2,5-Dihydro-2,4,5-trimethylthiazoline

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  • Identifiers

    CAS number
    4145-93-1

    Molecular formula
    C6H11NS

    SMILES
    CC1C(SC(=N1)C)C

  • Odor profile

    Fragrance
    Nutty 84.86%
    Meaty 83.88%
    Roasted 81.34%
    Cocoa 58.56%
    Vegetable 56.01%
    Beefy 51.45%
    Sulfurous 50.11%
    Chocolate 49.65%
    Coffee 45.23%
    Musty 44.34%

     

    Flavor
    Roasted 47.16%
    Nutty 44.5%
    Green 43.29%
    Meaty 38.54%
    Vegetable 34.09%
    Sulfurous 34.02%
    Earthy 30.2%
    Potato 27.88%
    Cocoa 26.01%
    Musty 25.89%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    6.03 (neutral)

    Molecular weight
    129.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    168°C

    Flash point

    • 64.7 ˚C est.

  • Synonyms

    • 2,4,5-trimethyl-4,5-dihydrothiazole
    • 4145-93-1
    • 2,5-dihydro-2,4,5-trimethylthiazoline
    • DTXSID20294803
    • 2,4,5-trimethyl-4,5-dihydro-1,3-thiazole
    • 2,4,5-trimethylthiazoline
    • NSC-98275
    • 2,5-TMT
    • NSC98275
    • SCHEMBL592600
    • DTXCID30245942
    • AKOS030227958
    • A10763

  • Applications

    2,5-Dihydro-2,4,5-trimethylthiazoline (CAS 4145-93-1) is primarily used as an odorant in olfactory research and animal behavior studies: it reliably elicits aversive and fear-related responses in predator–prey contexts, making it a standard model odor for investigating neural circuits of fear and odor processing. It is commonly employed as a reference odor in sensory testing and for calibration of olfactometry equipment or gas-sensor systems. In fragrance research and development, it can be used as a model odor to study odor perception, masking, and detection performance. Its use outside laboratory research is limited and subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 656.11
    methanol 918.27
    isopropanol 433.67
    water 25.22
    ethyl acetate 724.45
    n-propanol 490.48
    acetone 919.38
    n-butanol 465.91
    acetonitrile 793.65
    DMF 761.0
    toluene 603.89
    isobutanol 354.57
    1,4-dioxane 1269.53
    methyl acetate 715.31
    THF 1430.68
    2-butanone 735.42
    n-pentanol 313.82
    sec-butanol 393.69
    n-hexane 53.97
    ethylene glycol 237.95
    NMP 1191.39
    cyclohexane 148.0
    DMSO 810.3
    n-butyl acetate 490.67
    n-octanol 244.82
    chloroform 2699.71
    n-propyl acetate 327.95
    acetic acid 957.17
    dichloromethane 1986.92
    cyclohexanone 1079.91
    propylene glycol 283.21
    isopropyl acetate 407.14
    DMAc 777.3
    2-ethoxyethanol 531.84
    isopentanol 371.72
    n-heptane 71.91
    ethyl formate 490.23
    1,2-dichloroethane 879.5
    n-hexanol 407.18
    2-methoxyethanol 913.09
    isobutyl acetate 232.23
    tetrachloromethane 585.26
    n-pentyl acetate 348.69
    transcutol 1474.1
    n-heptanol 243.28
    ethylbenzene 204.97
    MIBK 305.29
    2-propoxyethanol 721.67
    tert-butanol 432.54
    MTBE 442.12
    2-butoxyethanol 450.94
    propionic acid 558.14
    o-xylene 322.59
    formic acid 451.28
    diethyl ether 564.86
    m-xylene 342.04
    p-xylene 274.31
    chlorobenzene 850.95
    dimethyl carbonate 257.93
    n-octane 30.75
    formamide 527.6
    cyclopentanone 1182.77
    2-pentanone 546.88
    anisole 512.57
    cyclopentyl methyl ether 661.45
    gamma-butyrolactone 1244.54
    1-methoxy-2-propanol 623.61
    pyridine 1132.63
    3-pentanone 472.39
    furfural 1326.69
    n-dodecane 28.07
    diethylene glycol 560.12
    diisopropyl ether 172.7
    tert-amyl alcohol 390.79
    acetylacetone 713.42
    n-hexadecane 32.11
    acetophenone 432.55
    methyl propionate 502.6
    isopentyl acetate 388.82
    trichloroethylene 1907.79
    n-nonanol 213.7
    cyclohexanol 510.44
    benzyl alcohol 392.01
    2-ethylhexanol 258.76
    isooctanol 188.37
    dipropyl ether 311.74
    1,2-dichlorobenzene 726.79
    ethyl lactate 180.14
    propylene carbonate 668.5
    n-methylformamide 571.19
    2-pentanol 307.22
    n-pentane 76.96
    1-propoxy-2-propanol 492.51
    1-methoxy-2-propyl acetate 510.16
    2-(2-methoxypropoxy) propanol 375.36
    mesitylene 197.26
    ε-caprolactone 913.37
    p-cymene 169.7
    epichlorohydrin 1246.08
    1,1,1-trichloroethane 1208.68
    2-aminoethanol 370.99
    morpholine-4-carbaldehyde 1135.09
    sulfolane 1143.05
    2,2,4-trimethylpentane 47.56
    2-methyltetrahydrofuran 1090.8
    n-hexyl acetate 471.44
    isooctane 31.32
    2-(2-butoxyethoxy)ethanol 512.99
    sec-butyl acetate 247.14
    tert-butyl acetate 399.35
    decalin 70.12
    glycerin 409.99
    diglyme 935.0
    acrylic acid 574.98
    isopropyl myristate 192.63
    n-butyric acid 684.61
    acetyl acetate 587.6
    di(2-ethylhexyl) phthalate 196.74
    ethyl propionate 278.96
    nitromethane 1289.93
    1,2-diethoxyethane 548.47
    benzonitrile 650.25
    trioctyl phosphate 132.15
    1-bromopropane 580.05
    gamma-valerolactone 1465.63
    n-decanol 154.45
    triethyl phosphate 180.0
    4-methyl-2-pentanol 178.63
    propionitrile 523.55
    vinylene carbonate 711.46
    1,1,2-trichlorotrifluoroethane 935.78
    DMS 365.65
    cumene 151.11
    2-octanol 162.78
    2-hexanone 349.37
    octyl acetate 247.61
    limonene 253.48
    1,2-dimethoxyethane 676.88
    ethyl orthosilicate 176.99
    tributyl phosphate 162.43
    diacetone alcohol 403.82
    N,N-dimethylaniline 306.77
    acrylonitrile 625.04
    aniline 637.93
    1,3-propanediol 489.5
    bromobenzene 893.97
    dibromomethane 1267.09
    1,1,2,2-tetrachloroethane 1367.98
    2-methyl-cyclohexyl acetate 288.44
    tetrabutyl urea 192.38
    diisobutyl methanol 144.1
    2-phenylethanol 437.04
    styrene 303.41
    dioctyl adipate 252.83
    dimethyl sulfate 393.3
    ethyl butyrate 327.86
    methyl lactate 289.48
    butyl lactate 246.29
    diethyl carbonate 231.03
    propanediol butyl ether 367.8
    triethyl orthoformate 258.3
    p-tert-butyltoluene 170.73
    methyl 4-tert-butylbenzoate 393.46
    morpholine 1165.07
    tert-butylamine 291.24
    n-dodecanol 118.34
    dimethoxymethane 573.51
    ethylene carbonate 570.68
    cyrene 373.17
    2-ethoxyethyl acetate 512.11
    2-ethylhexyl acetate 339.33
    1,2,4-trichlorobenzene 847.95
    4-methylpyridine 1069.74
    dibutyl ether 267.9
    2,6-dimethyl-4-heptanol 144.1
    DEF 563.88
    dimethyl isosorbide 626.38
    tetrachloroethylene 983.14
    eugenol 369.46
    triacetin 453.79
    span 80 369.22
    1,4-butanediol 205.8
    1,1-dichloroethane 1136.39
    2-methyl-1-pentanol 289.24
    methyl formate 469.92
    2-methyl-1-butanol 377.54
    n-decane 45.86
    butyronitrile 546.82
    3,7-dimethyl-1-octanol 235.45
    1-chlorooctane 183.08
    1-chlorotetradecane 79.56
    n-nonane 44.82
    undecane 34.3
    tert-butylcyclohexane 61.59
    cyclooctane 55.7
    cyclopentanol 528.88
    tetrahydropyran 963.07
    tert-amyl methyl ether 364.99
    2,5,8-trioxanonane 638.08
    1-hexene 178.13
    2-isopropoxyethanol 366.96
    2,2,2-trifluoroethanol 445.31
    methyl butyrate 348.99

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction