2,3-Dichloro-1,1,1,2,3-pentafluoropropane

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  • Identifiers

    CAS number
    422-48-0

    Molecular formula
    C3HCl2F5

    SMILES
    C(C(C(F)(F)F)(F)Cl)(F)Cl

  • Odor profile

    Fragrance
    Odorless 56.43%
    Fishy 26.76%
    Woody 23.36%
    Sweet 22.29%
    Cooling 21.82%
    Balsamic 17.73%
    Animal 16.59%
    Savory 15.77%
    Mint 15.71%
    Dry 15.13%

     

    Flavor
    Odorless 32.3%
    Bland 21.53%
    Sulfurous 21.08%
    Mild 18.11%
    Sweet-like 17.79%
    Bloody 17.7%
    Bitter 17.57%
    Glue 17.55%
    Bouillon 17.34%
    Skunky 17.04%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    4.94 (weak acid)

    Molecular weight
    202.93 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    49°C

    Flash point

    • -2.17 ˚C est.

  • Synonyms

    • 422-48-0
    • 2,3-DICHLORO-1,1,1,2,3-PENTAFLUOROPROPANE
    • HCFC-225ba
    • 2,3-dichloro-1,1,1,2,3-pentafluoro-propane
    • UNII-0B6C0Q1W0G
    • 0B6C0Q1W0G
    • DTXSID1042025
    • 1,2-Dichloro-1,2,3,3,3-pentafluoropropane
    • Propane, 2,3-dichloro-1,1,1,2,3-pentafluoro-
    • 2,3-dichloropentafluoropropane
    • SCHEMBL1993217
    • DTXCID9022025
    • YGFIGGVCQHKDOL-UHFFFAOYSA-N
    • MFCD03703429
    • AKOS025310409
    • FD86804
    • NS00126903

  • Applications

    2,3-Dichloro-1,1,1,2,3-pentafluoropropane (CAS 422-48-0) is a fluorinated building block used primarily as an intermediate in the synthesis of fluorinated organic compounds for industrial chemicals and materials. In practical applications, it is commonly evaluated as a building block for fluorinated polymers and coatings, enabling the introduction of fluorinated moieties into resin and surface formulations. Its fluorinated content also lends itself to exploration as a solvent or processing aid in electronics manufacturing and precision cleaning, as well as a component in specialty adhesives and ink/coating formulations. Use is subject to local regulations and formulation limits, and experimental or pilot-scale applications may vary by process requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 436.5
    methanol 801.35
    isopropanol 257.26
    water 121.79
    ethyl acetate 170.41
    n-propanol 251.63
    acetone 576.72
    n-butanol 195.13
    acetonitrile 369.7
    DMF 1093.82
    toluene 82.19
    isobutanol 166.98
    1,4-dioxane 308.6
    methyl acetate 203.9
    THF 499.41
    2-butanone 304.26
    n-pentanol 177.98
    sec-butanol 215.82
    n-hexane 39.14
    ethylene glycol 207.57
    NMP 792.44
    cyclohexane 62.78
    DMSO 1714.79
    n-butyl acetate 91.84
    n-octanol 122.55
    chloroform 119.22
    n-propyl acetate 148.21
    acetic acid 240.79
    dichloromethane 201.37
    cyclohexanone 256.69
    propylene glycol 118.92
    isopropyl acetate 125.1
    DMAc 895.22
    2-ethoxyethanol 485.92
    isopentanol 165.53
    n-heptane 51.02
    ethyl formate 148.14
    1,2-dichloroethane 194.37
    n-hexanol 116.73
    2-methoxyethanol 607.4
    isobutyl acetate 59.63
    tetrachloromethane 28.05
    n-pentyl acetate 87.09
    transcutol 640.39
    n-heptanol 88.05
    ethylbenzene 60.37
    MIBK 166.34
    2-propoxyethanol 254.7
    tert-butanol 259.64
    MTBE 187.23
    2-butoxyethanol 168.6
    propionic acid 123.94
    o-xylene 97.18
    formic acid 319.25
    diethyl ether 290.25
    m-xylene 75.78
    p-xylene 65.2
    chlorobenzene 37.14
    dimethyl carbonate 134.36
    n-octane 25.22
    formamide 663.38
    cyclopentanone 324.48
    2-pentanone 273.31
    anisole 152.88
    cyclopentyl methyl ether 255.03
    gamma-butyrolactone 287.64
    1-methoxy-2-propanol 422.5
    pyridine 229.46
    3-pentanone 220.08
    furfural 259.62
    n-dodecane 17.27
    diethylene glycol 266.59
    diisopropyl ether 95.47
    tert-amyl alcohol 218.88
    acetylacetone 290.51
    n-hexadecane 18.18
    acetophenone 188.86
    methyl propionate 203.27
    isopentyl acetate 66.48
    trichloroethylene 181.86
    n-nonanol 109.27
    cyclohexanol 169.46
    benzyl alcohol 143.64
    2-ethylhexanol 73.19
    isooctanol 68.53
    dipropyl ether 146.12
    1,2-dichlorobenzene 36.69
    ethyl lactate 116.15
    propylene carbonate 105.77
    n-methylformamide 513.31
    2-pentanol 178.04
    n-pentane 72.67
    1-propoxy-2-propanol 185.32
    1-methoxy-2-propyl acetate 128.42
    2-(2-methoxypropoxy) propanol 192.35
    mesitylene 60.73
    ε-caprolactone 191.28
    p-cymene 55.14
    epichlorohydrin 281.29
    1,1,1-trichloroethane 70.58
    2-aminoethanol 250.49
    morpholine-4-carbaldehyde 618.58
    sulfolane 467.17
    2,2,4-trimethylpentane 24.84
    2-methyltetrahydrofuran 287.36
    n-hexyl acetate 114.5
    isooctane 18.05
    2-(2-butoxyethoxy)ethanol 249.24
    sec-butyl acetate 88.9
    tert-butyl acetate 125.71
    decalin 22.76
    glycerin 180.81
    diglyme 447.3
    acrylic acid 129.08
    isopropyl myristate 60.0
    n-butyric acid 119.09
    acetyl acetate 101.09
    di(2-ethylhexyl) phthalate 47.7
    ethyl propionate 133.27
    nitromethane 586.0
    1,2-diethoxyethane 205.91
    benzonitrile 98.84
    trioctyl phosphate 43.26
    1-bromopropane 131.81
    gamma-valerolactone 374.15
    n-decanol 84.91
    triethyl phosphate 55.49
    4-methyl-2-pentanol 110.12
    propionitrile 186.22
    vinylene carbonate 95.51
    1,1,2-trichlorotrifluoroethane 208.27
    DMS 93.93
    cumene 50.07
    2-octanol 78.38
    2-hexanone 194.57
    octyl acetate 74.82
    limonene 81.51
    1,2-dimethoxyethane 586.75
    ethyl orthosilicate 53.96
    tributyl phosphate 45.17
    diacetone alcohol 214.69
    N,N-dimethylaniline 199.9
    acrylonitrile 228.06
    aniline 120.48
    1,3-propanediol 245.85
    bromobenzene 31.59
    dibromomethane 149.57
    1,1,2,2-tetrachloroethane 153.75
    2-methyl-cyclohexyl acetate 76.97
    tetrabutyl urea 107.36
    diisobutyl methanol 59.49
    2-phenylethanol 97.24
    styrene 67.0
    dioctyl adipate 84.64
    dimethyl sulfate 234.48
    ethyl butyrate 102.99
    methyl lactate 162.18
    butyl lactate 82.38
    diethyl carbonate 62.69
    propanediol butyl ether 164.93
    triethyl orthoformate 75.02
    p-tert-butyltoluene 50.18
    methyl 4-tert-butylbenzoate 141.67
    morpholine 410.89
    tert-butylamine 185.91
    n-dodecanol 64.22
    dimethoxymethane 581.66
    ethylene carbonate 83.24
    cyrene 208.7
    2-ethoxyethyl acetate 114.01
    2-ethylhexyl acetate 54.52
    1,2,4-trichlorobenzene 46.07
    4-methylpyridine 208.57
    dibutyl ether 111.19
    2,6-dimethyl-4-heptanol 59.49
    DEF 420.42
    dimethyl isosorbide 243.65
    tetrachloroethylene 117.98
    eugenol 143.01
    triacetin 121.6
    span 80 119.92
    1,4-butanediol 155.98
    1,1-dichloroethane 112.8
    2-methyl-1-pentanol 140.51
    methyl formate 342.5
    2-methyl-1-butanol 161.47
    n-decane 29.72
    butyronitrile 153.06
    3,7-dimethyl-1-octanol 91.78
    1-chlorooctane 60.5
    1-chlorotetradecane 28.01
    n-nonane 30.18
    undecane 22.1
    tert-butylcyclohexane 17.46
    cyclooctane 33.0
    cyclopentanol 173.56
    tetrahydropyran 237.98
    tert-amyl methyl ether 187.62
    2,5,8-trioxanonane 335.61
    1-hexene 83.28
    2-isopropoxyethanol 284.89
    2,2,2-trifluoroethanol 142.95
    methyl butyrate 174.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction