2,2'-Methylenebis(4-ethyl-6-tert-butylphenol)

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  • Identifiers

    CAS number
    88-24-4

    Molecular formula
    C25H36O2

    SMILES
    CCC1=CC(=C(C(=C1)C(C)(C)C)O)CC2=C(C(=CC(=C2)CC)C(C)(C)C)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 55.86%
    Leathery 44.87%
    Woody 41.33%
    Spicy 39.39%
    Smoky 34.72%
    Burnt 34.22%
    Dry 33.12%
    Animal 31.42%
    Medicinal 29.02%
    Musk 28.04%

     

    Flavor
    Phenolic 42.15%
    Camphor 38.25%
    Woody 34.1%
    Musty 28.94%
    Medicinal 28.57%
    Spice 28.04%
    Mild 27.81%
    Bitter 26.94%
    Thymol 23.06%
    Creosote 22.89%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    8.1

    pKa est.
    8.76 (weak base)

    Molecular weight
    368.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    474°C

    Flash point

    • 187.03 ˚C est.

  • Synonyms

    • 88-24-4
    • Antioxidant 425
    • 2,2'-Methylenebis(6-tert-butyl-4-ethylphenol)
    • 2,2'-Methylenebis(4-ethyl-6-tert-butylphenol)
    • Plastanox 425
    • Yoshinox 425
    • Plastanox 425 antioxidant
    • USAF CY-6
    • Agidol 7
    • Nocrac NS 5
    • Cyanox 425
    • Antage W 500
    • 2,2'-Methylenebis(ethyl-6-tert-butylphenol)
    • AO 425
    • Bis(2-hydroxy-3-tert-butyl-5-ethylphenyl)methane
    • Bis(3-tert-butyl-5-ethyl-2-hydroxyphenyl)methane
    • 2,2-Methylenebis(4-ethyl-6-t-butylphenol)
    • DTXSID7038864
    • Phenol, 2,2'-methylenebis(6-tert-butyl-4-ethyl-
    • RZW97F6CTS
    • Phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-ethyl-
    • 2,2'-Methylenebis(6-(1,1-dimethylethyl)-4-ethylphenol)
    • NSC-7782
    • Phenol, 2,2'-methylenebis(6-(1,1-dimethylethyl)-4-ethyl-
    • 2,2'-METHYLENEBIS(6-T-BUTYL-4-ETHYLPHENOL)
    • DTXCID5018864
    • Phenol, 2,2'-methylenebis[6-tert-butyl-4-ethyl-
    • MBEBP
    • RefChem:440322
    • 201-814-0
    • 6,6'-Methylenebis(2-(tert-butyl)-4-ethylphenol)
    • Chemanox 22
    • 2,2-Methylenebis(4-Ethyl-6-Tert-Butylphenol)
    • 2-tert-butyl-6-[(3-tert-butyl-5-ethyl-2-hydroxyphenyl)methyl]-4-ethylphenol
    • C25H36O2
    • NSC 7782
    • MFCD00026296
    • CHEMBL3182523
    • 2,2'-Methylenebis(6-(tert-butyl)-4-ethylphenol)
    • CCRIS 7788
    • HSDB 5257
    • 2,2'-Methylenebis[6-(tert-butyl)-4-ethylphenol]
    • EINECS 201-814-0
    • UNII-RZW97F6CTS
    • BRN 2016207
    • AI3-25275
    • 6-(tert-butyl)-2-{[3-(tert-butyl)-5-ethyl-2-hydroxyphenyl]methyl}-4-ethylpheno l
    • 6,6'-Di-tert-butyl-4,4'-diethyl-2,2'-methylenediphenol
    • 2,2'-methylene-bis(4-ethyl-6-tert-butylphenol)
    • SCHEMBL27533
    • 4-06-00-06806 (Beilstein Handbook Reference)
    • SCHEMBL30599778
    • MSK3121
    • NSC7782
    • Tox21_303358
    • BDBM50522652
    • SBB057156
    • AKOS015839099
    • 2,2'-Methylene-bis(4-ethyl-6-tert-butylphenol) 100 microg/mL in Acetonitrile
    • 2-tert-butyl-6-[(3-tert-butyl-5-ethyl-2-hydroxy-phenyl)methyl]-4-ethyl-phenol
    • CAS-88-24-4
    • NCGC00257360-01
    • DS-13037
    • MSK3121-1000
    • ST029251
    • CS-0152543
    • M0215
    • NS00008123
    • 2,2'-methylenebis(4-ethyl-6-t-butylphenol)
    • D71074
    • Phenol,2'-methylenebis[6-tert-butyl-4-ethyl-
    • 2,2'-methylene bis(4-ethyl-6-tert-butylphenol)
    • 2,2'-Methylene-bis(4-ethyl-6-t-butyl) phenol
    • 2,2'-methylenebis (6-tert-butyl-4-ethylphenol)
    • 2,2'-methanediylbis(6-tert-butyl-4-ethylphenol)
    • 2,2'-methylene-bis(4-ethyl-6-tert-butyl phenol)
    • 2,2'-methylene-bis-(4-ethyl-6-tert.butylphenol)
    • 2,2/'-Methylene bis(6-tert-butyl-4-ethylphenol)
    • 2,2'-methylene-bis(4-ethyl-6-tertiarybutyl phenol)
    • Antioxidant 425 Solution in Methanol, 1000?g/mL
    • Q27288370
    • WLN: 1X1&1&R BQ F2 C1R BQ D2 CX1&1&1
    • Phenol,2'-methylenebis[6-(1,1-dimethylethyl)-4-ethyl-
    • 2,2'-METHYLENEBIS(6-T-BUTYL-4-ETHYLPHENOL) [HSDB]
    • METHYLENEBIS(4-ETHYL-6-TERT-BUTYLPHENOL), 2-2'-
    • Phenol, 2,2'-methylenebis[4-ethyl-6(1,1-dimethylethyl)]-
    • 3,3'-Di-tert-butyl-5,5'-diethyl-2,2'-dihydroxydiphenylmethane
    • 2,2'-Methylenebis(6-tert-butyl-4-ethylphenol), certified reference material, TraceCERT(R)
    • 88-24-4

  • Applications

    2,2'-Methylenebis(4-ethyl-6-tert-butylphenol) (CAS 88-24-4) is used as a hindered phenol antioxidant and thermal-oxidative stabilizer in polymers and plastics, notably polyolefins and other resins, to retard degradation from heat and oxygen. It also serves as an oxidation stabilizer for lubricating oils and fuels, helping prevent sludge and varnish formation. The compound is added to coatings and inks to enhance oxidative resistance and shelf stability. It can function as a stabilizer in adhesives to improve the aging performance of polymeric bonds. In rubbers and elastomers, it is employed to extend service life under processing and elevated temperatures.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 130.09
    methanol 49.82
    isopropanol 156.92
    water 0.03
    ethyl acetate 527.94
    n-propanol 187.24
    acetone 594.34
    n-butanol 185.67
    acetonitrile 140.53
    DMF 1116.55
    toluene 356.89
    isobutanol 182.74
    1,4-dioxane 632.42
    methyl acetate 399.31
    THF 2055.48
    2-butanone 631.32
    n-pentanol 172.96
    sec-butanol 196.11
    n-hexane 91.95
    ethylene glycol 10.69
    NMP 908.61
    cyclohexane 60.76
    DMSO 432.53
    n-butyl acetate 535.63
    n-octanol 182.88
    chloroform 881.81
    n-propyl acetate 390.03
    acetic acid 123.69
    dichloromethane 722.63
    cyclohexanone 900.22
    propylene glycol 42.0
    isopropyl acetate 493.66
    DMAc 977.68
    2-ethoxyethanol 221.32
    isopentanol 184.78
    n-heptane 65.03
    ethyl formate 214.01
    1,2-dichloroethane 549.63
    n-hexanol 254.14
    2-methoxyethanol 275.25
    isobutyl acetate 365.89
    tetrachloromethane 119.36
    n-pentyl acetate 497.57
    transcutol 460.94
    n-heptanol 206.41
    ethylbenzene 220.59
    MIBK 471.93
    2-propoxyethanol 414.32
    tert-butanol 236.23
    MTBE 508.39
    2-butoxyethanol 342.76
    propionic acid 162.38
    o-xylene 211.28
    formic acid 17.65
    diethyl ether 463.94
    m-xylene 291.66
    p-xylene 289.42
    chlorobenzene 398.24
    dimethyl carbonate 290.06
    n-octane 44.3
    formamide 52.38
    cyclopentanone 1405.34
    2-pentanone 654.35
    anisole 348.74
    cyclopentyl methyl ether 875.79
    gamma-butyrolactone 1133.16
    1-methoxy-2-propanol 360.75
    pyridine 560.88
    3-pentanone 514.07
    furfural 582.56
    n-dodecane 23.54
    diethylene glycol 142.76
    diisopropyl ether 218.88
    tert-amyl alcohol 249.29
    acetylacetone 739.13
    n-hexadecane 28.25
    acetophenone 350.02
    methyl propionate 527.31
    isopentyl acetate 565.79
    trichloroethylene 1106.85
    n-nonanol 180.91
    cyclohexanol 219.19
    benzyl alcohol 190.15
    2-ethylhexanol 209.95
    isooctanol 192.49
    dipropyl ether 396.3
    1,2-dichlorobenzene 368.46
    ethyl lactate 159.95
    propylene carbonate 574.16
    n-methylformamide 249.07
    2-pentanol 191.75
    n-pentane 61.35
    1-propoxy-2-propanol 368.1
    1-methoxy-2-propyl acetate 576.65
    2-(2-methoxypropoxy) propanol 241.6
    mesitylene 175.45
    ε-caprolactone 695.9
    p-cymene 161.02
    epichlorohydrin 1157.45
    1,1,1-trichloroethane 636.1
    2-aminoethanol 44.41
    morpholine-4-carbaldehyde 786.83
    sulfolane 1165.03
    2,2,4-trimethylpentane 41.09
    2-methyltetrahydrofuran 988.3
    n-hexyl acetate 565.09
    isooctane 33.7
    2-(2-butoxyethoxy)ethanol 319.82
    sec-butyl acetate 332.68
    tert-butyl acetate 624.39
    decalin 57.71
    glycerin 50.24
    diglyme 663.97
    acrylic acid 124.34
    isopropyl myristate 231.93
    n-butyric acid 285.22
    acetyl acetate 312.38
    di(2-ethylhexyl) phthalate 162.16
    ethyl propionate 395.95
    nitromethane 359.05
    1,2-diethoxyethane 413.37
    benzonitrile 232.14
    trioctyl phosphate 149.12
    1-bromopropane 409.47
    gamma-valerolactone 1303.04
    n-decanol 131.33
    triethyl phosphate 170.94
    4-methyl-2-pentanol 144.76
    propionitrile 200.06
    vinylene carbonate 436.65
    1,1,2-trichlorotrifluoroethane 434.78
    DMS 411.91
    cumene 159.83
    2-octanol 180.45
    2-hexanone 434.63
    octyl acetate 283.97
    limonene 222.16
    1,2-dimethoxyethane 606.19
    ethyl orthosilicate 179.35
    tributyl phosphate 158.33
    diacetone alcohol 444.22
    N,N-dimethylaniline 302.4
    acrylonitrile 211.17
    aniline 247.86
    1,3-propanediol 90.4
    bromobenzene 453.48
    dibromomethane 499.23
    1,1,2,2-tetrachloroethane 902.3
    2-methyl-cyclohexyl acetate 319.27
    tetrabutyl urea 237.79
    diisobutyl methanol 140.68
    2-phenylethanol 265.92
    styrene 222.99
    dioctyl adipate 284.38
    dimethyl sulfate 481.55
    ethyl butyrate 370.96
    methyl lactate 197.25
    butyl lactate 299.48
    diethyl carbonate 211.6
    propanediol butyl ether 229.17
    triethyl orthoformate 274.9
    p-tert-butyltoluene 171.23
    methyl 4-tert-butylbenzoate 429.47
    morpholine 716.8
    tert-butylamine 167.17
    n-dodecanol 97.14
    dimethoxymethane 769.84
    ethylene carbonate 377.83
    cyrene 289.8
    2-ethoxyethyl acetate 516.03
    2-ethylhexyl acetate 469.81
    1,2,4-trichlorobenzene 400.63
    4-methylpyridine 633.39
    dibutyl ether 309.66
    2,6-dimethyl-4-heptanol 140.68
    DEF 660.6
    dimethyl isosorbide 605.94
    tetrachloroethylene 469.62
    eugenol 299.01
    triacetin 391.95
    span 80 251.81
    1,4-butanediol 48.53
    1,1-dichloroethane 581.89
    2-methyl-1-pentanol 180.49
    methyl formate 214.08
    2-methyl-1-butanol 200.15
    n-decane 52.83
    butyronitrile 238.75
    3,7-dimethyl-1-octanol 173.18
    1-chlorooctane 199.6
    1-chlorotetradecane 71.8
    n-nonane 52.38
    undecane 33.42
    tert-butylcyclohexane 61.7
    cyclooctane 33.31
    cyclopentanol 278.96
    tetrahydropyran 790.79
    tert-amyl methyl ether 422.2
    2,5,8-trioxanonane 373.32
    1-hexene 257.43
    2-isopropoxyethanol 217.1
    2,2,2-trifluoroethanol 58.8
    methyl butyrate 477.63

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction