2,4,6-Trimethylbenzoyl diphenylphosphine oxide

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  • Identifiers

    CAS number
    75980-60-8

    Molecular formula
    C22H21O2P

    SMILES
    CC1=CC(=C(C(=C1)C)C(=O)P(=O)(C2=CC=CC=C2)C3=CC=CC=C3)C

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Floral 60.47%
    Fruity 43.0%
    Neroli 38.47%
    Honey 35.17%
    Sweet 33.27%
    Powdery 33.12%
    Rose 32.49%
    Green 31.14%
    Grape 31.05%
    Dry 28.29%

     

    Flavor
    Bitter 71.3%
    Odorless 23.88%
    Nitrile 19.92%
    Heather 19.11%
    Genet 19.05%
    Broom 18.92%
    Very strong 18.76%
    Indole 18.67%
    Lovage 18.56%
    Moth ball 18.33%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.0

    pKa est.
    6.12 (neutral)

    Molecular weight
    348.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    637°C

    Flash point

    • 219.53 ˚C est.

  • Synonyms

    • 75980-60-8
    • Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
    • Phosphine oxide, diphenyl(2,4,6-trimethylbenzoyl)-
    • EINECS 278-355-8
    • DTXSID4052502
    • B9EIM2D97X
    • 2,4,6-trimethylbenzoyl diphenylphosphine oxide
    • trimethylbenzoyl diphenylphosphine oxide
    • CHIVACURE TPO
    • DOUBLECURE TPO
    • ADDITOL TPO
    • GENOCURE TPO
    • Methanone, (diphenylphosphinyl)(2,4,6-trimethylphenyl)-
    • DTXCID8031075
    • EC 278-355-8
    • (2,4,6-trimethylbenzoyl)diphenylphosphine oxide
    • (DIPHENYLPHOSPHINYL)(2,4,6-TRIMETHYLPHENYL)METHANONE
    • RefChem:442966
    • TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE [INCI]
    • 278-355-8
    • (Diphenylphosphoryl)(mesityl)methanone
    • 2,4,6-trimethyl benzoyldiphenyl phosphine oxide
    • diphenylphosphoryl-(2,4,6-trimethylphenyl)methanone
    • 2,4,6-Trimethylbenzoyldiphenylphosphine oxide
    • MFCD00192110
    • diphenyl(2,4,6-trimethylbenzoyl)phosphineoxide
    • diphenyl (2,4,6-trimethylbenzoyl)phosphine oxide
    • TPO
    • UNII-B9EIM2D97X
    • diphenylphosphino[(2,4,6-trimethylphenyl)carbonyl]-1-one
    • SCHEMBL27651
    • di(phenyl)phosphoryl-(2,4,6-trimethylphenyl)methanone
    • CHEMBL3561198
    • VFHVQBAGLAREND-UHFFFAOYSA-
    • MSK3458
    • Tox21_303757
    • MSK3458-100A
    • SBB057714
    • AKOS015840661
    • MSK3458-1000A
    • CS-W009334
    • FD40112
    • NCGC00357056-01
    • AC-10380
    • AS-14718
    • CAS-75980-60-8
    • 2,4,6-Trimethylbenzoyldi phenylphosphinoxide
    • D3358
    • NS00002047
    • ST51006885
    • 2,4,6-trimethylbenzoyl-diphenyl-phosphineoxide
    • 2,4,6-trimethylbenzoyl-diphenylphosphine oxide
    • O11728
    • diphenyl(2,4,6-trimethylbenzoyl)phosphorus oxide
    • 980D608
    • diphenyl-(2,4,6-trimethylbenzoyl) phosphine oxide
    • F079449
    • (Diphenylphosphoryl)(2,4,6-trimethylphenyl)methanone
    • Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide, 97%
    • Q27274548
    • DIPHENYL-(2,4,6-TRIMETHYLBENZOYL) PHOSPHINOXID
    • Lucirin TPO solid (2,4,6-trimethylbenzoyldiphenyl phosphine oxide)
    • Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide Solution in Acetonitrile, 1000ug/mL
    • Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide Solution in Acetonitrile, 100ug/mL
    • InChI=1/C22H21O2P/c1-16-14-17(2)21(18(3)15-16)22(23)25(24,19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-15H,1-3H3
    • 75980-60-8

  • Applications

    2,4,6-Trimethylbenzoyl diphenylphosphine oxide (CAS 75980-60-8) is a photoinitiator widely used to initiate free-radical polymerization in UV-curable systems, including coatings, inks, and varnishes for plastics, wood, paper, and packaging. It is commonly employed as a Type I photoinitiator in UV-curable adhesives and sealants, enabling rapid curing under near-UV/visible light. It serves as a photoinitiator for UV-curable resins used in 3D printing and rapid prototyping, providing good depth of cure. It is also used in specialty polymer formulations for electronics and optical applications where efficient curing is required.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 602.28
    methanol 793.55
    isopropanol 316.43
    water 0.74
    ethyl acetate 262.28
    n-propanol 524.33
    acetone 558.84
    n-butanol 419.18
    acetonitrile 479.93
    DMF 1427.98
    toluene 215.39
    isobutanol 334.91
    1,4-dioxane 551.26
    methyl acetate 391.49
    THF 1080.06
    2-butanone 605.62
    n-pentanol 212.43
    sec-butanol 255.69
    n-hexane 10.19
    ethylene glycol 76.23
    NMP 996.13
    cyclohexane 33.09
    DMSO 334.82
    n-butyl acetate 135.94
    n-octanol 37.94
    chloroform 1022.69
    n-propyl acetate 127.05
    acetic acid 308.64
    dichloromethane 1033.16
    cyclohexanone 827.15
    propylene glycol 119.13
    isopropyl acetate 119.63
    DMAc 821.87
    2-ethoxyethanol 262.43
    isopentanol 222.74
    n-heptane 10.07
    ethyl formate 333.92
    1,2-dichloroethane 882.07
    n-hexanol 178.42
    2-methoxyethanol 631.51
    isobutyl acetate 76.35
    tetrachloromethane 54.77
    n-pentyl acetate 102.02
    transcutol 166.29
    n-heptanol 70.38
    ethylbenzene 59.47
    MIBK 141.09
    2-propoxyethanol 296.69
    tert-butanol 149.54
    MTBE 134.23
    2-butoxyethanol 134.78
    propionic acid 254.08
    o-xylene 71.05
    formic acid 174.39
    diethyl ether 322.41
    m-xylene 73.79
    p-xylene 59.92
    chlorobenzene 351.24
    dimethyl carbonate 166.41
    n-octane 4.51
    formamide 430.23
    cyclopentanone 1011.53
    2-pentanone 409.12
    anisole 125.93
    cyclopentyl methyl ether 325.28
    gamma-butyrolactone 767.05
    1-methoxy-2-propanol 315.89
    pyridine 872.75
    3-pentanone 303.92
    furfural 586.66
    n-dodecane 2.79
    diethylene glycol 163.65
    diisopropyl ether 35.82
    tert-amyl alcohol 135.81
    acetylacetone 228.0
    n-hexadecane 3.23
    acetophenone 138.97
    methyl propionate 319.2
    isopentyl acetate 108.69
    trichloroethylene 1393.11
    n-nonanol 36.09
    cyclohexanol 243.15
    benzyl alcohol 175.84
    2-ethylhexanol 69.1
    isooctanol 50.92
    dipropyl ether 73.98
    1,2-dichlorobenzene 230.8
    ethyl lactate 65.97
    propylene carbonate 304.31
    n-methylformamide 922.27
    2-pentanol 166.76
    n-pentane 19.69
    1-propoxy-2-propanol 131.45
    1-methoxy-2-propyl acetate 129.82
    2-(2-methoxypropoxy) propanol 52.75
    mesitylene 31.04
    ε-caprolactone 495.58
    p-cymene 31.4
    epichlorohydrin 1237.95
    1,1,1-trichloroethane 328.0
    2-aminoethanol 253.95
    morpholine-4-carbaldehyde 655.67
    sulfolane 545.01
    2,2,4-trimethylpentane 7.02
    2-methyltetrahydrofuran 606.27
    n-hexyl acetate 92.33
    isooctane 4.49
    2-(2-butoxyethoxy)ethanol 82.42
    sec-butyl acetate 71.32
    tert-butyl acetate 90.62
    decalin 9.93
    glycerin 125.39
    diglyme 193.76
    acrylic acid 240.16
    isopropyl myristate 27.37
    n-butyric acid 372.17
    acetyl acetate 107.61
    di(2-ethylhexyl) phthalate 37.54
    ethyl propionate 105.84
    nitromethane 680.7
    1,2-diethoxyethane 104.31
    benzonitrile 252.06
    trioctyl phosphate 27.41
    1-bromopropane 384.8
    gamma-valerolactone 1130.09
    n-decanol 24.78
    triethyl phosphate 39.21
    4-methyl-2-pentanol 59.63
    propionitrile 395.37
    vinylene carbonate 332.88
    1,1,2-trichlorotrifluoroethane 417.71
    DMS 107.81
    cumene 30.34
    2-octanol 39.37
    2-hexanone 178.42
    octyl acetate 40.29
    limonene 47.52
    1,2-dimethoxyethane 327.52
    ethyl orthosilicate 38.53
    tributyl phosphate 30.56
    diacetone alcohol 131.04
    N,N-dimethylaniline 75.97
    acrylonitrile 521.94
    aniline 272.35
    1,3-propanediol 347.79
    bromobenzene 313.52
    dibromomethane 654.93
    1,1,2,2-tetrachloroethane 892.7
    2-methyl-cyclohexyl acetate 68.73
    tetrabutyl urea 48.75
    diisobutyl methanol 27.95
    2-phenylethanol 144.89
    styrene 89.3
    dioctyl adipate 43.52
    dimethyl sulfate 184.16
    ethyl butyrate 82.06
    methyl lactate 129.36
    butyl lactate 78.7
    diethyl carbonate 53.6
    propanediol butyl ether 78.56
    triethyl orthoformate 56.86
    p-tert-butyltoluene 28.04
    methyl 4-tert-butylbenzoate 76.14
    morpholine 934.05
    tert-butylamine 76.26
    n-dodecanol 17.8
    dimethoxymethane 554.58
    ethylene carbonate 270.23
    cyrene 125.24
    2-ethoxyethyl acetate 150.17
    2-ethylhexyl acetate 87.51
    1,2,4-trichlorobenzene 261.71
    4-methylpyridine 693.24
    dibutyl ether 37.75
    2,6-dimethyl-4-heptanol 27.95
    DEF 477.96
    dimethyl isosorbide 140.59
    tetrachloroethylene 473.58
    eugenol 83.05
    triacetin 69.93
    span 80 58.93
    1,4-butanediol 113.6
    1,1-dichloroethane 597.04
    2-methyl-1-pentanol 136.56
    methyl formate 552.93
    2-methyl-1-butanol 268.83
    n-decane 5.09
    butyronitrile 426.19
    3,7-dimethyl-1-octanol 32.95
    1-chlorooctane 29.07
    1-chlorotetradecane 9.92
    n-nonane 4.77
    undecane 3.6
    tert-butylcyclohexane 7.82
    cyclooctane 7.46
    cyclopentanol 327.07
    tetrahydropyran 680.16
    tert-amyl methyl ether 106.38
    2,5,8-trioxanonane 98.34
    1-hexene 59.2
    2-isopropoxyethanol 135.04
    2,2,2-trifluoroethanol 108.79
    methyl butyrate 172.55

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction