2,2',4,4'-Tetrahydroxybenzophenone

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  • Identifiers

    CAS number
    131-55-5

    Molecular formula
    C13H10O5

    SMILES
    C1=CC(=C(C=C1O)O)C(=O)C2=C(C=C(C=C2)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 67.48%
    Odorless 49.4%
    Medicinal 35.41%
    Burnt 33.41%
    Bitter 30.38%
    Sweet 29.54%
    Nutty 29.29%
    Balsamic 28.27%
    Spicy 26.47%
    Vanilla 25.58%

     

    Flavor
    Bitter 92.58%
    Odorless 32.26%
    Mild 21.43%
    Bland 21.35%
    Sweet-like 20.93%
    Nitrile 20.79%
    Very strong 20.63%
    Cedarleaf 20.36%
    Indole 20.31%
    Lovage 20.01%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    9.85 (weak base)

    Molecular weight
    246.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 198.8 °C

    Boiling point

    • 491 °C

    Flash point

    • 246.0 ˚C est.

    Solubility expt.

    • In water, 8,821 mg/L at 24.99 °C
    • In water, <1 g/100 mL at 30 °C
    • Very soluble in acetone, diethyl ether, ethanol
    • Ethyl acetate 10, methanol 50, methyl ethyl ketone 22, toluene < 1 (all g/100 ml at 25 °C)

  • Synonyms

    • 2,2',4,4'-Tetrahydroxybenzophenone
    • 131-55-5
    • Bis(2,4-dihydroxyphenyl)methanone
    • Benzophenone-2
    • Methanone, bis(2,4-dihydroxyphenyl)-
    • Uvinol D-50
    • Uvinul D-50
    • 2,4,2',4'-Tetrahydroxybenzophenone
    • DTXSID5041306
    • 2,2',4,4'-hydroxybenophenone
    • BENZOPHENONE, 2,2',4,4'-TETRAHYDROXY-
    • PRR8K3H9VN
    • NSC-38556
    • DTXCID3021306
    • RefChem:566254
    • 205-028-9
    • benzophenone 2
    • 2,2',4,4'-Tetrehydroxybenzophenone
    • MFCD00002278
    • NSC 38556
    • 2,2',4,4'-Tetrahydroxy-benzophenone
    • di2,4-dihydroxyphenyl ketone
    • ST055642
    • CAS-131-55-5
    • EINECS 205-028-9
    • UNII-PRR8K3H9VN
    • BRN 1914746
    • 4-(2,4-dihydroxybenzoyl)benzene-1,3-diol
    • 4mgc
    • 27M
    • UVINUL D50
    • Phloroglucinol Impurity 88
    • Oprea1_250768
    • SCHEMBL39507
    • 2,4'-Tetrahydroxybenzophenone
    • BIDD:ER0038
    • Methanone,4-dihydroxyphenyl)-
    • CHEMBL3185091
    • SCHEMBL29357695
    • HSDB 8386
    • 2,4,4'-Tetrahydroxybenzophenone
    • Di(2,4-dihydroxyphenyl)methanone
    • MSK3411
    • 2,2',4'-Tetrahydroxybenzophenone
    • BDBM234390
    • BP_28
    • BB_SC-01348
    • NSC38556
    • Tox21_202288
    • Tox21_303639
    • BBL012188
    • MSK3411-100A
    • SBB003178
    • STK803083
    • 2,2?,4,4?-Tetrahydroxybenzophenone
    • Benzophenone,2',4,4'-tetrahydroxy-
    • 2, 2',4,4'-tetrahydroxybenzophenone
    • 2,2',4,4'-tetrahydroxy benzophenone
    • AKOS002319293
    • MSK3411-1000A
    • EBC-611378
    • FT55663
    • 2,2\',4,4\'-Tetrahydroxybenzophenone
    • NCGC00249205-01
    • NCGC00249205-02
    • NCGC00257395-01
    • NCGC00259837-01
    • 2,2',4,4'-Tetrahydroxy diphenyl ketone
    • AC-10378
    • AS-13615
    • SY020047
    • DB-042043
    • 2,2',4,4'-Tetrahydroxybenzophenone, 97%
    • CS-0089098
    • NS00002972
    • T0118
    • H10707
    • F217123
    • SR-01000199334
    • SR-01000199334-1
    • Q27286728
    • 2,2',4,4'-Tetrahydroxybenzophenone Solution in Acetonitrile, 1000ug/mL
    • 2,2',4,4'-Tetrahydroxybenzophenone Solution in Acetonitrile, 100ug/mL
    • InChI=1/C13H10O5/c14-7-1-3-9(11(16)5-7)13(18)10-4-2-8(15)6-12(10)17/h1-6,14-17
    • 131-55-5

  • Applications

    2,2',4,4'-Tetrahydroxybenzophenone, CAS 131-55-5, is used primarily as a UV absorber and stabilizer in polymer and coating systems; it helps mitigate UV- and photo-oxidative degradation to extend the service life of plastics, paints, and inks. It also functions as a phenolic antioxidant in resin formulations, improving thermal and oxidative stability. The compound can serve as an intermediate or building block in the synthesis of specialty chemicals and functional additives for adhesives and coating formulations. It has been considered for electronics-related and printing applications that require UV stability, subject to regulatory and formulation constraints. In cosmetics and personal care, some studies evaluate benzophenone derivatives with multiple OH groups as UV filters or antioxidants, but actual use depends on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 23.57
    methanol 40.19
    isopropanol 35.86
    water 0.28
    ethyl acetate 21.88
    n-propanol 27.63
    acetone 50.89
    n-butanol 22.0
    acetonitrile 21.94
    DMF 261.16
    toluene 0.56
    isobutanol 15.49
    1,4-dioxane 36.29
    methyl acetate 27.08
    THF 285.45
    2-butanone 34.86
    n-pentanol 19.07
    sec-butanol 21.12
    n-hexane 0.12
    ethylene glycol 70.13
    NMP 138.12
    cyclohexane 0.06
    DMSO 1050.77
    n-butyl acetate 17.34
    n-octanol 10.46
    chloroform 0.11
    n-propyl acetate 20.95
    acetic acid 39.42
    dichloromethane 0.1
    cyclohexanone 27.53
    propylene glycol 130.79
    isopropyl acetate 20.13
    DMAc 230.28
    2-ethoxyethanol 107.39
    isopentanol 20.6
    n-heptane 0.25
    ethyl formate 20.01
    1,2-dichloroethane 0.52
    n-hexanol 11.98
    2-methoxyethanol 245.76
    isobutyl acetate 9.44
    tetrachloromethane 0.07
    n-pentyl acetate 13.09
    transcutol 222.02
    n-heptanol 10.21
    ethylbenzene 0.82
    MIBK 23.23
    2-propoxyethanol 112.17
    tert-butanol 58.63
    MTBE 11.42
    2-butoxyethanol 48.61
    propionic acid 35.66
    o-xylene 0.9
    formic acid 43.75
    diethyl ether 7.43
    m-xylene 1.06
    p-xylene 1.04
    chlorobenzene 0.46
    dimethyl carbonate 33.83
    n-octane 0.15
    formamide 129.82
    cyclopentanone 94.44
    2-pentanone 30.04
    anisole 8.5
    cyclopentyl methyl ether 21.61
    gamma-butyrolactone 142.19
    1-methoxy-2-propanol 226.16
    pyridine 8.08
    3-pentanone 14.98
    furfural 56.35
    n-dodecane 0.3
    diethylene glycol 153.04
    diisopropyl ether 3.21
    tert-amyl alcohol 29.32
    acetylacetone 54.17
    n-hexadecane 0.34
    acetophenone 13.16
    methyl propionate 37.89
    isopentyl acetate 15.87
    trichloroethylene 0.95
    n-nonanol 11.13
    cyclohexanol 11.21
    benzyl alcohol 11.71
    2-ethylhexanol 7.33
    isooctanol 8.65
    dipropyl ether 12.3
    1,2-dichlorobenzene 0.72
    ethyl lactate 40.61
    propylene carbonate 43.83
    n-methylformamide 116.22
    2-pentanol 16.97
    n-pentane 0.1
    1-propoxy-2-propanol 82.13
    1-methoxy-2-propyl acetate 50.54
    2-(2-methoxypropoxy) propanol 58.89
    mesitylene 1.05
    ε-caprolactone 37.35
    p-cymene 1.66
    epichlorohydrin 63.34
    1,1,1-trichloroethane 0.42
    2-aminoethanol 97.37
    morpholine-4-carbaldehyde 131.28
    sulfolane 238.34
    2,2,4-trimethylpentane 0.19
    2-methyltetrahydrofuran 39.03
    n-hexyl acetate 18.89
    isooctane 0.2
    2-(2-butoxyethoxy)ethanol 84.55
    sec-butyl acetate 13.11
    tert-butyl acetate 27.82
    decalin 0.16
    glycerin 229.87
    diglyme 114.52
    acrylic acid 35.69
    isopropyl myristate 10.0
    n-butyric acid 34.32
    acetyl acetate 12.05
    di(2-ethylhexyl) phthalate 10.01
    ethyl propionate 23.29
    nitromethane 139.94
    1,2-diethoxyethane 34.02
    benzonitrile 6.41
    trioctyl phosphate 9.88
    1-bromopropane 0.38
    gamma-valerolactone 128.98
    n-decanol 8.99
    triethyl phosphate 13.77
    4-methyl-2-pentanol 12.68
    propionitrile 16.51
    vinylene carbonate 24.74
    1,1,2-trichlorotrifluoroethane 65.06
    DMS 20.35
    cumene 0.95
    2-octanol 6.93
    2-hexanone 22.21
    octyl acetate 13.2
    limonene 2.17
    1,2-dimethoxyethane 110.41
    ethyl orthosilicate 11.98
    tributyl phosphate 11.27
    diacetone alcohol 86.6
    N,N-dimethylaniline 7.72
    acrylonitrile 26.53
    aniline 3.8
    1,3-propanediol 101.1
    bromobenzene 0.25
    dibromomethane 0.07
    1,1,2,2-tetrachloroethane 1.56
    2-methyl-cyclohexyl acetate 14.14
    tetrabutyl urea 19.23
    diisobutyl methanol 8.13
    2-phenylethanol 12.04
    styrene 0.75
    dioctyl adipate 16.82
    dimethyl sulfate 71.01
    ethyl butyrate 18.45
    methyl lactate 95.3
    butyl lactate 29.5
    diethyl carbonate 12.93
    propanediol butyl ether 60.2
    triethyl orthoformate 18.93
    p-tert-butyltoluene 1.98
    methyl 4-tert-butylbenzoate 23.72
    morpholine 74.59
    tert-butylamine 12.14
    n-dodecanol 6.66
    dimethoxymethane 150.6
    ethylene carbonate 22.91
    cyrene 67.29
    2-ethoxyethyl acetate 25.66
    2-ethylhexyl acetate 10.29
    1,2,4-trichlorobenzene 1.27
    4-methylpyridine 7.83
    dibutyl ether 10.52
    2,6-dimethyl-4-heptanol 8.13
    DEF 44.55
    dimethyl isosorbide 101.21
    tetrachloroethylene 0.64
    eugenol 29.7
    triacetin 28.53
    span 80 39.12
    1,4-butanediol 37.45
    1,1-dichloroethane 0.3
    2-methyl-1-pentanol 13.15
    methyl formate 73.12
    2-methyl-1-butanol 15.63
    n-decane 0.41
    butyronitrile 13.68
    3,7-dimethyl-1-octanol 9.46
    1-chlorooctane 1.66
    1-chlorotetradecane 1.05
    n-nonane 0.3
    undecane 0.36
    tert-butylcyclohexane 0.21
    cyclooctane 0.06
    cyclopentanol 26.16
    tetrahydropyran 13.18
    tert-amyl methyl ether 11.32
    2,5,8-trioxanonane 93.65
    1-hexene 0.68
    2-isopropoxyethanol 60.73
    2,2,2-trifluoroethanol 20.88
    methyl butyrate 28.63

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction