2,2'-Methylenebis(4-methyl-6-tert-butylphenol)

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  • Identifiers

    CAS number
    119-47-1

    Molecular formula
    C23H32O2

    SMILES
    CC1=CC(=C(C(=C1)C(C)(C)C)O)CC2=C(C(=CC(=C2)C)C(C)(C)C)O

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Phenolic 53.83%
    Leathery 47.31%
    Woody 43.78%
    Dry 36.77%
    Musk 35.28%
    Animal 34.45%
    Spicy 34.05%
    Smoky 32.21%
    Burnt 31.49%
    Medicinal 28.24%

     

    Flavor
    Phenolic 46.06%
    Camphor 39.75%
    Woody 30.76%
    Musty 30.63%
    Bitter 30.02%
    Mild 28.85%
    Medicinal 28.57%
    Leather 24.3%
    Spice 24.29%
    Thymol 22.91%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    7.2

    pKa est.
    9.37 (weak base)

    Molecular weight
    340.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    462°C

    Melting point expt.

    • 118-128 °C

    Flash point

    • 194.18 ˚C est.

    Solubility expt.

    • Soluble in oxygen and aromatic solvents.
    • Water solubility = 0.02 mg/l.

  • Synonyms

    • 119-47-1
    • 2,2'-Methylenebis(6-tert-butyl-p-cresol)
    • Antioxidant 2246
    • 2,2'-Methylenebis(4-methyl-6-tert-butylphenol)
    • Antioxidant BKF
    • Antioxidant 1
    • Anti Ox
    • Cyanox 2246
    • Advastab 405
    • Lederle 2246
    • Chemanox 21
    • Catolin 14
    • Vulkanox bkf
    • Nocrac NS 6
    • Plastanox 2246
    • Bisaklofen BP
    • Sumilizer MDP
    • AO 1 (Antioxidant)
    • Synox 5lt
    • Alterungsschutzmittel BKF
    • Calco 2246
    • Antioxidant OMB
    • Antage W 400
    • CAO 5
    • Plastanox 2246 Antioxidant
    • CAO 14
    • methylene di-t-butylcresol
    • AO 2246
    • Lowinox 22M46
    • OXY CHEK 114
    • DTXSID4020870
    • NG 2246
    • 2,2'-Bis-6-terc.butyl-p-kresylmethan
    • BIS(2-HYDROXY-3-TERT-BUTYL-5-METHYLPHENYL)METHANE
    • Phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methyl-
    • Methane, 2,2'-bis(6-t-butyl-p-cresyl)-
    • KVM0X4X57B
    • Bis(6-hydroxy-3-methyl-5-tert-butylphenyl)methane
    • NSC-7781
    • Phenol, 2,2'-methylenebis(6-(1,1-dimethylethyl)-4-methyl-
    • A 22-46
    • DTXCID20870
    • 2,2'-Methylenebis[6-tert-butyl-p-cresol]
    • MBMBP
    • 2,2'-Methylenebis[4-Methyl-6-tert-butylphenol]
    • 2,2'-methylenebis(6-tert-butyl-4-cresol)
    • RefChem:568754
    • 6,6'-Methylenebis(2-(tert-butyl)-4-methylphenol)
    • 2,2'-Methylenebis(6-tert-butyl-4-methylphenol)
    • Bisalkofen BP
    • GERI-BP002-A
    • Antioxidant NG-2246
    • Methylenebis
    • C23H32O2
    • 2,2-methylenebis(6-tert-butyl-p-cresol)
    • 2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
    • 2,2'-Methylene-bis(6-tert-butyl-4-methylphenol)
    • MFCD00043641
    • Nocrack NS 6
    • 6,6'-Di-tert-butyl-2,2'-methylenedi-p-cresol
    • A-22-46
    • Di(2-hydroxy-5-methyl-3-tert-butylphenyl)methane
    • p-Cresol, 2,2'-methylenebis(6-tert-butyl-
    • Methane, 2,2'-bis(6-tert-butyl-p-cresyl)-
    • 2,2-methylenebis(6-tert-butyl-4-methylphenol)
    • 2,2'-Methylenebis(6-tert-butyl-4-methyl-phenol)
    • 2,2'-Methylenebis(6-(1,1-dimethylethyl)-p-cresol)
    • AO 1
    • CHEMBL460648
    • BKF
    • 3,3'-Di-tert-butyl-2,2'-dihydroxy-5,5'-dimethyldiphenylmethane
    • p-Cresol, 2,2'-methylenebis[6-tert-butyl-
    • 2,2'-Bis(4-methyl-6-tert-butylphenol)methane
    • 2,2'-Methylenebis(4-methyl-6-t-butylphenol)
    • 2,2'-methylene-bis(4-methyl-6-t-butylphenol)
    • Bis(3-tert-butyl-2-hydroxy-5-methylphenyl)methane
    • 2,2'-methanediylbis[6-(1,1-dimethylethyl)-4-methylphenol]
    • 2-tert-Butyl-6-(2-hydroxy-3-tert-butyl-5-methyl-benzyl)-4-methyl-phenol
    • Agidol 2
    • CAS-119-47-1
    • AO 1 (VAN)
    • CCRIS 4919
    • HSDB 5585
    • Methylene bis methyl butyl phenol
    • NSC 7781
    • EINECS 204-327-1
    • UNII-KVM0X4X57B
    • BRN 2062676
    • AI3-18027
    • 2,2-Methylenebis(4-methyl-6-t-butylphenol)
    • 2,2'-Bis-6-terc.butyl-p-kresylmethan [Czech]
    • antioxidant 2264
    • Ionol 46
    • Ralox 46
    • p-Cresol, 2,2'-methylenebis(6-tert- butyl-
    • EC 204-327-1
    • Oprea1_122036
    • SCHEMBL34162
    • 2,2'-methylene-bis-(4-methyl-6-tert-butylphenol)
    • 4-06-00-06801 (Beilstein Handbook Reference)
    • BIDD:ER0324
    • 2,1-dimethylethyl)-p-cresol]
    • CAO-14
    • orb1301849
    • orb3026093
    • SCHEMBL2864273
    • SCHEMBL6431440
    • SCHEMBL29351672
    • SCHEMBL29415372
    • CHEBI:172336
    • Tox21_201529
    • Tox21_302923
    • BDBM50522651
    • MSK400021
    • SBB007695
    • STL377901
    • 2,2 inverted exclamation marka-Methylenebis(6-tert-butyl-4-methylphenol)
    • AKOS000447157
    • CCG-207916
    • CCG-208597
    • EBC-611638
    • FM62633
    • MSK400021-100M
    • 2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methyl-phenyl)methyl]-4-methyl-phenol
    • s12392
    • 2,2'-methylenebis(6-t-butyl-p-cresol)
    • NCGC00164172-01
    • 119-47-1

  • Applications

    2,2'-Methylenebis(4-methyl-6-tert-butylphenol) (CAS 119-47-1) is a hindered phenol antioxidant and heat stabilizer widely used as an oxidation inhibitor in polymers and rubber to prevent thermal-oxidative degradation during processing and service; typical applications include stabilization of polyolefins (PE, PP), PVC, and synthetic rubbers, as well as use in lubricants and industrial oils to improve oxidation stability, and it can serve as a stabilizer in coatings and inks and in adhesive formulations to extend product durability under heat and light.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 149.91
    methanol 81.77
    isopropanol 178.63
    water 0.1
    ethyl acetate 611.88
    n-propanol 211.37
    acetone 590.25
    n-butanol 219.03
    acetonitrile 187.36
    DMF 1297.94
    toluene 328.46
    isobutanol 205.46
    1,4-dioxane 611.13
    methyl acetate 469.84
    THF 2176.22
    2-butanone 671.25
    n-pentanol 187.68
    sec-butanol 222.93
    n-hexane 126.92
    ethylene glycol 22.71
    NMP 1014.43
    cyclohexane 69.33
    DMSO 496.41
    n-butyl acetate 582.79
    n-octanol 209.25
    chloroform 889.1
    n-propyl acetate 397.53
    acetic acid 155.35
    dichloromethane 666.82
    cyclohexanone 835.55
    propylene glycol 60.04
    isopropyl acetate 599.45
    DMAc 1115.33
    2-ethoxyethanol 262.08
    isopentanol 219.41
    n-heptane 86.33
    ethyl formate 248.02
    1,2-dichloroethane 570.29
    n-hexanol 317.96
    2-methoxyethanol 364.12
    isobutyl acetate 374.96
    tetrachloromethane 132.31
    n-pentyl acetate 485.31
    transcutol 533.45
    n-heptanol 223.59
    ethylbenzene 211.88
    MIBK 575.23
    2-propoxyethanol 540.7
    tert-butanol 264.09
    MTBE 567.3
    2-butoxyethanol 377.6
    propionic acid 193.09
    o-xylene 215.79
    formic acid 39.91
    diethyl ether 578.94
    m-xylene 313.74
    p-xylene 253.89
    chlorobenzene 335.09
    dimethyl carbonate 405.86
    n-octane 55.82
    formamide 88.52
    cyclopentanone 1407.25
    2-pentanone 721.04
    anisole 356.64
    cyclopentyl methyl ether 1085.51
    gamma-butyrolactone 1222.69
    1-methoxy-2-propanol 452.86
    pyridine 472.53
    3-pentanone 617.35
    furfural 629.0
    n-dodecane 29.52
    diethylene glycol 213.79
    diisopropyl ether 285.24
    tert-amyl alcohol 282.33
    acetylacetone 819.07
    n-hexadecane 34.87
    acetophenone 328.66
    methyl propionate 652.53
    isopentyl acetate 603.85
    trichloroethylene 1032.47
    n-nonanol 198.35
    cyclohexanol 256.48
    benzyl alcohol 176.46
    2-ethylhexanol 237.6
    isooctanol 201.49
    dipropyl ether 462.58
    1,2-dichlorobenzene 353.22
    ethyl lactate 178.88
    propylene carbonate 618.39
    n-methylformamide 342.11
    2-pentanol 232.33
    n-pentane 87.81
    1-propoxy-2-propanol 461.04
    1-methoxy-2-propyl acetate 706.95
    2-(2-methoxypropoxy) propanol 271.99
    mesitylene 189.39
    ε-caprolactone 690.76
    p-cymene 162.63
    epichlorohydrin 1287.06
    1,1,1-trichloroethane 668.29
    2-aminoethanol 67.88
    morpholine-4-carbaldehyde 853.77
    sulfolane 1245.07
    2,2,4-trimethylpentane 55.6
    2-methyltetrahydrofuran 1067.49
    n-hexyl acetate 589.53
    isooctane 46.99
    2-(2-butoxyethoxy)ethanol 359.7
    sec-butyl acetate 378.02
    tert-butyl acetate 752.32
    decalin 65.74
    glycerin 80.9
    diglyme 739.99
    acrylic acid 158.64
    isopropyl myristate 242.5
    n-butyric acid 337.41
    acetyl acetate 369.42
    di(2-ethylhexyl) phthalate 154.34
    ethyl propionate 449.05
    nitromethane 483.41
    1,2-diethoxyethane 450.36
    benzonitrile 223.74
    trioctyl phosphate 149.54
    1-bromopropane 478.46
    gamma-valerolactone 1254.18
    n-decanol 146.75
    triethyl phosphate 195.65
    4-methyl-2-pentanol 186.77
    propionitrile 248.63
    vinylene carbonate 453.35
    1,1,2-trichlorotrifluoroethane 543.56
    DMS 505.32
    cumene 155.45
    2-octanol 195.15
    2-hexanone 427.93
    octyl acetate 295.43
    limonene 223.97
    1,2-dimethoxyethane 661.73
    ethyl orthosilicate 204.26
    tributyl phosphate 173.1
    diacetone alcohol 550.81
    N,N-dimethylaniline 306.04
    acrylonitrile 275.12
    aniline 249.52
    1,3-propanediol 127.85
    bromobenzene 380.44
    dibromomethane 477.74
    1,1,2,2-tetrachloroethane 946.05
    2-methyl-cyclohexyl acetate 325.09
    tetrabutyl urea 246.9
    diisobutyl methanol 162.16
    2-phenylethanol 276.86
    styrene 192.65
    dioctyl adipate 271.74
    dimethyl sulfate 642.49
    ethyl butyrate 402.84
    methyl lactate 269.42
    butyl lactate 295.06
    diethyl carbonate 235.58
    propanediol butyl ether 255.34
    triethyl orthoformate 304.53
    p-tert-butyltoluene 180.05
    methyl 4-tert-butylbenzoate 408.21
    morpholine 726.94
    tert-butylamine 193.39
    n-dodecanol 111.55
    dimethoxymethane 972.3
    ethylene carbonate 383.88
    cyrene 288.11
    2-ethoxyethyl acetate 533.74
    2-ethylhexyl acetate 505.52
    1,2,4-trichlorobenzene 371.54
    4-methylpyridine 577.83
    dibutyl ether 348.12
    2,6-dimethyl-4-heptanol 162.16
    DEF 760.78
    dimethyl isosorbide 620.66
    tetrachloroethylene 505.09
    eugenol 303.38
    triacetin 397.09
    span 80 250.36
    1,4-butanediol 61.53
    1,1-dichloroethane 603.22
    2-methyl-1-pentanol 191.44
    methyl formate 306.43
    2-methyl-1-butanol 226.17
    n-decane 62.37
    butyronitrile 280.95
    3,7-dimethyl-1-octanol 198.66
    1-chlorooctane 230.86
    1-chlorotetradecane 80.83
    n-nonane 64.85
    undecane 41.56
    tert-butylcyclohexane 74.88
    cyclooctane 45.63
    cyclopentanol 305.83
    tetrahydropyran 775.49
    tert-amyl methyl ether 528.89
    2,5,8-trioxanonane 397.73
    1-hexene 296.14
    2-isopropoxyethanol 243.32
    2,2,2-trifluoroethanol 97.55
    methyl butyrate 489.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction