Molecular formula
C16H14O5

SMILES
COC1=C(C=CC(=C1)O)C(=O)CC(=O)C2=CC=C(C=C2)O

Fragrance
Sweet	56.49%
Phenolic	46.26%
Vanilla	44.16%
Balsamic	40.41%
Odorless	35.93%
Spicy	33.04%
Powdery	29.23%
Creamy	28.59%
Aromatic	27.91%
Bitter	27.57%

 

Flavor
Bitter	70.21%
Odorless	42.09%
Bland	25.71%
Mild	24.83%
Faint	21.62%
Sweet-like	20.77%
Lovage	20.56%
Ethyl benzoate	20.45%
Orange flower	20.45%
Very mild	20.37%

 

Odor impact est.
Low

XLogP3-AA
2.4

pKa est.
9.44 (weak base)

Molecular weight
286.28 g/mol

Vapor pressure est.

• hPa @ 20°C
• hPa @ 25°C

Evaporation rate
Ultra slow

Boiling point est.
509°C

Flash point

• 217.69 ˚C est.

• 2'-O-Methyllicodione
• Licodione 2'-methyl ether
• 1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propane-1,3-dione
• C02922
• SCHEMBL2935006
• CHEBI:15789
• LMPK12120397
• Q27098233
• 1-(4-Hydroxy-2-methoxy-phenyl)-3-(4-hydroxy-phenyl)-propane-1,3-dione
• 1-(4-hydroxy-2-methoxy-phenyl)-3-(4-hydroxyphenyl)propane-1,3-dione

2'-O-Methyllicodione is typically used as an organic synthesis intermediate and building block in the production of fine chemicals, pharmaceuticals, and agrochemicals. In perfumery and flavor research it may be evaluated as an odorant or aroma-modifier, contributing to scent profiles under controlled levels. It can serve as a specialty chemical for polymer/plastics formulations or as a starting material for functional additives in coatings, inks, and adhesives. In cosmetics or personal care contexts, it may be used as a fragrance-related ingredient or sensory modifier under appropriate formulation controls. Its use is typically subject to local regulations and formulation limits.

gpt-5-nano

Solvent	Solubility (g/L)
ethanol	6.42
methanol	18.8
isopropanol	14.44
water	0.07
ethyl acetate	23.02
n-propanol	12.11
acetone	133.31
n-butanol	7.57
acetonitrile	39.3
DMF	306.73
toluene	0.68
isobutanol	7.35
1,4-dioxane	79.47
methyl acetate	49.48
THF	504.08
2-butanone	58.43
n-pentanol	7.89
sec-butanol	9.93
n-hexane	0.05
ethylene glycol	27.41
NMP	138.4
cyclohexane	0.04
DMSO	1408.11
n-butyl acetate	11.38
n-octanol	4.03
chloroform	3.05
n-propyl acetate	17.37
acetic acid	44.74
dichloromethane	3.35
cyclohexanone	45.84
propylene glycol	50.51
isopropyl acetate	15.06
DMAc	367.54
2-ethoxyethanol	79.21
isopentanol	8.78
n-heptane	0.09
ethyl formate	17.15
1,2-dichloroethane	5.46
n-hexanol	3.48
2-methoxyethanol	163.1
isobutyl acetate	9.08
tetrachloromethane	0.35
n-pentyl acetate	5.41
transcutol	191.18
n-heptanol	3.54
ethylbenzene	0.98
MIBK	19.24
2-propoxyethanol	67.57
tert-butanol	35.84
MTBE	11.22
2-butoxyethanol	20.99
propionic acid	25.01
o-xylene	1.05
formic acid	30.76
diethyl ether	6.14
m-xylene	0.85
p-xylene	1.53
chlorobenzene	1.72
dimethyl carbonate	42.49
n-octane	0.06
formamide	109.45
cyclopentanone	153.91
2-pentanone	27.59
anisole	16.0
cyclopentyl methyl ether	20.99
gamma-butyrolactone	172.92
1-methoxy-2-propanol	125.01
pyridine	15.36
3-pentanone	19.26
furfural	73.63
n-dodecane	0.16
diethylene glycol	90.62
diisopropyl ether	1.84
tert-amyl alcohol	16.6
acetylacetone	81.27
n-hexadecane	0.19
acetophenone	18.82
methyl propionate	38.54
isopentyl acetate	12.21
trichloroethylene	13.38
n-nonanol	4.48
cyclohexanol	6.9
benzyl alcohol	13.1
2-ethylhexanol	3.43
isooctanol	3.65
dipropyl ether	7.61
1,2-dichlorobenzene	3.05
ethyl lactate	26.76
propylene carbonate	38.04
n-methylformamide	95.27
2-pentanol	5.06
n-pentane	0.02
1-propoxy-2-propanol	42.44
1-methoxy-2-propyl acetate	40.03
2-(2-methoxypropoxy) propanol	43.4
mesitylene	0.83
ε-caprolactone	38.08
p-cymene	1.43
epichlorohydrin	144.48
1,1,1-trichloroethane	3.29
2-aminoethanol	35.69
morpholine-4-carbaldehyde	145.24
sulfolane	283.95
2,2,4-trimethylpentane	0.1
2-methyltetrahydrofuran	46.18
n-hexyl acetate	10.24
isooctane	0.08
2-(2-butoxyethoxy)ethanol	50.75
sec-butyl acetate	11.25
tert-butyl acetate	23.54
decalin	0.14
glycerin	110.22
diglyme	107.35
acrylic acid	29.46
isopropyl myristate	5.91
n-butyric acid	18.88
acetyl acetate	19.68
di(2-ethylhexyl) phthalate	7.56
ethyl propionate	20.25
nitromethane	249.14
1,2-diethoxyethane	30.38
benzonitrile	9.79
trioctyl phosphate	5.33
1-bromopropane	1.07
gamma-valerolactone	163.35
n-decanol	3.6
triethyl phosphate	13.59
4-methyl-2-pentanol	4.53
propionitrile	20.81
vinylene carbonate	29.93
1,1,2-trichlorotrifluoroethane	78.19
DMS	23.93
cumene	1.03
2-octanol	2.36
2-hexanone	20.44
octyl acetate	7.08
limonene	1.86
1,2-dimethoxyethane	135.22
ethyl orthosilicate	11.14
tributyl phosphate	7.49
diacetone alcohol	56.54
N,N-dimethylaniline	10.2
acrylonitrile	35.26
aniline	4.91
1,3-propanediol	42.99
bromobenzene	1.19
dibromomethane	1.25
1,1,2,2-tetrachloroethane	13.73
2-methyl-cyclohexyl acetate	13.15
tetrabutyl urea	12.92
diisobutyl methanol	3.85
2-phenylethanol	9.94
styrene	1.24
dioctyl adipate	13.54
dimethyl sulfate	103.57
ethyl butyrate	13.91
methyl lactate	55.57
butyl lactate	12.58
diethyl carbonate	13.28
propanediol butyl ether	24.71
triethyl orthoformate	15.63
p-tert-butyltoluene	1.45
methyl 4-tert-butylbenzoate	21.32
morpholine	104.74
tert-butylamine	5.85
n-dodecanol	2.84
dimethoxymethane	169.83
ethylene carbonate	24.78
cyrene	51.86
2-ethoxyethyl acetate	16.4
2-ethylhexyl acetate	8.09
1,2,4-trichlorobenzene	5.29
4-methylpyridine	12.03
dibutyl ether	6.95
2,6-dimethyl-4-heptanol	3.85
DEF	40.67
dimethyl isosorbide	84.03
tetrachloroethylene	4.37
eugenol	22.8
triacetin	27.43
span 80	21.51
1,4-butanediol	17.8
1,1-dichloroethane	2.74
2-methyl-1-pentanol	7.23
methyl formate	84.96
2-methyl-1-butanol	6.82
n-decane	0.22
butyronitrile	11.0
3,7-dimethyl-1-octanol	4.86
1-chlorooctane	1.32
1-chlorotetradecane	0.74
n-nonane	0.15
undecane	0.19
tert-butylcyclohexane	0.15
cyclooctane	0.03
cyclopentanol	17.81
tetrahydropyran	20.82
tert-amyl methyl ether	9.4
2,5,8-trioxanonane	86.13
1-hexene	0.38
2-isopropoxyethanol	42.23
2,2,2-trifluoroethanol	21.4
methyl butyrate	25.25

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