2,3-Bis-O-(2,3-dihydroxypropyl)-L-ascorbic acid

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  • Identifiers

    CAS number
    1120360-14-6

    Molecular formula
    C12H20O10

    SMILES
    C([C@@H]([C@@H]1C(=C(C(=O)O1)OCC(CO)O)OCC(CO)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 60.54%
    Sweet 38.02%
    Buttery 26.29%
    Caramellic 25.95%
    Alcoholic 24.41%
    Clean 18.66%
    Oily 18.08%
    Milky 17.94%
    Savory 17.0%
    Ethereal 15.99%

     

    Flavor
    Odorless 57.22%
    Very mild 34.24%
    Bitter 33.27%
    Sweet-like 31.56%
    Sweet 31.25%
    Bland 29.07%
    Mild 22.06%
    Very slight 21.17%
    Yeast 19.73%
    Cauliflower 19.53%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.8

    pKa est.
    4.38 (weak acid)

    Molecular weight
    324.28 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2491°C

    Flash point

    • 284.23 ˚C est.

  • Synonyms

    • Bis-glyceryl ascorbate
    • Amitose DGA
    • 6H0B1V795F
    • L-Ascorbic acid, 2,3-bis-O-(2,3-dihydroxypropyl)-
    • 1120360-14-6
    • DTXSID80149840
    • RefChem:1059296
    • DTXCID7072331
    • 2,3-Bis-O-(2,3-dihydroxypropyl)-L-ascorbic acid
    • (+/-)-Bis-glyceryl ascorbate
    • UNII-6H0B1V795F
    • SCHEMBL2069097
    • NAQQWVCPJFBHCV-ABIFROTESA-N
    • Q27264897
    • (5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-bis(2,3-dihydroxypropoxy)furan-2(5H)-one
    • 1120360-14-6

  • Applications

    2,3-Bis-O-(2,3-dihydroxypropyl)-L-ascorbic acid (CAS 1120360-14-6) is a vitamin C derivative primarily viewed as an antioxidant and stabilizer in cosmetic and personal care formulations; it is also often evaluated as an intermediate in pharmaceutical synthesis and related chemical production; in the polymer and coating industries, it can serve as an antioxidant stabilizer to curb degradation; in broader industrial cleaning and formulation contexts, it may be added as an antioxidant to protect systems from oxidative damage.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.5
    methanol 36.93
    isopropanol 1.17
    water 392.8
    ethyl acetate 0.25
    n-propanol 2.44
    acetone 0.83
    n-butanol 1.15
    acetonitrile 0.59
    DMF 183.54
    toluene 0.14
    isobutanol 0.96
    1,4-dioxane 1.65
    methyl acetate 0.55
    THF 1.69
    2-butanone 0.55
    n-pentanol 0.64
    sec-butanol 0.92
    n-hexane 0.04
    ethylene glycol 119.61
    NMP 157.33
    cyclohexane 0.26
    DMSO 337.9
    n-butyl acetate 0.4
    n-octanol 0.93
    chloroform 0.32
    n-propyl acetate 0.27
    acetic acid 40.11
    dichloromethane 0.5
    cyclohexanone 2.27
    propylene glycol 57.94
    isopropyl acetate 0.2
    DMAc 86.4
    2-ethoxyethanol 11.89
    isopentanol 0.69
    n-heptane 0.18
    ethyl formate 1.4
    1,2-dichloroethane 0.53
    n-hexanol 0.86
    2-methoxyethanol 46.8
    isobutyl acetate 0.15
    tetrachloromethane 0.13
    n-pentyl acetate 0.52
    transcutol 19.76
    n-heptanol 1.2
    ethylbenzene 0.12
    MIBK 0.29
    2-propoxyethanol 8.07
    tert-butanol 1.32
    MTBE 0.21
    2-butoxyethanol 6.33
    propionic acid 8.57
    o-xylene 0.34
    formic acid 504.86
    diethyl ether 0.17
    m-xylene 0.17
    p-xylene 0.14
    chlorobenzene 0.11
    dimethyl carbonate 3.97
    n-octane 0.09
    formamide 336.59
    cyclopentanone 3.31
    2-pentanone 0.37
    anisole 0.34
    cyclopentyl methyl ether 0.93
    gamma-butyrolactone 7.84
    1-methoxy-2-propanol 20.24
    pyridine 1.49
    3-pentanone 0.55
    furfural 13.18
    n-dodecane 0.06
    diethylene glycol 36.67
    diisopropyl ether 0.09
    tert-amyl alcohol 1.33
    acetylacetone 1.15
    n-hexadecane 0.06
    acetophenone 1.1
    methyl propionate 1.31
    isopentyl acetate 0.38
    trichloroethylene 0.92
    n-nonanol 0.88
    cyclohexanol 2.02
    benzyl alcohol 1.74
    2-ethylhexanol 0.5
    isooctanol 0.78
    dipropyl ether 0.45
    1,2-dichlorobenzene 0.23
    ethyl lactate 3.98
    propylene carbonate 3.17
    n-methylformamide 62.47
    2-pentanol 0.5
    n-pentane 0.07
    1-propoxy-2-propanol 4.93
    1-methoxy-2-propyl acetate 1.98
    2-(2-methoxypropoxy) propanol 8.23
    mesitylene 0.19
    ε-caprolactone 3.11
    p-cymene 0.3
    epichlorohydrin 2.38
    1,1,1-trichloroethane 0.11
    2-aminoethanol 71.03
    morpholine-4-carbaldehyde 64.74
    sulfolane 63.86
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 0.7
    n-hexyl acetate 0.65
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 9.71
    sec-butyl acetate 0.15
    tert-butyl acetate 0.37
    decalin 0.08
    glycerin 227.68
    diglyme 14.68
    acrylic acid 24.71
    isopropyl myristate 0.29
    n-butyric acid 3.48
    acetyl acetate 0.42
    di(2-ethylhexyl) phthalate 1.11
    ethyl propionate 0.35
    nitromethane 26.46
    1,2-diethoxyethane 0.86
    benzonitrile 0.61
    trioctyl phosphate 0.96
    1-bromopropane 0.13
    gamma-valerolactone 14.43
    n-decanol 0.67
    triethyl phosphate 1.1
    4-methyl-2-pentanol 0.33
    propionitrile 0.49
    vinylene carbonate 4.17
    1,1,2-trichlorotrifluoroethane 34.7
    DMS 1.52
    cumene 0.13
    2-octanol 0.56
    2-hexanone 0.27
    octyl acetate 0.54
    limonene 0.48
    1,2-dimethoxyethane 4.71
    ethyl orthosilicate 0.85
    tributyl phosphate 0.87
    diacetone alcohol 3.34
    N,N-dimethylaniline 0.91
    acrylonitrile 1.9
    aniline 0.88
    1,3-propanediol 29.83
    bromobenzene 0.08
    dibromomethane 0.24
    1,1,2,2-tetrachloroethane 1.14
    2-methyl-cyclohexyl acetate 0.75
    tetrabutyl urea 2.19
    diisobutyl methanol 0.39
    2-phenylethanol 1.45
    styrene 0.11
    dioctyl adipate 0.92
    dimethyl sulfate 20.88
    ethyl butyrate 0.48
    methyl lactate 19.1
    butyl lactate 2.93
    diethyl carbonate 0.5
    propanediol butyl ether 13.4
    triethyl orthoformate 0.87
    p-tert-butyltoluene 0.33
    methyl 4-tert-butylbenzoate 3.22
    morpholine 4.46
    tert-butylamine 0.56
    n-dodecanol 0.52
    dimethoxymethane 10.78
    ethylene carbonate 2.23
    cyrene 22.28
    2-ethoxyethyl acetate 1.11
    2-ethylhexyl acetate 0.3
    1,2,4-trichlorobenzene 0.45
    4-methylpyridine 0.76
    dibutyl ether 0.27
    2,6-dimethyl-4-heptanol 0.39
    DEF 5.33
    dimethyl isosorbide 9.71
    tetrachloroethylene 1.09
    eugenol 4.4
    triacetin 2.61
    span 80 8.35
    1,4-butanediol 12.29
    1,1-dichloroethane 0.1
    2-methyl-1-pentanol 0.49
    methyl formate 22.82
    2-methyl-1-butanol 0.86
    n-decane 0.1
    butyronitrile 0.25
    3,7-dimethyl-1-octanol 0.55
    1-chlorooctane 0.18
    1-chlorotetradecane 0.1
    n-nonane 0.09
    undecane 0.07
    tert-butylcyclohexane 0.04
    cyclooctane 0.15
    cyclopentanol 2.55
    tetrahydropyran 0.61
    tert-amyl methyl ether 0.39
    2,5,8-trioxanonane 13.29
    1-hexene 0.06
    2-isopropoxyethanol 3.49
    2,2,2-trifluoroethanol 39.29
    methyl butyrate 0.62

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction