2,4-Dimethyl-5-ethyl-3-oxazoline

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  • Identifiers

    CAS number
    60633-22-9

    Molecular formula
    C7H13NO

    SMILES
    CCC1C(=NC(O1)C)C

    Safety labels

  • Odor profile

    Fragrance
    Nutty 75.81%
    Vegetable 61.57%
    Green 57.96%
    Roasted 57.31%
    Cocoa 51.93%
    Earthy 50.0%
    Musty 48.3%
    Woody 45.95%
    Chocolate 45.63%
    Meaty 44.04%

     

    Flavor
    Green 70.47%
    Nutty 55.08%
    Caramel 40.73%
    Earthy 38.71%
    Musty 38.55%
    Vegetable 37.14%
    Roasted 33.59%
    Raw 31.87%
    Potato 31.82%
    Wood 26.47%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    7.85 (neutral)

    Molecular weight
    127.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    143°C

    Flash point

    • 55.16 ˚C est.

  • Synonyms

    • SCHEMBL11327225
    • DTXSID801302316
    • 2,4-Dimethyl-5-ethyl-3-oxazoline
    • 60633-22-9
    • 5-ethyl-2,4-dimethyl-2,5-dihydro-1,3-oxazole
    • 60633-22-9

  • Applications

    2,4-Dimethyl-5-ethyl-3-oxazoline (CAS 60633-22-9) is primarily used as a monomer precursor for poly(2-oxazoline)s and related copolymers, enabling tunable hydrophilicity and thermal properties for specialty polymers employed in coatings, plastics, and adhesives. It also serves as an intermediate in organic synthesis for functional oxazoline compounds used in pharmaceutical and biomedical material development, and may be applied as a building block in industrial formulations for specialty chemicals and performance materials. The compound may be used in cosmetic and personal care formulations as part of polymeric conditioning or thickening systems. It can also be explored as an intermediate in agrochemical synthesis, contributing to heterocyclic scaffolds employed in crop protection chemistry, subject to regulatory constraints and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1368.19
    methanol 2413.86
    isopropanol 911.92
    water 51.13
    ethyl acetate 699.83
    n-propanol 1109.65
    acetone 884.64
    n-butanol 1049.31
    acetonitrile 1115.17
    DMF 1212.82
    toluene 649.99
    isobutanol 911.7
    1,4-dioxane 1067.67
    methyl acetate 719.2
    THF 1528.96
    2-butanone 821.99
    n-pentanol 692.83
    sec-butanol 958.09
    n-hexane 218.61
    ethylene glycol 545.58
    NMP 1298.35
    cyclohexane 258.99
    DMSO 1225.63
    n-butyl acetate 507.76
    n-octanol 435.7
    chloroform 3846.36
    n-propyl acetate 393.49
    acetic acid 1224.12
    dichloromethane 3759.8
    cyclohexanone 1198.0
    propylene glycol 539.39
    isopropyl acetate 498.36
    DMAc 1045.07
    2-ethoxyethanol 957.46
    isopentanol 855.94
    n-heptane 129.44
    ethyl formate 580.05
    1,2-dichloroethane 1543.99
    n-hexanol 713.89
    2-methoxyethanol 1529.58
    isobutyl acetate 305.22
    tetrachloromethane 900.55
    n-pentyl acetate 429.72
    transcutol 1729.74
    n-heptanol 380.19
    ethylbenzene 322.77
    MIBK 466.49
    2-propoxyethanol 1049.17
    tert-butanol 827.0
    MTBE 809.56
    2-butoxyethanol 625.42
    propionic acid 835.53
    o-xylene 432.79
    formic acid 834.72
    diethyl ether 878.39
    m-xylene 438.69
    p-xylene 424.84
    chlorobenzene 1006.82
    dimethyl carbonate 293.79
    n-octane 63.99
    formamide 646.65
    cyclopentanone 1278.74
    2-pentanone 675.24
    anisole 595.64
    cyclopentyl methyl ether 887.05
    gamma-butyrolactone 1388.29
    1-methoxy-2-propanol 1016.88
    pyridine 1181.74
    3-pentanone 585.78
    furfural 1455.71
    n-dodecane 55.12
    diethylene glycol 809.29
    diisopropyl ether 299.49
    tert-amyl alcohol 858.98
    acetylacetone 736.03
    n-hexadecane 60.37
    acetophenone 531.24
    methyl propionate 587.87
    isopentyl acetate 492.66
    trichloroethylene 2637.54
    n-nonanol 358.56
    cyclohexanol 852.66
    benzyl alcohol 579.01
    2-ethylhexanol 402.28
    isooctanol 309.37
    dipropyl ether 406.17
    1,2-dichlorobenzene 905.36
    ethyl lactate 281.69
    propylene carbonate 735.51
    n-methylformamide 856.18
    2-pentanol 677.91
    n-pentane 232.31
    1-propoxy-2-propanol 636.05
    1-methoxy-2-propyl acetate 518.14
    2-(2-methoxypropoxy) propanol 462.44
    mesitylene 292.77
    ε-caprolactone 1020.93
    p-cymene 239.26
    epichlorohydrin 1626.86
    1,1,1-trichloroethane 1535.32
    2-aminoethanol 852.88
    morpholine-4-carbaldehyde 1208.12
    sulfolane 1469.21
    2,2,4-trimethylpentane 148.97
    2-methyltetrahydrofuran 1321.45
    n-hexyl acetate 653.48
    isooctane 91.64
    2-(2-butoxyethoxy)ethanol 636.19
    sec-butyl acetate 322.09
    tert-butyl acetate 522.02
    decalin 151.75
    glycerin 760.88
    diglyme 1084.29
    acrylic acid 790.53
    isopropyl myristate 232.17
    n-butyric acid 970.93
    acetyl acetate 548.17
    di(2-ethylhexyl) phthalate 256.0
    ethyl propionate 383.14
    nitromethane 1335.47
    1,2-diethoxyethane 559.15
    benzonitrile 881.77
    trioctyl phosphate 175.4
    1-bromopropane 1098.95
    gamma-valerolactone 1446.33
    n-decanol 246.66
    triethyl phosphate 209.75
    4-methyl-2-pentanol 388.54
    propionitrile 914.55
    vinylene carbonate 764.29
    1,1,2-trichlorotrifluoroethane 1271.09
    DMS 434.61
    cumene 277.28
    2-octanol 280.99
    2-hexanone 439.01
    octyl acetate 297.68
    limonene 341.75
    1,2-dimethoxyethane 1093.75
    ethyl orthosilicate 211.8
    tributyl phosphate 210.27
    diacetone alcohol 537.28
    N,N-dimethylaniline 453.5
    acrylonitrile 1091.16
    aniline 732.58
    1,3-propanediol 957.64
    bromobenzene 1096.32
    dibromomethane 2539.0
    1,1,2,2-tetrachloroethane 2119.94
    2-methyl-cyclohexyl acetate 322.18
    tetrabutyl urea 256.38
    diisobutyl methanol 220.81
    2-phenylethanol 550.58
    styrene 412.47
    dioctyl adipate 301.81
    dimethyl sulfate 489.89
    ethyl butyrate 370.73
    methyl lactate 405.13
    butyl lactate 329.69
    diethyl carbonate 265.24
    propanediol butyl ether 537.7
    triethyl orthoformate 276.98
    p-tert-butyltoluene 230.76
    methyl 4-tert-butylbenzoate 471.18
    morpholine 1211.03
    tert-butylamine 637.2
    n-dodecanol 177.59
    dimethoxymethane 820.73
    ethylene carbonate 605.87
    cyrene 426.52
    2-ethoxyethyl acetate 493.44
    2-ethylhexyl acetate 398.16
    1,2,4-trichlorobenzene 1043.93
    4-methylpyridine 1241.17
    dibutyl ether 420.41
    2,6-dimethyl-4-heptanol 220.81
    DEF 811.15
    dimethyl isosorbide 657.45
    tetrachloroethylene 1546.9
    eugenol 499.7
    triacetin 474.36
    span 80 409.33
    1,4-butanediol 477.12
    1,1-dichloroethane 1615.94
    2-methyl-1-pentanol 657.01
    methyl formate 656.96
    2-methyl-1-butanol 942.84
    n-decane 90.86
    butyronitrile 914.42
    3,7-dimethyl-1-octanol 398.69
    1-chlorooctane 328.69
    1-chlorotetradecane 126.66
    n-nonane 97.07
    undecane 67.63
    tert-butylcyclohexane 154.09
    cyclooctane 108.57
    cyclopentanol 947.45
    tetrahydropyran 1042.06
    tert-amyl methyl ether 686.51
    2,5,8-trioxanonane 669.22
    1-hexene 478.2
    2-isopropoxyethanol 633.56
    2,2,2-trifluoroethanol 515.92
    methyl butyrate 516.54

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction