2-tert-Butyl-4-hydroxyanisole

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  • Identifiers

    CAS number
    88-32-4

    Molecular formula
    C11H16O2

    SMILES
    CC(C)(C)C1=C(C=CC(=C1)O)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 72.41%
    Woody 59.2%
    Leathery 55.54%
    Spicy 53.37%
    Smoky 47.57%
    Medicinal 44.83%
    Dry 40.08%
    Animal 34.46%
    Camphoreous 31.85%
    Burnt 31.13%

     

    Flavor
    Phenolic 54.18%
    Camphor 44.91%
    Woody 35.39%
    Musty 35.03%
    Medicinal 33.73%
    Spice 31.96%
    Leather 27.96%
    Bitter 27.88%
    Herbal 27.1%
    Smoky 24.92%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    9.72 (weak base)

    Molecular weight
    180.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    274°C

    Flash point

    • 120.04 ˚C est.

  • Synonyms

    • 88-32-4
    • 2-tert-Butyl-4-hydroxyanisole
    • 3-tert-Butyl-4-methoxyphenol
    • Phenol, 3-(1,1-dimethylethyl)-4-methoxy-
    • 2-BHA
    • Phenol, 3-tert-butyl-4-methoxy-
    • A03IJ8ROOP
    • DTXSID7058963
    • CHEBI:76357
    • RefChem:89406
    • Butylated Hydroxyanisole II
    • DTXCID7048611
    • 201-820-3
    • 3-(tert-Butyl)-4-methoxyphenol
    • 4-Methoxy-3-tert-butylphenol
    • MFCD00057667
    • 3-tert-butyl-4-methoxy-phenol
    • 3-Butyl-4-hydroxyanisole
    • CCRIS 3606
    • 2-tert-Butyl-4-hydroxy anisole
    • EINECS 201-820-3
    • UNII-A03IJ8ROOP
    • BRN 2209222
    • 3-(1,1-Dimethylethyl)-4-methoxyphenol
    • t-butyl-4-hydroxyanisole
    • m-tert-butyl-p-methoxyphenol
    • p-methoxy-m-tert-butylphenol
    • SCHEMBL61547
    • 4-methoxy-5-tert-butylphenol
    • 2-tert-Butyl-p-hydroxyanisole
    • 4-hydroxy-2-tert-butylanisole
    • orb1306917
    • orb3025049
    • SCHEMBL29361764
    • 3-T-BUTYL-4-METHOXYPHENOL
    • BDBM50377940
    • AKOS006274867
    • EBC-466091
    • HY-W024365
    • MB00490
    • tert-butyl-hydroquinone monomethyl ether
    • 2-(1,1-Dimethylethyl)-4-hydroxyanisole
    • AC-10352
    • DA-67960
    • DS-17538
    • FT158657
    • SY316299
    • CS-0060876
    • NS00002896
    • W17039
    • 2-TERT-BUTYL-4-HYDROXYANISOLE [USP-RS]
    • EN300-3212116
    • F226088
    • Z1198149489
    • 88-32-4

  • Applications

    2-tert-Butyl-4-hydroxyanisole (CAS 88-32-4) is used primarily as an antioxidant to inhibit oxidation in a range of industrial systems. In the food sector, it serves as an antioxidant preservative for fats and processed products to inhibit lipid degradation; in cosmetics and personal care, it acts as an antioxidant stabilizer to reduce oxidation of oil- and fat-containing formulations; in polymers and plastics, it serves as an antioxidant stabilizer for polyolefins, rubbers, and other polymers during processing and storage; in coatings and inks, as well as in adhesives, it provides oxidative stability to resin-based systems and joints, extending product lifetimes; and in industrial manufacturing, it may be used as an antioxidant in lubricants and fuels to prolong service life.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 257.78
    methanol 237.93
    isopropanol 318.34
    water 0.87
    ethyl acetate 317.31
    n-propanol 291.46
    acetone 506.41
    n-butanol 267.12
    acetonitrile 310.65
    DMF 750.9
    toluene 185.66
    isobutanol 250.07
    1,4-dioxane 608.38
    methyl acetate 384.99
    THF 1085.68
    2-butanone 453.15
    n-pentanol 175.73
    sec-butanol 304.23
    n-hexane 50.82
    ethylene glycol 126.93
    NMP 462.67
    cyclohexane 80.91
    DMSO 468.83
    n-butyl acetate 278.22
    n-octanol 198.73
    chloroform 703.41
    n-propyl acetate 209.81
    acetic acid 144.87
    dichloromethane 598.73
    cyclohexanone 558.13
    propylene glycol 192.31
    isopropyl acetate 197.15
    DMAc 479.95
    2-ethoxyethanol 235.93
    isopentanol 205.73
    n-heptane 72.83
    ethyl formate 288.28
    1,2-dichloroethane 414.58
    n-hexanol 366.46
    2-methoxyethanol 415.7
    isobutyl acetate 157.84
    tetrachloromethane 141.94
    n-pentyl acetate 174.4
    transcutol 269.57
    n-heptanol 187.28
    ethylbenzene 151.48
    MIBK 208.8
    2-propoxyethanol 431.28
    tert-butanol 463.25
    MTBE 380.1
    2-butoxyethanol 227.41
    propionic acid 221.39
    o-xylene 154.6
    formic acid 52.23
    diethyl ether 284.27
    m-xylene 171.49
    p-xylene 184.42
    chlorobenzene 240.23
    dimethyl carbonate 160.89
    n-octane 40.67
    formamide 87.38
    cyclopentanone 771.28
    2-pentanone 336.84
    anisole 289.67
    cyclopentyl methyl ether 409.64
    gamma-butyrolactone 720.46
    1-methoxy-2-propanol 395.37
    pyridine 333.54
    3-pentanone 272.74
    furfural 451.09
    n-dodecane 39.36
    diethylene glycol 292.04
    diisopropyl ether 110.02
    tert-amyl alcohol 369.02
    acetylacetone 332.33
    n-hexadecane 43.25
    acetophenone 230.52
    methyl propionate 296.56
    isopentyl acetate 237.91
    trichloroethylene 664.1
    n-nonanol 170.63
    cyclohexanol 298.56
    benzyl alcohol 196.29
    2-ethylhexanol 210.55
    isooctanol 145.95
    dipropyl ether 225.86
    1,2-dichlorobenzene 237.34
    ethyl lactate 154.13
    propylene carbonate 397.47
    n-methylformamide 296.68
    2-pentanol 219.02
    n-pentane 52.48
    1-propoxy-2-propanol 302.2
    1-methoxy-2-propyl acetate 275.96
    2-(2-methoxypropoxy) propanol 198.26
    mesitylene 118.49
    ε-caprolactone 425.34
    p-cymene 132.89
    epichlorohydrin 711.96
    1,1,1-trichloroethane 468.1
    2-aminoethanol 185.44
    morpholine-4-carbaldehyde 479.98
    sulfolane 711.51
    2,2,4-trimethylpentane 38.54
    2-methyltetrahydrofuran 592.8
    n-hexyl acetate 264.44
    isooctane 35.68
    2-(2-butoxyethoxy)ethanol 228.35
    sec-butyl acetate 149.91
    tert-butyl acetate 243.03
    decalin 56.68
    glycerin 207.34
    diglyme 390.82
    acrylic acid 176.08
    isopropyl myristate 134.38
    n-butyric acid 273.59
    acetyl acetate 182.19
    di(2-ethylhexyl) phthalate 117.75
    ethyl propionate 202.56
    nitromethane 356.94
    1,2-diethoxyethane 181.31
    benzonitrile 253.62
    trioctyl phosphate 114.03
    1-bromopropane 297.41
    gamma-valerolactone 686.25
    n-decanol 142.67
    triethyl phosphate 120.43
    4-methyl-2-pentanol 141.56
    propionitrile 316.45
    vinylene carbonate 341.58
    1,1,2-trichlorotrifluoroethane 348.96
    DMS 196.76
    cumene 126.57
    2-octanol 148.85
    2-hexanone 230.4
    octyl acetate 177.03
    limonene 173.11
    1,2-dimethoxyethane 470.62
    ethyl orthosilicate 106.9
    tributyl phosphate 104.05
    diacetone alcohol 290.14
    N,N-dimethylaniline 200.3
    acrylonitrile 341.2
    aniline 192.74
    1,3-propanediol 234.38
    bromobenzene 259.02
    dibromomethane 444.29
    1,1,2,2-tetrachloroethane 577.95
    2-methyl-cyclohexyl acetate 194.86
    tetrabutyl urea 146.71
    diisobutyl methanol 129.0
    2-phenylethanol 251.86
    styrene 160.86
    dioctyl adipate 165.05
    dimethyl sulfate 260.23
    ethyl butyrate 208.43
    methyl lactate 196.09
    butyl lactate 145.68
    diethyl carbonate 155.38
    propanediol butyl ether 211.42
    triethyl orthoformate 141.93
    p-tert-butyltoluene 141.47
    methyl 4-tert-butylbenzoate 244.74
    morpholine 566.89
    tert-butylamine 277.75
    n-dodecanol 120.44
    dimethoxymethane 426.64
    ethylene carbonate 300.62
    cyrene 241.34
    2-ethoxyethyl acetate 178.87
    2-ethylhexyl acetate 191.44
    1,2,4-trichlorobenzene 264.67
    4-methylpyridine 346.58
    dibutyl ether 162.41
    2,6-dimethyl-4-heptanol 129.0
    DEF 301.57
    dimethyl isosorbide 364.05
    tetrachloroethylene 306.41
    eugenol 211.61
    triacetin 202.42
    span 80 193.92
    1,4-butanediol 120.69
    1,1-dichloroethane 474.95
    2-methyl-1-pentanol 153.6
    methyl formate 292.2
    2-methyl-1-butanol 207.5
    n-decane 56.9
    butyronitrile 335.07
    3,7-dimethyl-1-octanol 165.17
    1-chlorooctane 165.75
    1-chlorotetradecane 81.4
    n-nonane 55.73
    undecane 46.43
    tert-butylcyclohexane 60.12
    cyclooctane 40.33
    cyclopentanol 369.23
    tetrahydropyran 567.33
    tert-amyl methyl ether 271.81
    2,5,8-trioxanonane 284.23
    1-hexene 138.17
    2-isopropoxyethanol 193.89
    2,2,2-trifluoroethanol 81.18
    methyl butyrate 263.7

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction