2,2-Dimethoxy-2-phenylacetophenone

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  • Identifiers

    CAS number
    24650-42-8

    Molecular formula
    C16H16O3

    SMILES
    COC(C1=CC=CC=C1)(C(=O)C2=CC=CC=C2)OC

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sweet 61.03%
    Green 49.67%
    Floral 48.94%
    Fruity 47.78%
    Balsamic 41.59%
    Earthy 38.77%
    Almond 38.49%
    Spicy 33.24%
    Honey 32.97%
    Bitter 32.94%

     

    Flavor
    Fruity 59.39%
    Sweet 37.64%
    Bitter 37.26%
    Floral 30.79%
    Balsam 30.55%
    Wine 27.92%
    Musty 27.35%
    Grape 26.07%
    Herbal 25.92%
    Strawberry 25.05%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.0

    pKa est.
    6.28 (neutral)

    Molecular weight
    256.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    361°C

    Flash point

    • 144.24 ˚C est.

  • Synonyms

    • 2,2-Dimethoxy-2-phenylacetophenone
    • 24650-42-8
    • 2,2-Dimethoxy-1,2-diphenylethanone
    • Benzil dimethyl ketal
    • Irgacure 651
    • Ethanone, 2,2-dimethoxy-1,2-diphenyl-
    • Kayacure BDMK
    • Benzil dimethyl acetal
    • Esacure KB 1
    • 1,2-Diphenyl-2,2-dimethoxyethanone
    • Lucirin BDK
    • Photomer 51
    • Irgacure 621
    • Irgacure 641
    • Phenyldimethoxyacetophenone
    • Irgacure E 651
    • Irgacure I 651
    • Benzil mono(dimethyl ketal)
    • Benzil mono(dimethyl acetal)
    • 2,2-Dimethoxyphenylacetophenone
    • Irgacure 951
    • 2,2-Dimethoxy-1,2-diphenyl-ethanone
    • DTXSID7037715
    • IRG 651
    • IR 651
    • 1DK0094V28
    • DTXCID5017715
    • RefChem:441198
    • 246-386-6
    • 2,2-Dimethoxy-1,2-diphenylethan-1-one
    • Benzil Dimethylketal
    • alpha,alpha-Dimethoxy-alpha-phenylacetophenone
    • KB 1
    • 2-Phenyl-2,2-dimethoxyacetophenone
    • MFCD00008475
    • Photocure 51
    • .alpha.,.alpha.-Dimethoxy-.alpha.-phenylacetophenone
    • alpha,alpha-Dimethoxydeoxybenzoin
    • EINECS 246-386-6
    • UNII-1DK0094V28
    • omega,omega,Dimethoxy-omega-phenylacetophenone
    • 1,2-Diphenylethane-1,2-dione, dimethyl ketal
    • Benzil alpha,alpha-dimethyl acetal
    • Photoinitiator-651
    • dimethoxyphenylacetophenone
    • ChemDiv3_000525
    • EC 246-386-6
    • 1,1-DIMETHOXY-1,2-DIPHENYL-2-OXOETHANE
    • Oprea1_031777
    • SCHEMBL15173
    • 2,2-Dimethoxy-2-phenylacetone
    • Benzoin dimethyl ether (DMPA)
    • CHEMBL364734
    • orb1909174
    • SCHEMBL27997116
    • BDBM22764
    • MSK3436
    • HMS1474H19
    • Tox21_302150
    • 2,2-dimethoxy-2-phenyl-acetophenone
    • 2,2-dimethoxy-2-phenylaceto-phenone
    • EBC-14283
    • MSK3436-100A
    • SBB067285
    • .alpha.,.alpha.-Dimethoxydeoxybenzoin
    • 2,2-dimethyloxy-2-phenyl acetophenone
    • AKOS001600311
    • MSK3436-1000A
    • FD22177
    • 2,2-dimethoxy-1,2-diphenyl-1-ethanone
    • NCGC00164347-01
    • NCGC00164347-02
    • NCGC00255445-01
    • 2,2-dimethoxy-1,2-diphenylethane-1-one
    • AC-10381
    • BS-22378
    • 2,2-Dimethoxy-2-phenylacetophenone, 99%
    • CAS-24650-42-8
    • CS-0150663
    • D1702
    • NS00009411
    • ST50308308
    • EN300-19690
    • E76467
    • F237885
    • SR-01000400510
    • Q4596747
    • SR-01000400510-1
    • BRD-K94681545-001-01-9
    • 2,2-Dimethoxy-2-phenylacetophenone Solution in Acetonitrile, 1000ug/mL
    • 2,2-Dimethoxy-2-phenylacetophenone Solution in Acetonitrile, 100ug/mL
    • ethanone, 2,2-dimethoxy-1,2-diphenyl-;2,2-dimethoxy-1,2-diphenylethan-1-one;2,2-dimethoxy-1,2-diphenylethanone;benzil dimethyl acetal;ethanone, 2,2-dimethoxy-1,2-diphenyl- 2,2-dimethoxy-1,2-diphenylethan-1-one 2,2-dimethoxy-1,2-diphenylethanone benzil dimethyl acetal
    • 24650-42-8

  • Applications

    2,2-Dimethoxy-2-phenylacetophenone (CAS 24650-42-8) is a photoinitiator of the α-diketonone class used primarily in UV-curable systems, where it absorbs UV light and generates free radicals to initiate rapid polymerization. Typical applications include acting as a photoinitiator for UV-curable coatings, inks, and adhesives; use in polymer systems for curing on substrates such as wood, metal, and plastics; participation in 3D printing resin formulations; application in electronics encapsulation/potting materials requiring fast UV-curing; and it may serve as an intermediate or precursor in the synthesis of other photoinitiators or acrylic resin systems. Availability and use are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 178.06
    methanol 183.77
    isopropanol 123.6
    water 2.24
    ethyl acetate 420.86
    n-propanol 158.86
    acetone 665.62
    n-butanol 152.55
    acetonitrile 479.92
    DMF 791.03
    toluene 243.98
    isobutanol 129.6
    1,4-dioxane 696.64
    methyl acetate 459.66
    THF 685.11
    2-butanone 462.27
    n-pentanol 119.74
    sec-butanol 118.37
    n-hexane 18.5
    ethylene glycol 57.73
    NMP 536.99
    cyclohexane 78.99
    DMSO 307.02
    n-butyl acetate 212.45
    n-octanol 104.29
    chloroform 2057.3
    n-propyl acetate 230.44
    acetic acid 408.05
    dichloromethane 1983.32
    cyclohexanone 773.72
    propylene glycol 39.12
    isopropyl acetate 209.32
    DMAc 509.5
    2-ethoxyethanol 230.67
    isopentanol 134.35
    n-heptane 22.92
    ethyl formate 429.38
    1,2-dichloroethane 1358.91
    n-hexanol 120.49
    2-methoxyethanol 345.98
    isobutyl acetate 140.52
    tetrachloromethane 240.22
    n-pentyl acetate 219.25
    transcutol 329.54
    n-heptanol 115.24
    ethylbenzene 142.48
    MIBK 180.88
    2-propoxyethanol 201.95
    tert-butanol 138.89
    MTBE 140.3
    2-butoxyethanol 188.15
    propionic acid 256.69
    o-xylene 154.96
    formic acid 164.46
    diethyl ether 278.58
    m-xylene 140.66
    p-xylene 164.25
    chlorobenzene 584.79
    dimethyl carbonate 294.61
    n-octane 19.25
    formamide 447.77
    cyclopentanone 857.94
    2-pentanone 350.55
    anisole 245.4
    cyclopentyl methyl ether 275.97
    gamma-butyrolactone 965.7
    1-methoxy-2-propanol 201.8
    pyridine 963.73
    3-pentanone 330.86
    furfural 877.87
    n-dodecane 12.7
    diethylene glycol 159.96
    diisopropyl ether 66.44
    tert-amyl alcohol 120.12
    acetylacetone 431.04
    n-hexadecane 15.11
    acetophenone 287.29
    methyl propionate 354.46
    isopentyl acetate 174.6
    trichloroethylene 2537.49
    n-nonanol 91.43
    cyclohexanol 214.69
    benzyl alcohol 244.5
    2-ethylhexanol 81.86
    isooctanol 93.0
    dipropyl ether 110.19
    1,2-dichlorobenzene 512.46
    ethyl lactate 107.22
    propylene carbonate 524.14
    n-methylformamide 537.89
    2-pentanol 97.67
    n-pentane 22.21
    1-propoxy-2-propanol 121.87
    1-methoxy-2-propyl acetate 174.67
    2-(2-methoxypropoxy) propanol 102.4
    mesitylene 87.72
    ε-caprolactone 537.06
    p-cymene 77.14
    epichlorohydrin 1126.78
    1,1,1-trichloroethane 814.54
    2-aminoethanol 103.66
    morpholine-4-carbaldehyde 517.96
    sulfolane 746.22
    2,2,4-trimethylpentane 13.45
    2-methyltetrahydrofuran 397.79
    n-hexyl acetate 238.94
    isooctane 9.52
    2-(2-butoxyethoxy)ethanol 153.97
    sec-butyl acetate 129.16
    tert-butyl acetate 173.18
    decalin 30.43
    glycerin 83.3
    diglyme 427.37
    acrylic acid 287.27
    isopropyl myristate 74.73
    n-butyric acid 343.37
    acetyl acetate 301.4
    di(2-ethylhexyl) phthalate 75.78
    ethyl propionate 198.07
    nitromethane 961.18
    1,2-diethoxyethane 194.99
    benzonitrile 405.63
    trioctyl phosphate 56.99
    1-bromopropane 379.22
    gamma-valerolactone 843.79
    n-decanol 62.26
    triethyl phosphate 89.35
    4-methyl-2-pentanol 59.64
    propionitrile 383.39
    vinylene carbonate 607.63
    1,1,2-trichlorotrifluoroethane 570.71
    DMS 216.65
    cumene 88.77
    2-octanol 82.84
    2-hexanone 208.6
    octyl acetate 101.66
    limonene 93.58
    1,2-dimethoxyethane 451.01
    ethyl orthosilicate 82.39
    tributyl phosphate 65.2
    diacetone alcohol 174.57
    N,N-dimethylaniline 149.93
    acrylonitrile 572.51
    aniline 283.31
    1,3-propanediol 167.0
    bromobenzene 569.34
    dibromomethane 1106.36
    1,1,2,2-tetrachloroethane 1634.12
    2-methyl-cyclohexyl acetate 130.54
    tetrabutyl urea 96.07
    diisobutyl methanol 49.62
    2-phenylethanol 185.95
    styrene 190.53
    dioctyl adipate 110.21
    dimethyl sulfate 340.26
    ethyl butyrate 170.27
    methyl lactate 154.63
    butyl lactate 118.81
    diethyl carbonate 134.96
    propanediol butyl ether 114.64
    triethyl orthoformate 118.2
    p-tert-butyltoluene 66.85
    methyl 4-tert-butylbenzoate 192.3
    morpholine 595.52
    tert-butylamine 87.72
    n-dodecanol 46.33
    dimethoxymethane 499.2
    ethylene carbonate 496.47
    cyrene 173.54
    2-ethoxyethyl acetate 245.82
    2-ethylhexyl acetate 144.32
    1,2,4-trichlorobenzene 503.38
    4-methylpyridine 611.99
    dibutyl ether 112.32
    2,6-dimethyl-4-heptanol 49.62
    DEF 429.65
    dimethyl isosorbide 217.28
    tetrachloroethylene 1233.52
    eugenol 169.29
    triacetin 194.25
    span 80 96.41
    1,4-butanediol 78.01
    1,1-dichloroethane 874.54
    2-methyl-1-pentanol 110.97
    methyl formate 557.6
    2-methyl-1-butanol 132.01
    n-decane 23.99
    butyronitrile 364.47
    3,7-dimethyl-1-octanol 70.26
    1-chlorooctane 103.71
    1-chlorotetradecane 36.5
    n-nonane 23.55
    undecane 16.43
    tert-butylcyclohexane 21.97
    cyclooctane 26.36
    cyclopentanol 223.15
    tetrahydropyran 532.99
    tert-amyl methyl ether 114.6
    2,5,8-trioxanonane 218.58
    1-hexene 69.16
    2-isopropoxyethanol 148.51
    2,2,2-trifluoroethanol 235.88
    methyl butyrate 283.93

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction