2,2-Diethoxyethanol

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  • Identifiers

    CAS number
    621-63-6

    Molecular formula
    C6H14O3

    SMILES
    CCOC(CO)OCC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 75.66%
    Ethereal 62.24%
    Alcoholic 46.91%
    Fermented 28.45%
    Odorless 28.29%
    Sweet 26.34%
    Solvent 26.18%
    Buttery 24.28%
    Pungent 24.13%
    Winey 22.17%

     

    Flavor
    Sweet 50.0%
    Green 41.19%
    Vegetable 41.15%
    Alcoholic 39.23%
    Fruit 38.24%
    Fruity 37.59%
    Fatty 34.51%
    Earthy 33.54%
    Musty 32.48%
    Ether 29.23%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    7.9 (neutral)

    Molecular weight
    134.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    177°C

    Flash point

    • 63.84 ˚C est.

  • Synonyms

    • 2,2-DIETHOXYETHANOL
    • 621-63-6
    • Ethanol, 2,2-diethoxy-
    • Glycolaldehyde, diethyl acetal
    • 6T6P26VUF6
    • NSC-9255
    • EINECS 210-697-5
    • HYDROXYACETALDEHYDE DIETHYL ACETAL
    • DTXSID60211155
    • 2-Hydroxyacetaldehyde diethylacetal
    • 2-hydroxyacetaldehyde diethyl acetal
    • NSC 9255
    • RefChem:80996
    • DTXCID60133646
    • 210-697-5
    • IKKUKDZKIIIKJK-UHFFFAOYSA-N
    • Glycolaldehyde diethyl acetal
    • 2,2-diethoxyethan-1-ol
    • 2,2-diethoxy-ethanol
    • MFCD00051486
    • Ethanol,2-diethoxy-
    • 2,2-Diethoxyethanol #
    • glycolaldehyde diethylacetal
    • glycol aldehyde diethylacetal
    • UNII-6T6P26VUF6
    • SCHEMBL605278
    • 1,1-Diethoxy-2-hydroxyethane
    • hydroxyacetaldehyde diethylacetal
    • orb3021411
    • SCHEMBL2452711
    • SCHEMBL3285903
    • NSC9255
    • Glycolaldehyde diethyl acetal, 98%
    • Glycolaldehyde diethyl acetal, stab. with ca 0.1% sodium carbonate
    • SBB056478
    • AKOS009159479
    • CS-W011070
    • MSK161450-1000M
    • AC-30958
    • AS-13204
    • SY002893
    • DB-005809
    • NS00034947
    • EN300-134809
    • 621G636
    • F069312
    • 2,2-Diethoxyethanol Solution in Methanol, 1000ug/mL
    • 2,2-Diethoxyethanol stabilized with ca. 0.1% Sodium Carbonate
    • Diethyl Acetal Glycolaldehyde; 2,2-Diethoxyethanol; 2-Hydroxyacetaldehyde Diethyl Acetal; Hydroxyacetaldehyde Diethyl Acetal; NSC 9255
    • 621-63-6

  • Applications

    2,2-Diethoxyethanol (CAS 621-63-6) is a versatile solvent and processing aid widely used in industrial coatings, inks, and adhesives to dissolve resins and additives, and to act as a co-solvent that reduces viscosity. It is also employed as a reactive diluent in UV-curable coatings and polymer formulations, helping to tailor viscosity and cure performance. In organic synthesis, it serves as an intermediate and as a protecting acetal for aldehyde groups, and as a precursor to other acetals. Additionally, it is used as a cleaning and degreasing solvent in industrial equipment maintenance and electronics cleaning. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 611.76
    methanol 1270.86
    isopropanol 416.7
    water 28.32
    ethyl acetate 182.64
    n-propanol 485.34
    acetone 315.12
    n-butanol 346.96
    acetonitrile 490.84
    DMF 648.07
    toluene 82.22
    isobutanol 308.75
    1,4-dioxane 583.16
    methyl acetate 250.21
    THF 524.41
    2-butanone 224.56
    n-pentanol 233.42
    sec-butanol 346.63
    n-hexane 47.57
    ethylene glycol 403.76
    NMP 608.07
    cyclohexane 135.44
    DMSO 910.82
    n-butyl acetate 163.83
    n-octanol 134.99
    chloroform 1094.52
    n-propyl acetate 145.87
    acetic acid 949.85
    dichloromethane 1264.89
    cyclohexanone 415.73
    propylene glycol 295.51
    isopropyl acetate 90.61
    DMAc 481.42
    2-ethoxyethanol 429.65
    isopentanol 192.1
    n-heptane 60.74
    ethyl formate 282.8
    1,2-dichloroethane 588.21
    n-hexanol 196.58
    2-methoxyethanol 724.16
    isobutyl acetate 85.64
    tetrachloromethane 226.55
    n-pentyl acetate 129.82
    transcutol 437.86
    n-heptanol 114.57
    ethylbenzene 66.47
    MIBK 72.75
    2-propoxyethanol 333.47
    tert-butanol 370.69
    MTBE 170.56
    2-butoxyethanol 193.34
    propionic acid 470.66
    o-xylene 83.57
    formic acid 556.21
    diethyl ether 200.24
    m-xylene 49.84
    p-xylene 102.37
    chlorobenzene 227.28
    dimethyl carbonate 82.5
    n-octane 25.29
    formamide 502.92
    cyclopentanone 420.7
    2-pentanone 135.92
    anisole 153.71
    cyclopentyl methyl ether 193.19
    gamma-butyrolactone 603.77
    1-methoxy-2-propanol 361.41
    pyridine 471.61
    3-pentanone 131.92
    furfural 610.08
    n-dodecane 21.81
    diethylene glycol 359.6
    diisopropyl ether 46.26
    tert-amyl alcohol 299.15
    acetylacetone 152.05
    n-hexadecane 23.72
    acetophenone 162.62
    methyl propionate 174.06
    isopentyl acetate 125.76
    trichloroethylene 828.47
    n-nonanol 112.48
    cyclohexanol 350.22
    benzyl alcohol 201.72
    2-ethylhexanol 134.17
    isooctanol 90.54
    dipropyl ether 142.44
    1,2-dichlorobenzene 241.58
    ethyl lactate 131.56
    propylene carbonate 322.9
    n-methylformamide 493.26
    2-pentanol 177.93
    n-pentane 56.54
    1-propoxy-2-propanol 221.74
    1-methoxy-2-propyl acetate 126.65
    2-(2-methoxypropoxy) propanol 158.17
    mesitylene 39.82
    ε-caprolactone 375.29
    p-cymene 70.17
    epichlorohydrin 563.17
    1,1,1-trichloroethane 388.13
    2-aminoethanol 487.95
    morpholine-4-carbaldehyde 560.28
    sulfolane 715.93
    2,2,4-trimethylpentane 29.94
    2-methyltetrahydrofuran 347.78
    n-hexyl acetate 167.65
    isooctane 14.09
    2-(2-butoxyethoxy)ethanol 200.31
    sec-butyl acetate 78.78
    tert-butyl acetate 87.64
    decalin 45.29
    glycerin 439.26
    diglyme 420.0
    acrylic acid 492.71
    isopropyl myristate 72.17
    n-butyric acid 403.4
    acetyl acetate 144.27
    di(2-ethylhexyl) phthalate 89.01
    ethyl propionate 133.01
    nitromethane 738.59
    1,2-diethoxyethane 178.16
    benzonitrile 277.39
    trioctyl phosphate 69.67
    1-bromopropane 313.6
    gamma-valerolactone 541.77
    n-decanol 82.29
    triethyl phosphate 106.89
    4-methyl-2-pentanol 75.05
    propionitrile 381.68
    vinylene carbonate 365.03
    1,1,2-trichlorotrifluoroethane 605.72
    DMS 125.89
    cumene 58.57
    2-octanol 90.95
    2-hexanone 128.95
    octyl acetate 99.75
    limonene 113.83
    1,2-dimethoxyethane 572.57
    ethyl orthosilicate 98.01
    tributyl phosphate 80.49
    diacetone alcohol 132.83
    N,N-dimethylaniline 125.0
    acrylonitrile 472.89
    aniline 199.27
    1,3-propanediol 473.08
    bromobenzene 215.32
    dibromomethane 779.85
    1,1,2,2-tetrachloroethane 710.3
    2-methyl-cyclohexyl acetate 134.07
    tetrabutyl urea 110.25
    diisobutyl methanol 73.42
    2-phenylethanol 149.51
    styrene 98.77
    dioctyl adipate 126.89
    dimethyl sulfate 164.27
    ethyl butyrate 155.62
    methyl lactate 172.43
    butyl lactate 130.64
    diethyl carbonate 131.47
    propanediol butyl ether 180.63
    triethyl orthoformate 135.64
    p-tert-butyltoluene 63.01
    methyl 4-tert-butylbenzoate 148.81
    morpholine 618.2
    tert-butylamine 249.57
    n-dodecanol 66.02
    dimethoxymethane 273.1
    ethylene carbonate 297.47
    cyrene 199.13
    2-ethoxyethyl acetate 143.57
    2-ethylhexyl acetate 106.75
    1,2,4-trichlorobenzene 278.05
    4-methylpyridine 332.24
    dibutyl ether 124.07
    2,6-dimethyl-4-heptanol 73.42
    DEF 273.45
    dimethyl isosorbide 248.32
    tetrachloroethylene 593.95
    eugenol 164.69
    triacetin 172.98
    span 80 168.58
    1,4-butanediol 266.52
    1,1-dichloroethane 448.24
    2-methyl-1-pentanol 160.73
    methyl formate 363.38
    2-methyl-1-butanol 228.01
    n-decane 33.19
    butyronitrile 330.63
    3,7-dimethyl-1-octanol 110.11
    1-chlorooctane 96.08
    1-chlorotetradecane 44.44
    n-nonane 33.44
    undecane 25.56
    tert-butylcyclohexane 36.39
    cyclooctane 33.97
    cyclopentanol 429.74
    tetrahydropyran 427.61
    tert-amyl methyl ether 134.5
    2,5,8-trioxanonane 292.38
    1-hexene 117.37
    2-isopropoxyethanol 239.28
    2,2,2-trifluoroethanol 304.49
    methyl butyrate 215.19

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction