2,4-Dimethoxybenzyl alcohol

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  • Identifiers

    CAS number
    7314-44-5

    Molecular formula
    C9H12O3

    SMILES
    COC1=CC(=C(C=C1)CO)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 86.26%
    Vanilla 67.85%
    Anisic 53.35%
    Fruity 50.63%
    Floral 48.88%
    Phenolic 45.69%
    Aromatic 45.52%
    Spicy 44.33%
    Powdery 39.65%
    Balsamic 39.4%

     

    Flavor
    Sweet 61.84%
    Fruity 49.73%
    Floral 46.67%
    Vanilla 40.66%
    Powdery 39.29%
    Bitter 37.89%
    Balsam 36.6%
    Flower 34.97%
    Creamy 33.74%
    Spicy 30.57%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    7.59 (neutral)

    Molecular weight
    168.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    288°C

    Flash point

    • 126.45 ˚C est.

  • Synonyms

    • 2,4-Dimethoxybenzyl alcohol
    • 7314-44-5
    • Benzenemethanol, 2,4-dimethoxy-
    • 5SV9LUD373
    • DTXSID40223397
    • RefChem:443698
    • DTXCID40145888
    • 230-775-2
    • (2,4-Dimethoxyphenyl)methanol
    • MFCD00004614
    • 2,4-Dimethoxybenzylalcohol
    • 1-hydroxymethyl-2,4-dimethoxybenzene
    • 2,4-Dimethoxybenzenemethanol
    • 2,4-dimethoxyphenylmethanol
    • (2,4-dimethoxyphenyl)methan-1-ol
    • EINECS 230-775-2
    • AI3-52354
    • 2,4-dimethoxy-benzylalcohol
    • 2,4-dimethoxybenzyl-alcohol
    • 2.4-Dimethoxybenzyl alcohol
    • UNII-5SV9LUD373
    • 2,4-dimethoxy-benzyl alcohol
    • SCHEMBL238087
    • orb1690306
    • SCHEMBL1046460
    • SCHEMBL6632089
    • SCHEMBL8835229
    • RNKOUSCCPHSCFE-UHFFFAOYSA-
    • (2,4-Dimethoxyphenyl)methanol #
    • 2,4-Dimethoxybenzyl alcohol, 98%
    • 2,4-Dimethoxybenzyl alcohol, 99%
    • CK2454
    • SBB063101
    • AKOS000249419
    • CS-W007584
    • FD34724
    • HY-W007584
    • PB47629
    • PS-4550
    • BENZYL ALCOHOL, 2,4-DIMETHOXY-
    • PD158235
    • ST094954
    • SY027624
    • DB-019966
    • D1835
    • NS00037476
    • EN300-173169
    • F209486
    • InChI=1/C9H12O3/c1-11-8-4-3-7(6-10)9(5-8)12-2/h3-5,10H,6H2,1-2H3
    • 7314-44-5

  • Applications

    2,4-Dimethoxybenzyl alcohol (CAS 7314-44-5) is primarily used as an intermediate and building block in organic synthesis. In fragrance and cosmetics, it is commonly employed as a precursor to more complex aroma compounds or as a scaffold for fragrance formulations. In pharmaceutical contexts, it may serve as an intermediate for the synthesis of more complex organic molecules. In the polymers and coatings sector, it can function as an intermediate or additive in material synthesis and coating systems. It may also be used as a solvent or formulation intermediate in cleaning and household-care products, depending on local regulations and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 256.06
    methanol 332.23
    isopropanol 153.13
    water 3.57
    ethyl acetate 181.94
    n-propanol 172.99
    acetone 203.83
    n-butanol 121.8
    acetonitrile 257.11
    DMF 485.3
    toluene 49.81
    isobutanol 96.27
    1,4-dioxane 635.98
    methyl acetate 221.71
    THF 423.03
    2-butanone 148.54
    n-pentanol 86.08
    sec-butanol 105.52
    n-hexane 4.48
    ethylene glycol 264.79
    NMP 248.66
    cyclohexane 22.6
    DMSO 976.44
    n-butyl acetate 65.35
    n-octanol 37.11
    chloroform 476.37
    n-propyl acetate 84.28
    acetic acid 350.64
    dichloromethane 535.77
    cyclohexanone 196.3
    propylene glycol 175.87
    isopropyl acetate 61.19
    DMAc 300.39
    2-ethoxyethanol 292.5
    isopentanol 77.1
    n-heptane 9.24
    ethyl formate 199.87
    1,2-dichloroethane 328.94
    n-hexanol 81.81
    2-methoxyethanol 575.86
    isobutyl acetate 43.99
    tetrachloromethane 88.69
    n-pentyl acetate 36.69
    transcutol 289.87
    n-heptanol 37.85
    ethylbenzene 30.28
    MIBK 48.47
    2-propoxyethanol 196.57
    tert-butanol 215.43
    MTBE 87.43
    2-butoxyethanol 89.86
    propionic acid 201.28
    o-xylene 46.78
    formic acid 243.93
    diethyl ether 110.98
    m-xylene 35.02
    p-xylene 38.04
    chlorobenzene 101.67
    dimethyl carbonate 92.07
    n-octane 3.72
    formamide 401.72
    cyclopentanone 242.76
    2-pentanone 91.53
    anisole 100.27
    cyclopentyl methyl ether 122.19
    gamma-butyrolactone 365.39
    1-methoxy-2-propanol 258.52
    pyridine 276.86
    3-pentanone 79.59
    furfural 344.56
    n-dodecane 3.7
    diethylene glycol 277.22
    diisopropyl ether 20.87
    tert-amyl alcohol 119.26
    acetylacetone 136.98
    n-hexadecane 4.31
    acetophenone 88.59
    methyl propionate 158.05
    isopentyl acetate 52.46
    trichloroethylene 500.86
    n-nonanol 34.1
    cyclohexanol 131.5
    benzyl alcohol 109.12
    2-ethylhexanol 45.31
    isooctanol 29.98
    dipropyl ether 52.84
    1,2-dichlorobenzene 97.41
    ethyl lactate 68.72
    propylene carbonate 168.77
    n-methylformamide 365.42
    2-pentanol 58.13
    n-pentane 5.88
    1-propoxy-2-propanol 98.85
    1-methoxy-2-propyl acetate 84.17
    2-(2-methoxypropoxy) propanol 83.31
    mesitylene 25.03
    ε-caprolactone 177.47
    p-cymene 24.05
    epichlorohydrin 420.69
    1,1,1-trichloroethane 222.52
    2-aminoethanol 272.83
    morpholine-4-carbaldehyde 372.63
    sulfolane 395.44
    2,2,4-trimethylpentane 5.39
    2-methyltetrahydrofuran 217.93
    n-hexyl acetate 53.99
    isooctane 3.76
    2-(2-butoxyethoxy)ethanol 110.51
    sec-butyl acetate 41.42
    tert-butyl acetate 66.66
    decalin 9.68
    glycerin 293.68
    diglyme 240.81
    acrylic acid 217.9
    isopropyl myristate 25.2
    n-butyric acid 196.71
    acetyl acetate 116.01
    di(2-ethylhexyl) phthalate 33.14
    ethyl propionate 71.83
    nitromethane 588.86
    1,2-diethoxyethane 78.0
    benzonitrile 109.63
    trioctyl phosphate 24.63
    1-bromopropane 108.97
    gamma-valerolactone 342.18
    n-decanol 26.67
    triethyl phosphate 50.57
    4-methyl-2-pentanol 29.41
    propionitrile 164.62
    vinylene carbonate 193.68
    1,1,2-trichlorotrifluoroethane 392.49
    DMS 68.6
    cumene 23.77
    2-octanol 21.73
    2-hexanone 66.7
    octyl acetate 33.18
    limonene 37.32
    1,2-dimethoxyethane 348.16
    ethyl orthosilicate 43.58
    tributyl phosphate 29.19
    diacetone alcohol 106.47
    N,N-dimethylaniline 67.33
    acrylonitrile 235.91
    aniline 131.0
    1,3-propanediol 305.48
    bromobenzene 92.33
    dibromomethane 303.46
    1,1,2,2-tetrachloroethane 376.64
    2-methyl-cyclohexyl acetate 53.81
    tetrabutyl urea 40.77
    diisobutyl methanol 27.62
    2-phenylethanol 79.36
    styrene 40.46
    dioctyl adipate 44.98
    dimethyl sulfate 161.89
    ethyl butyrate 66.34
    methyl lactate 118.52
    butyl lactate 42.78
    diethyl carbonate 61.33
    propanediol butyl ether 78.13
    triethyl orthoformate 54.17
    p-tert-butyltoluene 23.95
    methyl 4-tert-butylbenzoate 72.7
    morpholine 618.34
    tert-butylamine 95.9
    n-dodecanol 21.92
    dimethoxymethane 266.89
    ethylene carbonate 166.27
    cyrene 112.76
    2-ethoxyethyl acetate 63.89
    2-ethylhexyl acetate 41.73
    1,2,4-trichlorobenzene 120.17
    4-methylpyridine 174.52
    dibutyl ether 34.56
    2,6-dimethyl-4-heptanol 27.62
    DEF 159.05
    dimethyl isosorbide 137.15
    tetrachloroethylene 262.81
    eugenol 79.4
    triacetin 71.26
    span 80 69.83
    1,4-butanediol 120.02
    1,1-dichloroethane 225.41
    2-methyl-1-pentanol 61.69
    methyl formate 321.31
    2-methyl-1-butanol 76.71
    n-decane 5.91
    butyronitrile 127.67
    3,7-dimethyl-1-octanol 34.75
    1-chlorooctane 25.68
    1-chlorotetradecane 11.28
    n-nonane 5.38
    undecane 4.53
    tert-butylcyclohexane 7.95
    cyclooctane 7.07
    cyclopentanol 156.92
    tetrahydropyran 283.71
    tert-amyl methyl ether 61.34
    2,5,8-trioxanonane 169.47
    1-hexene 18.06
    2-isopropoxyethanol 132.99
    2,2,2-trifluoroethanol 168.57
    methyl butyrate 102.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction