2,4-Dimethyl-5-vinylthiazole

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  • Identifiers

    CAS number
    65505-18-2

    Molecular formula
    C7H9NS

    SMILES
    CC1=C(SC(=N1)C)C=C

  • Odor profile

    Fragrance
    Nutty 69.64%
    Roasted 62.63%
    Meaty 60.13%
    Cocoa 42.19%
    Burnt 41.04%
    Coffee 40.41%
    Hazelnut 37.28%
    Sulfurous 36.31%
    Musty 36.18%
    Popcorn 35.12%

     

    Flavor
    Nutty 72.84%
    Roasted 55.0%
    Cocoa 53.94%
    Hazelnut 41.33%
    Roast 40.45%
    Coffee 40.23%
    Popcorn 38.96%
    Musty 38.09%
    Chocolate 37.61%
    Burnt 34.49%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    6.38 (neutral)

    Molecular weight
    139.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point

    • 183.00 to 184.00 °C. @ 760.00 mm Hg

    Flash point

    • 54.74 ˚C est.

    Solubility expt.

    • Soluble in organic solvents
    • Miscible at room temperature (in ethanol)

  • Synonyms

    • 2,4-Dimethyl-5-vinylthiazole
    • 65505-18-2
    • 5-ethenyl-2,4-dimethyl-1,3-thiazole
    • Thiazole, 5-ethenyl-2,4-dimethyl-
    • 5-Ethenyl-2,4-dimethylthiazole
    • FEMA No. 3145
    • UNII-16G6IW897V
    • 16G6IW897V
    • DTXSID60215810
    • 2,4-DIMETHYL-5-VINYLTHIAZOLE [FHFI]
    • 2,4-dimethyl-5-vinyl thiazole
    • SCHEMBL3505953
    • FEMA 3145
    • DTXCID90138301
    • 5-Ethenyl-2,4-dimethyl-Thiazole
    • CHEBI:173374
    • MLBCDQHOBLVBQD-UHFFFAOYSA-N
    • QCA50518
    • AKOS006275599
    • 5-Ethenyl-2,4-dimethylthiazole, 9CI
    • DB-127448
    • NS00123491
    • G65311
    • EN300-3412548
    • Q27251809

  • Applications

    2,4-Dimethyl-5-vinylthiazole (CAS 65505-18-2) has practical applications as a fragrance ingredient in perfumery and cosmetics/personal care, contributing distinctive notes to formulations. The vinyl substituent enables polymerization, making it a candidate reactive monomer for specialty polymers and for use in coatings and inks. It can serve as an intermediate in organic synthesis for pharmaceutical and agrochemical development. Additionally, it may be employed as an odorant or fragrance component in industrial coating systems where formulation guidelines permit.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 291.32
    methanol 353.05
    isopropanol 230.84
    water 9.74
    ethyl acetate 372.2
    n-propanol 278.39
    acetone 482.59
    n-butanol 269.03
    acetonitrile 287.22
    DMF 836.21
    toluene 366.81
    isobutanol 217.03
    1,4-dioxane 790.87
    methyl acetate 349.84
    THF 1027.87
    2-butanone 409.9
    n-pentanol 194.09
    sec-butanol 235.78
    n-hexane 93.79
    ethylene glycol 138.74
    NMP 905.66
    cyclohexane 120.92
    DMSO 644.2
    n-butyl acetate 233.75
    n-octanol 163.39
    chloroform 824.48
    n-propyl acetate 201.15
    acetic acid 229.95
    dichloromethane 738.09
    cyclohexanone 608.88
    propylene glycol 136.23
    isopropyl acetate 252.45
    DMAc 664.08
    2-ethoxyethanol 358.47
    isopentanol 217.0
    n-heptane 74.82
    ethyl formate 222.54
    1,2-dichloroethane 466.66
    n-hexanol 257.51
    2-methoxyethanol 591.96
    isobutyl acetate 155.89
    tetrachloromethane 262.13
    n-pentyl acetate 208.28
    transcutol 576.03
    n-heptanol 149.9
    ethylbenzene 167.23
    MIBK 272.41
    2-propoxyethanol 494.89
    tert-butanol 271.32
    MTBE 338.69
    2-butoxyethanol 256.47
    propionic acid 210.51
    o-xylene 240.39
    formic acid 121.06
    diethyl ether 424.07
    m-xylene 284.38
    p-xylene 203.46
    chlorobenzene 403.75
    dimethyl carbonate 248.0
    n-octane 41.28
    formamide 174.45
    cyclopentanone 762.72
    2-pentanone 389.91
    anisole 365.75
    cyclopentyl methyl ether 614.88
    gamma-butyrolactone 722.58
    1-methoxy-2-propanol 482.01
    pyridine 510.95
    3-pentanone 341.34
    furfural 655.43
    n-dodecane 36.16
    diethylene glycol 377.63
    diisopropyl ether 172.94
    tert-amyl alcohol 253.65
    acetylacetone 481.29
    n-hexadecane 41.28
    acetophenone 292.82
    methyl propionate 359.57
    isopentyl acetate 220.44
    trichloroethylene 765.69
    n-nonanol 148.57
    cyclohexanol 289.93
    benzyl alcohol 231.88
    2-ethylhexanol 170.51
    isooctanol 126.91
    dipropyl ether 243.21
    1,2-dichlorobenzene 367.18
    ethyl lactate 132.44
    propylene carbonate 340.1
    n-methylformamide 334.76
    2-pentanol 206.7
    n-pentane 85.54
    1-propoxy-2-propanol 307.21
    1-methoxy-2-propyl acetate 305.72
    2-(2-methoxypropoxy) propanol 246.55
    mesitylene 202.42
    ε-caprolactone 460.42
    p-cymene 127.38
    epichlorohydrin 765.81
    1,1,1-trichloroethane 552.59
    2-aminoethanol 195.26
    morpholine-4-carbaldehyde 813.12
    sulfolane 898.85
    2,2,4-trimethylpentane 54.46
    2-methyltetrahydrofuran 726.72
    n-hexyl acetate 297.59
    isooctane 45.45
    2-(2-butoxyethoxy)ethanol 304.03
    sec-butyl acetate 166.01
    tert-butyl acetate 301.0
    decalin 81.84
    glycerin 223.57
    diglyme 525.76
    acrylic acid 202.76
    isopropyl myristate 144.95
    n-butyric acid 265.68
    acetyl acetate 258.35
    di(2-ethylhexyl) phthalate 142.02
    ethyl propionate 225.71
    nitromethane 461.68
    1,2-diethoxyethane 290.11
    benzonitrile 282.99
    trioctyl phosphate 105.34
    1-bromopropane 336.3
    gamma-valerolactone 866.5
    n-decanol 117.56
    triethyl phosphate 139.92
    4-methyl-2-pentanol 135.69
    propionitrile 261.11
    vinylene carbonate 335.82
    1,1,2-trichlorotrifluoroethane 444.94
    DMS 260.51
    cumene 130.13
    2-octanol 127.12
    2-hexanone 246.18
    octyl acetate 181.13
    limonene 192.39
    1,2-dimethoxyethane 549.2
    ethyl orthosilicate 138.77
    tributyl phosphate 119.13
    diacetone alcohol 296.26
    N,N-dimethylaniline 263.81
    acrylonitrile 287.35
    aniline 311.93
    1,3-propanediol 258.03
    bromobenzene 422.34
    dibromomethane 544.5
    1,1,2,2-tetrachloroethane 605.54
    2-methyl-cyclohexyl acetate 209.75
    tetrabutyl urea 158.69
    diisobutyl methanol 110.61
    2-phenylethanol 250.48
    styrene 209.88
    dioctyl adipate 175.55
    dimethyl sulfate 431.59
    ethyl butyrate 201.17
    methyl lactate 218.72
    butyl lactate 145.38
    diethyl carbonate 146.49
    propanediol butyl ether 198.51
    triethyl orthoformate 165.83
    p-tert-butyltoluene 136.24
    methyl 4-tert-butylbenzoate 269.62
    morpholine 707.3
    tert-butylamine 192.76
    n-dodecanol 97.38
    dimethoxymethane 667.79
    ethylene carbonate 281.99
    cyrene 293.61
    2-ethoxyethyl acetate 277.68
    2-ethylhexyl acetate 200.42
    1,2,4-trichlorobenzene 426.31
    4-methylpyridine 547.5
    dibutyl ether 203.37
    2,6-dimethyl-4-heptanol 110.61
    DEF 436.11
    dimethyl isosorbide 458.7
    tetrachloroethylene 428.03
    eugenol 257.5
    triacetin 245.52
    span 80 225.15
    1,4-butanediol 140.61
    1,1-dichloroethane 484.34
    2-methyl-1-pentanol 185.23
    methyl formate 303.21
    2-methyl-1-butanol 228.1
    n-decane 51.49
    butyronitrile 265.48
    3,7-dimethyl-1-octanol 154.34
    1-chlorooctane 151.13
    1-chlorotetradecane 79.02
    n-nonane 52.22
    undecane 42.23
    tert-butylcyclohexane 77.05
    cyclooctane 67.94
    cyclopentanol 335.35
    tetrahydropyran 627.23
    tert-amyl methyl ether 310.66
    2,5,8-trioxanonane 399.14
    1-hexene 173.96
    2-isopropoxyethanol 257.43
    2,2,2-trifluoroethanol 149.39
    methyl butyrate 244.18

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction