2,4-Dimethylphenol

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  • Identifiers

    CAS number
    105-67-9

    Molecular formula
    C8H10O

    SMILES
    CC1=CC(=C(C=C1)O)C

    Safety labels

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 86.01%
    Smoky 67.24%
    Medicinal 63.91%
    Leathery 54.26%
    Spicy 53.05%
    Burnt 44.05%
    Woody 40.88%
    Animal 39.95%
    Sweet 37.33%
    Musty 36.94%

     

    Flavor
    Phenolic 75.62%
    Medicinal 59.33%
    Sweet 53.12%
    Smoke 41.99%
    Phenol 41.25%
    Smoky 40.75%
    Bacon 35.73%
    Medicine 33.85%
    Clove 31.85%
    Spicy 31.69%

     

    Odor impact est.
    High

    Odor threshold

    • 0.001 mg/cu m (recognition in air); 0.0005-0.4 mg/cu m (detection in air)
    • 0.4 mg/l (detection in water)

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    10.08 (weak base)

    Molecular weight
    122.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Melting point expt.

    • 72 to 73 °F (NTP, 1992)
    • 25.4-26 °C; 24.54 °C
    • 25.4-26 °C

    Boiling point

    • 414 °F at 766 mmHg (NTP, 1992)
    • 211.5 °C @ 766 mm Hg; 210.8 @ 760 mm Hg
    • 211.5 °C

    Flash point

    • 86.92 ˚C est.
    • greater than 235 °F (NTP, 1992)
    • Flash point > 112 °C
    • >112 °C (closed cup)
    • >112 °C c.c.

    Solubility expt.

    • less than 1 mg/mL at 64 °F (NTP, 1992)
    • Miscible in ethyl alcohol, ethyl ether; soluble in carbon tetrachloride
    • Very sol in benzene, chloroform
    • In water, 7.87X10+3 mg/l @ 25 °C.
    • Soluble in oxygenated and aromatic solvents
    • 7.2 x 10 (-2) mol/l, at pH 5.1 and 25 °C.
    • Solubility in water, g/100ml at 25 °C: 0.79

  • Synonyms

    • 2,4-DIMETHYLPHENOL
    • 105-67-9
    • 2,4-Xylenol
    • m-Xylenol
    • Gallex
    • Phenol, 2,4-dimethyl-
    • 4,6-Dimethylphenol
    • 1-Hydroxy-2,4-dimethylbenzene
    • RCRA waste number U101
    • Caswell No. 907A
    • Lysol Brand disinfectant
    • 4-Hydroxy-1,3-dimethylbenzene
    • NSC 3829
    • 2,4-Dimethyl phenol
    • Bulk Lysol Brand Disinfectant
    • CCRIS 721
    • HSDB 4253
    • Gable-Tite Dark Creosote (Creola)
    • Benzene, 2,4-dimethyl-1-hydroxy-
    • Gable-Tite Light Creosote (Creola)
    • EINECS 203-321-6
    • EPA Pesticide Chemical Code 086804
    • BRN 0636244
    • DTXSID2021864
    • UNII-5OD803C081
    • 2,4-Dimethyl-phenol
    • CHEBI:34241
    • AI3-17612
    • NSC-3829
    • MFCD00002233
    • 5OD803C081
    • 2,4-Dimethylphenol-d10
    • DIMETHYLPHENOL, 2,4-
    • DTXCID101864
    • EC 203-321-6
    • XYLENOL 2,4-DIMETHYLPHENOL
    • 2,4-DIMETHYLPHENOL [HSDB]
    • 4-06-00-03126 (Beilstein Handbook Reference)
    • (R)-Lysine;
    • XYLENOL 2,4-DIMETHYLPHENOL [MI]
    • METACRESOL IMPURITY F [EP IMPURITY]
    • CAS-105-67-9
    • METACRESOL IMPURITY F (EP IMPURITY)
    • 2,4-DMP
    • RCRA waste no. U101
    • mXylenol
    • asym-m-xylenol
    • As-m-xylenol
    • 2,4dimethylphenol
    • 2,4xylenol
    • 4,6Dimethylphenol
    • 2-methyl-p-cresol
    • 2.4-dimethylphenol
    • 4-Hydroxy-m-xylene
    • Caswell No 907A
    • Phenol, 2,4dimethyl
    • M-4-XYLENOL
    • 1Hydroxy2,4dimethylbenzene
    • 4Hydroxy1,3dimethylbenzene
    • 2,4-Dimethylphenol Standard
    • SCHEMBL92167
    • 2,4-Dimethylphenol, 98%
    • MLS002152861
    • Benzene, 2,4dimethyl1hydroxy
    • BIDD:ER0275
    • CHEMBL29878
    • WLN: QR B1 D1
    • 1,3-Dimethyl-4-hydroxybenzene
    • 1-Hydroxy-2.4-dimethylbenzene
    • 2,4-Xylenol, >=98%
    • NSC3829
    • 2,4-Dimethylphenol 2,4-Xylenol
    • GableTite Dark Creosote (Creola)
    • GableTite Light Creosote (Creola)
    • HMS3039J10
    • MSK20388
    • Tox21_201787
    • Tox21_300051
    • BBL011443
    • STL146554
    • AKOS000121556
    • 2,4-Dimethylphenol, analytical standard
    • NCGC00091611-01
    • NCGC00091611-02
    • NCGC00091611-03
    • NCGC00091611-04
    • NCGC00091611-05
    • NCGC00253938-01
    • NCGC00259336-01
    • 1ST20388
    • PS-11923
    • SMR001224485
    • MSK20388-1000
    • DB-010714
    • D0774
    • NS00010821
    • EN300-21109
    • 2,4-Dimethylphenol 100 microg/mL in Methanol
    • 1ST20388-1000
    • Q2437536
    • 2,4-Dimethylphenol Solution in Methanol, 1000?g/mL
    • 2,4-Dimethylphenol Solution in Methanol, 1000mug/mL
    • 2,4-Dimethylphenol, PESTANAL(R), analytical standard
    • F0001-0111
    • Z104492084
    • N0D

  • Applications

    2,4-Dimethylphenol (CAS 105-67-9) is used as an aromatic building block in organic synthesis and as an intermediate in the production of specialty dyes and pigments. It can serve as an odorant or fragrance intermediate in fragrance and flavor chemistry. In polymer and coating formulations, it functions as a precursor for phenolic resins and for various polymer additives used in coatings, inks, and plastics. It is also encountered as an intermediate in the synthesis of pharmaceutical and agrochemical compounds, enabling selective functionalization of substituted phenols.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1716.0
    methanol 1965.26
    isopropanol 1212.14
    water 6.46
    ethyl acetate 1117.16
    n-propanol 1228.63
    acetone 1105.51
    n-butanol 993.27
    acetonitrile 1407.91
    DMF 849.25
    toluene 234.08
    isobutanol 738.26
    1,4-dioxane 2271.09
    methyl acetate 1018.66
    THF 2393.49
    2-butanone 958.06
    n-pentanol 659.09
    sec-butanol 830.2
    n-hexane 178.13
    ethylene glycol 231.25
    NMP 393.63
    cyclohexane 75.03
    DMSO 807.47
    n-butyl acetate 734.11
    n-octanol 388.67
    chloroform 1214.1
    n-propyl acetate 583.83
    acetic acid 522.62
    dichloromethane 1004.41
    cyclohexanone 667.29
    propylene glycol 272.32
    isopropyl acetate 506.73
    DMAc 404.2
    2-ethoxyethanol 859.63
    isopentanol 658.36
    n-heptane 115.28
    ethyl formate 665.93
    1,2-dichloroethane 721.25
    n-hexanol 984.5
    2-methoxyethanol 1210.8
    isobutyl acetate 333.81
    tetrachloromethane 277.85
    n-pentyl acetate 316.79
    transcutol 1213.92
    n-heptanol 443.62
    ethylbenzene 169.7
    MIBK 449.21
    2-propoxyethanol 1354.63
    tert-butanol 1222.83
    MTBE 1088.01
    2-butoxyethanol 627.8
    propionic acid 615.96
    o-xylene 143.29
    formic acid 258.69
    diethyl ether 1359.2
    m-xylene 193.35
    p-xylene 183.89
    chlorobenzene 281.84
    dimethyl carbonate 246.44
    n-octane 57.41
    formamide 456.61
    cyclopentanone 922.03
    2-pentanone 783.88
    anisole 413.18
    cyclopentyl methyl ether 783.21
    gamma-butyrolactone 1002.89
    1-methoxy-2-propanol 924.35
    pyridine 607.43
    3-pentanone 486.06
    furfural 597.23
    n-dodecane 38.45
    diethylene glycol 702.78
    diisopropyl ether 317.91
    tert-amyl alcohol 803.23
    acetylacetone 545.04
    n-hexadecane 41.84
    acetophenone 243.8
    methyl propionate 682.98
    isopentyl acetate 497.6
    trichloroethylene 978.99
    n-nonanol 315.11
    cyclohexanol 428.21
    benzyl alcohol 264.79
    2-ethylhexanol 440.0
    isooctanol 329.5
    dipropyl ether 565.45
    1,2-dichlorobenzene 220.84
    ethyl lactate 188.91
    propylene carbonate 447.62
    n-methylformamide 766.48
    2-pentanol 646.7
    n-pentane 126.55
    1-propoxy-2-propanol 757.66
    1-methoxy-2-propyl acetate 488.88
    2-(2-methoxypropoxy) propanol 324.12
    mesitylene 125.96
    ε-caprolactone 570.56
    p-cymene 107.5
    epichlorohydrin 1354.48
    1,1,1-trichloroethane 692.52
    2-aminoethanol 533.23
    morpholine-4-carbaldehyde 739.01
    sulfolane 672.09
    2,2,4-trimethylpentane 61.68
    2-methyltetrahydrofuran 1277.94
    n-hexyl acetate 471.79
    isooctane 72.92
    2-(2-butoxyethoxy)ethanol 573.87
    sec-butyl acetate 327.61
    tert-butyl acetate 507.11
    decalin 61.24
    glycerin 281.18
    diglyme 926.29
    acrylic acid 369.27
    isopropyl myristate 175.93
    n-butyric acid 823.56
    acetyl acetate 340.3
    di(2-ethylhexyl) phthalate 115.21
    ethyl propionate 438.52
    nitromethane 1049.2
    1,2-diethoxyethane 698.35
    benzonitrile 294.39
    trioctyl phosphate 117.01
    1-bromopropane 584.58
    gamma-valerolactone 1060.09
    n-decanol 233.36
    triethyl phosphate 128.95
    4-methyl-2-pentanol 344.1
    propionitrile 928.12
    vinylene carbonate 400.5
    1,1,2-trichlorotrifluoroethane 445.14
    DMS 225.55
    cumene 130.59
    2-octanol 292.96
    2-hexanone 570.31
    octyl acetate 239.38
    limonene 164.83
    1,2-dimethoxyethane 1182.84
    ethyl orthosilicate 138.65
    tributyl phosphate 123.55
    diacetone alcohol 528.25
    N,N-dimethylaniline 240.14
    acrylonitrile 796.84
    aniline 303.29
    1,3-propanediol 737.11
    bromobenzene 258.4
    dibromomethane 743.08
    1,1,2,2-tetrachloroethane 711.74
    2-methyl-cyclohexyl acetate 230.65
    tetrabutyl urea 136.46
    diisobutyl methanol 230.84
    2-phenylethanol 374.61
    styrene 189.71
    dioctyl adipate 169.0
    dimethyl sulfate 253.88
    ethyl butyrate 404.58
    methyl lactate 238.22
    butyl lactate 202.46
    diethyl carbonate 214.92
    propanediol butyl ether 351.94
    triethyl orthoformate 220.47
    p-tert-butyltoluene 117.69
    methyl 4-tert-butylbenzoate 241.47
    morpholine 1957.64
    tert-butylamine 788.47
    n-dodecanol 176.04
    dimethoxymethane 966.78
    ethylene carbonate 393.51
    cyrene 252.76
    2-ethoxyethyl acetate 412.68
    2-ethylhexyl acetate 360.28
    1,2,4-trichlorobenzene 223.44
    4-methylpyridine 562.48
    dibutyl ether 376.28
    2,6-dimethyl-4-heptanol 230.84
    DEF 540.67
    dimethyl isosorbide 459.08
    tetrachloroethylene 468.73
    eugenol 263.26
    triacetin 218.32
    span 80 287.78
    1,4-butanediol 314.45
    1,1-dichloroethane 925.93
    2-methyl-1-pentanol 463.28
    methyl formate 580.94
    2-methyl-1-butanol 604.9
    n-decane 70.3
    butyronitrile 961.02
    3,7-dimethyl-1-octanol 303.39
    1-chlorooctane 228.64
    1-chlorotetradecane 86.79
    n-nonane 73.1
    undecane 49.91
    tert-butylcyclohexane 84.3
    cyclooctane 37.58
    cyclopentanol 530.31
    tetrahydropyran 1504.31
    tert-amyl methyl ether 575.11
    2,5,8-trioxanonane 518.95
    1-hexene 488.77
    2-isopropoxyethanol 632.93
    2,2,2-trifluoroethanol 206.05
    methyl butyrate 524.93

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction