2,2,5,5-Tetramethyltetrahydrofuran

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  • Identifiers

    CAS number
    15045-43-9

    Molecular formula
    C8H16O

    SMILES
    CC1(CCC(O1)(C)C)C

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Camphoreous 68.03%
    Mint 61.88%
    Herbal 60.28%
    Fresh 53.88%
    Woody 52.8%
    Citrus 48.47%
    Pine 47.45%
    Cooling 47.17%
    Terpenic 44.76%
    Sweet 42.84%

     

    Flavor
    Camphor 42.15%
    Sweet 38.37%
    Herbal 34.18%
    Pungent 31.46%
    Earthy 28.78%
    Pine 26.7%
    Woody 22.95%
    Dry 21.12%
    Old paper 20.73%
    Terpenic 20.32%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    9.22 (weak base)

    Molecular weight
    128.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    118°C

    Flash point

    • 11.42 ˚C est.

  • Synonyms

    • 2,2,5,5-TETRAMETHYLTETRAHYDROFURAN
    • 15045-43-9
    • 2,2,5,5-tetramethyloxolane
    • Furan, tetrahydro-2,2,5,5-tetramethyl-
    • Tetrahydro-2,2,5,5-tetramethylfuran
    • MFCD00005368
    • 83Z08D4U0T
    • EINECS 239-117-9
    • UNII-83Z08D4U0T
    • AI3-25141
    • SCHEMBL380315
    • DTXSID1022263
    • SCHEMBL10871250
    • CHEBI:210533
    • GEO-03959
    • AKOS015912795
    • 2,2,5,5-Tetramethyl-tetrahydro-furan
    • AS-63484
    • FT172401
    • SY225987
    • DB-043055
    • NS00021680
    • D92900
    • EN300-7353614
    • Q25323734
    • 15045-43-9

  • Applications

    2,2,5,5-Tetramethyltetrahydrofuran (CAS 15045-43-9) is used primarily as a specialized organic solvent and reaction medium in industrial manufacturing, providing an inert, high-boiling environment for synthetic and polymerization processes. It often serves as a solvent or co-solvent in polymer and plastics processing, aiding dissolution and stabilization of monomers and oligomers. In coatings and inks, it functions as a solvent dispersant and resin carrier for formulation and application. It is commonly evaluated as an alternative to THF in research and development and for handling sensitive organometallic or coordination chemistry reactions. It may also be explored for electronics and advanced materials processing where controlled volatility and solvent properties are advantageous.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 601.41
    methanol 685.8
    isopropanol 587.91
    water 18.61
    ethyl acetate 752.06
    n-propanol 634.56
    acetone 513.09
    n-butanol 638.37
    acetonitrile 505.86
    DMF 521.42
    toluene 556.23
    isobutanol 536.66
    1,4-dioxane 988.2
    methyl acetate 670.44
    THF 1224.84
    2-butanone 617.52
    n-pentanol 389.94
    sec-butanol 666.37
    n-hexane 533.1
    ethylene glycol 207.22
    NMP 853.83
    cyclohexane 548.85
    DMSO 332.1
    n-butyl acetate 610.52
    n-octanol 539.05
    chloroform 1833.78
    n-propyl acetate 377.14
    acetic acid 562.48
    dichloromethane 1275.16
    cyclohexanone 889.21
    propylene glycol 315.86
    isopropyl acetate 522.08
    DMAc 743.51
    2-ethoxyethanol 399.3
    isopentanol 504.69
    n-heptane 448.11
    ethyl formate 365.08
    1,2-dichloroethane 646.68
    n-hexanol 867.01
    2-methoxyethanol 648.63
    isobutyl acetate 322.13
    tetrachloromethane 636.44
    n-pentyl acetate 483.55
    transcutol 1129.42
    n-heptanol 456.22
    ethylbenzene 311.3
    MIBK 356.7
    2-propoxyethanol 911.04
    tert-butanol 681.72
    MTBE 797.74
    2-butoxyethanol 496.6
    propionic acid 582.24
    o-xylene 431.92
    formic acid 240.43
    diethyl ether 885.83
    m-xylene 418.32
    p-xylene 397.87
    chlorobenzene 515.42
    dimethyl carbonate 281.93
    n-octane 174.67
    formamide 228.75
    cyclopentanone 802.29
    2-pentanone 502.44
    anisole 419.09
    cyclopentyl methyl ether 885.96
    gamma-butyrolactone 905.21
    1-methoxy-2-propanol 606.08
    pyridine 578.1
    3-pentanone 563.51
    furfural 646.4
    n-dodecane 136.25
    diethylene glycol 551.03
    diisopropyl ether 422.35
    tert-amyl alcohol 717.73
    acetylacetone 507.15
    n-hexadecane 149.11
    acetophenone 353.95
    methyl propionate 623.88
    isopentyl acetate 530.87
    trichloroethylene 1034.74
    n-nonanol 486.97
    cyclohexanol 749.92
    benzyl alcohol 288.41
    2-ethylhexanol 564.76
    isooctanol 357.95
    dipropyl ether 711.14
    1,2-dichlorobenzene 492.14
    ethyl lactate 243.13
    propylene carbonate 617.06
    n-methylformamide 366.5
    2-pentanol 551.42
    n-pentane 450.07
    1-propoxy-2-propanol 757.08
    1-methoxy-2-propyl acetate 629.69
    2-(2-methoxypropoxy) propanol 482.6
    mesitylene 290.84
    ε-caprolactone 898.19
    p-cymene 297.9
    epichlorohydrin 822.44
    1,1,1-trichloroethane 1039.66
    2-aminoethanol 365.2
    morpholine-4-carbaldehyde 810.69
    sulfolane 791.94
    2,2,4-trimethylpentane 231.6
    2-methyltetrahydrofuran 1143.66
    n-hexyl acetate 793.2
    isooctane 161.89
    2-(2-butoxyethoxy)ethanol 586.05
    sec-butyl acetate 359.85
    tert-butyl acetate 536.28
    decalin 262.0
    glycerin 360.61
    diglyme 842.17
    acrylic acid 437.92
    isopropyl myristate 349.5
    n-butyric acid 620.8
    acetyl acetate 563.31
    di(2-ethylhexyl) phthalate 259.04
    ethyl propionate 443.22
    nitromethane 641.1
    1,2-diethoxyethane 586.58
    benzonitrile 355.51
    trioctyl phosphate 208.39
    1-bromopropane 704.87
    gamma-valerolactone 895.54
    n-decanol 357.69
    triethyl phosphate 267.06
    4-methyl-2-pentanol 324.44
    propionitrile 501.78
    vinylene carbonate 521.15
    1,1,2-trichlorotrifluoroethane 725.56
    DMS 501.92
    cumene 259.62
    2-octanol 372.27
    2-hexanone 371.1
    octyl acetate 432.89
    limonene 478.2
    1,2-dimethoxyethane 583.38
    ethyl orthosilicate 277.71
    tributyl phosphate 258.21
    diacetone alcohol 451.5
    N,N-dimethylaniline 338.19
    acrylonitrile 444.44
    aniline 488.64
    1,3-propanediol 374.6
    bromobenzene 563.96
    dibromomethane 1063.01
    1,1,2,2-tetrachloroethane 1061.57
    2-methyl-cyclohexyl acetate 428.97
    tetrabutyl urea 307.19
    diisobutyl methanol 304.12
    2-phenylethanol 431.68
    styrene 315.34
    dioctyl adipate 360.09
    dimethyl sulfate 366.4
    ethyl butyrate 446.03
    methyl lactate 323.91
    butyl lactate 361.2
    diethyl carbonate 309.46
    propanediol butyl ether 450.58
    triethyl orthoformate 393.08
    p-tert-butyltoluene 316.23
    methyl 4-tert-butylbenzoate 470.96
    morpholine 1020.64
    tert-butylamine 616.67
    n-dodecanol 281.37
    dimethoxymethane 526.22
    ethylene carbonate 493.68
    cyrene 328.91
    2-ethoxyethyl acetate 529.09
    2-ethylhexyl acetate 513.39
    1,2,4-trichlorobenzene 597.53
    4-methylpyridine 674.54
    dibutyl ether 593.65
    2,6-dimethyl-4-heptanol 304.12
    DEF 594.07
    dimethyl isosorbide 662.97
    tetrachloroethylene 776.4
    eugenol 354.02
    triacetin 557.9
    span 80 504.07
    1,4-butanediol 188.02
    1,1-dichloroethane 862.29
    2-methyl-1-pentanol 368.07
    methyl formate 299.42
    2-methyl-1-butanol 574.31
    n-decane 223.32
    butyronitrile 481.93
    3,7-dimethyl-1-octanol 485.88
    1-chlorooctane 454.43
    1-chlorotetradecane 218.09
    n-nonane 235.7
    undecane 167.32
    tert-butylcyclohexane 277.86
    cyclooctane 282.54
    cyclopentanol 684.77
    tetrahydropyran 1096.61
    tert-amyl methyl ether 740.34
    2,5,8-trioxanonane 595.0
    1-hexene 608.61
    2-isopropoxyethanol 369.13
    2,2,2-trifluoroethanol 315.08
    methyl butyrate 432.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction