2,3-Diethylpyrazine

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  • Identifiers

    CAS number
    15707-24-1

    Molecular formula
    C8H12N2

    SMILES
    CCC1=NC=CN=C1CC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Nutty 85.88%
    Roasted 75.9%
    Earthy 70.6%
    Cocoa 62.79%
    Musty 62.54%
    Green 61.33%
    Potato 59.1%
    Hazelnut 58.66%
    Coffee 50.53%
    Vegetable 48.65%

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  • Properties

    XLogP3-AA
    1.5

    pKa est.
    5.26 (weak acid)

    Molecular weight
    136.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point

    • 180.00 to 182.00 °C. @ 760.00 mm Hg

    Flash point est.
    73.07 ˚C

    Solubility expt.

    • soluble in water, soluble in oils, organic solvents
    • miscible at room temperature (in ethanol)

  • Synonyms

    • 2,3-DIETHYLPYRAZINE
    • 15707-24-1
    • Pyrazine, 2,3-diethyl-
    • shoyu pyrazine
    • FEMA No. 3136
    • 2,3-Diethyl-pyrazine
    • EINECS 239-800-1
    • UNII-AD31A42VY0
    • AD31A42VY0
    • DTXSID6047101
    • DTXCID4027101
    • FEMA 3136
    • 2,3-DIETHYLPYRAZINE [FHFI]
    • Pyrazine, diethyl-
    • MFCD00006151
    • 23-Diethyl-pyrazine
    • 2,3-Diethylpyrazine, 98%
    • CHEMBL327303
    • SCHEMBL1131513
    • CHEBI:166525
    • Tox21_301820
    • 2,3-Diethylpyrazine, >=98%, FG
    • AKOS015838584
    • NCGC00255463-01
    • AC-16406
    • AS-57714
    • CAS-15707-24-1
    • DB-019731
    • CS-0196830
    • D1581
    • NS00012223
    • D89888
    • 2,3-Diethylpyrazine, analytical reference material
    • Q27273877
    • 239-800-1

  • Applications

    2,3-Diethylpyrazine (CAS 15707-24-1) is a roasted, nutty-smelling pyrazine widely used in the flavour and fragrance industry as a key modifier for coffee, cocoa, cereal, bakery and grilled-meat profiles, and is likewise incorporated into tobacco top notes, premium pet food, beverage bases, seasoning blends and sports-nutrition products; because of its very low odour threshold and high thermal stability it enriches aroma complexity, masks off-notes from plant proteins and protects volatile flavour fractions during roasting, drying or extrusion; beyond flavour creation it functions as an intermediate for pharmaceutical and agrochemical synthesis, a reference standard in sensory and analytical studies, and an important analyte for developing odour-sensitive materials in electrochemical sensors and electronic-nose technologies.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 275.66
    methanol 415.09
    isopropanol 200.4
    water 3.19
    ethyl acetate 676.68
    n-propanol 271.43
    acetone 768.79
    n-butanol 263.63
    acetonitrile 649.56
    DMF 1074.78
    toluene 505.0
    isobutanol 219.18
    1,4-dioxane 952.45
    methyl acetate 623.49
    THF 1235.06
    2-butanone 656.83
    n-pentanol 219.6
    sec-butanol 223.78
    n-hexane 181.19
    ethylene glycol 96.22
    NMP 1564.97
    cyclohexane 262.3
    DMSO 923.06
    n-butyl acetate 733.06
    n-octanol 221.86
    chloroform 2891.36
    n-propyl acetate 560.21
    acetic acid 509.42
    dichloromethane 3209.46
    cyclohexanone 1274.67
    propylene glycol 91.4
    isopropyl acetate 421.94
    DMAc 819.74
    2-ethoxyethanol 340.25
    isopentanol 229.2
    n-heptane 129.51
    ethyl formate 608.46
    1,2-dichloroethane 1854.13
    n-hexanol 278.86
    2-methoxyethanol 471.69
    isobutyl acetate 347.42
    tetrachloromethane 896.34
    n-pentyl acetate 494.09
    transcutol 739.51
    n-heptanol 188.76
    ethylbenzene 337.93
    MIBK 347.22
    2-propoxyethanol 409.62
    tert-butanol 233.0
    MTBE 361.7
    2-butoxyethanol 315.82
    propionic acid 431.93
    o-xylene 360.61
    formic acid 178.08
    diethyl ether 519.67
    m-xylene 362.19
    p-xylene 462.79
    chlorobenzene 1096.65
    dimethyl carbonate 357.61
    n-octane 71.46
    formamide 271.34
    cyclopentanone 1561.61
    2-pentanone 573.1
    anisole 509.93
    cyclopentyl methyl ether 722.49
    gamma-butyrolactone 1964.82
    1-methoxy-2-propanol 334.31
    pyridine 1160.75
    3-pentanone 612.0
    furfural 1651.63
    n-dodecane 52.87
    diethylene glycol 264.61
    diisopropyl ether 205.55
    tert-amyl alcohol 254.42
    acetylacetone 711.56
    n-hexadecane 62.52
    acetophenone 517.63
    methyl propionate 611.59
    isopentyl acetate 560.45
    trichloroethylene 3237.57
    n-nonanol 194.3
    cyclohexanol 358.61
    benzyl alcohol 343.76
    2-ethylhexanol 250.52
    isooctanol 165.28
    dipropyl ether 406.36
    1,2-dichlorobenzene 1168.72
    ethyl lactate 223.36
    propylene carbonate 1043.81
    n-methylformamide 604.35
    2-pentanol 198.02
    n-pentane 121.74
    1-propoxy-2-propanol 328.6
    1-methoxy-2-propyl acetate 462.84
    2-(2-methoxypropoxy) propanol 243.6
    mesitylene 278.08
    ε-caprolactone 1062.17
    p-cymene 256.06
    epichlorohydrin 1715.46
    1,1,1-trichloroethane 1814.23
    2-aminoethanol 146.52
    morpholine-4-carbaldehyde 1141.68
    sulfolane 2371.88
    2,2,4-trimethylpentane 85.66
    2-methyltetrahydrofuran 978.63
    n-hexyl acetate 585.47
    isooctane 58.52
    2-(2-butoxyethoxy)ethanol 318.72
    sec-butyl acetate 342.37
    tert-butyl acetate 437.62
    decalin 148.66
    glycerin 144.53
    diglyme 752.33
    acrylic acid 472.9
    isopropyl myristate 232.19
    n-butyric acid 563.32
    acetyl acetate 514.41
    di(2-ethylhexyl) phthalate 205.13
    ethyl propionate 529.49
    nitromethane 1079.17
    1,2-diethoxyethane 532.08
    benzonitrile 781.75
    trioctyl phosphate 174.77
    1-bromopropane 920.18
    gamma-valerolactone 1521.94
    n-decanol 145.21
    triethyl phosphate 283.08
    4-methyl-2-pentanol 123.62
    propionitrile 575.35
    vinylene carbonate 1072.57
    1,1,2-trichlorotrifluoroethane 951.66
    DMS 535.75
    cumene 243.46
    2-octanol 165.34
    2-hexanone 505.31
    octyl acetate 283.23
    limonene 339.14
    1,2-dimethoxyethane 790.95
    ethyl orthosilicate 268.9
    tributyl phosphate 235.94
    diacetone alcohol 324.01
    N,N-dimethylaniline 368.22
    acrylonitrile 816.43
    aniline 489.65
    1,3-propanediol 215.37
    bromobenzene 1345.17
    dibromomethane 2065.96
    1,1,2,2-tetrachloroethane 2401.69
    2-methyl-cyclohexyl acetate 390.74
    tetrabutyl urea 290.73
    diisobutyl methanol 159.69
    2-phenylethanol 352.29
    styrene 442.58
    dioctyl adipate 299.91
    dimethyl sulfate 630.68
    ethyl butyrate 554.6
    methyl lactate 258.48
    butyl lactate 312.39
    diethyl carbonate 417.9
    propanediol butyl ether 226.01
    triethyl orthoformate 366.92
    p-tert-butyltoluene 235.79
    methyl 4-tert-butylbenzoate 386.89
    morpholine 817.91
    tert-butylamine 193.25
    n-dodecanol 114.96
    dimethoxymethane 682.56
    ethylene carbonate 887.17
    cyrene 303.94
    2-ethoxyethyl acetate 525.93
    2-ethylhexyl acetate 529.82
    1,2,4-trichlorobenzene 1204.05
    4-methylpyridine 1069.74
    dibutyl ether 399.17
    2,6-dimethyl-4-heptanol 159.69
    DEF 765.92
    dimethyl isosorbide 564.42
    tetrachloroethylene 1944.64
    eugenol 350.86
    triacetin 435.51
    span 80 249.87
    1,4-butanediol 120.67
    1,1-dichloroethane 1430.63
    2-methyl-1-pentanol 221.69
    methyl formate 637.07
    2-methyl-1-butanol 248.24
    n-decane 85.94
    butyronitrile 605.34
    3,7-dimethyl-1-octanol 197.04
    1-chlorooctane 292.12
    1-chlorotetradecane 124.78
    n-nonane 92.9
    undecane 64.87
    tert-butylcyclohexane 126.14
    cyclooctane 119.97
    cyclopentanol 453.66
    tetrahydropyran 868.39
    tert-amyl methyl ether 342.19
    2,5,8-trioxanonane 445.12
    1-hexene 351.76
    2-isopropoxyethanol 239.24
    2,2,2-trifluoroethanol 299.42
    methyl butyrate 711.42

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1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction