2-Piperidone

Overview IFRA Request a quote

  • Identifiers

    CAS number
    675-20-7

    Molecular formula
    C5H9NO

    SMILES
    C1CCNC(=O)C1

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 44.24%
    Spicy 43.4%
    Fishy 38.28%
    Sweet 34.87%
    Roasted 34.08%
    Burnt 33.66%
    Popcorn 33.54%
    Animal 32.99%
    Caramellic 30.94%
    Coconut 24.01%

     

    Flavor
    Bitter 60.16%
    Spicy 32.74%
    Amine 29.85%
    Animal 26.17%
    Alkaline 23.4%
    Shrimp 23.29%
    Minty 23.16%
    Cauliflower 21.84%
    Ammoniacal 20.8%
    Others 20.74%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.5

    pKa est.
    8.55 (weak base)

    Molecular weight
    99.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    259°C

    Melting point expt.

    • 39.5 °C

    Flash point

    • 96.69 ˚C est.

    Solubility expt.

    • 291 mg/mL at 25 °C

  • Synonyms

    • 2-Piperidone
    • piperidin-2-one
    • 675-20-7
    • 2-Piperidinone
    • DELTA-VALEROLACTAM
    • Valerolactim
    • 5-Pentanolactam
    • Piperidon
    • alpha-Piperidone
    • Piperidone-2
    • 2-oxopiperidine
    • WLN0GQQ6EK
    • DTXSID1060976
    • NSC-2305
    • NSC-18894
    • CHEBI:77761
    • RefChem:910229
    • DTXCID7044897
    • 211-622-9
    • Piperidone
    • Valerolactam
    • Piperidinone
    • PIPERIDONE,2-
    • .alpha.-Piperidone
    • 2-Azacyclohexanone
    • Piperidon [German]
    • Pentanoic acid, 5-amino-, lactam
    • .delta.-Valerolactam
    • MFCD00006037
    • d-Valerolactam
    • 2-oxo-piperidine
    • NSC 2305
    • NSC 18894
    • CHEMBL12193
    • 27154-43-4
    • NSC18894
    • Piperidon (german)
    • Pentanoic acid, lactam
    • WLN: T6NVTJ
    • Piperidones
    • Piperidone-2 [French]
    • 25036-00-4
    • UNII-WLN0GQQ6EK
    • EINECS 211-622-9
    • ketopiperidine
    • oxopiperidine
    • 5-pentanelactam
    • 2-piperadinone
    • A-Piperidone
    • AI3-33342
    • d-Valero-lactam
    • piperadine-2-one
    • piperidine-2-one
    • delta -Valerolactam
    • V1L
    • 5-amino-lactam-Pentanoate
    • delta-Valerolactam, 98%
    • BDBM10
    • SCHEMBL2338
    • SCHEMBL5542
    • 5-amino-lactam-Pentanoic acid
    • piperidin-2-one;2-Piperidone
    • SCHEMBL293677
    • SCHEMBL745074
    • SCHEMBL864016
    • orb3023648
    • SCHEMBL1766104
    • SCHEMBL1898175
    • SCHEMBL2369077
    • SCHEMBL3276357
    • SCHEMBL3605194
    • SCHEMBL4294656
    • SCHEMBL4295098
    • SCHEMBL4299448
    • SCHEMBL4300386
    • SCHEMBL5080129
    • SCHEMBL5080175
    • SCHEMBL5082980
    • SCHEMBL5086136
    • SCHEMBL5086137
    • SCHEMBL6761700
    • NSC2305
    • BB_SC-06941
    • Piperidin-2-one; delta-Valerolactam
    • BBL027557
    • STL281850
    • AKOS005206867
    • CS-W022933
    • EBC-615339
    • FP09656
    • HY-W042193
    • SB41073
    • AC-15619
    • AC-33837
    • NCI60_001574
    • SY011119
    • DB-031244
    • A9047
    • NS00015672
    • P0455
    • EN300-24025
    • F10312
    • 675V207
    • F043484
    • Q4596918
    • F0001-1780
    • Z168817684
    • InChI=1/C5H9NO/c7-5-3-1-2-4-6-5/h1-4H2,(H,6,7
    • 675-20-7

  • Applications

    2-Piperidone, CAS 675-20-7, is a lactam of the piperidine ring primarily used as an intermediate in the synthesis of pharmaceutical and agrochemical compounds; it also serves as a building block for piperidine derivatives and other heterocyclic structures in medicinal chemistry and related research. Additionally, 2-Piperidone is employed as a building material for polymer polyamides and high-performance plastics, and can act as a precursor for related polymer systems. In industrial settings, it is viewed as a precursor for the synthesis of materials used in coatings/inks and adhesives, as well as other specialty chemicals for process development, with applications depending on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 286.56
    methanol 627.46
    isopropanol 125.77
    water 87.66
    ethyl acetate 35.38
    n-propanol 153.16
    acetone 83.88
    n-butanol 104.07
    acetonitrile 78.04
    DMF 292.0
    toluene 5.23
    isobutanol 83.87
    1,4-dioxane 69.41
    methyl acetate 39.86
    THF 105.58
    2-butanone 45.43
    n-pentanol 66.01
    sec-butanol 72.69
    n-hexane 1.44
    ethylene glycol 143.47
    NMP 213.34
    cyclohexane 1.21
    DMSO 294.26
    n-butyl acetate 27.65
    n-octanol 22.31
    chloroform 136.92
    n-propyl acetate 22.38
    acetic acid 639.69
    dichloromethane 97.07
    cyclohexanone 80.1
    propylene glycol 140.99
    isopropyl acetate 18.46
    DMAc 150.81
    2-ethoxyethanol 99.22
    isopentanol 63.61
    n-heptane 1.25
    ethyl formate 59.81
    1,2-dichloroethane 37.57
    n-hexanol 44.51
    2-methoxyethanol 218.67
    isobutyl acetate 13.97
    tetrachloromethane 11.57
    n-pentyl acetate 28.02
    transcutol 321.69
    n-heptanol 26.53
    ethylbenzene 3.83
    MIBK 20.2
    2-propoxyethanol 93.83
    tert-butanol 67.15
    MTBE 14.36
    2-butoxyethanol 67.93
    propionic acid 203.56
    o-xylene 6.59
    formic acid 483.69
    diethyl ether 15.29
    m-xylene 6.23
    p-xylene 7.71
    chlorobenzene 23.88
    dimethyl carbonate 16.59
    n-octane 0.72
    formamide 388.83
    cyclopentanone 135.56
    2-pentanone 33.04
    anisole 15.69
    cyclopentyl methyl ether 26.76
    gamma-butyrolactone 195.68
    1-methoxy-2-propanol 119.18
    pyridine 93.95
    3-pentanone 18.8
    furfural 193.93
    n-dodecane 0.76
    diethylene glycol 121.7
    diisopropyl ether 3.87
    tert-amyl alcohol 51.5
    acetylacetone 39.3
    n-hexadecane 0.81
    acetophenone 24.12
    methyl propionate 34.56
    isopentyl acetate 24.06
    trichloroethylene 104.87
    n-nonanol 18.8
    cyclohexanol 40.23
    benzyl alcohol 39.59
    2-ethylhexanol 17.53
    isooctanol 19.46
    dipropyl ether 9.49
    1,2-dichlorobenzene 24.41
    ethyl lactate 24.08
    propylene carbonate 80.46
    n-methylformamide 265.15
    2-pentanol 37.91
    n-pentane 1.37
    1-propoxy-2-propanol 55.65
    1-methoxy-2-propyl acetate 29.4
    2-(2-methoxypropoxy) propanol 56.83
    mesitylene 4.61
    ε-caprolactone 76.84
    p-cymene 5.3
    epichlorohydrin 109.13
    1,1,1-trichloroethane 25.1
    2-aminoethanol 232.87
    morpholine-4-carbaldehyde 146.25
    sulfolane 180.44
    2,2,4-trimethylpentane 1.19
    2-methyltetrahydrofuran 59.45
    n-hexyl acetate 35.16
    isooctane 0.87
    2-(2-butoxyethoxy)ethanol 90.72
    sec-butyl acetate 11.8
    tert-butyl acetate 17.06
    decalin 1.15
    glycerin 199.53
    diglyme 119.29
    acrylic acid 229.35
    isopropyl myristate 9.75
    n-butyric acid 182.71
    acetyl acetate 29.57
    di(2-ethylhexyl) phthalate 21.88
    ethyl propionate 15.08
    nitromethane 384.78
    1,2-diethoxyethane 36.02
    benzonitrile 52.87
    trioctyl phosphate 13.71
    1-bromopropane 14.71
    gamma-valerolactone 177.43
    n-decanol 13.15
    triethyl phosphate 11.4
    4-methyl-2-pentanol 20.3
    propionitrile 55.29
    vinylene carbonate 79.01
    1,1,2-trichlorotrifluoroethane 153.64
    DMS 25.49
    cumene 4.58
    2-octanol 15.31
    2-hexanone 23.28
    octyl acetate 16.17
    limonene 6.76
    1,2-dimethoxyethane 72.08
    ethyl orthosilicate 10.53
    tributyl phosphate 17.02
    diacetone alcohol 43.58
    N,N-dimethylaniline 13.43
    acrylonitrile 106.52
    aniline 38.27
    1,3-propanediol 193.4
    bromobenzene 16.46
    dibromomethane 46.41
    1,1,2,2-tetrachloroethane 79.55
    2-methyl-cyclohexyl acetate 16.65
    tetrabutyl urea 22.82
    diisobutyl methanol 9.08
    2-phenylethanol 33.7
    styrene 5.45
    dioctyl adipate 19.38
    dimethyl sulfate 37.26
    ethyl butyrate 17.06
    methyl lactate 46.23
    butyl lactate 37.71
    diethyl carbonate 12.57
    propanediol butyl ether 89.2
    triethyl orthoformate 13.74
    p-tert-butyltoluene 4.91
    methyl 4-tert-butylbenzoate 31.47
    morpholine 108.22
    tert-butylamine 27.32
    n-dodecanol 9.44
    dimethoxymethane 50.77
    ethylene carbonate 53.35
    cyrene 50.77
    2-ethoxyethyl acetate 40.68
    2-ethylhexyl acetate 17.06
    1,2,4-trichlorobenzene 31.8
    4-methylpyridine 59.24
    dibutyl ether 11.96
    2,6-dimethyl-4-heptanol 9.08
    DEF 56.33
    dimethyl isosorbide 63.23
    tetrachloroethylene 62.16
    eugenol 44.27
    triacetin 39.66
    span 80 57.17
    1,4-butanediol 82.62
    1,1-dichloroethane 35.08
    2-methyl-1-pentanol 44.74
    methyl formate 120.71
    2-methyl-1-butanol 62.0
    n-decane 1.14
    butyronitrile 54.23
    3,7-dimethyl-1-octanol 20.1
    1-chlorooctane 5.75
    1-chlorotetradecane 2.44
    n-nonane 1.02
    undecane 0.9
    tert-butylcyclohexane 1.22
    cyclooctane 0.5
    cyclopentanol 84.86
    tetrahydropyran 39.67
    tert-amyl methyl ether 11.62
    2,5,8-trioxanonane 89.99
    1-hexene 6.54
    2-isopropoxyethanol 49.42
    2,2,2-trifluoroethanol 157.87
    methyl butyrate 27.08

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction