2,5-Dihydrofuran

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  • Identifiers

    CAS number
    1708-29-8

    Molecular formula
    C4H6O

    SMILES
    C1C=CCO1

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 70.54%
    Ethereal 38.5%
    Fruity 34.09%
    Pungent 33.97%
    Solvent 29.36%
    Spicy 28.42%
    Nutty 27.66%
    Burnt 27.33%
    Aromatic 26.65%
    Almond 25.92%

     

    Flavor
    Amine 24.82%
    Shrimp 24.09%
    Ammoniacal 23.34%
    Alkaline 21.88%
    Animal 21.73%
    Bitter 21.36%
    Cauliflower 20.96%
    Clam 20.56%
    Others 19.18%
    Cereal 18.82%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.5

    pKa est.
    6.37 (neutral)

    Molecular weight
    70.09 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    62°C

    Flash point

    • -13.77 ˚C est.

  • Synonyms

    • 2,5-DIHYDROFURAN
    • 1708-29-8
    • Furan, 2,5-dihydro-
    • HD0TIE091T
    • NSC-60532
    • DTXSID5051785
    • RefChem:82859
    • DTXCID8030340
    • 216-957-4
    • 3-Oxolene
    • 1-Oxa-3-cyclopentene
    • MFCD00003219
    • 2,5-Dihydro-furan
    • 2,5-Dihydrofuran; NSC 60532
    • EINECS 216-957-4
    • NSC 60532
    • Furan,5-dihydro-
    • NSC60532
    • UNII-HD0TIE091T
    • EC 216-957-4
    • 2,5-Dihydrofuran, 97%
    • SCHEMBL19341
    • SCHEMBL59324
    • SCHEMBL155148
    • CHEMBL117135
    • orb3029528
    • SCHEMBL1762395
    • SCHEMBL3918390
    • SCHEMBL5069925
    • SCHEMBL5069926
    • SCHEMBL15067980
    • SCHEMBL16797711
    • SCHEMBL20979832
    • AKOS009156845
    • GS-6750
    • DB-015919
    • CS-0198111
    • D0551
    • NS00004933
    • EN300-36329
    • F11214
    • A811245
    • F500282
    • Q2813802
    • F0001-0622
    • InChI=1/C4H6O/c1-2-4-5-3-1/h1-2H,3-4H
    • 1708-29-8

  • Applications

    2,5-Dihydrofuran (CAS 1708-29-8) is primarily used as an organic-chemical intermediate and building block, enabling access to heterocyclic compounds and saturated furan derivatives. It can function as a reactive solvent or co-solvent in industrial manufacturing, supporting various synthesis and processing steps. In polymer and resin chemistry, it serves as a precursor for cyclic ether containing monomers and derivatives, contributing to specialty polymers and coatings formulations after functionalization. It also finds use as a starting material for the preparation of reactive intermediates that feed into adhesives and other resin systems, and it can be transformed into downstream derivatives for chemical processing routes.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 527.69
    methanol 504.35
    isopropanol 386.68
    water 25.87
    ethyl acetate 158.94
    n-propanol 379.01
    acetone 310.05
    n-butanol 280.62
    acetonitrile 284.18
    DMF 479.23
    toluene 66.46
    isobutanol 231.1
    1,4-dioxane 298.55
    methyl acetate 219.63
    THF 388.45
    2-butanone 225.24
    n-pentanol 167.09
    sec-butanol 285.04
    n-hexane 43.9
    ethylene glycol 314.55
    NMP 343.45
    cyclohexane 61.56
    DMSO 389.22
    n-butyl acetate 110.86
    n-octanol 93.08
    chloroform 530.94
    n-propyl acetate 92.28
    acetic acid 759.66
    dichloromethane 369.02
    cyclohexanone 172.84
    propylene glycol 377.5
    isopropyl acetate 81.33
    DMAc 356.83
    2-ethoxyethanol 280.48
    isopentanol 165.61
    n-heptane 56.5
    ethyl formate 106.42
    1,2-dichloroethane 187.94
    n-hexanol 186.5
    2-methoxyethanol 475.07
    isobutyl acetate 56.25
    tetrachloromethane 113.08
    n-pentyl acetate 59.2
    transcutol 533.41
    n-heptanol 87.46
    ethylbenzene 36.32
    MIBK 74.65
    2-propoxyethanol 299.37
    tert-butanol 308.0
    MTBE 159.04
    2-butoxyethanol 169.67
    propionic acid 371.81
    o-xylene 54.55
    formic acid 313.01
    diethyl ether 205.99
    m-xylene 47.34
    p-xylene 45.85
    chlorobenzene 83.6
    dimethyl carbonate 80.74
    n-octane 15.87
    formamide 302.36
    cyclopentanone 255.91
    2-pentanone 146.49
    anisole 95.11
    cyclopentyl methyl ether 175.75
    gamma-butyrolactone 262.35
    1-methoxy-2-propanol 342.84
    pyridine 243.26
    3-pentanone 137.79
    furfural 225.83
    n-dodecane 12.81
    diethylene glycol 306.07
    diisopropyl ether 51.81
    tert-amyl alcohol 227.97
    acetylacetone 125.47
    n-hexadecane 13.28
    acetophenone 81.74
    methyl propionate 161.11
    isopentyl acetate 80.99
    trichloroethylene 338.39
    n-nonanol 81.09
    cyclohexanol 193.49
    benzyl alcohol 97.18
    2-ethylhexanol 100.36
    isooctanol 62.23
    dipropyl ether 140.25
    1,2-dichlorobenzene 74.5
    ethyl lactate 80.67
    propylene carbonate 132.23
    n-methylformamide 287.57
    2-pentanol 182.09
    n-pentane 64.41
    1-propoxy-2-propanol 232.02
    1-methoxy-2-propyl acetate 113.2
    2-(2-methoxypropoxy) propanol 150.24
    mesitylene 29.6
    ε-caprolactone 151.35
    p-cymene 39.98
    epichlorohydrin 242.34
    1,1,1-trichloroethane 214.55
    2-aminoethanol 445.21
    morpholine-4-carbaldehyde 302.48
    sulfolane 276.23
    2,2,4-trimethylpentane 25.66
    2-methyltetrahydrofuran 257.86
    n-hexyl acetate 90.83
    isooctane 16.44
    2-(2-butoxyethoxy)ethanol 200.84
    sec-butyl acetate 58.37
    tert-butyl acetate 80.08
    decalin 21.32
    glycerin 414.12
    diglyme 306.54
    acrylic acid 382.09
    isopropyl myristate 41.63
    n-butyric acid 273.58
    acetyl acetate 107.36
    di(2-ethylhexyl) phthalate 46.3
    ethyl propionate 87.31
    nitromethane 466.75
    1,2-diethoxyethane 136.71
    benzonitrile 88.87
    trioctyl phosphate 35.28
    1-bromopropane 155.34
    gamma-valerolactone 246.56
    n-decanol 60.93
    triethyl phosphate 47.05
    4-methyl-2-pentanol 80.29
    propionitrile 191.71
    vinylene carbonate 119.01
    1,1,2-trichlorotrifluoroethane 363.76
    DMS 80.14
    cumene 30.67
    2-octanol 52.16
    2-hexanone 92.99
    octyl acetate 58.9
    limonene 67.22
    1,2-dimethoxyethane 249.62
    ethyl orthosilicate 49.37
    tributyl phosphate 40.07
    diacetone alcohol 135.98
    N,N-dimethylaniline 73.96
    acrylonitrile 228.01
    aniline 139.84
    1,3-propanediol 351.49
    bromobenzene 73.54
    dibromomethane 269.61
    1,1,2,2-tetrachloroethane 303.2
    2-methyl-cyclohexyl acetate 68.31
    tetrabutyl urea 53.51
    diisobutyl methanol 57.12
    2-phenylethanol 97.41
    styrene 50.03
    dioctyl adipate 66.32
    dimethyl sulfate 109.65
    ethyl butyrate 86.48
    methyl lactate 143.1
    butyl lactate 71.07
    diethyl carbonate 60.63
    propanediol butyl ether 175.95
    triethyl orthoformate 68.42
    p-tert-butyltoluene 40.13
    methyl 4-tert-butylbenzoate 87.59
    morpholine 391.21
    tert-butylamine 217.41
    n-dodecanol 49.24
    dimethoxymethane 203.68
    ethylene carbonate 94.14
    cyrene 112.57
    2-ethoxyethyl acetate 92.16
    2-ethylhexyl acetate 66.69
    1,2,4-trichlorobenzene 101.74
    4-methylpyridine 152.42
    dibutyl ether 73.62
    2,6-dimethyl-4-heptanol 57.12
    DEF 183.26
    dimethyl isosorbide 148.6
    tetrachloroethylene 224.75
    eugenol 93.17
    triacetin 111.35
    span 80 145.57
    1,4-butanediol 171.75
    1,1-dichloroethane 250.08
    2-methyl-1-pentanol 111.55
    methyl formate 168.01
    2-methyl-1-butanol 182.35
    n-decane 20.06
    butyronitrile 150.29
    3,7-dimethyl-1-octanol 79.58
    1-chlorooctane 51.74
    1-chlorotetradecane 23.97
    n-nonane 20.37
    undecane 15.13
    tert-butylcyclohexane 21.99
    cyclooctane 22.06
    cyclopentanol 250.03
    tetrahydropyran 263.55
    tert-amyl methyl ether 132.78
    2,5,8-trioxanonane 231.26
    1-hexene 92.59
    2-isopropoxyethanol 178.53
    2,2,2-trifluoroethanol 271.66
    methyl butyrate 100.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction