2-Propylpiperidine hydrochloride

Overview IFRA Request a quote

  • Identifiers

    CAS number
    15991-59-0

    Molecular formula
    C8H18ClN

    SMILES
    CCCC1CCCCN1.Cl

    Safety labels

  • Odor profile

    Fragrance
    Fishy 60.5%
    Cheesy 54.97%
    Nutty 39.86%
    Animal 39.36%
    Roasted 37.21%
    Musty 33.33%
    Floral 33.03%
    Ripe 29.54%
    Oily 29.17%
    Sweet 29.17%

     

    Flavor
    Sweet 41.32%
    Floral 32.93%
    Animal 28.79%
    Ammoniacal 27.65%
    Bitter 26.12%
    Herbal 25.95%
    Alkaline 25.83%
    Fruity 24.56%
    Green 23.62%
    Spicy 23.11%

     

    Odor impact est.
    High

  • Properties

    pKa est.
    7.26 (neutral)

    Molecular weight
    163.69 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    168°C

    Flash point

    • 44.48 ˚C est.

  • Synonyms

    • 2-propylpiperidine hydrochloride
    • RefChem:483288
    • 818-918-2
    • 15991-59-0
    • 51541-42-5
    • 2-propylpiperidine HCl
    • 2-propylpiperidine;hydrochloride
    • MFCD00050919
    • Piperidine, 2-propyl-, hydrochloride (1:1)
    • (+/-)-2-PROPYLPIPERIDINE HYDROCHLORIDE*
    • ( inverted exclamation markA)-Coniine (hydrochloride)
    • DL-Coniine hydrochloride
    • Prestwick_126
    • SCHEMBL25356
    • Coniine hydrochloride (D,L)
    • 2-Propylpiperidinehydrochloride
    • orb1297112
    • 2-propyl-piperidine hydrochloride
    • DTXSID60936194
    • HMS5091O07
    • QAA99159
    • AKOS000277464
    • AKOS016845961
    • HY-W099757
    • SB43089
    • SB44547
    • AS-65456
    • DB-214561
    • DB-303648
    • CS-0152399
    • 2-Propylpiperidine--hydrogen chloride (1/1)
    • EN300-135239
    • Y10685
    • 555C920
    • Z1665033554
    • 15991-59-0

  • Applications

    2-Propylpiperidine hydrochloride, CAS 15991-59-0, is primarily used as an intermediate in pharmaceutical manufacturing and as a building block for piperidine-containing active pharmaceutical ingredients; it is also evaluated as a precursor for the synthesis of piperidine-based APIs and is used in medicinal chemistry research to explore structure-activity relationships (SAR) of piperidine scaffolds; the hydrochloride salt form improves handling, storage, and processability in synthesis and can serve as an amine source in organic reactions to form amides, imines, or other piperidine derivatives; beyond pharmaceuticals, it may be investigated in agrochemical R&D as a starting scaffold for piperidine-based actives; overall, its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1952.54
    methanol 1328.89
    isopropanol 1750.82
    water 0.36
    ethyl acetate 1463.04
    n-propanol 1828.14
    acetone 1790.27
    n-butanol 2067.21
    acetonitrile 1294.46
    DMF 1026.9
    toluene 761.98
    isobutanol 1373.21
    1,4-dioxane 2027.92
    methyl acetate 953.08
    THF 4115.12
    2-butanone 1400.89
    n-pentanol 1174.73
    sec-butanol 1420.34
    n-hexane 576.78
    ethylene glycol 173.53
    NMP 950.57
    cyclohexane 1080.6
    DMSO 2009.57
    n-butyl acetate 2645.18
    n-octanol 625.28
    chloroform 4113.94
    n-propyl acetate 906.24
    acetic acid 1183.47
    dichloromethane 3312.86
    cyclohexanone 2193.38
    propylene glycol 361.84
    isopropyl acetate 863.32
    DMAc 555.82
    2-ethoxyethanol 775.77
    isopentanol 1471.42
    n-heptane 1049.04
    ethyl formate 937.85
    1,2-dichloroethane 1762.24
    n-hexanol 2611.97
    2-methoxyethanol 1306.77
    isobutyl acetate 554.92
    tetrachloromethane 900.37
    n-pentyl acetate 762.2
    transcutol 1787.21
    n-heptanol 747.79
    ethylbenzene 280.3
    MIBK 705.21
    2-propoxyethanol 1839.59
    tert-butanol 1722.59
    MTBE 1321.35
    2-butoxyethanol 798.03
    propionic acid 1100.24
    o-xylene 361.31
    formic acid 180.4
    diethyl ether 1749.33
    m-xylene 433.57
    p-xylene 332.98
    chlorobenzene 1057.88
    dimethyl carbonate 215.88
    n-octane 230.2
    formamide 216.45
    cyclopentanone 2280.1
    2-pentanone 1397.38
    anisole 428.45
    cyclopentyl methyl ether 1732.76
    gamma-butyrolactone 2024.26
    1-methoxy-2-propanol 1118.13
    pyridine 1884.11
    3-pentanone 881.39
    furfural 1301.29
    n-dodecane 130.21
    diethylene glycol 703.0
    diisopropyl ether 560.18
    tert-amyl alcohol 1105.13
    acetylacetone 918.92
    n-hexadecane 146.75
    acetophenone 364.48
    methyl propionate 820.44
    isopentyl acetate 1623.55
    trichloroethylene 2477.05
    n-nonanol 518.75
    cyclohexanol 1554.54
    benzyl alcohol 378.22
    2-ethylhexanol 1537.21
    isooctanol 523.49
    dipropyl ether 2254.65
    1,2-dichlorobenzene 728.31
    ethyl lactate 265.0
    propylene carbonate 1314.25
    n-methylformamide 667.37
    2-pentanol 1273.2
    n-pentane 645.71
    1-propoxy-2-propanol 1744.05
    1-methoxy-2-propyl acetate 1042.89
    2-(2-methoxypropoxy) propanol 406.36
    mesitylene 270.16
    ε-caprolactone 1612.77
    p-cymene 418.46
    epichlorohydrin 1965.72
    1,1,1-trichloroethane 1742.56
    2-aminoethanol 477.41
    morpholine-4-carbaldehyde 914.48
    sulfolane 1871.61
    2,2,4-trimethylpentane 191.76
    2-methyltetrahydrofuran 2970.41
    n-hexyl acetate 872.27
    isooctane 178.91
    2-(2-butoxyethoxy)ethanol 654.44
    sec-butyl acetate 520.69
    tert-butyl acetate 768.01
    decalin 226.06
    glycerin 335.43
    diglyme 1248.34
    acrylic acid 685.45
    isopropyl myristate 338.65
    n-butyric acid 2196.05
    acetyl acetate 699.09
    di(2-ethylhexyl) phthalate 244.84
    ethyl propionate 602.26
    nitromethane 1359.54
    1,2-diethoxyethane 1301.05
    benzonitrile 791.64
    trioctyl phosphate 234.02
    1-bromopropane 2053.57
    gamma-valerolactone 1782.41
    n-decanol 386.97
    triethyl phosphate 327.77
    4-methyl-2-pentanol 580.53
    propionitrile 1438.57
    vinylene carbonate 938.27
    1,1,2-trichlorotrifluoroethane 993.19
    DMS 335.56
    cumene 185.63
    2-octanol 445.3
    2-hexanone 926.36
    octyl acetate 396.72
    limonene 870.81
    1,2-dimethoxyethane 1388.73
    ethyl orthosilicate 351.68
    tributyl phosphate 300.77
    diacetone alcohol 625.4
    N,N-dimethylaniline 258.42
    acrylonitrile 1184.37
    aniline 842.94
    1,3-propanediol 819.25
    bromobenzene 1194.83
    dibromomethane 2815.73
    1,1,2,2-tetrachloroethane 1870.26
    2-methyl-cyclohexyl acetate 625.94
    tetrabutyl urea 353.32
    diisobutyl methanol 686.24
    2-phenylethanol 664.77
    styrene 401.56
    dioctyl adipate 387.59
    dimethyl sulfate 262.02
    ethyl butyrate 1389.6
    methyl lactate 296.55
    butyl lactate 449.9
    diethyl carbonate 588.77
    propanediol butyl ether 523.85
    triethyl orthoformate 796.22
    p-tert-butyltoluene 398.85
    methyl 4-tert-butylbenzoate 347.71
    morpholine 2338.02
    tert-butylamine 1334.8
    n-dodecanol 306.67
    dimethoxymethane 859.6
    ethylene carbonate 968.71
    cyrene 307.88
    2-ethoxyethyl acetate 668.54
    2-ethylhexyl acetate 1266.53
    1,2,4-trichlorobenzene 744.65
    4-methylpyridine 1475.65
    dibutyl ether 1188.65
    2,6-dimethyl-4-heptanol 686.24
    DEF 1081.3
    dimethyl isosorbide 696.4
    tetrachloroethylene 1425.66
    eugenol 301.77
    triacetin 442.77
    span 80 553.97
    1,4-butanediol 282.23
    1,1-dichloroethane 2217.36
    2-methyl-1-pentanol 746.41
    methyl formate 468.91
    2-methyl-1-butanol 1265.19
    n-decane 238.69
    butyronitrile 1998.92
    3,7-dimethyl-1-octanol 670.61
    1-chlorooctane 577.59
    1-chlorotetradecane 219.25
    n-nonane 276.34
    undecane 167.23
    tert-butylcyclohexane 204.21
    cyclooctane 335.82
    cyclopentanol 1701.08
    tetrahydropyran 3442.17
    tert-amyl methyl ether 816.82
    2,5,8-trioxanonane 728.81
    1-hexene 1245.56
    2-isopropoxyethanol 537.88
    2,2,2-trifluoroethanol 235.45
    methyl butyrate 910.59

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction