2-tert-Butyl-6-methylphenol

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  • Identifiers

    CAS number
    2219-82-1

    Molecular formula
    C11H16O

    SMILES
    CC1=C(C(=CC=C1)C(C)(C)C)O

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Phenolic 78.21%
    Leathery 59.74%
    Smoky 54.7%
    Medicinal 54.07%
    Spicy 49.25%
    Woody 45.57%
    Burnt 39.09%
    Camphoreous 38.41%
    Dry 32.8%
    Animal 32.18%

     

    Flavor
    Phenolic 63.9%
    Camphor 44.66%
    Medicinal 44.0%
    Musty 35.43%
    Woody 34.83%
    Leather 32.49%
    Smoky 30.97%
    Spice 30.58%
    Smoke 29.54%
    Spicy 28.9%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    3.6

    pKa est.
    9.83 (weak base)

    Molecular weight
    164.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    229°C

    Flash point

    • 106.43 ˚C est.

  • Synonyms

    • 2-tert-Butyl-6-methylphenol
    • 2219-82-1
    • 2-(tert-Butyl)-6-methylphenol
    • 6-tert-Butyl-o-cresol
    • 6-tert-Butyl-2-methylphenol
    • 2-tert-Butyl-6-methyl-phenol
    • o-Cresol, 6-tert-butyl-
    • Phenol, 2-(1,1-dimethylethyl)-6-methyl-
    • 2-Methyl-6-tert-butylphenol
    • o-tert-Butyl-o-cresol
    • Phenol, 2-tert-butyl-6-methyl-
    • UNII-LT9E3VZD1C
    • LT9E3VZD1C
    • EINECS 218-734-7
    • MFCD00002239
    • NSC 78461
    • BRN 1862362
    • DTXSID4047468
    • AI3-26294
    • NSC-78461
    • 2-(1,1-dimethylethyl)-6-methylphenol
    • CHEMBL29790
    • DTXCID2027468
    • 4-06-00-03396 (Beilstein Handbook Reference)
    • 4-HYDROXY-3-METHYL-5-TERT-BUTYLBENZOL
    • otertButylocresol
    • 6tertButylocresol
    • NSC78461
    • t-butylhydroxytoluene
    • oCresol, 6tertbutyl
    • 2Methyl6tertbutylphenol
    • 6tertButyl2methylphenol
    • Phenol, 2tertbutyl6methyl
    • 2-methyl-6-t-butylphenol
    • 2-t-butyl-6-methylphenol
    • 2-tertbutyl-6-methylphenol
    • SCHEMBL56224
    • oCresol, 6tertbutyl (8CI)
    • o-Cresol, 6-tert-butyl-(8CI)
    • CAA21982
    • Phenol,1-dimethylethyl)-6-methyl-
    • Tox21_302562
    • 2-tert-Butyl-6-methylphenol, 99%
    • BDBM50409548
    • Phenol, 2(1,1dimethylethyl)6methyl
    • STL453581
    • 2-tert-Butyl-6-methyl-phenol, 99%
    • AKOS015890403
    • CS-W010829
    • NCGC00256916-01
    • DA-25641
    • LS-13986
    • CAS-2219-82-1
    • B0728
    • NS00021867
    • D78087
    • EN300-100137
    • A816009
    • Q17310083
    • 2-tert-Butyl-6-methyl-phenol, purum, >=98.0% (GC)
    • Z1255464948

  • Applications

    2-tert-Butyl-6-methylphenol (CAS 2219-82-1) is a hindered phenolic antioxidant used as a stabilizer to prevent heat- and oxidation-induced degradation in polymers and rubbers, helping processing and service life. In industrial applications, it is commonly employed to protect plastics such as polyolefins and polyesters from oxidative aging and color changes; it acts as an antioxidant in rubbers and elastomers to improve aging resistance. It is also used as an antioxidant additive in lubricants and fuels to retard oxidation during storage and use. Additionally, it can serve as a stabilizer in coatings and inks to reduce yellowing and degradation, and may be incorporated in adhesive formulations to improve oxidative stability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1253.55
    methanol 1063.03
    isopropanol 1525.37
    water 2.0
    ethyl acetate 1724.99
    n-propanol 1368.06
    acetone 2356.91
    n-butanol 1251.65
    acetonitrile 2186.84
    DMF 1974.42
    toluene 808.16
    isobutanol 1188.77
    1,4-dioxane 3104.35
    methyl acetate 1716.86
    THF 5521.21
    2-butanone 1988.67
    n-pentanol 849.19
    sec-butanol 1319.57
    n-hexane 810.16
    ethylene glycol 175.55
    NMP 1448.97
    cyclohexane 665.62
    DMSO 1203.1
    n-butyl acetate 1504.3
    n-octanol 883.21
    chloroform 2917.14
    n-propyl acetate 1025.23
    acetic acid 606.82
    dichloromethane 2238.81
    cyclohexanone 2333.84
    propylene glycol 337.83
    isopropyl acetate 1137.21
    DMAc 1039.39
    2-ethoxyethanol 842.2
    isopentanol 1039.09
    n-heptane 450.16
    ethyl formate 1014.41
    1,2-dichloroethane 1760.22
    n-hexanol 1749.99
    2-methoxyethanol 1201.63
    isobutyl acetate 759.96
    tetrachloromethane 629.93
    n-pentyl acetate 794.4
    transcutol 1373.15
    n-heptanol 797.56
    ethylbenzene 611.49
    MIBK 1163.03
    2-propoxyethanol 1601.27
    tert-butanol 1957.2
    MTBE 2222.48
    2-butoxyethanol 848.18
    propionic acid 869.4
    o-xylene 501.77
    formic acid 162.7
    diethyl ether 2399.25
    m-xylene 652.36
    p-xylene 733.74
    chlorobenzene 875.19
    dimethyl carbonate 537.55
    n-octane 234.0
    formamide 273.31
    cyclopentanone 3113.97
    2-pentanone 1795.55
    anisole 928.54
    cyclopentyl methyl ether 2365.42
    gamma-butyrolactone 2879.23
    1-methoxy-2-propanol 1260.71
    pyridine 1376.23
    3-pentanone 1264.88
    furfural 1264.72
    n-dodecane 159.41
    diethylene glycol 715.21
    diisopropyl ether 897.43
    tert-amyl alcohol 1379.67
    acetylacetone 1252.23
    n-hexadecane 182.59
    acetophenone 611.45
    methyl propionate 1346.29
    isopentyl acetate 1304.72
    trichloroethylene 2520.41
    n-nonanol 718.81
    cyclohexanol 1236.5
    benzyl alcohol 505.23
    2-ethylhexanol 911.01
    isooctanol 645.74
    dipropyl ether 1336.62
    1,2-dichlorobenzene 701.52
    ethyl lactate 405.95
    propylene carbonate 1440.86
    n-methylformamide 986.47
    2-pentanol 1161.06
    n-pentane 585.06
    1-propoxy-2-propanol 1166.93
    1-methoxy-2-propyl acetate 1083.38
    2-(2-methoxypropoxy) propanol 494.03
    mesitylene 477.3
    ε-caprolactone 1724.52
    p-cymene 386.63
    epichlorohydrin 2877.87
    1,1,1-trichloroethane 2026.99
    2-aminoethanol 379.7
    morpholine-4-carbaldehyde 1462.9
    sulfolane 2347.94
    2,2,4-trimethylpentane 231.49
    2-methyltetrahydrofuran 3398.26
    n-hexyl acetate 1312.57
    isooctane 247.01
    2-(2-butoxyethoxy)ethanol 829.36
    sec-butyl acetate 722.76
    tert-butyl acetate 1259.67
    decalin 306.86
    glycerin 334.69
    diglyme 1366.21
    acrylic acid 547.94
    isopropyl myristate 509.86
    n-butyric acid 1173.38
    acetyl acetate 726.9
    di(2-ethylhexyl) phthalate 276.64
    ethyl propionate 935.65
    nitromethane 1500.04
    1,2-diethoxyethane 1140.98
    benzonitrile 770.13
    trioctyl phosphate 303.89
    1-bromopropane 1562.61
    gamma-valerolactone 2518.46
    n-decanol 556.97
    triethyl phosphate 323.59
    4-methyl-2-pentanol 711.5
    propionitrile 1881.99
    vinylene carbonate 1006.39
    1,1,2-trichlorotrifluoroethane 865.02
    DMS 645.57
    cumene 447.5
    2-octanol 664.18
    2-hexanone 1205.1
    octyl acetate 643.2
    limonene 600.91
    1,2-dimethoxyethane 1845.17
    ethyl orthosilicate 341.64
    tributyl phosphate 325.47
    diacetone alcohol 1026.71
    N,N-dimethylaniline 634.76
    acrylonitrile 1574.19
    aniline 673.63
    1,3-propanediol 631.67
    bromobenzene 969.31
    dibromomethane 1676.13
    1,1,2,2-tetrachloroethane 2052.35
    2-methyl-cyclohexyl acetate 644.01
    tetrabutyl urea 392.18
    diisobutyl methanol 532.02
    2-phenylethanol 757.38
    styrene 631.16
    dioctyl adipate 462.86
    dimethyl sulfate 696.16
    ethyl butyrate 893.36
    methyl lactate 475.87
    butyl lactate 500.7
    diethyl carbonate 497.79
    propanediol butyl ether 687.92
    triethyl orthoformate 540.28
    p-tert-butyltoluene 431.42
    methyl 4-tert-butylbenzoate 627.18
    morpholine 2855.2
    tert-butylamine 1431.47
    n-dodecanol 438.47
    dimethoxymethane 1575.73
    ethylene carbonate 1001.41
    cyrene 489.86
    2-ethoxyethyl acetate 731.23
    2-ethylhexyl acetate 974.98
    1,2,4-trichlorobenzene 695.6
    4-methylpyridine 1416.15
    dibutyl ether 1007.87
    2,6-dimethyl-4-heptanol 532.02
    DEF 1323.45
    dimethyl isosorbide 951.34
    tetrachloroethylene 1227.77
    eugenol 522.76
    triacetin 549.78
    span 80 548.36
    1,4-butanediol 301.93
    1,1-dichloroethane 2235.36
    2-methyl-1-pentanol 729.92
    methyl formate 918.41
    2-methyl-1-butanol 984.75
    n-decane 273.44
    butyronitrile 1948.33
    3,7-dimethyl-1-octanol 685.22
    1-chlorooctane 789.23
    1-chlorotetradecane 311.47
    n-nonane 301.98
    undecane 204.85
    tert-butylcyclohexane 335.61
    cyclooctane 314.22
    cyclopentanol 1489.27
    tetrahydropyran 3472.49
    tert-amyl methyl ether 1294.58
    2,5,8-trioxanonane 751.94
    1-hexene 1465.05
    2-isopropoxyethanol 709.98
    2,2,2-trifluoroethanol 258.82
    methyl butyrate 1137.34

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction