2,2'-Methylenebis(6-cyclohexyl-p-cresol)

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  • Identifiers

    CAS number
    4066-02-8

    Molecular formula
    C27H36O2

    SMILES
    CC1=CC(=C(C(=C1)C2CCCCC2)O)CC3=C(C(=CC(=C3)C)C4CCCCC4)O

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Spicy 42.19%
    Phenolic 42.04%
    Animal 36.93%
    Leathery 31.16%
    Woody 28.88%
    Smoky 27.67%
    Sweet 25.44%
    Fruity 24.64%
    Musk 23.84%
    Dry 23.73%

     

    Flavor
    Bitter 41.91%
    Woody 25.5%
    Animal 22.11%
    Sweet 21.92%
    Very strong 20.94%
    Indole 20.69%
    Flat 20.69%
    Parsley 20.25%
    Thymol 20.17%
    Sandalwood 20.11%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    8.9

    pKa est.
    8.91 (weak base)

    Molecular weight
    392.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    703°C

    Flash point

    • 212.69 ˚C est.

  • Synonyms

    • 2,2'-Methylenebis(6-cyclohexyl-p-cresol)
    • Antioxidant ZKF
    • Vulkanox ZKF
    • 2,2'-Methylenebis(6-cyclohexyl-4-methylphenol)
    • Bis(2-hydroxy-3-cyclohexyl-5-methylphenyl)methane
    • EINECS 223-773-8
    • Phenol, 2,2'-methylenebis[6-cyclohexyl-4-methyl-
    • p-Cresol, 2,2'-methylenebis(6-cyclohexyl-
    • 6825HV3123
    • Phenol, 2,2'-methylenebis(5-cyclohexyl-4-methyl-
    • Phenol, 2,2'-methylenebis(6-cyclohexyl-4-methyl-
    • 2,2'-METHYLENEBIS(4-METHYL-6-CYCLOHEXYLPHENOL)
    • BIS(3-CYCLOHEXYL-5-METHYL-2-HYDROXYPHENYL)METHANE
    • 2,2'-methylenebis[6-cyclohexyl-p-cresol]
    • RefChem:440321
    • p-Cresol, 2,2'-methylenebis(6-cyclohexyl-(6CI,7CI,8CI)
    • 223-773-8
    • 4066-02-8
    • 6,6'-Methylenebis(2-cyclohexyl-4-methylphenol)
    • 2-cyclohexyl-6-[(3-cyclohexyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
    • MFCD10000968
    • 2,2'-Methylenebis(6-cyclohexyl-4-methyl)phenol
    • 2 pound not2 inverted exclamation mark -methylenebis[6-cyclohexyl-p-cresol]
    • SCHEMBL34995
    • ZKF
    • DTXSID6052081
    • SCHEMBL29381510
    • SCHEMBL29556326
    • MSK3125
    • UNII-6825HV3123
    • AKOS015915460
    • 2-cyclohexyl-6-[(3-cyclohexyl-2-hydroxy-5-methyl-phenyl)methyl]-4-methyl-phenol
    • 2,2-Methylenebis(6-cyclohexyl-p-cresol)
    • AS-66973
    • SY054741
    • Bis(5-cyclohexyl-6-hydroxy-m-tolyl)methane
    • M1896
    • NS00020645
    • D91548
    • 2,2'-methylenbis-(4-methyl-6-cyclohexylphenol)
    • 2,2'-Methanediylbis(6-cyclohexyl-4-methylphenol)
    • 2,2'-methylenebis (4-methyl-6-cyclohexylphenol)
    • Q27264202
    • 2,2 inverted exclamation mark -Methylenebis(6-cyclohexyl-p-cresol)
    • 4066-02-8

  • Applications

    2,2'-Methylenebis(6-cyclohexyl-p-cresol) (CAS 4066-02-8) is primarily used as a hindered phenolic antioxidant and heat stabilizer for polymers and rubber, improving oxidative and thermal stability of polyolefins, engineering plastics, and PVC during processing. It is also commonly employed as an antioxidant additive in lubricants and industrial oils, as well as in coatings and inks to resist oxidation and color degradation. Additionally, it may serve as an additive for adhesives to enhance long-term stability and can be considered a precursor in the synthesis of other antioxidant materials.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 26.99
    methanol 12.07
    isopropanol 28.71
    water 0.01
    ethyl acetate 151.72
    n-propanol 45.93
    acetone 182.66
    n-butanol 54.43
    acetonitrile 21.2
    DMF 251.45
    toluene 151.14
    isobutanol 40.4
    1,4-dioxane 186.63
    methyl acetate 107.16
    THF 713.96
    2-butanone 209.1
    n-pentanol 37.59
    sec-butanol 38.41
    n-hexane 7.77
    ethylene glycol 1.08
    NMP 254.49
    cyclohexane 10.34
    DMSO 84.75
    n-butyl acetate 139.17
    n-octanol 26.63
    chloroform 389.67
    n-propyl acetate 99.33
    acetic acid 30.06
    dichloromethane 383.55
    cyclohexanone 338.62
    propylene glycol 4.21
    isopropyl acetate 133.65
    DMAc 335.71
    2-ethoxyethanol 58.23
    isopentanol 58.72
    n-heptane 6.89
    ethyl formate 52.71
    1,2-dichloroethane 278.56
    n-hexanol 44.63
    2-methoxyethanol 67.36
    isobutyl acetate 90.17
    tetrachloromethane 40.83
    n-pentyl acetate 143.95
    transcutol 216.21
    n-heptanol 38.15
    ethylbenzene 53.71
    MIBK 137.02
    2-propoxyethanol 99.16
    tert-butanol 44.63
    MTBE 143.82
    2-butoxyethanol 92.08
    propionic acid 36.51
    o-xylene 67.69
    formic acid 4.3
    diethyl ether 141.95
    m-xylene 80.67
    p-xylene 64.0
    chlorobenzene 170.63
    dimethyl carbonate 77.5
    n-octane 4.27
    formamide 12.25
    cyclopentanone 490.74
    2-pentanone 209.44
    anisole 108.87
    cyclopentyl methyl ether 248.06
    gamma-butyrolactone 347.05
    1-methoxy-2-propanol 85.3
    pyridine 232.07
    3-pentanone 168.77
    furfural 201.05
    n-dodecane 2.34
    diethylene glycol 26.88
    diisopropyl ether 46.15
    tert-amyl alcohol 50.63
    acetylacetone 232.37
    n-hexadecane 2.93
    acetophenone 113.44
    methyl propionate 149.58
    isopentyl acetate 149.77
    trichloroethylene 544.99
    n-nonanol 31.25
    cyclohexanol 58.24
    benzyl alcohol 62.47
    2-ethylhexanol 40.15
    isooctanol 38.11
    dipropyl ether 85.42
    1,2-dichlorobenzene 142.17
    ethyl lactate 37.92
    propylene carbonate 161.7
    n-methylformamide 48.45
    2-pentanol 43.69
    n-pentane 6.48
    1-propoxy-2-propanol 90.29
    1-methoxy-2-propyl acetate 174.59
    2-(2-methoxypropoxy) propanol 68.78
    mesitylene 42.46
    ε-caprolactone 250.29
    p-cymene 35.12
    epichlorohydrin 468.0
    1,1,1-trichloroethane 227.27
    2-aminoethanol 6.01
    morpholine-4-carbaldehyde 223.44
    sulfolane 323.32
    2,2,4-trimethylpentane 6.25
    2-methyltetrahydrofuran 294.82
    n-hexyl acetate 128.39
    isooctane 4.64
    2-(2-butoxyethoxy)ethanol 100.59
    sec-butyl acetate 87.45
    tert-butyl acetate 166.42
    decalin 8.32
    glycerin 7.12
    diglyme 240.5
    acrylic acid 26.74
    isopropyl myristate 46.34
    n-butyric acid 94.22
    acetyl acetate 87.87
    di(2-ethylhexyl) phthalate 42.61
    ethyl propionate 96.14
    nitromethane 84.23
    1,2-diethoxyethane 146.44
    benzonitrile 70.36
    trioctyl phosphate 31.68
    1-bromopropane 140.69
    gamma-valerolactone 484.05
    n-decanol 21.3
    triethyl phosphate 47.03
    4-methyl-2-pentanol 34.95
    propionitrile 43.87
    vinylene carbonate 124.72
    1,1,2-trichlorotrifluoroethane 165.23
    DMS 107.7
    cumene 34.27
    2-octanol 28.79
    2-hexanone 111.68
    octyl acetate 58.3
    limonene 47.54
    1,2-dimethoxyethane 172.53
    ethyl orthosilicate 53.0
    tributyl phosphate 36.53
    diacetone alcohol 123.26
    N,N-dimethylaniline 69.77
    acrylonitrile 46.53
    aniline 99.45
    1,3-propanediol 20.0
    bromobenzene 193.56
    dibromomethane 213.13
    1,1,2,2-tetrachloroethane 398.75
    2-methyl-cyclohexyl acetate 84.51
    tetrabutyl urea 52.95
    diisobutyl methanol 31.15
    2-phenylethanol 72.74
    styrene 66.35
    dioctyl adipate 65.96
    dimethyl sulfate 122.42
    ethyl butyrate 100.31
    methyl lactate 43.15
    butyl lactate 79.73
    diethyl carbonate 60.27
    propanediol butyl ether 48.82
    triethyl orthoformate 81.0
    p-tert-butyltoluene 35.56
    methyl 4-tert-butylbenzoate 119.71
    morpholine 234.21
    tert-butylamine 28.2
    n-dodecanol 14.98
    dimethoxymethane 236.86
    ethylene carbonate 110.7
    cyrene 81.57
    2-ethoxyethyl acetate 186.99
    2-ethylhexyl acetate 119.38
    1,2,4-trichlorobenzene 170.72
    4-methylpyridine 248.17
    dibutyl ether 60.39
    2,6-dimethyl-4-heptanol 31.15
    DEF 209.12
    dimethyl isosorbide 189.51
    tetrachloroethylene 212.07
    eugenol 89.47
    triacetin 108.21
    span 80 62.0
    1,4-butanediol 7.57
    1,1-dichloroethane 225.06
    2-methyl-1-pentanol 45.61
    methyl formate 43.34
    2-methyl-1-butanol 54.91
    n-decane 5.4
    butyronitrile 55.0
    3,7-dimethyl-1-octanol 34.65
    1-chlorooctane 30.66
    1-chlorotetradecane 10.04
    n-nonane 4.63
    undecane 3.36
    tert-butylcyclohexane 8.13
    cyclooctane 4.72
    cyclopentanol 58.28
    tetrahydropyran 266.26
    tert-amyl methyl ether 102.5
    2,5,8-trioxanonane 126.21
    1-hexene 36.37
    2-isopropoxyethanol 56.21
    2,2,2-trifluoroethanol 14.7
    methyl butyrate 121.55

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction