2-O-Ethyl ascorbic acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    112894-37-8

    Molecular formula
    C8H12O6

    SMILES
    CCOC1=C([C@H](OC1=O)[C@H](CO)O)O

    Safety labels

  • Odor profile

    Fragrance
    Caramellic 54.25%
    Odorless 43.66%
    Fruity 38.06%
    Sweet 35.94%
    Buttery 33.04%
    Milky 25.56%
    Burnt 22.72%
    Creamy 21.79%
    Dairy 20.1%
    Winey 19.67%

     

    Flavor
    Odorless 38.0%
    Bitter 32.6%
    Very mild 32.39%
    Sweet-like 25.76%
    Bland 25.38%
    Fruity 23.08%
    Caramel 22.69%
    Cotton candy 21.49%
    Seedy 21.41%
    Extremely sweet 21.38%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.9

    pKa est.
    6.0 (neutral)

    Molecular weight
    204.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    662°C

    Flash point

    • 189.91 ˚C est.

  • Synonyms

    • 112894-37-8
    • 2-O-Ethyl ascorbic acid
    • EVC-2
    • L-Ascorbic acid, 2-O-Ethyl-
    • 801M14RK9K
    • DTXSID80150198
    • Vitamin C Facial Serum
    • RefChem:88812
    • GlyTouCan:G98983CL
    • DTXCID6072689
    • G98983CL
    • (R)-5-((S)-1,2-Dihydroxyethyl)-3-ethoxy-4-hydroxyfuran-2(5H)-one
    • (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-2H-furan-5-one
    • 2-O-ETHYL-L-ASCORBIC ACID
    • UNII-801M14RK9K
    • (5R)-5-[(1S)-1,2-dihydroxyethyl]-3-ethoxy-4-hydroxy-2,5-dihydrofuran-2-one
    • L-ascorbic acid ethyl ester
    • SCHEMBL728498
    • CHEBI:81688
    • GXRFOOHMMLYYNW-UJURSFKZSA-N
    • C18342
    • Q27155556
    • 5-(1,2-Dihydroxy-ethyl)-3-ethoxy-4-hydroxy-5H-furan-2-one
    • (5R)-5-[(1S)-1,2-Dihydroxyethyl]-3-ethoxy-4-hydroxyfuran-2(5H)-one
    • 112894-37-8

  • Applications

    2-O-Ethyl ascorbic acid (CAS 112894-37-8) is a stabilized derivative of vitamin C that is commonly used in cosmetics and personal care as an antioxidant and skin-conditioning ingredient. In formulations such as serums, creams, and lotions it provides oxidative protection for actives and may contribute to brightening effects. It is also used as a stabilizer and antioxidant additive in coatings, inks, and other polymer formulations to improve oxidative stability. Additionally, it can appear in cleaning and household product formulations as a reducing antioxidant to prevent degradation of ingredients. In pharmaceutical and cosmetic excipients, it may serve as a processing aid or stabilizer under appropriate regulatory guidance.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 65.88
    methanol 230.3
    isopropanol 23.44
    water 105.85
    ethyl acetate 6.42
    n-propanol 26.41
    acetone 17.4
    n-butanol 20.33
    acetonitrile 9.54
    DMF 389.16
    toluene 1.74
    isobutanol 11.65
    1,4-dioxane 27.31
    methyl acetate 10.21
    THF 36.15
    2-butanone 8.72
    n-pentanol 13.68
    sec-butanol 13.3
    n-hexane 0.3
    ethylene glycol 283.1
    NMP 214.55
    cyclohexane 1.04
    DMSO 823.53
    n-butyl acetate 7.08
    n-octanol 10.38
    chloroform 6.48
    n-propyl acetate 6.32
    acetic acid 104.2
    dichloromethane 13.25
    cyclohexanone 23.87
    propylene glycol 98.33
    isopropyl acetate 4.96
    DMAc 232.26
    2-ethoxyethanol 102.41
    isopentanol 15.96
    n-heptane 0.78
    ethyl formate 23.8
    1,2-dichloroethane 14.6
    n-hexanol 13.98
    2-methoxyethanol 237.19
    isobutyl acetate 3.65
    tetrachloromethane 1.96
    n-pentyl acetate 6.47
    transcutol 83.3
    n-heptanol 11.7
    ethylbenzene 2.19
    MIBK 6.69
    2-propoxyethanol 61.9
    tert-butanol 30.26
    MTBE 6.02
    2-butoxyethanol 37.6
    propionic acid 34.13
    o-xylene 3.65
    formic acid 496.24
    diethyl ether 4.07
    m-xylene 2.47
    p-xylene 2.57
    chlorobenzene 3.63
    dimethyl carbonate 21.29
    n-octane 0.51
    formamide 449.21
    cyclopentanone 29.69
    2-pentanone 7.44
    anisole 8.62
    cyclopentyl methyl ether 9.5
    gamma-butyrolactone 59.04
    1-methoxy-2-propanol 99.4
    pyridine 17.23
    3-pentanone 5.71
    furfural 98.71
    n-dodecane 0.55
    diethylene glycol 161.09
    diisopropyl ether 1.51
    tert-amyl alcohol 20.91
    acetylacetone 19.73
    n-hexadecane 0.59
    acetophenone 17.16
    methyl propionate 13.85
    isopentyl acetate 7.37
    trichloroethylene 18.07
    n-nonanol 9.47
    cyclohexanol 17.76
    benzyl alcohol 25.38
    2-ethylhexanol 8.11
    isooctanol 8.63
    dipropyl ether 4.32
    1,2-dichlorobenzene 6.28
    ethyl lactate 26.43
    propylene carbonate 32.01
    n-methylformamide 176.39
    2-pentanol 8.62
    n-pentane 0.47
    1-propoxy-2-propanol 30.93
    1-methoxy-2-propyl acetate 17.05
    2-(2-methoxypropoxy) propanol 33.66
    mesitylene 2.38
    ε-caprolactone 30.49
    p-cymene 3.67
    epichlorohydrin 46.69
    1,1,1-trichloroethane 3.06
    2-aminoethanol 175.89
    morpholine-4-carbaldehyde 162.62
    sulfolane 184.43
    2,2,4-trimethylpentane 0.53
    2-methyltetrahydrofuran 13.11
    n-hexyl acetate 9.12
    isooctane 0.32
    2-(2-butoxyethoxy)ethanol 43.24
    sec-butyl acetate 3.5
    tert-butyl acetate 7.94
    decalin 0.8
    glycerin 286.84
    diglyme 75.08
    acrylic acid 60.46
    isopropyl myristate 4.3
    n-butyric acid 29.56
    acetyl acetate 7.71
    di(2-ethylhexyl) phthalate 11.63
    ethyl propionate 6.39
    nitromethane 116.86
    1,2-diethoxyethane 10.43
    benzonitrile 13.73
    trioctyl phosphate 9.13
    1-bromopropane 3.01
    gamma-valerolactone 79.64
    n-decanol 7.25
    triethyl phosphate 9.95
    4-methyl-2-pentanol 6.58
    propionitrile 6.92
    vinylene carbonate 35.2
    1,1,2-trichlorotrifluoroethane 127.39
    DMS 13.57
    cumene 2.4
    2-octanol 6.09
    2-hexanone 5.89
    octyl acetate 6.84
    limonene 4.96
    1,2-dimethoxyethane 74.77
    ethyl orthosilicate 8.11
    tributyl phosphate 8.0
    diacetone alcohol 30.89
    N,N-dimethylaniline 12.22
    acrylonitrile 21.39
    aniline 10.5
    1,3-propanediol 141.52
    bromobenzene 2.54
    dibromomethane 6.28
    1,1,2,2-tetrachloroethane 18.48
    2-methyl-cyclohexyl acetate 9.98
    tetrabutyl urea 15.03
    diisobutyl methanol 5.47
    2-phenylethanol 20.43
    styrene 2.46
    dioctyl adipate 10.02
    dimethyl sulfate 68.43
    ethyl butyrate 7.29
    methyl lactate 58.41
    butyl lactate 15.95
    diethyl carbonate 7.03
    propanediol butyl ether 41.15
    triethyl orthoformate 8.13
    p-tert-butyltoluene 3.64
    methyl 4-tert-butylbenzoate 23.56
    morpholine 45.13
    tert-butylamine 10.37
    n-dodecanol 5.68
    dimethoxymethane 76.21
    ethylene carbonate 25.06
    cyrene 63.21
    2-ethoxyethyl acetate 11.56
    2-ethylhexyl acetate 5.37
    1,2,4-trichlorobenzene 8.89
    4-methylpyridine 12.93
    dibutyl ether 3.54
    2,6-dimethyl-4-heptanol 5.47
    DEF 37.9
    dimethyl isosorbide 51.4
    tetrachloroethylene 15.72
    eugenol 29.2
    triacetin 16.4
    span 80 28.36
    1,4-butanediol 72.44
    1,1-dichloroethane 3.19
    2-methyl-1-pentanol 11.62
    methyl formate 116.93
    2-methyl-1-butanol 13.29
    n-decane 0.73
    butyronitrile 6.55
    3,7-dimethyl-1-octanol 8.03
    1-chlorooctane 2.82
    1-chlorotetradecane 1.51
    n-nonane 0.65
    undecane 0.63
    tert-butylcyclohexane 0.55
    cyclooctane 0.63
    cyclopentanol 19.34
    tetrahydropyran 8.68
    tert-amyl methyl ether 7.26
    2,5,8-trioxanonane 61.34
    1-hexene 0.97
    2-isopropoxyethanol 41.44
    2,2,2-trifluoroethanol 82.11
    methyl butyrate 11.7

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction