2,2,4-Trimethyl-1,6-hexanediamine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    3236-53-1

    Molecular formula
    C9H22N2

    SMILES
    CC(CCN)CC(C)(C)CN

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 60.25%
    Cheesy 47.99%
    Ripe 40.63%
    Animal 30.86%
    Meaty 25.79%
    Cooling 25.27%
    Mint 24.95%
    Savory 24.56%
    Grapefruit 23.59%
    Citrus 23.44%

     

    Flavor
    Mild 23.5%
    Glue 21.75%
    Fishy 21.72%
    Delicate 21.67%
    Bloody 21.51%
    Yeasty 21.32%
    Leathery 21.26%
    Skunky 21.01%
    Sulfurous 20.59%
    Ammoniacal 20.57%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    6.23 (neutral)

    Molecular weight
    158.28 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    237°C

    Flash point

    • 91.71 ˚C est.

  • Synonyms

    • 2,2,4-Trimethylhexane-1,6-diamine
    • 2,2,4-Trimethyl-1,6-hexanediamine
    • 1,6-Hexanediamine, 2,2,4-trimethyl-
    • UNII-PN9C5291DR
    • PN9C5291DR
    • EINECS 221-792-6
    • DTXSID10863128
    • RefChem:80873
    • 2,2,4Trimethylhexane1,6diamine
    • DTXCID00811794
    • 1,6Hexanediamine, 2,2,4trimethyl
    • Trimethyl1,6hexanediamine, 2,2,4
    • 3236-53-1
    • 1,6-Hexanediamine, 2,2,4(or 2,4,4)-trimethyl-
    • 2,2,4-trimethyl-1,6-diaminohexane
    • 2,2,4-trimethylhexamethylenediamine
    • EINECS 247-063-2
    • starbld0017057
    • UNII-00PFI6E4JT
    • EC 247-063-2
    • trimethyl-1,6-hexanediamine
    • 00PFI6E4JT
    • 2,2,4(Or 2,4,4)-trimethylhexane-1,6-diamine
    • SCHEMBL22488
    • 2,2,4-(or 2,4,4)-Trimethyl-1,6-hexanediamine
    • SCHEMBL11261982
    • AKOS015894804
    • 2,2,4-Trimethyl-1,6-hexanediamine #
    • LS-13728
    • NS00004764
    • Q27286647
    • 3236-53-1

  • Applications

    2,2,4-Trimethyl-1,6-hexanediamine (CAS 3236-53-1) is a bulky aliphatic diamine primarily employed as a reactive intermediate and curing agent in polymer formulations. In coatings and composites, it functions as an epoxy resin hardener, contributing to improved solvent resistance and thermal stability. It is also used as a hardener or chain extender in polyurethane and polyurethane‑urea systems for durable coatings, sealants, and adhesives. As a building block for specialty polymers and polyamides, it supports the synthesis of high‑performance materials used in industrial manufacturing. Additional roles include serving as a crosslinking component in high‑strength coatings and adhesive formulations for automotive, aerospace, and electronics applications, subject to formulation specifics and regulatory guidelines.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 145.83
    methanol 277.0
    isopropanol 76.96
    water 15.66
    ethyl acetate 51.14
    n-propanol 123.92
    acetone 63.53
    n-butanol 104.7
    acetonitrile 54.86
    DMF 64.49
    toluene 18.37
    isobutanol 87.59
    1,4-dioxane 89.47
    methyl acetate 55.02
    THF 236.64
    2-butanone 52.92
    n-pentanol 46.88
    sec-butanol 59.37
    n-hexane 3.79
    ethylene glycol 91.9
    NMP 194.72
    cyclohexane 8.73
    DMSO 188.48
    n-butyl acetate 133.4
    n-octanol 34.0
    chloroform 113.41
    n-propyl acetate 43.85
    acetic acid 380.84
    dichloromethane 73.47
    cyclohexanone 162.62
    propylene glycol 112.28
    isopropyl acetate 37.5
    DMAc 64.71
    2-ethoxyethanol 88.97
    isopentanol 83.64
    n-heptane 12.68
    ethyl formate 104.66
    1,2-dichloroethane 38.82
    n-hexanol 140.04
    2-methoxyethanol 213.41
    isobutyl acetate 36.95
    tetrachloromethane 52.13
    n-pentyl acetate 41.62
    transcutol 162.84
    n-heptanol 71.71
    ethylbenzene 7.41
    MIBK 33.0
    2-propoxyethanol 224.29
    tert-butanol 107.99
    MTBE 41.85
    2-butoxyethanol 122.7
    propionic acid 211.34
    o-xylene 16.84
    formic acid 252.3
    diethyl ether 21.68
    m-xylene 18.47
    p-xylene 12.81
    chlorobenzene 40.7
    dimethyl carbonate 25.09
    n-octane 3.06
    formamide 135.53
    cyclopentanone 214.09
    2-pentanone 45.49
    anisole 22.15
    cyclopentyl methyl ether 85.47
    gamma-butyrolactone 300.03
    1-methoxy-2-propanol 115.59
    pyridine 75.45
    3-pentanone 32.87
    furfural 292.58
    n-dodecane 1.88
    diethylene glycol 189.58
    diisopropyl ether 10.67
    tert-amyl alcohol 82.33
    acetylacetone 63.74
    n-hexadecane 2.03
    acetophenone 33.51
    methyl propionate 48.66
    isopentyl acetate 111.69
    trichloroethylene 112.21
    n-nonanol 28.31
    cyclohexanol 95.45
    benzyl alcohol 40.58
    2-ethylhexanol 87.79
    isooctanol 53.13
    dipropyl ether 50.92
    1,2-dichlorobenzene 43.13
    ethyl lactate 46.74
    propylene carbonate 195.8
    n-methylformamide 126.42
    2-pentanol 43.46
    n-pentane 4.81
    1-propoxy-2-propanol 172.87
    1-methoxy-2-propyl acetate 112.1
    2-(2-methoxypropoxy) propanol 65.8
    mesitylene 13.39
    ε-caprolactone 150.36
    p-cymene 24.34
    epichlorohydrin 143.46
    1,1,1-trichloroethane 57.59
    2-aminoethanol 153.22
    morpholine-4-carbaldehyde 150.96
    sulfolane 369.36
    2,2,4-trimethylpentane 5.75
    2-methyltetrahydrofuran 132.05
    n-hexyl acetate 44.98
    isooctane 4.09
    2-(2-butoxyethoxy)ethanol 94.79
    sec-butyl acetate 26.39
    tert-butyl acetate 54.48
    decalin 4.24
    glycerin 183.38
    diglyme 150.95
    acrylic acid 203.15
    isopropyl myristate 14.78
    n-butyric acid 304.21
    acetyl acetate 56.7
    di(2-ethylhexyl) phthalate 37.54
    ethyl propionate 31.41
    nitromethane 248.91
    1,2-diethoxyethane 34.35
    benzonitrile 54.43
    trioctyl phosphate 31.16
    1-bromopropane 21.07
    gamma-valerolactone 264.86
    n-decanol 19.26
    triethyl phosphate 42.14
    4-methyl-2-pentanol 31.9
    propionitrile 54.24
    vinylene carbonate 160.9
    1,1,2-trichlorotrifluoroethane 251.87
    DMS 33.3
    cumene 8.44
    2-octanol 28.15
    2-hexanone 31.88
    octyl acetate 23.86
    limonene 38.57
    1,2-dimethoxyethane 84.6
    ethyl orthosilicate 42.84
    tributyl phosphate 32.19
    diacetone alcohol 88.51
    N,N-dimethylaniline 16.44
    acrylonitrile 68.78
    aniline 55.78
    1,3-propanediol 183.02
    bromobenzene 33.18
    dibromomethane 48.39
    1,1,2,2-tetrachloroethane 89.96
    2-methyl-cyclohexyl acetate 76.57
    tetrabutyl urea 30.77
    diisobutyl methanol 40.25
    2-phenylethanol 74.99
    styrene 8.43
    dioctyl adipate 27.97
    dimethyl sulfate 57.56
    ethyl butyrate 74.88
    methyl lactate 62.63
    butyl lactate 60.81
    diethyl carbonate 47.08
    propanediol butyl ether 86.49
    triethyl orthoformate 65.24
    p-tert-butyltoluene 26.47
    methyl 4-tert-butylbenzoate 61.02
    morpholine 117.84
    tert-butylamine 53.54
    n-dodecanol 13.92
    dimethoxymethane 44.18
    ethylene carbonate 126.54
    cyrene 93.15
    2-ethoxyethyl acetate 48.36
    2-ethylhexyl acetate 81.98
    1,2,4-trichlorobenzene 60.26
    4-methylpyridine 57.28
    dibutyl ether 16.35
    2,6-dimethyl-4-heptanol 40.25
    DEF 45.73
    dimethyl isosorbide 144.25
    tetrachloroethylene 93.55
    eugenol 61.28
    triacetin 55.58
    span 80 81.08
    1,4-butanediol 57.82
    1,1-dichloroethane 34.01
    2-methyl-1-pentanol 42.45
    methyl formate 108.03
    2-methyl-1-butanol 79.55
    n-decane 3.15
    butyronitrile 65.82
    3,7-dimethyl-1-octanol 33.31
    1-chlorooctane 12.0
    1-chlorotetradecane 4.55
    n-nonane 3.06
    undecane 2.33
    tert-butylcyclohexane 5.23
    cyclooctane 3.9
    cyclopentanol 131.72
    tetrahydropyran 78.31
    tert-amyl methyl ether 33.55
    2,5,8-trioxanonane 100.95
    1-hexene 8.63
    2-isopropoxyethanol 56.0
    2,2,2-trifluoroethanol 145.11
    methyl butyrate 50.45

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction