2,4-Dioxaspiro[5.5]undec-8-ene, 3-ethyl-

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  • Identifiers

    CAS number
    64165-57-7

    Molecular formula
    C11H18O2

    SMILES
    CCC1OCC2(CCC=CC2)CO1

  • Odor profile

    Fragrance
    Fruity 70.66%
    Floral 65.29%
    Sweet 60.83%
    Herbal 59.2%
    Green 43.98%
    Rose 39.12%
    Woody 36.94%
    Spicy 34.35%
    Fresh 31.6%
    Anisic 29.02%

     

    Flavor
    Floral 29.16%
    Green 26.27%
    Fruity 25.97%
    Spicy 25.13%
    Earthy 23.86%
    Sweet 23.44%
    Herbal 22.14%
    Shrimp 21.77%
    Alkaline 21.39%
    Naphthalic 20.8%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    7.05 (neutral)

    Molecular weight
    182.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    228°C

    Flash point

    • 91.04 ˚C est.

  • Synonyms

    • 64165-57-7
    • 2,4-Dioxaspiro[5.5]undec-8-ene, 3-ethyl-
    • EINECS 264-716-7
    • 3-ethyl-2,4-dioxaspiro[5.5]undec-9-ene
    • 3-Ethyl-2,4-dioxaspiro(5.5)undec-8-ene
    • 3-ethyl-2,4-dioxaspiro[5.5]undec-8-ene
    • DTXSID1070060
    • 2,4-Dioxaspiro(5.5)undec-8-ene, 3-ethyl-
    • SCHEMBL873775
    • DTXCID4044242
    • TRANS-3-ETHYL-2,4-DIOXASPIRO[5.5]UNDEC-8-ENE
    • HGDOZLGKGGHYFC-UHFFFAOYSA-N
    • DB-315391
    • NS00012400
    • 264-716-7

  • Applications

    Chemical name: 2,4-Dioxaspiro[5.5]undec-8-ene, 3-ethyl-; CAS number: 64165-57-7 is primarily encountered as an organic-synthesis intermediate and a carbonyl-protecting spiroacetal, enabling selective stepwise syntheses via acid-labile deprotection. It may also function as a masked reactive moiety that can participate in polymerization or crosslinking in specialty polymers, coatings, and adhesive formulations. In materials and formulation contexts, it is sometimes evaluated as a functionalized monomer or crosslinkable component for advanced coatings and adhesives. Under controlled process conditions, it can serve as an intermediate in pharmaceutical synthesis. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 242.04
    methanol 182.75
    isopropanol 173.09
    water 0.41
    ethyl acetate 388.69
    n-propanol 192.23
    acetone 128.74
    n-butanol 255.88
    acetonitrile 174.54
    DMF 85.99
    toluene 388.29
    isobutanol 155.41
    1,4-dioxane 545.61
    methyl acetate 205.06
    THF 524.23
    2-butanone 194.2
    n-pentanol 183.43
    sec-butanol 166.39
    n-hexane 61.33
    ethylene glycol 23.26
    NMP 90.48
    cyclohexane 143.8
    DMSO 137.22
    n-butyl acetate 366.8
    n-octanol 147.31
    chloroform 1209.55
    n-propyl acetate 240.55
    acetic acid 215.01
    dichloromethane 894.62
    cyclohexanone 290.31
    propylene glycol 41.75
    isopropyl acetate 271.97
    DMAc 130.31
    2-ethoxyethanol 223.77
    isopentanol 257.78
    n-heptane 65.05
    ethyl formate 181.47
    1,2-dichloroethane 417.72
    n-hexanol 281.14
    2-methoxyethanol 241.98
    isobutyl acetate 191.46
    tetrachloromethane 183.96
    n-pentyl acetate 205.74
    transcutol 1055.34
    n-heptanol 147.16
    ethylbenzene 174.34
    MIBK 195.22
    2-propoxyethanol 301.12
    tert-butanol 237.77
    MTBE 243.18
    2-butoxyethanol 212.43
    propionic acid 139.42
    o-xylene 202.35
    formic acid 53.37
    diethyl ether 372.51
    m-xylene 249.3
    p-xylene 203.52
    chlorobenzene 339.13
    dimethyl carbonate 73.4
    n-octane 29.5
    formamide 71.26
    cyclopentanone 219.36
    2-pentanone 217.01
    anisole 235.3
    cyclopentyl methyl ether 282.68
    gamma-butyrolactone 258.0
    1-methoxy-2-propanol 216.97
    pyridine 462.8
    3-pentanone 165.52
    furfural 309.85
    n-dodecane 26.9
    diethylene glycol 157.46
    diisopropyl ether 148.36
    tert-amyl alcohol 197.17
    acetylacetone 222.72
    n-hexadecane 30.99
    acetophenone 204.6
    methyl propionate 176.31
    isopentyl acetate 320.45
    trichloroethylene 798.96
    n-nonanol 139.73
    cyclohexanol 224.02
    benzyl alcohol 186.09
    2-ethylhexanol 211.04
    isooctanol 130.51
    dipropyl ether 236.17
    1,2-dichlorobenzene 288.36
    ethyl lactate 94.87
    propylene carbonate 227.98
    n-methylformamide 68.46
    2-pentanol 190.91
    n-pentane 79.48
    1-propoxy-2-propanol 249.77
    1-methoxy-2-propyl acetate 259.42
    2-(2-methoxypropoxy) propanol 223.87
    mesitylene 164.21
    ε-caprolactone 317.1
    p-cymene 134.15
    epichlorohydrin 401.28
    1,1,1-trichloroethane 434.68
    2-aminoethanol 63.05
    morpholine-4-carbaldehyde 223.1
    sulfolane 205.19
    2,2,4-trimethylpentane 45.1
    2-methyltetrahydrofuran 364.23
    n-hexyl acetate 264.17
    isooctane 48.24
    2-(2-butoxyethoxy)ethanol 321.15
    sec-butyl acetate 197.8
    tert-butyl acetate 249.75
    decalin 66.74
    glycerin 61.5
    diglyme 516.74
    acrylic acid 109.51
    isopropyl myristate 124.43
    n-butyric acid 315.29
    acetyl acetate 250.07
    di(2-ethylhexyl) phthalate 110.02
    ethyl propionate 194.02
    nitromethane 194.38
    1,2-diethoxyethane 409.65
    benzonitrile 299.62
    trioctyl phosphate 78.55
    1-bromopropane 370.03
    gamma-valerolactone 290.4
    n-decanol 105.32
    triethyl phosphate 114.31
    4-methyl-2-pentanol 155.96
    propionitrile 209.99
    vinylene carbonate 236.22
    1,1,2-trichlorotrifluoroethane 230.78
    DMS 155.86
    cumene 124.98
    2-octanol 99.11
    2-hexanone 192.15
    octyl acetate 143.56
    limonene 162.22
    1,2-dimethoxyethane 379.65
    ethyl orthosilicate 127.14
    tributyl phosphate 105.21
    diacetone alcohol 190.95
    N,N-dimethylaniline 151.82
    acrylonitrile 192.22
    aniline 259.1
    1,3-propanediol 140.59
    bromobenzene 440.87
    dibromomethane 707.38
    1,1,2,2-tetrachloroethane 598.02
    2-methyl-cyclohexyl acetate 190.49
    tetrabutyl urea 111.65
    diisobutyl methanol 144.23
    2-phenylethanol 216.74
    styrene 219.29
    dioctyl adipate 158.54
    dimethyl sulfate 73.36
    ethyl butyrate 263.64
    methyl lactate 77.34
    butyl lactate 135.65
    diethyl carbonate 181.46
    propanediol butyl ether 158.1
    triethyl orthoformate 186.9
    p-tert-butyltoluene 129.47
    methyl 4-tert-butylbenzoate 194.31
    morpholine 459.7
    tert-butylamine 199.51
    n-dodecanol 84.33
    dimethoxymethane 187.65
    ethylene carbonate 215.47
    cyrene 146.14
    2-ethoxyethyl acetate 251.24
    2-ethylhexyl acetate 261.13
    1,2,4-trichlorobenzene 295.09
    4-methylpyridine 392.11
    dibutyl ether 221.36
    2,6-dimethyl-4-heptanol 144.23
    DEF 186.4
    dimethyl isosorbide 296.31
    tetrachloroethylene 410.73
    eugenol 171.04
    triacetin 239.23
    span 80 196.31
    1,4-butanediol 58.18
    1,1-dichloroethane 441.71
    2-methyl-1-pentanol 194.92
    methyl formate 58.46
    2-methyl-1-butanol 208.29
    n-decane 44.91
    butyronitrile 308.91
    3,7-dimethyl-1-octanol 168.83
    1-chlorooctane 136.7
    1-chlorotetradecane 61.51
    n-nonane 41.79
    undecane 33.34
    tert-butylcyclohexane 59.54
    cyclooctane 67.21
    cyclopentanol 142.29
    tetrahydropyran 508.06
    tert-amyl methyl ether 182.51
    2,5,8-trioxanonane 356.48
    1-hexene 171.14
    2-isopropoxyethanol 181.39
    2,2,2-trifluoroethanol 65.53
    methyl butyrate 247.53

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction