2,4-Dimethyl-3-thiazoline

Overview IFRA Request a quote

  • Identifiers

    CAS number
    60755-05-7

    Molecular formula
    C5H9NS

    SMILES
    CC1N=C(CS1)C

  • Odor profile

    Fragrance
    Meaty 79.78%
    Nutty 79.66%
    Roasted 74.26%
    Vegetable 63.55%
    Sulfurous 54.9%
    Cocoa 50.34%
    Beefy 46.5%
    Chocolate 42.73%
    Cooked 42.67%
    Musty 41.23%

     

    Flavor
    Nutty 60.38%
    Roasted 53.56%
    Green 49.11%
    Vegetable 43.71%
    Meaty 42.42%
    Potato 33.1%
    Sulfurous 31.55%
    Roast 31.53%
    Sulfur 30.09%
    Musty 29.72%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    5.87 (weak acid)

    Molecular weight
    115.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    183°C

    Flash point

    • 53.13 ˚C est.

  • Synonyms

    • 2,4-Dimethyl-3-thiazoline
    • 60755-05-7
    • 2,5-Dihydro-2,4-dimethylthiazole
    • 2,4-dimethyl-2,5-dihydro-1,3-thiazole
    • EINECS 262-405-0
    • 42OL7K019G
    • Thiazole, 2,5-dihydro-2,4-dimethyl-
    • 3-THIAZOLINE, 2,4-DIMETHYL-
    • xi-2,5-Dihydro-2,4-dimethylthiazole
    • UNII-42OL7K019G
    • SCHEMBL11314980
    • DTXSID80866823
    • CHEBI:184674
    • PLOCKLWJINZHTI-UHFFFAOYSA-N
    • DB-302458
    • NS00054746
    • Q27258566

  • Applications

    2,4-Dimethyl-3-thiazoline is primarily used as a chemical building block and intermediate in organic synthesis, enabling the preparation of heterocyclic compounds for pharmaceuticals, agrochemicals, and specialty polymers and coatings; in perfumery and cosmetics it can function as a fragrance odorant or fragrance intermediate, contributing to scent profiles in fragrances and personal care products; it may be evaluated for flavor and aroma applications in food and beverage contexts; in research and development, it serves as a reagent for accessing thiazoline-containing motifs and related materials; its use in other markets remains possible subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 573.48
    methanol 756.18
    isopropanol 341.8
    water 19.44
    ethyl acetate 680.42
    n-propanol 416.19
    acetone 964.86
    n-butanol 335.03
    acetonitrile 781.8
    DMF 768.91
    toluene 574.7
    isobutanol 256.43
    1,4-dioxane 1298.01
    methyl acetate 753.68
    THF 1157.65
    2-butanone 728.84
    n-pentanol 229.66
    sec-butanol 298.59
    n-hexane 40.16
    ethylene glycol 248.12
    NMP 1092.58
    cyclohexane 137.41
    DMSO 909.42
    n-butyl acetate 362.36
    n-octanol 173.49
    chloroform 2581.58
    n-propyl acetate 253.34
    acetic acid 860.83
    dichloromethane 1910.13
    cyclohexanone 944.22
    propylene glycol 280.23
    isopropyl acetate 315.71
    DMAc 815.42
    2-ethoxyethanol 437.88
    isopentanol 227.8
    n-heptane 55.08
    ethyl formate 407.92
    1,2-dichloroethane 824.3
    n-hexanol 283.75
    2-methoxyethanol 762.04
    isobutyl acetate 160.76
    tetrachloromethane 469.87
    n-pentyl acetate 252.49
    transcutol 1471.03
    n-heptanol 162.73
    ethylbenzene 142.17
    MIBK 223.12
    2-propoxyethanol 583.51
    tert-butanol 302.26
    MTBE 301.99
    2-butoxyethanol 332.54
    propionic acid 540.22
    o-xylene 269.25
    formic acid 409.52
    diethyl ether 508.66
    m-xylene 279.1
    p-xylene 188.24
    chlorobenzene 704.9
    dimethyl carbonate 227.65
    n-octane 21.16
    formamide 512.79
    cyclopentanone 1032.18
    2-pentanone 457.11
    anisole 382.54
    cyclopentyl methyl ether 541.54
    gamma-butyrolactone 1100.64
    1-methoxy-2-propanol 521.05
    pyridine 1171.98
    3-pentanone 438.8
    furfural 1117.93
    n-dodecane 19.98
    diethylene glycol 517.67
    diisopropyl ether 120.25
    tert-amyl alcohol 240.96
    acetylacetone 633.33
    n-hexadecane 23.24
    acetophenone 336.45
    methyl propionate 510.78
    isopentyl acetate 266.57
    trichloroethylene 1771.94
    n-nonanol 151.5
    cyclohexanol 390.04
    benzyl alcohol 299.87
    2-ethylhexanol 164.08
    isooctanol 115.72
    dipropyl ether 237.46
    1,2-dichlorobenzene 532.79
    ethyl lactate 142.08
    propylene carbonate 540.54
    n-methylformamide 554.19
    2-pentanol 209.95
    n-pentane 58.83
    1-propoxy-2-propanol 387.38
    1-methoxy-2-propyl acetate 425.07
    2-(2-methoxypropoxy) propanol 297.69
    mesitylene 142.83
    ε-caprolactone 752.94
    p-cymene 118.94
    epichlorohydrin 1068.75
    1,1,1-trichloroethane 1036.53
    2-aminoethanol 356.02
    morpholine-4-carbaldehyde 1094.93
    sulfolane 966.28
    2,2,4-trimethylpentane 28.85
    2-methyltetrahydrofuran 926.38
    n-hexyl acetate 339.1
    isooctane 19.76
    2-(2-butoxyethoxy)ethanol 437.04
    sec-butyl acetate 176.16
    tert-butyl acetate 288.48
    decalin 46.31
    glycerin 393.8
    diglyme 786.15
    acrylic acid 559.27
    isopropyl myristate 133.38
    n-butyric acid 566.76
    acetyl acetate 524.83
    di(2-ethylhexyl) phthalate 141.97
    ethyl propionate 222.37
    nitromethane 1312.22
    1,2-diethoxyethane 500.41
    benzonitrile 492.11
    trioctyl phosphate 92.75
    1-bromopropane 513.68
    gamma-valerolactone 1261.94
    n-decanol 110.91
    triethyl phosphate 120.85
    4-methyl-2-pentanol 108.08
    propionitrile 479.05
    vinylene carbonate 557.77
    1,1,2-trichlorotrifluoroethane 838.39
    DMS 306.84
    cumene 95.83
    2-octanol 104.5
    2-hexanone 270.87
    octyl acetate 178.86
    limonene 184.53
    1,2-dimethoxyethane 540.11
    ethyl orthosilicate 117.1
    tributyl phosphate 115.06
    diacetone alcohol 303.82
    N,N-dimethylaniline 218.76
    acrylonitrile 608.61
    aniline 596.4
    1,3-propanediol 391.78
    bromobenzene 770.14
    dibromomethane 1194.9
    1,1,2,2-tetrachloroethane 1299.19
    2-methyl-cyclohexyl acetate 199.36
    tetrabutyl urea 147.05
    diisobutyl methanol 88.0
    2-phenylethanol 318.69
    styrene 228.87
    dioctyl adipate 187.69
    dimethyl sulfate 351.47
    ethyl butyrate 237.65
    methyl lactate 247.43
    butyl lactate 183.03
    diethyl carbonate 162.39
    propanediol butyl ether 288.33
    triethyl orthoformate 178.68
    p-tert-butyltoluene 117.85
    methyl 4-tert-butylbenzoate 280.05
    morpholine 1115.57
    tert-butylamine 187.38
    n-dodecanol 85.3
    dimethoxymethane 530.54
    ethylene carbonate 440.04
    cyrene 277.95
    2-ethoxyethyl acetate 430.44
    2-ethylhexyl acetate 226.95
    1,2,4-trichlorobenzene 684.37
    4-methylpyridine 963.02
    dibutyl ether 200.93
    2,6-dimethyl-4-heptanol 88.0
    DEF 496.38
    dimethyl isosorbide 482.93
    tetrachloroethylene 894.8
    eugenol 261.97
    triacetin 365.49
    span 80 289.35
    1,4-butanediol 172.06
    1,1-dichloroethane 1034.69
    2-methyl-1-pentanol 183.45
    methyl formate 432.06
    2-methyl-1-butanol 241.33
    n-decane 32.01
    butyronitrile 412.07
    3,7-dimethyl-1-octanol 155.16
    1-chlorooctane 129.13
    1-chlorotetradecane 56.8
    n-nonane 31.66
    undecane 24.75
    tert-butylcyclohexane 37.81
    cyclooctane 44.9
    cyclopentanol 434.09
    tetrahydropyran 925.22
    tert-amyl methyl ether 249.82
    2,5,8-trioxanonane 544.86
    1-hexene 126.05
    2-isopropoxyethanol 292.47
    2,2,2-trifluoroethanol 385.67
    methyl butyrate 262.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction