2,3-Dimethylhydroquinone

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  • Identifiers

    CAS number
    608-43-5

    Molecular formula
    C8H10O2

    SMILES
    CC1=C(C=CC(=C1C)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 88.42%
    Smoky 66.97%
    Medicinal 61.38%
    Spicy 57.17%
    Burnt 53.84%
    Woody 49.78%
    Leathery 37.51%
    Sweet 37.14%
    Vanilla 31.76%
    Musty 28.11%

     

    Flavor
    Phenolic 63.67%
    Bitter 44.63%
    Medicinal 42.95%
    Smoke 38.16%
    Smoky 36.07%
    Bacon 33.01%
    Sweet 32.94%
    Phenol 31.71%
    Mild 30.18%
    Medical 29.34%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    10.76 (weak base)

    Molecular weight
    138.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    288°C

    Flash point

    • 139.86 ˚C est.

  • Synonyms

    • 2,3-Dimethylhydroquinone
    • 608-43-5
    • 2,3-dimethylbenzene-1,4-diol
    • o-Xylohydroquinone
    • 1,4-Benzenediol, 2,3-dimethyl-
    • Hydroquinone, 2,3-dimethyl-
    • F0L7HG609J
    • NSC-108080
    • DTXSID50870679
    • RefChem:442533
    • DTXCID50818379
    • 629-372-8
    • 2,3-Xylohydroquinone
    • o-Xylene-3,6-diol
    • 1,4-Benzenediol, dimethyl-
    • MFCD00009997
    • 2,3-Dimethyl-1,4-benzenediol
    • 1,4-Dihydroxy-2,3-dimethylbenzene
    • 3,6-Dihydroxy-o-xylene
    • UNII-F0L7HG609J
    • Xylohydroquinone
    • NSC 108080
    • Hydroquinone, dimethyl-
    • Hydroquinone,3-dimethyl-
    • 2,3 dimethyl hydroquinone
    • 2,3-dimethyl-hydroquinone
    • 2,3-Dimethyl hydroquinone
    • 2,3-DMHYDROP
    • SCHEMBL68013
    • orb3023783
    • SCHEMBL9159439
    • CHEMBL1269256
    • SCHEMBL29457565
    • 2,3-Dimethylhydroquinone, 97%
    • 2,3-dimethyl-benzene-1,4-diol
    • 2,3-Dimethyl-1,4-benzenediol #
    • ALBB-028839
    • BB_NC-02204
    • EINECS 215-317-1
    • BBL027769
    • NSC108080
    • SBB007823
    • STL146345
    • AKOS003632178
    • AC-1261
    • CS-W005767
    • DS-1328
    • EBC-462074
    • FD41886
    • SY035521
    • AI3-02932
    • D3877
    • NS00045363
    • ST50828262
    • EN300-54724
    • F093670
    • Q27277483
    • InChI=1/C8H10O2/c1-5-6(2)8(10)4-3-7(5)9/h3-4,9-10H,1-2H
    • 608-43-5

  • Applications

    2,3-Dimethylhydroquinone (CAS 608-43-5) is typically used as a phenolic antioxidant and polymer stabilizer, helping to retard oxidative degradation in plastics, rubbers, and coatings. It also serves as an industrial chemical intermediate, acting as a building block in organic synthesis for dyes and fragrance compounds. In the fragrance and cosmetic sectors, it may be evaluated as a precursor for aroma-related derivatives; in research and development, it provides a versatile starting material for synthesizing related hydroquinone derivatives. For adhesive formulations, it can function as a stabilizer to extend shelf life. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 87.13
    methanol 138.33
    isopropanol 59.2
    water 7.35
    ethyl acetate 32.9
    n-propanol 73.74
    acetone 48.56
    n-butanol 57.68
    acetonitrile 40.35
    DMF 140.43
    toluene 6.59
    isobutanol 37.93
    1,4-dioxane 203.37
    methyl acetate 40.72
    THF 240.1
    2-butanone 50.48
    n-pentanol 44.67
    sec-butanol 46.63
    n-hexane 8.76
    ethylene glycol 29.19
    NMP 69.67
    cyclohexane 4.14
    DMSO 197.19
    n-butyl acetate 41.95
    n-octanol 38.23
    chloroform 94.17
    n-propyl acetate 23.48
    acetic acid 43.5
    dichloromethane 73.75
    cyclohexanone 54.7
    propylene glycol 18.69
    isopropyl acetate 25.02
    DMAc 91.73
    2-ethoxyethanol 100.97
    isopentanol 44.4
    n-heptane 10.59
    ethyl formate 37.45
    1,2-dichloroethane 64.76
    n-hexanol 68.62
    2-methoxyethanol 147.21
    isobutyl acetate 14.59
    tetrachloromethane 40.94
    n-pentyl acetate 41.43
    transcutol 128.26
    n-heptanol 48.45
    ethylbenzene 11.16
    MIBK 34.73
    2-propoxyethanol 123.14
    tert-butanol 99.99
    MTBE 66.07
    2-butoxyethanol 84.56
    propionic acid 38.68
    o-xylene 11.48
    formic acid 53.82
    diethyl ether 66.66
    m-xylene 10.22
    p-xylene 14.61
    chlorobenzene 14.35
    dimethyl carbonate 20.85
    n-octane 6.96
    formamide 118.03
    cyclopentanone 95.46
    2-pentanone 40.52
    anisole 35.64
    cyclopentyl methyl ether 63.78
    gamma-butyrolactone 114.97
    1-methoxy-2-propanol 94.58
    pyridine 35.06
    3-pentanone 31.53
    furfural 84.68
    n-dodecane 4.39
    diethylene glycol 95.15
    diisopropyl ether 22.92
    tert-amyl alcohol 75.71
    acetylacetone 40.21
    n-hexadecane 4.93
    acetophenone 27.29
    methyl propionate 31.65
    isopentyl acetate 41.26
    trichloroethylene 86.36
    n-nonanol 37.38
    cyclohexanol 29.25
    benzyl alcohol 21.76
    2-ethylhexanol 37.81
    isooctanol 37.93
    dipropyl ether 49.76
    1,2-dichlorobenzene 22.86
    ethyl lactate 19.37
    propylene carbonate 42.22
    n-methylformamide 97.63
    2-pentanol 37.88
    n-pentane 6.1
    1-propoxy-2-propanol 72.45
    1-methoxy-2-propyl acetate 49.03
    2-(2-methoxypropoxy) propanol 51.28
    mesitylene 10.25
    ε-caprolactone 52.3
    p-cymene 15.44
    epichlorohydrin 147.86
    1,1,1-trichloroethane 61.99
    2-aminoethanol 54.71
    morpholine-4-carbaldehyde 119.68
    sulfolane 144.69
    2,2,4-trimethylpentane 6.0
    2-methyltetrahydrofuran 97.87
    n-hexyl acetate 49.79
    isooctane 5.68
    2-(2-butoxyethoxy)ethanol 77.86
    sec-butyl acetate 17.04
    tert-butyl acetate 50.52
    decalin 6.39
    glycerin 40.2
    diglyme 153.99
    acrylic acid 29.42
    isopropyl myristate 23.27
    n-butyric acid 45.22
    acetyl acetate 18.69
    di(2-ethylhexyl) phthalate 20.81
    ethyl propionate 24.33
    nitromethane 99.07
    1,2-diethoxyethane 66.79
    benzonitrile 20.14
    trioctyl phosphate 20.01
    1-bromopropane 34.42
    gamma-valerolactone 133.81
    n-decanol 28.46
    triethyl phosphate 26.74
    4-methyl-2-pentanol 26.74
    propionitrile 37.05
    vinylene carbonate 37.18
    1,1,2-trichlorotrifluoroethane 81.98
    DMS 31.24
    cumene 13.18
    2-octanol 34.33
    2-hexanone 35.4
    octyl acetate 29.23
    limonene 20.76
    1,2-dimethoxyethane 177.34
    ethyl orthosilicate 28.07
    tributyl phosphate 20.89
    diacetone alcohol 62.23
    N,N-dimethylaniline 33.3
    acrylonitrile 44.1
    aniline 16.17
    1,3-propanediol 77.01
    bromobenzene 12.48
    dibromomethane 51.94
    1,1,2,2-tetrachloroethane 83.37
    2-methyl-cyclohexyl acetate 34.52
    tetrabutyl urea 26.76
    diisobutyl methanol 28.76
    2-phenylethanol 36.49
    styrene 9.01
    dioctyl adipate 26.82
    dimethyl sulfate 53.53
    ethyl butyrate 33.37
    methyl lactate 26.39
    butyl lactate 29.1
    diethyl carbonate 23.94
    propanediol butyl ether 43.43
    triethyl orthoformate 31.0
    p-tert-butyltoluene 18.21
    methyl 4-tert-butylbenzoate 49.55
    morpholine 164.39
    tert-butylamine 59.55
    n-dodecanol 21.56
    dimethoxymethane 122.24
    ethylene carbonate 34.45
    cyrene 46.76
    2-ethoxyethyl acetate 52.91
    2-ethylhexyl acetate 32.53
    1,2,4-trichlorobenzene 25.14
    4-methylpyridine 27.85
    dibutyl ether 38.45
    2,6-dimethyl-4-heptanol 28.76
    DEF 51.23
    dimethyl isosorbide 102.47
    tetrachloroethylene 72.3
    eugenol 50.95
    triacetin 33.09
    span 80 40.53
    1,4-butanediol 30.75
    1,1-dichloroethane 44.69
    2-methyl-1-pentanol 36.91
    methyl formate 58.17
    2-methyl-1-butanol 38.8
    n-decane 7.83
    butyronitrile 35.81
    3,7-dimethyl-1-octanol 30.61
    1-chlorooctane 24.46
    1-chlorotetradecane 10.58
    n-nonane 7.23
    undecane 5.69
    tert-butylcyclohexane 8.79
    cyclooctane 3.07
    cyclopentanol 47.53
    tetrahydropyran 87.56
    tert-amyl methyl ether 50.32
    2,5,8-trioxanonane 98.01
    1-hexene 19.72
    2-isopropoxyethanol 61.01
    2,2,2-trifluoroethanol 39.42
    methyl butyrate 31.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction