2,4-Dihydroxy-3-methylbenzaldehyde

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  • Identifiers

    CAS number
    6248-20-0

    Molecular formula
    C8H8O3

    SMILES
    CC1=C(C=CC(=C1O)C=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 72.03%
    Sweet 60.89%
    Medicinal 47.92%
    Burnt 46.96%
    Spicy 46.27%
    Smoky 43.0%
    Vanilla 41.37%
    Bitter 39.87%
    Caramellic 35.36%
    Almond 34.23%

     

    Flavor
    Bitter 65.11%
    Phenolic 44.82%
    Mild 31.25%
    Almond 27.14%
    Medical 25.02%
    Odorless 24.78%
    Nutty 24.63%
    Sweet 23.16%
    Curry 22.52%
    Vanilla 22.32%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    8.66 (weak base)

    Molecular weight
    152.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    340°C

    Flash point

    • 142.55 ˚C est.

  • Synonyms

    • 2,4-Dihydroxy-3-methylbenzaldehyde
    • 6248-20-0
    • 3-Methyl-2,4-dihydroxybenzaldehyde
    • Benzaldehyde, 2,4-dihydroxy-3-methyl-
    • 4-Formyl-2-methylresorcinol
    • EINECS 228-369-5
    • UNII-8X373W842S
    • MFCD00156883
    • 8X373W842S
    • 2,4-DIHYDROXY-3-METHYL-BENZALDEHYDE
    • DTXSID6064161
    • 2,4-DIHYDROXY-M-TOLUALDEHYDE
    • .BETA.-RESORCYLALDEHYDE, 3-METHYL-
    • 2,4-Dihydroxy-3-methylbenzaldehyd
    • 4-Hydroxy-3-methylsalicylaldehyde
    • ss-Resorcylaldehyde, 3-methyl- (8CI); 2,4-Dihydroxy-3-methylbenzaldehyde; 2,4-Dihydroxy-m-tolualdehyde; 3-Methyl-2,4-dihydroxybenzaldehyde; 4-Formyl-2-methylresorcinol
    • SCHEMBL767452
    • DTXCID3043360
    • 2.4-dihydroxy-3-methylbenzalde hyde
    • STL183328
    • AKOS006273608
    • AC-1026
    • CS-W005716
    • DS-0784
    • BETA-RESORCYLALDEHYDE, 3-METHYL-
    • SY030927
    • 2 pound not4-Dihydroxy-3-methylbenzaldehyde
    • NS00035047
    • EN300-108369
    • Q27271146
    • Z1198151439
    • 2,4-Dihydroxy-3-methylbenzaldehyde 100 microg/mL in Acetonitrile
    • ?-Resorcylaldehyde, 3-methyl- (8CI); 2,4-Dihydroxy-3-methylbenzaldehyde; 2,4-Dihydroxy-m-tolualdehyde; 3-Methyl-2,4-dihydroxybenzaldehyde; 4-Formyl-2-methylresorcinol
    • 228-369-5

  • Applications

    2,4-Dihydroxy-3-methylbenzaldehyde (CAS 6248-20-0) is commonly used as an intermediate in organic synthesis for the preparation of dyes and pigments and for phenolic resin–based materials. It may serve as a building block in fragrance chemistry, acting as a precursor for aroma compounds used in perfumery. In coatings and inks, it can function as a reactive component enabling crosslinking or functionalization of resins. It is also evaluated as a building block in pharmaceutical and agrochemical research, supporting the synthesis of more complex molecules. The phenolic functionality can contribute antioxidant properties in polymer formulations and provides handles for further chemical modification.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 112.92
    methanol 146.05
    isopropanol 84.46
    water 2.21
    ethyl acetate 103.06
    n-propanol 90.32
    acetone 183.87
    n-butanol 63.39
    acetonitrile 85.04
    DMF 238.99
    toluene 6.44
    isobutanol 51.56
    1,4-dioxane 214.27
    methyl acetate 125.06
    THF 681.59
    2-butanone 126.19
    n-pentanol 50.22
    sec-butanol 59.03
    n-hexane 1.21
    ethylene glycol 49.42
    NMP 159.06
    cyclohexane 0.64
    DMSO 389.7
    n-butyl acetate 45.48
    n-octanol 26.49
    chloroform 19.38
    n-propyl acetate 59.17
    acetic acid 80.76
    dichloromethane 32.76
    cyclohexanone 84.19
    propylene glycol 35.87
    isopropyl acetate 60.79
    DMAc 142.09
    2-ethoxyethanol 138.54
    isopentanol 58.4
    n-heptane 2.82
    ethyl formate 62.07
    1,2-dichloroethane 44.43
    n-hexanol 54.65
    2-methoxyethanol 227.14
    isobutyl acetate 29.17
    tetrachloromethane 6.68
    n-pentyl acetate 31.72
    transcutol 216.96
    n-heptanol 32.17
    ethylbenzene 6.4
    MIBK 70.55
    2-propoxyethanol 127.84
    tert-butanol 148.83
    MTBE 80.16
    2-butoxyethanol 69.35
    propionic acid 68.39
    o-xylene 8.65
    formic acid 87.8
    diethyl ether 78.64
    m-xylene 10.48
    p-xylene 8.79
    chlorobenzene 11.76
    dimethyl carbonate 64.16
    n-octane 1.51
    formamide 199.11
    cyclopentanone 243.92
    2-pentanone 106.35
    anisole 40.17
    cyclopentyl methyl ether 100.11
    gamma-butyrolactone 315.8
    1-methoxy-2-propanol 163.74
    pyridine 44.84
    3-pentanone 62.06
    furfural 128.84
    n-dodecane 1.54
    diethylene glycol 117.38
    diisopropyl ether 21.61
    tert-amyl alcohol 86.48
    acetylacetone 118.28
    n-hexadecane 1.73
    acetophenone 38.3
    methyl propionate 94.87
    isopentyl acetate 41.18
    trichloroethylene 58.95
    n-nonanol 25.33
    cyclohexanol 31.23
    benzyl alcohol 31.58
    2-ethylhexanol 25.86
    isooctanol 26.75
    dipropyl ether 32.38
    1,2-dichlorobenzene 14.62
    ethyl lactate 36.93
    propylene carbonate 93.87
    n-methylformamide 171.27
    2-pentanol 46.58
    n-pentane 1.17
    1-propoxy-2-propanol 73.43
    1-methoxy-2-propyl acetate 67.65
    2-(2-methoxypropoxy) propanol 65.01
    mesitylene 8.83
    ε-caprolactone 84.24
    p-cymene 10.01
    epichlorohydrin 286.84
    1,1,1-trichloroethane 31.24
    2-aminoethanol 75.37
    morpholine-4-carbaldehyde 151.14
    sulfolane 284.4
    2,2,4-trimethylpentane 1.98
    2-methyltetrahydrofuran 211.08
    n-hexyl acetate 44.82
    isooctane 2.27
    2-(2-butoxyethoxy)ethanol 91.5
    sec-butyl acetate 38.08
    tert-butyl acetate 85.87
    decalin 1.63
    glycerin 74.28
    diglyme 155.33
    acrylic acid 58.75
    isopropyl myristate 21.56
    n-butyric acid 69.82
    acetyl acetate 53.01
    di(2-ethylhexyl) phthalate 20.62
    ethyl propionate 53.19
    nitromethane 245.57
    1,2-diethoxyethane 61.4
    benzonitrile 26.66
    trioctyl phosphate 18.81
    1-bromopropane 16.79
    gamma-valerolactone 214.45
    n-decanol 19.54
    triethyl phosphate 26.14
    4-methyl-2-pentanol 34.86
    propionitrile 58.09
    vinylene carbonate 63.09
    1,1,2-trichlorotrifluoroethane 93.74
    DMS 43.37
    cumene 7.52
    2-octanol 21.63
    2-hexanone 63.51
    octyl acetate 27.28
    limonene 13.53
    1,2-dimethoxyethane 172.33
    ethyl orthosilicate 23.68
    tributyl phosphate 19.38
    diacetone alcohol 118.59
    N,N-dimethylaniline 26.14
    acrylonitrile 72.79
    aniline 21.46
    1,3-propanediol 107.34
    bromobenzene 8.0
    dibromomethane 15.5
    1,1,2,2-tetrachloroethane 40.67
    2-methyl-cyclohexyl acetate 32.49
    tetrabutyl urea 26.58
    diisobutyl methanol 21.08
    2-phenylethanol 36.51
    styrene 6.58
    dioctyl adipate 30.84
    dimethyl sulfate 109.78
    ethyl butyrate 39.35
    methyl lactate 57.18
    butyl lactate 28.74
    diethyl carbonate 29.67
    propanediol butyl ether 54.29
    triethyl orthoformate 29.74
    p-tert-butyltoluene 10.62
    methyl 4-tert-butylbenzoate 51.12
    morpholine 219.94
    tert-butylamine 51.88
    n-dodecanol 14.79
    dimethoxymethane 217.77
    ethylene carbonate 55.85
    cyrene 71.65
    2-ethoxyethyl acetate 55.82
    2-ethylhexyl acetate 28.48
    1,2,4-trichlorobenzene 19.47
    4-methylpyridine 39.06
    dibutyl ether 24.01
    2,6-dimethyl-4-heptanol 21.08
    DEF 80.91
    dimethyl isosorbide 115.48
    tetrachloroethylene 26.47
    eugenol 49.5
    triacetin 47.04
    span 80 44.94
    1,4-butanediol 43.39
    1,1-dichloroethane 32.3
    2-methyl-1-pentanol 40.87
    methyl formate 143.64
    2-methyl-1-butanol 45.86
    n-decane 2.43
    butyronitrile 50.37
    3,7-dimethyl-1-octanol 25.09
    1-chlorooctane 11.71
    1-chlorotetradecane 5.23
    n-nonane 2.07
    undecane 1.92
    tert-butylcyclohexane 2.25
    cyclooctane 0.6
    cyclopentanol 72.31
    tetrahydropyran 117.84
    tert-amyl methyl ether 49.9
    2,5,8-trioxanonane 110.93
    1-hexene 6.83
    2-isopropoxyethanol 86.44
    2,2,2-trifluoroethanol 52.68
    methyl butyrate 62.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
Prohibition
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 0 % Category 7A
Rinse-off products applied to the hair with some hand contact
 0 %
Category 2
Products applied to the axillae
 0 % Category 7B
Leave-on products applied to the hair with some hand contact
 0 %
Category 3
Products applied to the face/body using fingertips
 0 % Category 8
Products with significant anogenital exposure
 0 %
Category 4
Products related to fine fragrance
 0 % Category 9
Products with body and hand exposure, primarily rinse off
 0 %
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 0 % Category 10A
Household care products with mostly hand contact
 0 %
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 0 % Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 0 %
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 0 % Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 0 %
Category 5D
Baby Creams, baby Oils and baby talc
 0 % Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 0 %
Category 6
Products with oral and lip exposure
 0 % Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 0 %

Prohibition
2,4-Dihydroxy-3-methylbenzaldehyde should not be used as a fragrance ingredient.