2,3-Dimethoxybenzyl alcohol

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  • Identifiers

    CAS number
    5653-67-8

    Molecular formula
    C9H12O3

    SMILES
    COC1=CC=CC(=C1OC)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Vanilla 77.05%
    Sweet 76.19%
    Fruity 52.67%
    Phenolic 48.67%
    Balsamic 43.47%
    Aromatic 41.97%
    Creamy 39.99%
    Anisic 39.9%
    Spicy 39.49%
    Floral 37.92%

     

    Flavor
    Sweet 69.32%
    Vanilla 56.92%
    Powdery 47.04%
    Phenolic 44.63%
    Woody 43.18%
    Smoky 42.85%
    Creamy 41.12%
    Spicy 39.41%
    Spice 38.44%
    Bitter 38.33%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    8.07 (weak base)

    Molecular weight
    168.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    277°C

    Flash point

    • 118.84 ˚C est.

  • Synonyms

    • 2,3-Dimethoxybenzyl alcohol
    • (2,3-Dimethoxyphenyl)methanol
    • 5653-67-8
    • o-Veratryl alcohol
    • Benzenemethanol, 2,3-dimethoxy-
    • 2,3-Dimethoxybenzylalcohol
    • 2,3-Dimethoxybenzylic Alcohol
    • EINECS 227-099-5
    • MFCD00004612
    • AI3-20629
    • DTXSID20205090
    • NSC 87568
    • NSC-87568
    • NSC 403220
    • NSC-403220
    • (2,3-Dimethoxyphenyl)methanol; 2,3-Dimethoxybenzenemethanol; 2,3-Dimethoxybenzyl alcohol; 2,3-Dimethoxybenzylic alcohol; NSC 403220; NSC 87568
    • 2-Veratryl alcohol
    • 2,3-Dimethoxybenzenemethanol
    • SCHEMBL95873
    • 67HS6Y2X2R
    • DTXCID20127581
    • (2,3-Dimethoxyphenyl)methanol #
    • CS-Z0027
    • NSC87568
    • 2,3-Dimethoxybenzyl alcohol, 99%
    • BBL027468
    • NSC403220
    • STL354191
    • AKOS000120834
    • FD71165
    • AS-40108
    • SY051617
    • D1764
    • NS00033540
    • EN300-20826
    • AP-065/41950909
    • 227-099-5

  • Applications

    2,3-Dimethoxybenzyl alcohol (CAS 5653-67-8) is primarily used as a synthetic intermediate in fragrance chemistry, serving as a building block for targeted fragrance ingredients and odorants. It can be employed in fragrance and flavor applications as a precursor to aroma compounds, and in cosmetics/personal care as an intermediate for formulations that rely on fragrance; in industrial manufacturing it provides a versatile starting material for organic synthesis, enabling routes to specialty chemicals, and it may be used as an intermediate in polymer or material applications. Its role is typically that of an intermediate or precursor rather than a final consumer ingredient, and use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 362.65
    methanol 496.69
    isopropanol 210.24
    water 9.3
    ethyl acetate 318.02
    n-propanol 239.4
    acetone 566.05
    n-butanol 172.41
    acetonitrile 601.69
    DMF 899.79
    toluene 80.74
    isobutanol 145.95
    1,4-dioxane 923.21
    methyl acetate 417.15
    THF 742.3
    2-butanone 315.05
    n-pentanol 136.68
    sec-butanol 154.02
    n-hexane 13.65
    ethylene glycol 582.01
    NMP 523.09
    cyclohexane 42.4
    DMSO 1506.76
    n-butyl acetate 164.43
    n-octanol 105.14
    chloroform 1016.28
    n-propyl acetate 224.24
    acetic acid 645.4
    dichloromethane 1430.36
    cyclohexanone 445.09
    propylene glycol 227.5
    isopropyl acetate 149.16
    DMAc 392.72
    2-ethoxyethanol 467.47
    isopentanol 111.39
    n-heptane 28.36
    ethyl formate 460.43
    1,2-dichloroethane 834.31
    n-hexanol 139.03
    2-methoxyethanol 820.95
    isobutyl acetate 117.58
    tetrachloromethane 235.02
    n-pentyl acetate 121.15
    transcutol 386.84
    n-heptanol 98.8
    ethylbenzene 63.91
    MIBK 116.23
    2-propoxyethanol 334.39
    tert-butanol 258.55
    MTBE 149.96
    2-butoxyethanol 201.55
    propionic acid 344.83
    o-xylene 79.64
    formic acid 419.07
    diethyl ether 204.26
    m-xylene 72.53
    p-xylene 90.94
    chlorobenzene 226.72
    dimethyl carbonate 231.19
    n-octane 16.17
    formamide 706.74
    cyclopentanone 640.58
    2-pentanone 215.24
    anisole 189.85
    cyclopentyl methyl ether 239.46
    gamma-butyrolactone 925.41
    1-methoxy-2-propanol 383.62
    pyridine 434.89
    3-pentanone 174.72
    furfural 748.35
    n-dodecane 14.88
    diethylene glycol 479.25
    diisopropyl ether 53.77
    tert-amyl alcohol 168.64
    acetylacetone 320.24
    n-hexadecane 17.23
    acetophenone 201.99
    methyl propionate 290.2
    isopentyl acetate 127.67
    trichloroethylene 1218.37
    n-nonanol 90.11
    cyclohexanol 176.04
    benzyl alcohol 188.74
    2-ethylhexanol 95.24
    isooctanol 80.83
    dipropyl ether 125.42
    1,2-dichlorobenzene 259.2
    ethyl lactate 163.9
    propylene carbonate 451.77
    n-methylformamide 745.61
    2-pentanol 96.25
    n-pentane 17.18
    1-propoxy-2-propanol 190.06
    1-methoxy-2-propyl acetate 173.27
    2-(2-methoxypropoxy) propanol 139.79
    mesitylene 60.58
    ε-caprolactone 401.46
    p-cymene 66.09
    epichlorohydrin 990.15
    1,1,1-trichloroethane 562.3
    2-aminoethanol 392.93
    morpholine-4-carbaldehyde 665.25
    sulfolane 1149.18
    2,2,4-trimethylpentane 13.87
    2-methyltetrahydrofuran 394.78
    n-hexyl acetate 158.82
    isooctane 11.92
    2-(2-butoxyethoxy)ethanol 192.94
    sec-butyl acetate 104.16
    tert-butyl acetate 148.95
    decalin 25.89
    glycerin 419.7
    diglyme 487.03
    acrylic acid 402.13
    isopropyl myristate 71.29
    n-butyric acid 326.48
    acetyl acetate 237.49
    di(2-ethylhexyl) phthalate 73.34
    ethyl propionate 174.98
    nitromethane 1269.18
    1,2-diethoxyethane 173.9
    benzonitrile 268.16
    trioctyl phosphate 70.5
    1-bromopropane 231.14
    gamma-valerolactone 742.63
    n-decanol 71.71
    triethyl phosphate 102.66
    4-methyl-2-pentanol 56.9
    propionitrile 316.61
    vinylene carbonate 491.55
    1,1,2-trichlorotrifluoroethane 749.55
    DMS 166.32
    cumene 57.12
    2-octanol 69.55
    2-hexanone 164.16
    octyl acetate 94.14
    limonene 90.09
    1,2-dimethoxyethane 657.49
    ethyl orthosilicate 90.09
    tributyl phosphate 72.67
    diacetone alcohol 196.61
    N,N-dimethylaniline 127.81
    acrylonitrile 507.67
    aniline 162.78
    1,3-propanediol 407.74
    bromobenzene 232.83
    dibromomethane 782.0
    1,1,2,2-tetrachloroethane 860.88
    2-methyl-cyclohexyl acetate 125.14
    tetrabutyl urea 97.68
    diisobutyl methanol 62.97
    2-phenylethanol 160.29
    styrene 85.62
    dioctyl adipate 116.41
    dimethyl sulfate 396.77
    ethyl butyrate 153.74
    methyl lactate 224.21
    butyl lactate 109.15
    diethyl carbonate 135.41
    propanediol butyl ether 164.05
    triethyl orthoformate 112.31
    p-tert-butyltoluene 65.0
    methyl 4-tert-butylbenzoate 168.91
    morpholine 744.03
    tert-butylamine 139.95
    n-dodecanol 57.5
    dimethoxymethane 568.29
    ethylene carbonate 413.83
    cyrene 205.99
    2-ethoxyethyl acetate 163.13
    2-ethylhexyl acetate 101.57
    1,2,4-trichlorobenzene 276.39
    4-methylpyridine 292.44
    dibutyl ether 95.31
    2,6-dimethyl-4-heptanol 62.97
    DEF 298.98
    dimethyl isosorbide 271.03
    tetrachloroethylene 678.36
    eugenol 170.77
    triacetin 177.71
    span 80 122.13
    1,4-butanediol 215.9
    1,1-dichloroethane 510.46
    2-methyl-1-pentanol 95.38
    methyl formate 798.67
    2-methyl-1-butanol 109.87
    n-decane 23.03
    butyronitrile 271.18
    3,7-dimethyl-1-octanol 78.74
    1-chlorooctane 85.84
    1-chlorotetradecane 37.43
    n-nonane 22.66
    undecane 18.26
    tert-butylcyclohexane 21.81
    cyclooctane 17.85
    cyclopentanol 269.1
    tetrahydropyran 397.77
    tert-amyl methyl ether 106.86
    2,5,8-trioxanonane 281.18
    1-hexene 44.72
    2-isopropoxyethanol 251.11
    2,2,2-trifluoroethanol 357.16
    methyl butyrate 252.0

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction