2,4,5-Trimethyl-2,5-dihydro-1,3-thiazole

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  • Identifiers

    CAS number
    60633-24-1

    Molecular formula
    C6H11NS

    SMILES
    CC1C(=NC(S1)C)C

  • Odor profile

    Fragrance
    Nutty 82.39%
    Meaty 80.61%
    Roasted 74.86%
    Vegetable 66.97%
    Cocoa 59.58%
    Sulfurous 55.58%
    Chocolate 53.02%
    Musty 50.28%
    Beefy 46.28%
    Coffee 46.26%

     

    Flavor
    Nutty 53.37%
    Green 51.36%
    Roasted 45.67%
    Meaty 39.19%
    Vegetable 37.62%
    Earthy 32.56%
    Sulfurous 31.53%
    Potato 31.25%
    Musty 30.95%
    Cocoa 26.47%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    6.16 (neutral)

    Molecular weight
    129.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    183°C

    Flash point

    • 63.6 ˚C est.

  • Synonyms

    • 60633-24-1
    • 2,4,5-trimethyl-2,5-dihydro-1,3-thiazole
    • 2,4,5-trimethyl-3-thiazoline
    • Thiazole, 2,5-dihydro-2,4,5-trimethyl-
    • 2,4,5-Trimethyl-2,5-dihydrothiazole
    • 2,5-dihydro-2,4,5-trimethylthiazole
    • 1,3-Thiazole, 2,5-dihydro-2,4,5-trimethyl-
    • SCHEMBL4779305
    • DTXSID50976064
    • AIVVNNYXOSPRCW-UHFFFAOYSA-N
    • MFCD18451959
    • 2,4,5-Trimethyl-3-thiazoline, 8CI
    • AS-83189
    • E77713

  • Applications

    2,4,5-Trimethyl-2,5-dihydro-1,3-thiazole (CAS 60633-24-1) is primarily used as an intermediate in organic synthesis, serving as a building block for further elaboration of heterocyclic compounds in pharmaceutical research and other specialty chemicals. In industrial manufacturing, it may be employed as a synthetic precursor for formulation components and as a scaffold for new materials. In perfumery and cosmetics, it can be evaluated as an odorant or fragrance precursor, contributing to select scent profiles in fragrances and personal-care products. In coatings and inks, it may act as a chemical intermediate for specialty formulations, enabling downstream functionalization. Usage is typically governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 699.64
    methanol 1013.21
    isopropanol 458.04
    water 29.42
    ethyl acetate 770.47
    n-propanol 537.87
    acetone 917.87
    n-butanol 506.01
    acetonitrile 846.93
    DMF 811.45
    toluene 667.61
    isobutanol 373.51
    1,4-dioxane 1369.54
    methyl acetate 757.68
    THF 1484.85
    2-butanone 760.01
    n-pentanol 339.3
    sec-butanol 424.61
    n-hexane 63.89
    ethylene glycol 250.34
    NMP 1234.83
    cyclohexane 174.91
    DMSO 848.42
    n-butyl acetate 479.93
    n-octanol 249.07
    chloroform 2985.87
    n-propyl acetate 340.44
    acetic acid 977.78
    dichloromethane 2230.75
    cyclohexanone 1136.92
    propylene glycol 291.57
    isopropyl acetate 424.71
    DMAc 809.73
    2-ethoxyethanol 562.07
    isopentanol 390.84
    n-heptane 80.96
    ethyl formate 518.06
    1,2-dichloroethane 1002.36
    n-hexanol 407.29
    2-methoxyethanol 955.37
    isobutyl acetate 234.94
    tetrachloromethane 653.41
    n-pentyl acetate 351.14
    transcutol 1525.37
    n-heptanol 252.14
    ethylbenzene 227.53
    MIBK 313.45
    2-propoxyethanol 724.72
    tert-butanol 446.26
    MTBE 448.24
    2-butoxyethanol 456.28
    propionic acid 590.45
    o-xylene 356.01
    formic acid 487.16
    diethyl ether 610.09
    m-xylene 371.26
    p-xylene 298.19
    chlorobenzene 930.77
    dimethyl carbonate 266.92
    n-octane 34.97
    formamide 594.51
    cyclopentanone 1226.53
    2-pentanone 563.41
    anisole 553.21
    cyclopentyl methyl ether 703.03
    gamma-butyrolactone 1300.79
    1-methoxy-2-propanol 653.98
    pyridine 1252.2
    3-pentanone 491.51
    furfural 1379.85
    n-dodecane 30.43
    diethylene glycol 561.99
    diisopropyl ether 183.4
    tert-amyl alcohol 406.75
    acetylacetone 726.84
    n-hexadecane 34.8
    acetophenone 461.23
    methyl propionate 534.02
    isopentyl acetate 378.73
    trichloroethylene 2078.88
    n-nonanol 219.25
    cyclohexanol 546.13
    benzyl alcohol 417.17
    2-ethylhexanol 263.11
    isooctanol 193.97
    dipropyl ether 325.23
    1,2-dichlorobenzene 790.88
    ethyl lactate 186.98
    propylene carbonate 682.53
    n-methylformamide 616.97
    2-pentanol 327.27
    n-pentane 88.9
    1-propoxy-2-propanol 491.87
    1-methoxy-2-propyl acetate 507.63
    2-(2-methoxypropoxy) propanol 372.51
    mesitylene 211.48
    ε-caprolactone 951.43
    p-cymene 178.05
    epichlorohydrin 1319.98
    1,1,1-trichloroethane 1311.58
    2-aminoethanol 402.39
    morpholine-4-carbaldehyde 1178.0
    sulfolane 1162.23
    2,2,4-trimethylpentane 51.78
    2-methyltetrahydrofuran 1157.99
    n-hexyl acetate 470.08
    isooctane 33.86
    2-(2-butoxyethoxy)ethanol 519.18
    sec-butyl acetate 256.64
    tert-butyl acetate 407.84
    decalin 79.37
    glycerin 421.53
    diglyme 958.14
    acrylic acid 617.14
    isopropyl myristate 195.47
    n-butyric acid 714.67
    acetyl acetate 614.91
    di(2-ethylhexyl) phthalate 194.22
    ethyl propionate 298.42
    nitromethane 1353.71
    1,2-diethoxyethane 564.66
    benzonitrile 693.16
    trioctyl phosphate 130.62
    1-bromopropane 651.29
    gamma-valerolactone 1515.8
    n-decanol 157.24
    triethyl phosphate 186.57
    4-methyl-2-pentanol 186.87
    propionitrile 566.17
    vinylene carbonate 731.57
    1,1,2-trichlorotrifluoroethane 978.72
    DMS 367.19
    cumene 163.4
    2-octanol 167.32
    2-hexanone 358.2
    octyl acetate 247.56
    limonene 264.3
    1,2-dimethoxyethane 712.79
    ethyl orthosilicate 183.0
    tributyl phosphate 160.97
    diacetone alcohol 405.21
    N,N-dimethylaniline 332.92
    acrylonitrile 679.65
    aniline 699.19
    1,3-propanediol 516.61
    bromobenzene 985.61
    dibromomethane 1408.14
    1,1,2,2-tetrachloroethane 1496.36
    2-methyl-cyclohexyl acetate 290.68
    tetrabutyl urea 193.81
    diisobutyl methanol 146.73
    2-phenylethanol 446.61
    styrene 337.63
    dioctyl adipate 255.0
    dimethyl sulfate 399.44
    ethyl butyrate 337.58
    methyl lactate 296.69
    butyl lactate 244.34
    diethyl carbonate 237.97
    propanediol butyl ether 363.69
    triethyl orthoformate 265.91
    p-tert-butyltoluene 179.37
    methyl 4-tert-butylbenzoate 403.57
    morpholine 1250.03
    tert-butylamine 303.9
    n-dodecanol 120.17
    dimethoxymethane 595.1
    ethylene carbonate 597.14
    cyrene 370.19
    2-ethoxyethyl acetate 511.41
    2-ethylhexyl acetate 334.57
    1,2,4-trichlorobenzene 910.34
    4-methylpyridine 1140.26
    dibutyl ether 280.32
    2,6-dimethyl-4-heptanol 146.73
    DEF 591.79
    dimethyl isosorbide 629.23
    tetrachloroethylene 1095.85
    eugenol 379.63
    triacetin 454.14
    span 80 365.01
    1,4-butanediol 218.75
    1,1-dichloroethane 1268.35
    2-methyl-1-pentanol 305.63
    methyl formate 495.38
    2-methyl-1-butanol 399.43
    n-decane 50.47
    butyronitrile 591.35
    3,7-dimethyl-1-octanol 239.23
    1-chlorooctane 193.84
    1-chlorotetradecane 83.39
    n-nonane 49.83
    undecane 37.38
    tert-butylcyclohexane 68.19
    cyclooctane 64.84
    cyclopentanol 563.16
    tetrahydropyran 1052.01
    tert-amyl methyl ether 372.93
    2,5,8-trioxanonane 650.9
    1-hexene 195.18
    2-isopropoxyethanol 379.68
    2,2,2-trifluoroethanol 465.1
    methyl butyrate 370.36

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction