2,2'-Methylenebis(6-bromo-4-chlorophenol)

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  • Identifiers

    CAS number
    15435-29-7

    Molecular formula
    C13H8Br2Cl2O2

    SMILES
    C1=C(C=C(C(=C1CC2=C(C(=CC(=C2)Cl)Br)O)O)Br)Cl

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Phenolic 41.9%
    Odorless 35.77%
    Burnt 33.92%
    Smoky 27.84%
    Spicy 24.87%
    Fruity 22.86%
    Animal 22.27%
    Meaty 21.93%
    Dry 20.05%
    Savory 19.99%

     

    Flavor
    Bitter 71.22%
    Odorless 31.01%
    Mild 26.19%
    Sweet-like 20.86%
    Very strong 20.28%
    Bland 19.93%
    Indole 19.7%
    Nitrile 19.66%
    Scallion 19.42%
    Orange flower 19.24%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.8

    pKa est.
    9.79 (weak base)

    Molecular weight
    426.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    488°C

    Flash point

    • 193.11 ˚C est.

  • Synonyms

    • Bromochlorophen
    • 15435-29-7
    • Bromochlorophene
    • 2,2'-Methylenebis(6-bromo-4-chlorophenol)
    • Bromchlorophene
    • Brophen
    • Bromochlorofen
    • 2JZV1D2GW7
    • 6,6'-Dibrom-4,4'-dichlor-2,2'-methylendiphenol
    • DTXSID90165596
    • 3,3-Dibromo-5,5-dichloro-2,2-dihydroxydiphenylmethane
    • RefChem:121562
    • DTXCID1088087
    • 239-446-8
    • 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol
    • MFCD00152965
    • 6,6'-METHYLENEBIS(2-BROMO-4-CHLOROPHENOL)
    • 3,3-Dibromo-5,5-dichloro-2,2-dihydroxy-diphenylmethane
    • 3,3'-Dibromo-5,5'-dichloro-2,2'-dihydroxydiphenylmethane
    • Phenol, 2,2'-methylenebis(6-bromo-4-chloro-
    • 3,3'-Dwubromo-5,5'-dwuchloro-2,2'-dwuhydroksy-dwufenylo-metan
    • Bis(3-bromo-5-chloro-2-hydroxyphenyl)methane
    • Phenol, 2,2'-methylenebis[6-bromo-4-chloro-
    • Bromochlorofen [Polish]
    • C13H8Br2Cl2O2
    • EINECS 239-446-8
    • UNII-2JZV1D2GW7
    • BRN 2293981
    • 2-BROMO-6-((3-BROMO-5-CHLORO-2-HYDROXYPHENYL)METHYL)-4-CHLOROPHENOL
    • BROMCHLOROPHEN
    • 3,3'-Dwubromo-5,5'-dwuchloro-2,2'-dwuhydroksy-dwufenylo-metan [Polish]
    • Oprea1_679083
    • SCHEMBL67605
    • BROMCHLOROPHEN [MART.]
    • BROMCHLOROPHENE [WHO-DD]
    • BDBM420282
    • KUC106498N
    • STK366925
    • AKOS005443698
    • KSC-19-057
    • MSK002125-100M
    • NCGC00342164-01
    • SY053762
    • CS-0447176
    • M1940
    • NS00009862
    • ST50878141
    • 2,2'-methanediylbis(6-bromo-4-chlorophenol)
    • Bromochlorophen Solution in Methanol, 100ug/mL
    • D91559
    • AB01334489-02
    • Q27254844
    • 2,2 inverted exclamation mark -Methylenebis(6-bromo-4-chlorophenol)
    • 2-bromo-6-[(3-bromo-5-chloro-2-hydroxy-phenyl)methyl]-4-chloro-phenol
    • 6-bromo-2-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol
    • 15435-29-7

  • Applications

    2,2'-Methylenebis(6-bromo-4-chlorophenol) (CAS 15435-29-7) is used as an intermediate in the synthesis of halogenated polymer additives and crosslinkers for epoxy and phenolic resins, contributing to flame-retardant properties. It is often employed as a reactive crosslinking component in coatings, paints, and inks based on epoxy/phenolic chemistries. It serves as a precursor for halogenated bisphenol derivatives used in specialty polymers and high-performance materials with flame-retardant and thermal-stability requirements. It may also act as a building block in industrial adhesives and composite formulations where a polyfunctional phenol is advantageous. In electronics-related applications, it can be considered for flame-retardant epoxy systems and related coatings, subject to formulation limits and regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.65
    methanol 5.11
    isopropanol 5.24
    water 0.01
    ethyl acetate 14.93
    n-propanol 9.19
    acetone 13.06
    n-butanol 9.93
    acetonitrile 3.99
    DMF 44.09
    toluene 13.73
    isobutanol 6.32
    1,4-dioxane 42.44
    methyl acetate 13.54
    THF 188.96
    2-butanone 20.72
    n-pentanol 12.92
    sec-butanol 8.99
    n-hexane 1.21
    ethylene glycol 1.56
    NMP 52.98
    cyclohexane 0.88
    DMSO 10.47
    n-butyl acetate 28.18
    n-octanol 15.02
    chloroform 28.59
    n-propyl acetate 21.33
    acetic acid 7.42
    dichloromethane 19.73
    cyclohexanone 31.68
    propylene glycol 3.22
    isopropyl acetate 15.64
    DMAc 62.94
    2-ethoxyethanol 30.85
    isopentanol 9.15
    n-heptane 4.17
    ethyl formate 10.61
    1,2-dichloroethane 8.19
    n-hexanol 16.03
    2-methoxyethanol 33.74
    isobutyl acetate 17.07
    tetrachloromethane 2.1
    n-pentyl acetate 31.33
    transcutol 77.01
    n-heptanol 15.14
    ethylbenzene 9.85
    MIBK 16.73
    2-propoxyethanol 43.81
    tert-butanol 6.61
    MTBE 17.71
    2-butoxyethanol 31.67
    propionic acid 5.13
    o-xylene 9.37
    formic acid 3.2
    diethyl ether 16.1
    m-xylene 10.86
    p-xylene 10.45
    chlorobenzene 9.54
    dimethyl carbonate 12.44
    n-octane 2.55
    formamide 8.13
    cyclopentanone 54.75
    2-pentanone 20.82
    anisole 30.22
    cyclopentyl methyl ether 50.39
    gamma-butyrolactone 50.73
    1-methoxy-2-propanol 29.95
    pyridine 40.0
    3-pentanone 14.55
    furfural 48.31
    n-dodecane 1.93
    diethylene glycol 19.37
    diisopropyl ether 7.83
    tert-amyl alcohol 10.78
    acetylacetone 23.9
    n-hexadecane 2.27
    acetophenone 26.13
    methyl propionate 17.18
    isopentyl acetate 27.04
    trichloroethylene 30.42
    n-nonanol 16.57
    cyclohexanol 12.71
    benzyl alcohol 19.79
    2-ethylhexanol 16.62
    isooctanol 14.22
    dipropyl ether 31.98
    1,2-dichlorobenzene 9.4
    ethyl lactate 12.7
    propylene carbonate 24.83
    n-methylformamide 14.28
    2-pentanol 8.84
    n-pentane 1.23
    1-propoxy-2-propanol 38.93
    1-methoxy-2-propyl acetate 42.74
    2-(2-methoxypropoxy) propanol 35.73
    mesitylene 6.4
    ε-caprolactone 40.89
    p-cymene 13.16
    epichlorohydrin 63.65
    1,1,1-trichloroethane 8.82
    2-aminoethanol 4.68
    morpholine-4-carbaldehyde 67.42
    sulfolane 34.19
    2,2,4-trimethylpentane 1.58
    2-methyltetrahydrofuran 65.61
    n-hexyl acetate 29.33
    isooctane 1.26
    2-(2-butoxyethoxy)ethanol 41.82
    sec-butyl acetate 18.51
    tert-butyl acetate 23.16
    decalin 1.62
    glycerin 5.8
    diglyme 70.58
    acrylic acid 5.08
    isopropyl myristate 16.19
    n-butyric acid 10.34
    acetyl acetate 9.98
    di(2-ethylhexyl) phthalate 15.69
    ethyl propionate 18.42
    nitromethane 15.25
    1,2-diethoxyethane 46.77
    benzonitrile 16.52
    trioctyl phosphate 11.02
    1-bromopropane 9.49
    gamma-valerolactone 85.53
    n-decanol 13.08
    triethyl phosphate 12.52
    4-methyl-2-pentanol 8.2
    propionitrile 6.36
    vinylene carbonate 20.48
    1,1,2-trichlorotrifluoroethane 37.5
    DMS 21.13
    cumene 7.72
    2-octanol 14.06
    2-hexanone 26.33
    octyl acetate 19.22
    limonene 16.58
    1,2-dimethoxyethane 66.14
    ethyl orthosilicate 15.34
    tributyl phosphate 11.6
    diacetone alcohol 23.56
    N,N-dimethylaniline 28.27
    acrylonitrile 8.41
    aniline 15.71
    1,3-propanediol 8.7
    bromobenzene 9.92
    dibromomethane 11.89
    1,1,2,2-tetrachloroethane 23.44
    2-methyl-cyclohexyl acetate 25.51
    tetrabutyl urea 22.02
    diisobutyl methanol 12.96
    2-phenylethanol 24.31
    styrene 10.68
    dioctyl adipate 21.3
    dimethyl sulfate 14.73
    ethyl butyrate 25.62
    methyl lactate 12.39
    butyl lactate 24.1
    diethyl carbonate 14.09
    propanediol butyl ether 22.71
    triethyl orthoformate 26.73
    p-tert-butyltoluene 13.45
    methyl 4-tert-butylbenzoate 31.87
    morpholine 63.07
    tert-butylamine 4.65
    n-dodecanol 10.05
    dimethoxymethane 48.92
    ethylene carbonate 14.83
    cyrene 40.89
    2-ethoxyethyl acetate 40.39
    2-ethylhexyl acetate 24.94
    1,2,4-trichlorobenzene 13.83
    4-methylpyridine 36.09
    dibutyl ether 24.46
    2,6-dimethyl-4-heptanol 12.96
    DEF 31.2
    dimethyl isosorbide 75.16
    tetrachloroethylene 12.01
    eugenol 34.25
    triacetin 26.49
    span 80 29.28
    1,4-butanediol 5.02
    1,1-dichloroethane 9.09
    2-methyl-1-pentanol 12.65
    methyl formate 12.17
    2-methyl-1-butanol 9.53
    n-decane 3.56
    butyronitrile 9.46
    3,7-dimethyl-1-octanol 16.09
    1-chlorooctane 10.15
    1-chlorotetradecane 4.68
    n-nonane 3.13
    undecane 2.56
    tert-butylcyclohexane 2.12
    cyclooctane 0.87
    cyclopentanol 16.53
    tetrahydropyran 39.63
    tert-amyl methyl ether 23.27
    2,5,8-trioxanonane 52.88
    1-hexene 6.48
    2-isopropoxyethanol 24.87
    2,2,2-trifluoroethanol 3.99
    methyl butyrate 23.47

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction