2,4-Dimethylpyridine

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  • Identifiers

    CAS number
    108-47-4

    Molecular formula
    C7H9N

    SMILES
    CC1=CC(=NC=C1)C

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 87.97%
    Fishy 62.1%
    Animal 54.66%
    Herbal 48.33%
    Nutty 48.26%
    Earthy 47.13%
    Tobacco 45.47%
    Woody 43.45%
    Vegetable 42.43%
    Musty 42.19%

     

    Flavor
    Nutty 51.43%
    Woody 44.45%
    Cocoa 42.97%
    Roasted 37.3%
    Coffee 33.09%
    Leather 28.83%
    Musty 28.67%
    Medicinal 27.32%
    Phenolic 26.29%
    Oily 25.31%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    5.89 (weak acid)

    Molecular weight
    107.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    158°C

    Melting point expt.

    • -64 °C

    Flash point

    • 41.97 ˚C est.

    Solubility expt.

    • 350 mg/mL at 25 °C
    • Slightly soluble in water
    • Soluble (in ethanol)

  • Synonyms

    • 2,4-Lutidine
    • 2,4-DIMETHYLPYRIDINE
    • 108-47-4
    • Pyridine, 2,4-dimethyl-
    • 2,4-Lutidene
    • alpha,gamma-Dimethylpyridine
    • 2,4-dimethyl-pyridine
    • NSC 2156
    • EINECS 203-586-8
    • UNII-83903UJ0WW
    • BRN 0001506
    • AI3-24281
    • .alpha.,.gamma.-Dimethylpyridine
    • NSC-2156
    • MFCD00006337
    • CHEMBL5286019
    • DTXSID2051556
    • FEMA NO. 4389
    • 83903UJ0WW
    • 5-20-06-00019 (Beilstein Handbook Reference)
    • 2,4-DIMETHYLPYRIDINE [FHFI]
    • 2,4-Dimethylpyridine; NSC 2156; alpha,gamma-Dimethylpyridine
    • 2,4lutidine
    • NSC2156
    • 2.4-lutidine
    • 2,4 Lutidine
    • 2,4-dimethyl pyridine
    • 4,6-dimethyl-pyridine
    • Pyridine, 2,4dimethyl
    • alpha,gammaDimethylpyridine
    • 2,4-Lutidine, 99%
    • SCHEMBL44068
    • DTXCID6030108
    • CHEBI:192115
    • 2,4-Lutidine, analytical standard
    • STR07571
    • BBL027575
    • BDBM50608079
    • STL280318
    • AKOS005258307
    • CS-W020592
    • FL03759
    • alpha,Laquo gammaRaquo -dimethylpyridine
    • AC-26213
    • BP-30083
    • DB-023691
    • DB-260379
    • L0085
    • NS00012337
    • EN300-19112
    • Q22266828
    • RVV

  • Applications

    2,4-Dimethylpyridine (CAS 108-47-4) is used as a building block and intermediate in the synthesis of pharmaceuticals and agrochemicals, providing the pyridine ring framework for related compounds. It is also used as a precursor in dye and pigment chemistry. As a specialty intermediate in organic synthesis, it can serve as a reagent or base in various reactions. In the polymer and plastics industry, it may be used as a precursor to pyridine-containing monomers or for functionalizing polymers. In catalysis and coordination chemistry, it can act as a ligand or precursor for metal-catalyzed processes.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 928.28
    methanol 922.75
    isopropanol 517.8
    water 13.01
    ethyl acetate 747.81
    n-propanol 672.16
    acetone 678.33
    n-butanol 630.66
    acetonitrile 636.08
    DMF 470.18
    toluene 431.06
    isobutanol 415.13
    1,4-dioxane 1150.17
    methyl acetate 651.89
    THF 1170.37
    2-butanone 598.62
    n-pentanol 391.75
    sec-butanol 501.51
    n-hexane 258.13
    ethylene glycol 173.31
    NMP 712.88
    cyclohexane 273.26
    DMSO 506.31
    n-butyl acetate 477.98
    n-octanol 205.48
    chloroform 1468.67
    n-propyl acetate 255.31
    acetic acid 727.59
    dichloromethane 1244.63
    cyclohexanone 769.02
    propylene glycol 186.88
    isopropyl acetate 311.33
    DMAc 491.39
    2-ethoxyethanol 342.43
    isopentanol 406.64
    n-heptane 178.59
    ethyl formate 340.38
    1,2-dichloroethane 612.34
    n-hexanol 667.63
    2-methoxyethanol 637.47
    isobutyl acetate 156.44
    tetrachloromethane 347.16
    n-pentyl acetate 224.01
    transcutol 937.04
    n-heptanol 208.98
    ethylbenzene 111.32
    MIBK 210.46
    2-propoxyethanol 708.8
    tert-butanol 466.71
    MTBE 477.95
    2-butoxyethanol 292.39
    propionic acid 527.94
    o-xylene 199.07
    formic acid 325.58
    diethyl ether 900.15
    m-xylene 224.1
    p-xylene 143.74
    chlorobenzene 391.37
    dimethyl carbonate 168.23
    n-octane 47.02
    formamide 321.36
    cyclopentanone 692.03
    2-pentanone 476.85
    anisole 216.74
    cyclopentyl methyl ether 686.49
    gamma-butyrolactone 802.14
    1-methoxy-2-propanol 430.29
    pyridine 651.41
    3-pentanone 437.97
    furfural 516.54
    n-dodecane 32.42
    diethylene glycol 405.36
    diisopropyl ether 199.08
    tert-amyl alcohol 410.99
    acetylacetone 365.98
    n-hexadecane 35.9
    acetophenone 161.73
    methyl propionate 511.16
    isopentyl acetate 337.58
    trichloroethylene 887.17
    n-nonanol 176.33
    cyclohexanol 530.0
    benzyl alcohol 180.11
    2-ethylhexanol 318.64
    isooctanol 144.16
    dipropyl ether 420.82
    1,2-dichlorobenzene 263.31
    ethyl lactate 106.88
    propylene carbonate 375.29
    n-methylformamide 363.54
    2-pentanol 388.33
    n-pentane 225.64
    1-propoxy-2-propanol 471.96
    1-methoxy-2-propyl acetate 351.6
    2-(2-methoxypropoxy) propanol 211.22
    mesitylene 119.11
    ε-caprolactone 629.01
    p-cymene 99.97
    epichlorohydrin 769.95
    1,1,1-trichloroethane 691.0
    2-aminoethanol 319.13
    morpholine-4-carbaldehyde 660.19
    sulfolane 631.27
    2,2,4-trimethylpentane 73.25
    2-methyltetrahydrofuran 1067.16
    n-hexyl acetate 318.54
    isooctane 48.07
    2-(2-butoxyethoxy)ethanol 304.65
    sec-butyl acetate 159.28
    tert-butyl acetate 249.17
    decalin 75.66
    glycerin 222.69
    diglyme 477.95
    acrylic acid 384.88
    isopropyl myristate 111.98
    n-butyric acid 589.15
    acetyl acetate 342.95
    di(2-ethylhexyl) phthalate 104.92
    ethyl propionate 233.66
    nitromethane 788.97
    1,2-diethoxyethane 467.65
    benzonitrile 249.43
    trioctyl phosphate 75.49
    1-bromopropane 597.16
    gamma-valerolactone 792.22
    n-decanol 131.22
    triethyl phosphate 100.42
    4-methyl-2-pentanol 166.15
    propionitrile 455.88
    vinylene carbonate 343.45
    1,1,2-trichlorotrifluoroethane 415.59
    DMS 208.32
    cumene 80.4
    2-octanol 135.13
    2-hexanone 259.94
    octyl acetate 157.91
    limonene 192.41
    1,2-dimethoxyethane 456.49
    ethyl orthosilicate 106.07
    tributyl phosphate 99.84
    diacetone alcohol 246.9
    N,N-dimethylaniline 141.01
    acrylonitrile 397.25
    aniline 425.4
    1,3-propanediol 404.3
    bromobenzene 402.34
    dibromomethane 929.13
    1,1,2,2-tetrachloroethane 692.48
    2-methyl-cyclohexyl acetate 175.51
    tetrabutyl urea 121.13
    diisobutyl methanol 131.4
    2-phenylethanol 256.86
    styrene 150.48
    dioctyl adipate 131.99
    dimethyl sulfate 194.33
    ethyl butyrate 252.55
    methyl lactate 171.22
    butyl lactate 138.17
    diethyl carbonate 143.9
    propanediol butyl ether 190.44
    triethyl orthoformate 169.48
    p-tert-butyltoluene 98.45
    methyl 4-tert-butylbenzoate 162.85
    morpholine 1079.6
    tert-butylamine 349.52
    n-dodecanol 102.15
    dimethoxymethane 432.92
    ethylene carbonate 329.55
    cyrene 165.13
    2-ethoxyethyl acetate 296.44
    2-ethylhexyl acetate 290.27
    1,2,4-trichlorobenzene 302.96
    4-methylpyridine 625.68
    dibutyl ether 267.88
    2,6-dimethyl-4-heptanol 131.4
    DEF 487.92
    dimethyl isosorbide 318.82
    tetrachloroethylene 511.76
    eugenol 152.32
    triacetin 201.71
    span 80 203.19
    1,4-butanediol 151.59
    1,1-dichloroethane 736.59
    2-methyl-1-pentanol 302.18
    methyl formate 281.35
    2-methyl-1-butanol 443.15
    n-decane 54.14
    butyronitrile 476.76
    3,7-dimethyl-1-octanol 185.09
    1-chlorooctane 157.88
    1-chlorotetradecane 66.2
    n-nonane 60.25
    undecane 40.24
    tert-butylcyclohexane 73.17
    cyclooctane 91.49
    cyclopentanol 520.53
    tetrahydropyran 1129.04
    tert-amyl methyl ether 381.46
    2,5,8-trioxanonane 325.32
    1-hexene 404.37
    2-isopropoxyethanol 234.85
    2,2,2-trifluoroethanol 226.53
    methyl butyrate 264.83

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction