2,5-Di-tert-butylhydroquinone

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  • Identifiers

    CAS number
    88-58-4

    Molecular formula
    C14H22O2

    SMILES
    CC(C)(C)C1=CC(=C(C=C1O)C(C)(C)C)O

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 64.05%
    Woody 48.08%
    Leathery 46.71%
    Dry 39.41%
    Medicinal 36.69%
    Smoky 35.44%
    Spicy 32.26%
    Camphoreous 32.02%
    Burnt 31.37%
    Musk 30.05%

     

    Flavor
    Phenolic 54.07%
    Camphor 45.12%
    Musty 37.95%
    Mild 32.56%
    Medicinal 28.77%
    Woody 26.8%
    Leather 26.22%
    Creosote 23.52%
    Thymol 22.58%
    Eugenol 22.23%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.6

    pKa est.
    10.11 (weak base)

    Molecular weight
    222.32 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    326°C

    Flash point

    • 156.43 ˚C est.

  • Synonyms

    • 2,5-Di-tert-butylhydroquinone
    • 88-58-4
    • 2,5-Di-tert-butylbenzene-1,4-diol
    • DTBHQ
    • Dibug
    • Di-t-butylhydroquinone
    • Dybug
    • Santovar O
    • 2,5-Di-tert-butylquinol
    • Nonflex Alba
    • Naugard 451
    • Antage DBH
    • Nocrac NS 7
    • 1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-
    • 2,5-Di-tert-butyl-1,4-benzenediol
    • 2,5-Di-tert-butyl-1,4-hydroquinone
    • di-tert-butylhydroquinone
    • 1,4-Dihydroxy-2,5-di-tert-butylbenzene
    • 2,5-Di-tert-butyl-1,4-benzohydroquinone
    • HYDROQUINONE, 2,5-DI-tert-BUTYL-
    • DTXSID8041248
    • 26XK13B61B
    • DTXCID6021248
    • CHEBI:41094
    • tBuBHQ
    • 2,5-di-t-butylquinol
    • 2,5-di(tert-butyl)-1,4-benzohydroquinone
    • RefChem:444201
    • 201-841-8
    • 2,5-Di-t-butylhydroquinone
    • bhq
    • 2,5-DITERT-BUTYLBENZENE-1,4-DIOL
    • MFCD00008825
    • NSC 11
    • NSC-11
    • 2,5-Bis(1,1-dimethylethyl)-1,4-benzenediol
    • 2,5-Di-tert-butylhydroquinone (DBHQ)
    • Hydroquinone,5-di-tert-butyl-
    • 1, 2,5-bis(1,1-dimethylethyl)-
    • CCRIS 5218
    • WLN: L6V DVJ BX1&1&1 EX1&1&1
    • Hydrpquinone, 2,5-di-tert-butyl-
    • EINECS 201-841-8
    • BRN 2049542
    • UNII-26XK13B61B
    • AI3-16630
    • 2agv
    • Eastman DTBHQ
    • 2,5-bis(tert-butyl)benzene-1,4-diol
    • Tocris-1236
    • Cambridge id 5105618
    • NSC11
    • Oprea1_534698
    • SCHEMBL38604
    • 2,5-di-tertbutylhydroquinone
    • BSPBio_001029
    • CBDivE_001992
    • KBioGR_000369
    • KBioSS_000369
    • 2,5-di-t-butyl hydroquinone
    • MLS001066345
    • 2,5-DI-(TERT-BUTYL)-1,4,BENZOHYDROQUINONE
    • 2,5-ditert-butyl hydroquinone
    • 2,5-TBHQ
    • CHEMBL480626
    • orb1299727
    • SCHEMBL9153073
    • 2,5-di-tert-butyl hydroquinone
    • 2,5-di-tert-butyl-hydroquinone
    • KBio2_000369
    • KBio2_002937
    • KBio2_005505
    • KBio3_000717
    • KBio3_000718
    • 2,5-di-tert--butyl-hydroquinone
    • NSC9886
    • BDBM176764
    • Bio1_000419
    • Bio1_000908
    • Bio1_001397
    • Bio2_000345
    • Bio2_000825
    • GLXC-15206
    • HMS1362C11
    • HMS1792C11
    • HMS1990C11
    • HMS3267F19
    • HMS3403C11
    • HMS3412A14
    • HMS3676A14
    • NSC-9886
    • Tox21_300385
    • CA-420
    • EBC-03748
    • HSCI1_000289
    • MSK001633
    • s3628
    • 2,5-Di-tert-butylhydroquinone DTBHQ
    • 2,5-di-tert--butylbenzene-1,4-diol
    • 2,5-Di-tert-butylhydroquinone, 99%
    • AKOS003627062
    • 2,5-Ditert-butyl-1,4-benzenediol #
    • AC-2488
    • CCG-266736
    • CS-W013115
    • DB04638
    • FD41543
    • HY-W012399
    • PS-7822
    • CAS-88-58-4
    • IDI1_002100
    • BUTYLHYDROQUINONE, 2,5-DI-TERT-
    • NCGC00025066-01
    • NCGC00025066-02
    • NCGC00025066-03
    • NCGC00025066-04
    • NCGC00254338-01
    • CAS# 88-58-4
    • SMR000135117
    • DB-057086
    • D0940
    • NS00013645
    • ST50308012
    • EN300-213340
    • US9688816, 7
    • F821762
    • SR-01000597417
    • 88-58-4

  • Applications

    2,5-Di-tert-butylhydroquinone (CAS 88-58-4) is widely used as a hindered phenolic antioxidant and stabilizer in polymers and plastics to slow oxidative degradation; it is also employed as a processing stabilizer in lubricants, oils, and fuels to extend shelf life and performance; in coatings and inks it helps inhibit aging and color changes over time; in rubbers and elastomers it functions as an antioxidant to improve durability; and in industrial manufacturing it serves as a stabilizer to protect reactive formulations and polymer blends during processing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 246.93
    methanol 310.58
    isopropanol 206.66
    water 1.5
    ethyl acetate 345.64
    n-propanol 252.45
    acetone 218.54
    n-butanol 241.79
    acetonitrile 166.22
    DMF 650.16
    toluene 148.79
    isobutanol 195.75
    1,4-dioxane 496.79
    methyl acetate 299.28
    THF 1172.0
    2-butanone 291.62
    n-pentanol 171.97
    sec-butanol 225.51
    n-hexane 128.66
    ethylene glycol 71.65
    NMP 609.78
    cyclohexane 119.43
    DMSO 259.21
    n-butyl acetate 326.4
    n-octanol 178.39
    chloroform 431.39
    n-propyl acetate 188.57
    acetic acid 206.69
    dichloromethane 262.35
    cyclohexanone 393.14
    propylene glycol 96.03
    isopropyl acetate 264.15
    DMAc 564.74
    2-ethoxyethanol 213.88
    isopentanol 208.24
    n-heptane 83.15
    ethyl formate 204.89
    1,2-dichloroethane 296.33
    n-hexanol 370.53
    2-methoxyethanol 377.74
    isobutyl acetate 153.46
    tetrachloromethane 117.03
    n-pentyl acetate 189.42
    transcutol 376.64
    n-heptanol 191.84
    ethylbenzene 127.39
    MIBK 219.81
    2-propoxyethanol 519.6
    tert-butanol 298.15
    MTBE 374.4
    2-butoxyethanol 277.54
    propionic acid 193.1
    o-xylene 121.1
    formic acid 116.79
    diethyl ether 329.68
    m-xylene 144.96
    p-xylene 159.11
    chlorobenzene 180.06
    dimethyl carbonate 186.41
    n-octane 40.52
    formamide 141.7
    cyclopentanone 561.0
    2-pentanone 283.26
    anisole 204.63
    cyclopentyl methyl ether 465.33
    gamma-butyrolactone 627.93
    1-methoxy-2-propanol 343.26
    pyridine 277.84
    3-pentanone 256.15
    furfural 402.49
    n-dodecane 23.62
    diethylene glycol 283.53
    diisopropyl ether 162.23
    tert-amyl alcohol 269.55
    acetylacetone 285.54
    n-hexadecane 26.53
    acetophenone 167.95
    methyl propionate 312.14
    isopentyl acetate 317.53
    trichloroethylene 457.49
    n-nonanol 160.04
    cyclohexanol 231.96
    benzyl alcohol 124.11
    2-ethylhexanol 206.28
    isooctanol 149.39
    dipropyl ether 261.9
    1,2-dichlorobenzene 184.36
    ethyl lactate 122.36
    propylene carbonate 373.48
    n-methylformamide 285.78
    2-pentanol 195.93
    n-pentane 93.21
    1-propoxy-2-propanol 360.59
    1-methoxy-2-propyl acetate 361.45
    2-(2-methoxypropoxy) propanol 191.95
    mesitylene 105.2
    ε-caprolactone 398.25
    p-cymene 102.32
    epichlorohydrin 599.22
    1,1,1-trichloroethane 336.2
    2-aminoethanol 146.89
    morpholine-4-carbaldehyde 510.27
    sulfolane 559.68
    2,2,4-trimethylpentane 54.28
    2-methyltetrahydrofuran 593.9
    n-hexyl acetate 274.39
    isooctane 44.89
    2-(2-butoxyethoxy)ethanol 261.69
    sec-butyl acetate 176.73
    tert-butyl acetate 316.24
    decalin 61.96
    glycerin 135.18
    diglyme 428.39
    acrylic acid 161.3
    isopropyl myristate 115.97
    n-butyric acid 274.98
    acetyl acetate 211.86
    di(2-ethylhexyl) phthalate 93.09
    ethyl propionate 228.26
    nitromethane 324.57
    1,2-diethoxyethane 208.92
    benzonitrile 146.88
    trioctyl phosphate 88.93
    1-bromopropane 235.07
    gamma-valerolactone 598.13
    n-decanol 116.97
    triethyl phosphate 131.0
    4-methyl-2-pentanol 151.21
    propionitrile 227.86
    vinylene carbonate 286.64
    1,1,2-trichlorotrifluoroethane 341.48
    DMS 221.5
    cumene 99.16
    2-octanol 134.55
    2-hexanone 191.14
    octyl acetate 150.3
    limonene 140.78
    1,2-dimethoxyethane 435.67
    ethyl orthosilicate 131.59
    tributyl phosphate 101.96
    diacetone alcohol 273.75
    N,N-dimethylaniline 169.83
    acrylonitrile 226.11
    aniline 158.14
    1,3-propanediol 203.01
    bromobenzene 171.11
    dibromomethane 221.61
    1,1,2,2-tetrachloroethane 466.64
    2-methyl-cyclohexyl acetate 202.64
    tetrabutyl urea 130.41
    diisobutyl methanol 123.9
    2-phenylethanol 210.6
    styrene 112.58
    dioctyl adipate 123.83
    dimethyl sulfate 250.86
    ethyl butyrate 233.77
    methyl lactate 176.51
    butyl lactate 162.03
    diethyl carbonate 166.07
    propanediol butyl ether 189.48
    triethyl orthoformate 183.6
    p-tert-butyltoluene 114.29
    methyl 4-tert-butylbenzoate 201.95
    morpholine 542.9
    tert-butylamine 225.71
    n-dodecanol 87.46
    dimethoxymethane 417.79
    ethylene carbonate 276.74
    cyrene 188.75
    2-ethoxyethyl acetate 207.14
    2-ethylhexyl acetate 264.42
    1,2,4-trichlorobenzene 200.39
    4-methylpyridine 287.62
    dibutyl ether 167.47
    2,6-dimethyl-4-heptanol 123.9
    DEF 343.38
    dimethyl isosorbide 378.08
    tetrachloroethylene 294.67
    eugenol 181.24
    triacetin 163.41
    span 80 184.11
    1,4-butanediol 82.86
    1,1-dichloroethane 289.86
    2-methyl-1-pentanol 160.62
    methyl formate 236.4
    2-methyl-1-butanol 208.39
    n-decane 44.62
    butyronitrile 228.05
    3,7-dimethyl-1-octanol 151.55
    1-chlorooctane 134.49
    1-chlorotetradecane 51.38
    n-nonane 46.66
    undecane 31.41
    tert-butylcyclohexane 67.5
    cyclooctane 56.29
    cyclopentanol 273.75
    tetrahydropyran 550.29
    tert-amyl methyl ether 324.56
    2,5,8-trioxanonane 253.91
    1-hexene 223.99
    2-isopropoxyethanol 160.67
    2,2,2-trifluoroethanol 116.5
    methyl butyrate 259.69

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction