2,3,5-Trimethyl-6-propylpyrazine

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  • Identifiers

    CAS number
    92233-82-4

    Molecular formula
    C10H16N2

    SMILES
    CCCC1=NC(=C(N=C1C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Nutty 63.88%
    Roasted 57.43%
    Burnt 56.08%
    Earthy 54.96%
    Musty 50.76%
    Cocoa 48.2%
    Hazelnut 46.45%
    Chocolate 40.77%
    Coffee 40.69%
    Sweet 35.45%

     

    Flavor
    Nutty 60.05%
    Roasted 54.81%
    Earthy 51.64%
    Musty 50.88%
    Burnt 46.33%
    Cocoa 45.79%
    Hazelnut 45.07%
    Potato 44.29%
    Coffee 42.1%
    Meaty 41.69%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    5.19 (weak acid)

    Molecular weight
    164.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    231°C

    Flash point

    • 84.86 ˚C est.

  • Synonyms

    • 2,3,5-Trimethyl-6-propylpyrazine
    • trimethylpropylpyrazine
    • 92233-82-4
    • 2-propyl-3,5,6-trimethylpyrazine
    • Pyrazine, trimethylpropyl
    • Pyrazine, trimethylpropyl-
    • T9BZ8DX9HK
    • 2,3,5-trimethyl-6-propyl-pyrazine
    • UNII-T9BZ8DX9HK
    • Pyrazine, 2,3,5-trimethyl-6-propyl-
    • SCHEMBL7154330
    • DTXSID20342934
    • CHEBI:192302
    • GEPYSCIASYXPCY-UHFFFAOYSA-N
    • HS-3536
    • NS00113832
    • 92233-82-4

  • Applications

    2,3,5-Trimethyl-6-propylpyrazine, CAS 92233-82-4, is a pyrazine derivative with a distinctive aroma, commonly used as a fragrance and aroma ingredient in various industrial applications. Its applications include use as a flavor and fragrance ingredient in perfumery/fragrance and flavor to impart roasted, nutty notes; used in cosmetics/personal care and household products as an odorant or fragrance additive to extend scent; incorporated into coatings/inks and cleaning products to enhance aroma profiles; used as an intermediate or precursor in the synthesis of other aroma-bearing pyrazines in industrial manufacturing; and may be used as an odorant additive in polymers/plastics to mask unwanted odors, depending on formulation and regulatory constraints. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 493.55
    methanol 595.44
    isopropanol 410.62
    water 2.04
    ethyl acetate 539.85
    n-propanol 543.32
    acetone 502.89
    n-butanol 544.82
    acetonitrile 375.58
    DMF 786.06
    toluene 625.89
    isobutanol 480.92
    1,4-dioxane 930.57
    methyl acetate 499.63
    THF 1243.27
    2-butanone 581.46
    n-pentanol 434.38
    sec-butanol 514.59
    n-hexane 374.45
    ethylene glycol 95.91
    NMP 925.29
    cyclohexane 479.67
    DMSO 522.17
    n-butyl acetate 754.44
    n-octanol 389.23
    chloroform 2877.79
    n-propyl acetate 402.35
    acetic acid 371.74
    dichloromethane 2330.02
    cyclohexanone 1114.42
    propylene glycol 137.61
    isopropyl acetate 368.72
    DMAc 767.54
    2-ethoxyethanol 378.96
    isopentanol 460.97
    n-heptane 242.09
    ethyl formate 451.3
    1,2-dichloroethane 1209.77
    n-hexanol 629.69
    2-methoxyethanol 544.94
    isobutyl acetate 337.81
    tetrachloromethane 777.26
    n-pentyl acetate 493.64
    transcutol 664.05
    n-heptanol 355.29
    ethylbenzene 432.35
    MIBK 350.89
    2-propoxyethanol 579.05
    tert-butanol 445.76
    MTBE 601.46
    2-butoxyethanol 405.53
    propionic acid 384.31
    o-xylene 459.56
    formic acid 124.85
    diethyl ether 675.33
    m-xylene 435.83
    p-xylene 607.13
    chlorobenzene 863.84
    dimethyl carbonate 245.11
    n-octane 133.16
    formamide 147.23
    cyclopentanone 1069.26
    2-pentanone 508.42
    anisole 480.71
    cyclopentyl methyl ether 761.39
    gamma-butyrolactone 1083.25
    1-methoxy-2-propanol 414.62
    pyridine 911.27
    3-pentanone 508.34
    furfural 971.46
    n-dodecane 94.9
    diethylene glycol 298.93
    diisopropyl ether 255.37
    tert-amyl alcohol 489.55
    acetylacetone 477.43
    n-hexadecane 109.13
    acetophenone 447.47
    methyl propionate 459.7
    isopentyl acetate 649.26
    trichloroethylene 2065.93
    n-nonanol 319.42
    cyclohexanol 591.55
    benzyl alcohol 394.11
    2-ethylhexanol 478.21
    isooctanol 291.83
    dipropyl ether 502.65
    1,2-dichlorobenzene 830.83
    ethyl lactate 208.88
    propylene carbonate 735.78
    n-methylformamide 364.16
    2-pentanol 396.81
    n-pentane 266.46
    1-propoxy-2-propanol 445.41
    1-methoxy-2-propyl acetate 452.19
    2-(2-methoxypropoxy) propanol 290.04
    mesitylene 307.56
    ε-caprolactone 853.1
    p-cymene 335.73
    epichlorohydrin 1135.69
    1,1,1-trichloroethane 1314.82
    2-aminoethanol 201.39
    morpholine-4-carbaldehyde 771.02
    sulfolane 1084.47
    2,2,4-trimethylpentane 150.36
    2-methyltetrahydrofuran 1011.32
    n-hexyl acetate 623.89
    isooctane 91.15
    2-(2-butoxyethoxy)ethanol 355.91
    sec-butyl acetate 305.83
    tert-butyl acetate 357.84
    decalin 216.16
    glycerin 164.48
    diglyme 655.65
    acrylic acid 317.81
    isopropyl myristate 263.06
    n-butyric acid 558.81
    acetyl acetate 383.89
    di(2-ethylhexyl) phthalate 243.67
    ethyl propionate 393.46
    nitromethane 469.37
    1,2-diethoxyethane 493.39
    benzonitrile 652.46
    trioctyl phosphate 192.73
    1-bromopropane 985.87
    gamma-valerolactone 1063.33
    n-decanol 241.81
    triethyl phosphate 252.5
    4-methyl-2-pentanol 237.62
    propionitrile 485.43
    vinylene carbonate 738.11
    1,1,2-trichlorotrifluoroethane 641.64
    DMS 430.25
    cumene 321.52
    2-octanol 309.85
    2-hexanone 464.76
    octyl acetate 327.69
    limonene 447.44
    1,2-dimethoxyethane 721.37
    ethyl orthosilicate 257.84
    tributyl phosphate 238.15
    diacetone alcohol 308.3
    N,N-dimethylaniline 407.83
    acrylonitrile 498.1
    aniline 508.42
    1,3-propanediol 311.7
    bromobenzene 1051.98
    dibromomethane 1734.69
    1,1,2,2-tetrachloroethane 1799.75
    2-methyl-cyclohexyl acetate 405.3
    tetrabutyl urea 288.18
    diisobutyl methanol 227.95
    2-phenylethanol 466.38
    styrene 480.78
    dioctyl adipate 323.32
    dimethyl sulfate 341.11
    ethyl butyrate 463.34
    methyl lactate 199.4
    butyl lactate 327.46
    diethyl carbonate 347.77
    propanediol butyl ether 312.01
    triethyl orthoformate 348.1
    p-tert-butyltoluene 308.76
    methyl 4-tert-butylbenzoate 388.09
    morpholine 853.68
    tert-butylamine 390.62
    n-dodecanol 193.85
    dimethoxymethane 582.56
    ethylene carbonate 611.88
    cyrene 308.42
    2-ethoxyethyl acetate 449.84
    2-ethylhexyl acetate 593.75
    1,2,4-trichlorobenzene 877.74
    4-methylpyridine 1001.3
    dibutyl ether 504.34
    2,6-dimethyl-4-heptanol 227.95
    DEF 651.45
    dimethyl isosorbide 541.34
    tetrachloroethylene 1373.53
    eugenol 354.05
    triacetin 388.22
    span 80 316.87
    1,4-butanediol 171.6
    1,1-dichloroethane 1229.91
    2-methyl-1-pentanol 430.47
    methyl formate 349.71
    2-methyl-1-butanol 514.69
    n-decane 158.87
    butyronitrile 618.95
    3,7-dimethyl-1-octanol 330.83
    1-chlorooctane 427.85
    1-chlorotetradecane 177.94
    n-nonane 175.48
    undecane 117.96
    tert-butylcyclohexane 194.39
    cyclooctane 197.79
    cyclopentanol 603.31
    tetrahydropyran 1079.96
    tert-amyl methyl ether 514.31
    2,5,8-trioxanonane 431.52
    1-hexene 657.79
    2-isopropoxyethanol 291.38
    2,2,2-trifluoroethanol 164.68
    methyl butyrate 532.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction