2-(Oxolan-2-yl)ethan-1-ol

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  • Identifiers

    CAS number
    33606-34-7

    Molecular formula
    C6H12O2

    SMILES
    C1CC(OC1)CCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 68.22%
    Ethereal 58.44%
    Fermented 52.08%
    Alcoholic 50.98%
    Sweet 46.33%
    Solvent 44.63%
    Oily 42.37%
    Green 41.94%
    Musty 31.42%
    Winey 30.54%

     

    Flavor
    Vegetable 41.87%
    Caramel 39.75%
    Sweet 38.99%
    Oily 37.71%
    Bitter 28.75%
    Cauliflower 28.26%
    Musty 27.61%
    Warm 26.75%
    Alcoholic 24.44%
    Roasted 24.36%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.3

    pKa est.
    7.6 (neutral)

    Molecular weight
    116.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    202°C

    Flash point

    • 80.59 ˚C est.

  • Synonyms

    • 33606-34-7
    • 2-(tetrahydrofuran-2-yl)ethanol
    • 2-(oxolan-2-yl)ethan-1-ol
    • 2-(oxolan-2-yl)ethanol
    • 2-(tetrahydrofuran-2-yl)ethan-1-ol
    • 2-(tetrahydro-2-furanyl)ethanol
    • tetrahydrofuran-ethanol
    • tetrahydrofuranethanol
    • MFCD19105106
    • 2-tetrahydrofuran-2-ylethanol
    • SCHEMBL313343
    • FCAJYRVEBULFKS-UHFFFAOYSA-N
    • 2-Tetrahydro-2-furanyl-1-ethanol
    • 2-(tetrahydro-furan-2-yl)-ethanol
    • IBA60634
    • AKOS013283788
    • AS-37103
    • DB-293336
    • CS-0451231
    • EN300-100202
    • Z1183459210
    • 856-522-1

  • Applications

    2-(Oxolan-2-yl)ethan-1-ol is a versatile chemical intermediate used primarily in organic synthesis, providing a building block for functionalized THF derivatives and polyols to enable chain extension or crosslinking in polyurethane and epoxy systems used in polymers and coatings. It can serve as a solvent or co-solvent in specialty formulations such as coatings, inks, and cleaning products, owing to its polar ether functionality that improves solubility and processability. The hydroxyl group allows derivatization to esters and ethers to access fragrance- and cosmetics-related intermediates or specialty compounds. In pharmaceutical and agrochemical synthesis, it may be considered as an intermediate to access more complex molecules, subject to regulatory and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3767.46
    methanol 5437.0
    isopropanol 2756.37
    water 80.59
    ethyl acetate 723.67
    n-propanol 2503.32
    acetone 1474.7
    n-butanol 1726.52
    acetonitrile 1227.02
    DMF 1982.12
    toluene 163.85
    isobutanol 1430.11
    1,4-dioxane 1597.37
    methyl acetate 823.42
    THF 1680.47
    2-butanone 822.4
    n-pentanol 848.9
    sec-butanol 1411.92
    n-hexane 48.74
    ethylene glycol 1687.8
    NMP 1028.65
    cyclohexane 79.57
    DMSO 2506.55
    n-butyl acetate 299.17
    n-octanol 244.83
    chloroform 1940.61
    n-propyl acetate 303.54
    acetic acid 2587.65
    dichloromethane 1584.37
    cyclohexanone 848.94
    propylene glycol 1832.64
    isopropyl acetate 336.44
    DMAc 927.8
    2-ethoxyethanol 1252.29
    isopentanol 964.08
    n-heptane 49.45
    ethyl formate 578.1
    1,2-dichloroethane 753.49
    n-hexanol 699.08
    2-methoxyethanol 2483.21
    isobutyl acetate 177.76
    tetrachloromethane 323.91
    n-pentyl acetate 172.37
    transcutol 1539.4
    n-heptanol 264.11
    ethylbenzene 64.17
    MIBK 323.48
    2-propoxyethanol 1176.83
    tert-butanol 1698.26
    MTBE 588.66
    2-butoxyethanol 511.69
    propionic acid 1689.09
    o-xylene 108.57
    formic acid 1521.06
    diethyl ether 709.92
    m-xylene 128.8
    p-xylene 87.72
    chlorobenzene 311.37
    dimethyl carbonate 212.38
    n-octane 16.42
    formamide 1220.24
    cyclopentanone 1095.35
    2-pentanone 603.29
    anisole 244.86
    cyclopentyl methyl ether 590.64
    gamma-butyrolactone 1271.07
    1-methoxy-2-propanol 1600.07
    pyridine 853.79
    3-pentanone 350.66
    furfural 959.82
    n-dodecane 16.14
    diethylene glycol 1367.08
    diisopropyl ether 133.69
    tert-amyl alcohol 845.17
    acetylacetone 524.91
    n-hexadecane 17.74
    acetophenone 207.72
    methyl propionate 543.65
    isopentyl acetate 227.01
    trichloroethylene 1221.41
    n-nonanol 191.22
    cyclohexanol 781.6
    benzyl alcohol 336.82
    2-ethylhexanol 247.34
    isooctanol 186.85
    dipropyl ether 279.46
    1,2-dichlorobenzene 245.14
    ethyl lactate 225.6
    propylene carbonate 550.52
    n-methylformamide 1611.65
    2-pentanol 834.05
    n-pentane 76.42
    1-propoxy-2-propanol 692.18
    1-methoxy-2-propyl acetate 324.35
    2-(2-methoxypropoxy) propanol 336.42
    mesitylene 85.75
    ε-caprolactone 646.42
    p-cymene 65.8
    epichlorohydrin 1135.78
    1,1,1-trichloroethane 664.03
    2-aminoethanol 2464.39
    morpholine-4-carbaldehyde 1126.23
    sulfolane 1144.06
    2,2,4-trimethylpentane 34.27
    2-methyltetrahydrofuran 1033.57
    n-hexyl acetate 258.26
    isooctane 31.07
    2-(2-butoxyethoxy)ethanol 517.31
    sec-butyl acetate 167.96
    tert-butyl acetate 291.93
    decalin 26.6
    glycerin 1829.92
    diglyme 873.58
    acrylic acid 1392.46
    isopropyl myristate 89.7
    n-butyric acid 1472.9
    acetyl acetate 381.85
    di(2-ethylhexyl) phthalate 109.41
    ethyl propionate 233.36
    nitromethane 2170.69
    1,2-diethoxyethane 352.19
    benzonitrile 365.75
    trioctyl phosphate 88.18
    1-bromopropane 504.94
    gamma-valerolactone 1219.88
    n-decanol 134.59
    triethyl phosphate 91.9
    4-methyl-2-pentanol 311.12
    propionitrile 883.99
    vinylene carbonate 528.54
    1,1,2-trichlorotrifluoroethane 1010.87
    DMS 178.71
    cumene 53.62
    2-octanol 147.27
    2-hexanone 313.77
    octyl acetate 122.22
    limonene 106.11
    1,2-dimethoxyethane 1051.31
    ethyl orthosilicate 92.37
    tributyl phosphate 94.68
    diacetone alcohol 488.36
    N,N-dimethylaniline 147.43
    acrylonitrile 1055.22
    aniline 484.03
    1,3-propanediol 2123.71
    bromobenzene 267.22
    dibromomethane 934.19
    1,1,2,2-tetrachloroethane 993.28
    2-methyl-cyclohexyl acetate 143.45
    tetrabutyl urea 125.34
    diisobutyl methanol 133.55
    2-phenylethanol 284.15
    styrene 101.36
    dioctyl adipate 133.76
    dimethyl sulfate 321.47
    ethyl butyrate 201.8
    methyl lactate 442.8
    butyl lactate 192.08
    diethyl carbonate 125.54
    propanediol butyl ether 530.98
    triethyl orthoformate 143.2
    p-tert-butyltoluene 67.57
    methyl 4-tert-butylbenzoate 198.43
    morpholine 1904.27
    tert-butylamine 885.9
    n-dodecanol 98.32
    dimethoxymethane 829.65
    ethylene carbonate 447.38
    cyrene 281.73
    2-ethoxyethyl acetate 243.72
    2-ethylhexyl acetate 156.49
    1,2,4-trichlorobenzene 291.28
    4-methylpyridine 606.49
    dibutyl ether 165.12
    2,6-dimethyl-4-heptanol 133.55
    DEF 613.61
    dimethyl isosorbide 380.89
    tetrachloroethylene 710.35
    eugenol 234.17
    triacetin 238.61
    span 80 320.71
    1,4-butanediol 934.1
    1,1-dichloroethane 956.35
    2-methyl-1-pentanol 458.6
    methyl formate 882.35
    2-methyl-1-butanol 869.15
    n-decane 26.68
    butyronitrile 806.35
    3,7-dimethyl-1-octanol 200.97
    1-chlorooctane 103.92
    1-chlorotetradecane 40.87
    n-nonane 26.05
    undecane 19.84
    tert-butylcyclohexane 31.1
    cyclooctane 23.53
    cyclopentanol 1175.78
    tetrahydropyran 1210.82
    tert-amyl methyl ether 320.14
    2,5,8-trioxanonane 566.96
    1-hexene 186.31
    2-isopropoxyethanol 648.84
    2,2,2-trifluoroethanol 740.6
    methyl butyrate 336.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction