2,5-Diethyl-3-methylpyrazine

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  • Identifiers

    CAS number
    32736-91-7

    Molecular formula
    C9H14N2

    SMILES
    CCC1=CN=C(C(=N1)C)CC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 82.51%
    Roasted 76.53%
    Earthy 67.08%
    Cocoa 64.68%
    Hazelnut 61.67%
    Musty 58.36%
    Potato 56.3%
    Burnt 53.93%
    Coffee 52.74%
    Chocolate 50.92%

     

    Flavor
    Nutty 65.73%
    Earthy 58.84%
    Roasted 53.63%
    Potato 53.51%
    Meaty 50.87%
    Hazelnut 45.56%
    Vegetable 44.78%
    Musty 43.57%
    Roast 42.39%
    Green 41.29%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    4.77 (weak acid)

    Molecular weight
    150.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point

    • 95.00 °C. @ 14.00 mm Hg

    Flash point

    • 78.84 ˚C est.

    Solubility expt.

    • slightly
    • moderately soluble in water; soluble in oils, organic solvents
    • miscible at room temperature (in ethanol)

  • Synonyms

    • 2,5-DIETHYL-3-METHYLPYRAZINE
    • 32736-91-7
    • Pyrazine, 2,5-diethyl-3-methyl- (8CI,9CI)
    • Pyrazine, 2,5-diethyl-3-methyl-
    • 3,6-diethyl-2-methylpyrazine
    • N079TRL8P5
    • 2,5-diethyl-3-methyl pyrazine
    • FEMA NO. 3915
    • DTXSID70186406
    • 2,5-DIETHYL-3-METHYL-1,4-DIAZINE
    • 2,5-DIETHYL-3-METHYLPYRAZINE [FHFI]
    • UNII-N079TRL8P5
    • SCHEMBL1426102
    • FEMA 3915
    • DTXCID40108897
    • CHEBI:193681
    • NS00125005
    • G71114
    • Q27284338
    • 639-092-8

  • Applications

    2,5-Diethyl-3-methylpyrazine (CAS 32736-91-7) is primarily used as an odorant and fragrance ingredient in perfumery, and as a flavor compound in taste formulations; it also serves in cosmetics and personal care as a fragrance constituent, in household products such as air fresheners and cleaners as an aroma additive, and as an industrial intermediate for the synthesis of other heterocycles or aroma-related compounds; it may also find uses in coatings and inks as a fragrance additive, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 822.5
    methanol 1191.77
    isopropanol 520.31
    water 4.28
    ethyl acetate 833.36
    n-propanol 724.27
    acetone 865.97
    n-butanol 777.23
    acetonitrile 852.62
    DMF 1050.71
    toluene 724.13
    isobutanol 610.76
    1,4-dioxane 1293.23
    methyl acetate 717.06
    THF 1506.69
    2-butanone 813.99
    n-pentanol 661.99
    sec-butanol 598.52
    n-hexane 405.87
    ethylene glycol 138.58
    NMP 1153.1
    cyclohexane 540.4
    DMSO 794.2
    n-butyl acetate 1220.49
    n-octanol 432.52
    chloroform 4464.71
    n-propyl acetate 697.23
    acetic acid 861.98
    dichloromethane 4207.63
    cyclohexanone 1528.94
    propylene glycol 152.66
    isopropyl acetate 518.47
    DMAc 865.21
    2-ethoxyethanol 624.62
    isopentanol 659.86
    n-heptane 253.21
    ethyl formate 835.23
    1,2-dichloroethane 1956.65
    n-hexanol 803.04
    2-methoxyethanol 824.65
    isobutyl acetate 484.7
    tetrachloromethane 1158.4
    n-pentyl acetate 663.67
    transcutol 1195.51
    n-heptanol 411.92
    ethylbenzene 506.71
    MIBK 446.31
    2-propoxyethanol 797.8
    tert-butanol 579.32
    MTBE 736.4
    2-butoxyethanol 525.13
    propionic acid 596.04
    o-xylene 472.9
    formic acid 314.83
    diethyl ether 974.41
    m-xylene 467.04
    p-xylene 721.72
    chlorobenzene 1339.76
    dimethyl carbonate 330.95
    n-octane 129.85
    formamide 360.36
    cyclopentanone 1352.52
    2-pentanone 717.63
    anisole 629.8
    cyclopentyl methyl ether 876.15
    gamma-butyrolactone 1594.79
    1-methoxy-2-propanol 496.48
    pyridine 1444.22
    3-pentanone 671.72
    furfural 1501.93
    n-dodecane 86.3
    diethylene glycol 406.97
    diisopropyl ether 309.73
    tert-amyl alcohol 636.56
    acetylacetone 697.03
    n-hexadecane 97.99
    acetophenone 574.99
    methyl propionate 595.4
    isopentyl acetate 904.77
    trichloroethylene 3509.35
    n-nonanol 348.95
    cyclohexanol 740.01
    benzyl alcohol 556.4
    2-ethylhexanol 568.61
    isooctanol 332.51
    dipropyl ether 639.59
    1,2-dichlorobenzene 1213.08
    ethyl lactate 260.73
    propylene carbonate 1029.52
    n-methylformamide 670.4
    2-pentanol 506.01
    n-pentane 291.9
    1-propoxy-2-propanol 553.62
    1-methoxy-2-propyl acetate 557.97
    2-(2-methoxypropoxy) propanol 359.56
    mesitylene 321.68
    ε-caprolactone 1144.27
    p-cymene 367.68
    epichlorohydrin 1708.54
    1,1,1-trichloroethane 1953.36
    2-aminoethanol 278.72
    morpholine-4-carbaldehyde 1004.04
    sulfolane 1561.12
    2,2,4-trimethylpentane 152.9
    2-methyltetrahydrofuran 1199.41
    n-hexyl acetate 783.51
    isooctane 97.46
    2-(2-butoxyethoxy)ethanol 474.06
    sec-butyl acetate 435.12
    tert-butyl acetate 449.84
    decalin 218.55
    glycerin 195.34
    diglyme 932.58
    acrylic acid 524.39
    isopropyl myristate 303.43
    n-butyric acid 961.37
    acetyl acetate 603.4
    di(2-ethylhexyl) phthalate 282.27
    ethyl propionate 582.19
    nitromethane 1123.85
    1,2-diethoxyethane 827.17
    benzonitrile 1124.42
    trioctyl phosphate 217.28
    1-bromopropane 1401.67
    gamma-valerolactone 1474.06
    n-decanol 257.57
    triethyl phosphate 313.15
    4-methyl-2-pentanol 284.32
    propionitrile 848.08
    vinylene carbonate 1086.3
    1,1,2-trichlorotrifluoroethane 951.61
    DMS 503.77
    cumene 354.72
    2-octanol 326.17
    2-hexanone 690.27
    octyl acetate 373.57
    limonene 501.85
    1,2-dimethoxyethane 1176.16
    ethyl orthosilicate 321.75
    tributyl phosphate 291.31
    diacetone alcohol 372.83
    N,N-dimethylaniline 479.19
    acrylonitrile 978.74
    aniline 711.91
    1,3-propanediol 460.9
    bromobenzene 1642.39
    dibromomethane 2798.57
    1,1,2,2-tetrachloroethane 2622.98
    2-methyl-cyclohexyl acetate 501.97
    tetrabutyl urea 339.77
    diisobutyl methanol 267.14
    2-phenylethanol 594.22
    styrene 657.4
    dioctyl adipate 372.55
    dimethyl sulfate 441.16
    ethyl butyrate 710.2
    methyl lactate 237.43
    butyl lactate 395.41
    diethyl carbonate 509.1
    propanediol butyl ether 373.16
    triethyl orthoformate 475.37
    p-tert-butyltoluene 315.27
    methyl 4-tert-butylbenzoate 442.45
    morpholine 1127.58
    tert-butylamine 520.25
    n-dodecanol 204.74
    dimethoxymethane 757.77
    ethylene carbonate 919.7
    cyrene 362.03
    2-ethoxyethyl acetate 623.5
    2-ethylhexyl acetate 777.55
    1,2,4-trichlorobenzene 1190.93
    4-methylpyridine 1414.97
    dibutyl ether 664.23
    2,6-dimethyl-4-heptanol 267.14
    DEF 907.0
    dimethyl isosorbide 660.81
    tetrachloroethylene 2177.05
    eugenol 455.81
    triacetin 488.55
    span 80 370.91
    1,4-butanediol 251.8
    1,1-dichloroethane 1868.29
    2-methyl-1-pentanol 629.33
    methyl formate 652.78
    2-methyl-1-butanol 682.94
    n-decane 148.87
    butyronitrile 1080.92
    3,7-dimethyl-1-octanol 374.32
    1-chlorooctane 452.18
    1-chlorotetradecane 181.66
    n-nonane 166.69
    undecane 107.11
    tert-butylcyclohexane 192.9
    cyclooctane 194.17
    cyclopentanol 695.29
    tetrahydropyran 1364.4
    tert-amyl methyl ether 582.95
    2,5,8-trioxanonane 567.53
    1-hexene 811.13
    2-isopropoxyethanol 412.85
    2,2,2-trifluoroethanol 306.26
    methyl butyrate 830.47

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction