2,4-Diaminophenoxyethanol Dihydrochloride

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  • Identifiers

    CAS number
    66422-95-5

    Molecular formula
    C8H13ClN2O2

    SMILES
    C1=CC(=C(C=C1N)N)OCCO.Cl

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 40.9%
    Meaty 27.57%
    Sweet 26.97%
    Savory 23.67%
    Burnt 23.41%
    Animal 23.4%
    Fruity 21.72%
    Cheesy 20.71%
    Grape 20.48%
    Vanilla 20.41%

     

    Flavor
    Sweet 68.46%
    Fruity 53.75%
    Bitter 49.74%
    Floral 39.54%
    Mild 37.92%
    Powdery 32.41%
    Grape 27.43%
    Creamy 27.18%
    Vanilla 25.92%
    Musty 25.2%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.57 (weak acid)

    Molecular weight
    204.65 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    417°C

    Flash point

    • 200.36 ˚C est.

  • Synonyms

    • 2,4-Diaminophenoxyethanol dihydrochloride
    • RefChem:1059692
    • 66422-95-5
    • Ethanol, 2-(2,4-diaminophenoxy)-, dihydrochloride
    • 2,4-DiaminophenoxyethanolHcl
    • 2,4-DIAMINOPHENOXYETHANOL HYDROCHLORIDE
    • 847455-21-4
    • SCHEMBL33976
    • SCHEMBL29356501
    • DTXSID00624725
    • AKOS015890399
    • H43D195
    • 2-(2,4-diaminophenoxy)ethan-1-ol hydrochloride
    • 2-(2,4-Diaminophenoxy)ethan-1-ol--hydrogen chloride (1/1)
    • 66422-95-5

  • Applications

    2,4-Diaminophenoxyethanol Dihydrochloride (CAS 66422-95-5) is typically encountered as a water-soluble salt with practical applications across several industries: as a cosmetic preservative/antimicrobial agent in personal care products; as a dye/pigment precursor or related intermediate in hair dye chemistry; as a functional additive in coatings, inks and adhesives (potentially participating in curing or crosslinking); as a processing aid or crosslinking/coupling agent in polymers and plastics; and as an intermediate in pharmaceutical manufacturing. Its exact use depends on formulation requirements and local regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 19.78
    methanol 62.9
    isopropanol 6.35
    water 41.59
    ethyl acetate 5.78
    n-propanol 9.11
    acetone 12.73
    n-butanol 7.03
    acetonitrile 11.21
    DMF 101.25
    toluene 0.88
    isobutanol 5.18
    1,4-dioxane 30.3
    methyl acetate 5.6
    THF 54.21
    2-butanone 4.9
    n-pentanol 5.31
    sec-butanol 4.02
    n-hexane 0.12
    ethylene glycol 68.23
    NMP 98.46
    cyclohexane 0.39
    DMSO 431.54
    n-butyl acetate 4.12
    n-octanol 3.58
    chloroform 1.76
    n-propyl acetate 4.35
    acetic acid 174.93
    dichloromethane 3.03
    cyclohexanone 18.07
    propylene glycol 38.63
    isopropyl acetate 2.74
    DMAc 89.0
    2-ethoxyethanol 53.93
    isopentanol 5.7
    n-heptane 0.58
    ethyl formate 13.55
    1,2-dichloroethane 2.45
    n-hexanol 6.66
    2-methoxyethanol 112.93
    isobutyl acetate 2.71
    tetrachloromethane 0.7
    n-pentyl acetate 2.93
    transcutol 57.69
    n-heptanol 4.94
    ethylbenzene 0.61
    MIBK 3.42
    2-propoxyethanol 35.97
    tert-butanol 10.34
    MTBE 2.59
    2-butoxyethanol 18.48
    propionic acid 23.71
    o-xylene 1.55
    formic acid 315.49
    diethyl ether 2.0
    m-xylene 1.34
    p-xylene 0.93
    chlorobenzene 1.75
    dimethyl carbonate 8.84
    n-octane 0.27
    formamide 236.73
    cyclopentanone 34.93
    2-pentanone 4.22
    anisole 3.82
    cyclopentyl methyl ether 7.94
    gamma-butyrolactone 71.82
    1-methoxy-2-propanol 41.54
    pyridine 9.51
    3-pentanone 2.96
    furfural 71.03
    n-dodecane 0.22
    diethylene glycol 77.39
    diisopropyl ether 0.79
    tert-amyl alcohol 6.16
    acetylacetone 13.58
    n-hexadecane 0.24
    acetophenone 7.2
    methyl propionate 7.13
    isopentyl acetate 4.16
    trichloroethylene 4.97
    n-nonanol 3.61
    cyclohexanol 6.81
    benzyl alcohol 8.47
    2-ethylhexanol 3.91
    isooctanol 4.13
    dipropyl ether 3.69
    1,2-dichlorobenzene 2.38
    ethyl lactate 11.74
    propylene carbonate 29.23
    n-methylformamide 69.93
    2-pentanol 2.48
    n-pentane 0.15
    1-propoxy-2-propanol 18.36
    1-methoxy-2-propyl acetate 10.91
    2-(2-methoxypropoxy) propanol 19.39
    mesitylene 1.17
    ε-caprolactone 20.06
    p-cymene 1.72
    epichlorohydrin 31.65
    1,1,1-trichloroethane 1.35
    2-aminoethanol 53.81
    morpholine-4-carbaldehyde 84.87
    sulfolane 126.09
    2,2,4-trimethylpentane 0.17
    2-methyltetrahydrofuran 14.09
    n-hexyl acetate 4.43
    isooctane 0.13
    2-(2-butoxyethoxy)ethanol 25.86
    sec-butyl acetate 2.15
    tert-butyl acetate 4.3
    decalin 0.24
    glycerin 122.12
    diglyme 47.48
    acrylic acid 41.56
    isopropyl myristate 2.16
    n-butyric acid 26.31
    acetyl acetate 7.36
    di(2-ethylhexyl) phthalate 6.11
    ethyl propionate 3.68
    nitromethane 170.61
    1,2-diethoxyethane 6.68
    benzonitrile 6.24
    trioctyl phosphate 4.35
    1-bromopropane 0.78
    gamma-valerolactone 72.2
    n-decanol 2.8
    triethyl phosphate 5.55
    4-methyl-2-pentanol 2.14
    propionitrile 4.6
    vinylene carbonate 24.73
    1,1,2-trichlorotrifluoroethane 65.41
    DMS 6.07
    cumene 0.83
    2-octanol 2.24
    2-hexanone 3.69
    octyl acetate 3.51
    limonene 2.46
    1,2-dimethoxyethane 42.3
    ethyl orthosilicate 4.93
    tributyl phosphate 4.15
    diacetone alcohol 15.25
    N,N-dimethylaniline 4.12
    acrylonitrile 10.49
    aniline 5.05
    1,3-propanediol 53.47
    bromobenzene 1.12
    dibromomethane 1.47
    1,1,2,2-tetrachloroethane 4.18
    2-methyl-cyclohexyl acetate 6.08
    tetrabutyl urea 6.81
    diisobutyl methanol 2.48
    2-phenylethanol 8.49
    styrene 0.66
    dioctyl adipate 5.41
    dimethyl sulfate 28.28
    ethyl butyrate 4.92
    methyl lactate 24.21
    butyl lactate 7.61
    diethyl carbonate 4.43
    propanediol butyl ether 19.98
    triethyl orthoformate 5.53
    p-tert-butyltoluene 1.63
    methyl 4-tert-butylbenzoate 12.1
    morpholine 39.41
    tert-butylamine 2.87
    n-dodecanol 2.17
    dimethoxymethane 29.37
    ethylene carbonate 17.84
    cyrene 35.53
    2-ethoxyethyl acetate 6.64
    2-ethylhexyl acetate 3.03
    1,2,4-trichlorobenzene 3.59
    4-methylpyridine 6.72
    dibutyl ether 2.09
    2,6-dimethyl-4-heptanol 2.48
    DEF 15.66
    dimethyl isosorbide 32.74
    tetrachloroethylene 3.36
    eugenol 15.17
    triacetin 10.77
    span 80 17.26
    1,4-butanediol 26.82
    1,1-dichloroethane 0.91
    2-methyl-1-pentanol 4.6
    methyl formate 50.31
    2-methyl-1-butanol 5.19
    n-decane 0.31
    butyronitrile 5.16
    3,7-dimethyl-1-octanol 3.28
    1-chlorooctane 0.97
    1-chlorotetradecane 0.54
    n-nonane 0.28
    undecane 0.26
    tert-butylcyclohexane 0.21
    cyclooctane 0.27
    cyclopentanol 11.81
    tetrahydropyran 7.19
    tert-amyl methyl ether 2.64
    2,5,8-trioxanonane 38.98
    1-hexene 0.34
    2-isopropoxyethanol 22.06
    2,2,2-trifluoroethanol 62.82
    methyl butyrate 6.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction