,5-Dimethoxybenzyl alcohol
    • 33524-31-1
    • EINECS 251-562-0
    • DTXSID80187166
    • RefChem:444468
    • DTXCID90109657
    • 251-562-0
    • (2,5-Dimethoxyphenyl)methanol
    • MFCD00004615
    • Benzenemethanol, 2,5-dimethoxy-
    • (2,5-Dimethoxyphenyl)methanol; 1-(Hydroxymethyl)-2,5-dimethoxybenzene; 2,5-Dimethoxybenzenemethanol;
    • 2,5-dimethoxylbenzylalcohol
    • SCHEMBL487942
    • SCHEMBL487944
    • SCHEMBL6631188
    • (2,5-dimethoxyphenyl)-methanol
    • CHEMBL3415519
    • WGQMUABRZGUAOS-UHFFFAOYSA-
    • (2,5-Dimethoxyphenyl)methanol #
    • (2,5-dimethoxyphenyl)methan-1-ol
    • 2,5-Dimethoxybenzyl alcohol, 99%
    • AKOS000121223
    • CS-W017805
    • FD70220
    • 1-(Hydroxymethyl)-2,5-dimethoxybenzene
    • BS-42237
    • SY283768
    • NS00029503
    • ST50406652
    • EN300-21707
    • D94697
    • F240767
    • Z104509944
    • InChI=1/C9H12O3/c1-11-8-3-4-9(12-2)7(5-8)6-10/h3-5,10H,6H2,1-2H3
    • 33524-31-1

  • Applications

    2,5-Dimethoxybenzyl alcohol (CAS 33524-31-1) may serve as a synthetic intermediate in specialty chemicals, with typical applications including as a precursor for fragrance and aroma compounds in the perfumery and flavor sectors; as a building block in cosmetics and personal care formulations; as a precursor in household cleaning products; as a synthetic intermediate for pharmaceutical manufacturing; as a general building block in industrial manufacturing for specialty resins, dyes and related materials; and as an intermediate or additive in coatings and inks formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 109.58
    methanol 147.46
    isopropanol 79.74
    water 5.9
    ethyl acetate 160.93
    n-propanol 98.38
    acetone 134.51
    n-butanol 78.04
    acetonitrile 151.39
    DMF 235.24
    toluene 46.56
    isobutanol 65.42
    1,4-dioxane 423.0
    methyl acetate 170.04
    THF 354.64
    2-butanone 107.49
    n-pentanol 53.4
    sec-butanol 62.16
    n-hexane 5.37
    ethylene glycol 128.34
    NMP 196.58
    cyclohexane 16.94
    DMSO 337.72
    n-butyl acetate 63.97
    n-octanol 29.41
    chloroform 353.01
    n-propyl acetate 81.15
    acetic acid 252.37
    dichloromethane 398.9
    cyclohexanone 157.31
    propylene glycol 61.33
    isopropyl acetate 79.84
    DMAc 199.07
    2-ethoxyethanol 201.04
    isopentanol 66.78
    n-heptane 9.27
    ethyl formate 123.0
    1,2-dichloroethane 268.81
    n-hexanol 54.15
    2-methoxyethanol 348.7
    isobutyl acetate 51.22
    tetrachloromethane 77.94
    n-pentyl acetate 39.26
    transcutol 217.2
    n-heptanol 31.62
    ethylbenzene 32.38
    MIBK 58.49
    2-propoxyethanol 132.13
    tert-butanol 168.3
    MTBE 109.88
    2-butoxyethanol 75.28
    propionic acid 123.41
    o-xylene 43.21
    formic acid 158.43
    diethyl ether 116.36
    m-xylene 38.68
    p-xylene 40.63
    chlorobenzene 84.18
    dimethyl carbonate 93.92
    n-octane 4.67
    formamide 237.54
    cyclopentanone 201.86
    2-pentanone 78.46
    anisole 99.95
    cyclopentyl methyl ether 121.87
    gamma-butyrolactone 301.97
    1-methoxy-2-propanol 156.6
    pyridine 168.88
    3-pentanone 83.17
    furfural 275.6
    n-dodecane 4.56
    diethylene glycol 182.36
    diisopropyl ether 32.74
    tert-amyl alcohol 98.99
    acetylacetone 137.24
    n-hexadecane 5.14
    acetophenone 85.74
    methyl propionate 122.02
    isopentyl acetate 60.59
    trichloroethylene 416.93
    n-nonanol 29.22
    cyclohexanol 87.61
    benzyl alcohol 74.89
    2-ethylhexanol 38.94
    isooctanol 28.55
    dipropyl ether 54.99
    1,2-dichlorobenzene 94.62
    ethyl lactate 56.14
    propylene carbonate 148.33
    n-methylformamide 160.32
    2-pentanol 45.91
    n-pentane 6.83
    1-propoxy-2-propanol 73.88
    1-methoxy-2-propyl acetate 83.72
    2-(2-methoxypropoxy) propanol 73.01
    mesitylene 29.7
    ε-caprolactone 150.97
    p-cymene 26.78
    epichlorohydrin 353.18
    1,1,1-trichloroethane 246.11
    2-aminoethanol 124.25
    morpholine-4-carbaldehyde 263.93
    sulfolane 305.43
    2,2,4-trimethylpentane 7.41
    2-methyltetrahydrofuran 195.69
    n-hexyl acetate 51.86
    isooctane 5.31
    2-(2-butoxyethoxy)ethanol 88.91
    sec-butyl acetate 55.68
    tert-butyl acetate 96.73
    decalin 11.44
    glycerin 146.58
    diglyme 204.1
    acrylic acid 141.25
    isopropyl myristate 29.86
    n-butyric acid 133.36
    acetyl acetate 140.42
    di(2-ethylhexyl) phthalate 31.56
    ethyl propionate 81.52
    nitromethane 411.77
    1,2-diethoxyethane 79.19
    benzonitrile 79.03
    trioctyl phosphate 24.29
    1-bromopropane 95.14
    gamma-valerolactone 262.71
    n-decanol 23.71
    triethyl phosphate 53.44
    4-methyl-2-pentanol 32.58
    propionitrile 112.91
    vinylene carbonate 162.07
    1,1,2-trichlorotrifluoroethane 270.07
    DMS 74.88
    cumene 27.38
    2-octanol 20.77
    2-hexanone 60.65
    octyl acetate 35.03
    limonene 37.4
    1,2-dimethoxyethane 250.8
    ethyl orthosilicate 49.96
    tributyl phosphate 28.71
    diacetone alcohol 100.73
    N,N-dimethylaniline 67.48
    acrylonitrile 151.12
    aniline 87.68
    1,3-propanediol 165.88
    bromobenzene 81.36
    dibromomethane 226.17
    1,1,2,2-tetrachloroethane 297.36
    2-methyl-cyclohexyl acetate 61.69
    tetrabutyl urea 38.16
    diisobutyl methanol 28.8
    2-phenylethanol 64.92
    styrene 39.0
    dioctyl adipate 47.42
    dimethyl sulfate 146.58
    ethyl butyrate 69.96
    methyl lactate 82.46
    butyl lactate 33.89
    diethyl carbonate 64.3
    propanediol butyl ether 49.96
    triethyl orthoformate 57.43
    p-tert-butyltoluene 27.34
    methyl 4-tert-butylbenzoate 75.84
    morpholine 376.36
    tert-butylamine 84.96
    n-dodecanol 19.92
    dimethoxymethane 205.88
    ethylene carbonate 141.93
    cyrene 106.92
    2-ethoxyethyl acetate 66.31
    2-ethylhexyl acetate 49.74
    1,2,4-trichlorobenzene 114.43
    4-methylpyridine 109.87
    dibutyl ether 35.57
    2,6-dimethyl-4-heptanol 28.8
    DEF 114.44
    dimethyl isosorbide 141.6
    tetrachloroethylene 217.89
    eugenol 72.7
    triacetin 76.31
    span 80 55.39
    1,4-butanediol 58.54
    1,1-dichloroethane 194.75
    2-methyl-1-pentanol 48.58
    methyl formate 154.61
    2-methyl-1-butanol 61.02
    n-decane 6.82
    butyronitrile 84.28
    3,7-dimethyl-1-octanol 30.9
    1-chlorooctane 25.09
    1-chlorotetradecane 12.66
    n-nonane 6.21
    undecane 5.38
    tert-butylcyclohexane 10.14
    cyclooctane 6.89
    cyclopentanol 106.77
    tetrahydropyran 220.92
    tert-amyl methyl ether 77.71
    2,5,8-trioxanonane 142.98
    1-hexene 19.09
    2-isopropoxyethanol 110.9
    2,2,2-trifluoroethanol 149.01
    methyl butyrate 94.64

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction