2-Methylthiazolidine

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  • Identifiers

    CAS number
    24050-16-6

    Molecular formula
    C4H9NS

    SMILES
    CC1NCCS1

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Meaty 73.26%
    Nutty 61.5%
    Roasted 59.0%
    Sweet 57.26%
    Fishy 47.79%
    Cooked 41.56%
    Beefy 39.44%
    Popcorn 36.59%
    Sulfurous 35.62%
    Vegetable 32.04%

     

    Flavor
    Roasted 49.74%
    Sulfurous 47.03%
    Meaty 32.68%
    Alliaceous 28.78%
    Ammoniacal 27.91%
    Fishy 27.52%
    Chicken 26.96%
    Onion 26.19%
    Egg 25.68%
    Alkaline 25.57%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.7

    pKa est.
    4.76 (weak acid)

    Molecular weight
    103.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    156°C

    Flash point

    • 46.74 ˚C est.

  • Synonyms

    • 2-Methylthiazolidine
    • 24050-16-6
    • 2-Methyl-1,3-thiazolidine
    • THIAZOLIDINE, 2-METHYL-
    • 2-Methyltetrahydrothiazole
    • Methyl-2 thiazolidine
    • BRN 0102519
    • UNII-938P672IFL
    • 938P672IFL
    • DTXSID60865132
    • 4-27-00-00661 (Beilstein Handbook Reference)
    • Methyl-2 thiazolidine [French]
    • MFCD00053110
    • 2-methyl thiazolidine
    • Thiazolidine,2-methyl-
    • SCHEMBL4957
    • 2-Methylthiazolidine, 98%
    • (+/-)-2-Methylthiazolidine
    • 2-Methyl-1,3-thiazolidine #
    • DTXCID20813578
    • CHEBI:166517
    • (2R)-2-methyl-1,3-thiazolidine
    • AKOS009157533
    • 2-Methyl-1,3-thiazolidine, AldrichCPR
    • BP-10919
    • BS-22937
    • CS-0206098
    • Q27271575
    • 607-310-0
    • XVT

  • Applications

    2-Methylthiazolidine is primarily used as an intermediate in organic synthesis, providing a thiazolidine-based scaffold for subsequent derivatization. In fragrance and flavor chemistry, related thiazolidine structures are evaluated for odor and taste-modifying properties, so this compound may serve as a precursor or building block in fragrance formulations and flavor synthesis. It also appears in cosmetics and personal care as a synthesis intermediate for fragrance ingredients. In industrial manufacturing, it can function as a reactive building block for specialty polymers and crosslinking or functional additives. Additionally, it is considered for use in coatings and inks as a functional intermediate, with its role dependent on formulation needs and regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 524.27
    methanol 730.79
    isopropanol 290.57
    water 50.42
    ethyl acetate 383.22
    n-propanol 378.63
    acetone 643.07
    n-butanol 332.21
    acetonitrile 392.55
    DMF 650.48
    toluene 96.85
    isobutanol 215.17
    1,4-dioxane 521.89
    methyl acetate 367.03
    THF 761.74
    2-butanone 379.19
    n-pentanol 179.41
    sec-butanol 232.74
    n-hexane 8.04
    ethylene glycol 290.05
    NMP 617.05
    cyclohexane 26.59
    DMSO 714.28
    n-butyl acetate 297.29
    n-octanol 126.49
    chloroform 951.94
    n-propyl acetate 165.58
    acetic acid 969.19
    dichloromethane 570.38
    cyclohexanone 480.1
    propylene glycol 341.25
    isopropyl acetate 175.94
    DMAc 532.41
    2-ethoxyethanol 346.77
    isopentanol 193.4
    n-heptane 22.61
    ethyl formate 340.1
    1,2-dichloroethane 269.3
    n-hexanol 260.02
    2-methoxyethanol 726.79
    isobutyl acetate 95.6
    tetrachloromethane 182.75
    n-pentyl acetate 161.49
    transcutol 743.18
    n-heptanol 160.11
    ethylbenzene 24.92
    MIBK 125.96
    2-propoxyethanol 488.59
    tert-butanol 230.1
    MTBE 131.41
    2-butoxyethanol 300.86
    propionic acid 516.14
    o-xylene 60.91
    formic acid 622.84
    diethyl ether 170.28
    m-xylene 64.66
    p-xylene 40.95
    chlorobenzene 191.6
    dimethyl carbonate 130.95
    n-octane 8.02
    formamide 590.81
    cyclopentanone 693.19
    2-pentanone 297.13
    anisole 104.49
    cyclopentyl methyl ether 271.94
    gamma-butyrolactone 744.86
    1-methoxy-2-propanol 452.91
    pyridine 462.24
    3-pentanone 210.35
    furfural 714.92
    n-dodecane 7.05
    diethylene glycol 442.02
    diisopropyl ether 42.58
    tert-amyl alcohol 190.08
    acetylacetone 342.02
    n-hexadecane 7.77
    acetophenone 124.87
    methyl propionate 286.31
    isopentyl acetate 171.04
    trichloroethylene 695.39
    n-nonanol 111.11
    cyclohexanol 232.83
    benzyl alcohol 149.0
    2-ethylhexanol 133.7
    isooctanol 101.36
    dipropyl ether 125.64
    1,2-dichlorobenzene 165.41
    ethyl lactate 116.54
    propylene carbonate 374.26
    n-methylformamide 576.05
    2-pentanol 175.99
    n-pentane 16.01
    1-propoxy-2-propanol 361.26
    1-methoxy-2-propyl acetate 258.38
    2-(2-methoxypropoxy) propanol 161.49
    mesitylene 35.72
    ε-caprolactone 373.77
    p-cymene 45.64
    epichlorohydrin 527.03
    1,1,1-trichloroethane 322.1
    2-aminoethanol 419.92
    morpholine-4-carbaldehyde 563.34
    sulfolane 623.22
    2,2,4-trimethylpentane 9.61
    2-methyltetrahydrofuran 409.69
    n-hexyl acetate 161.15
    isooctane 6.59
    2-(2-butoxyethoxy)ethanol 282.48
    sec-butyl acetate 89.45
    tert-butyl acetate 137.93
    decalin 8.98
    glycerin 512.07
    diglyme 488.7
    acrylic acid 507.41
    isopropyl myristate 52.49
    n-butyric acid 625.59
    acetyl acetate 258.13
    di(2-ethylhexyl) phthalate 70.68
    ethyl propionate 134.41
    nitromethane 1131.88
    1,2-diethoxyethane 228.41
    benzonitrile 201.45
    trioctyl phosphate 53.9
    1-bromopropane 125.65
    gamma-valerolactone 777.36
    n-decanol 79.91
    triethyl phosphate 68.62
    4-methyl-2-pentanol 79.68
    propionitrile 258.55
    vinylene carbonate 387.47
    1,1,2-trichlorotrifluoroethane 599.17
    DMS 113.88
    cumene 21.09
    2-octanol 82.85
    2-hexanone 142.61
    octyl acetate 85.87
    limonene 74.08
    1,2-dimethoxyethane 307.63
    ethyl orthosilicate 66.29
    tributyl phosphate 61.27
    diacetone alcohol 212.83
    N,N-dimethylaniline 63.67
    acrylonitrile 361.03
    aniline 259.15
    1,3-propanediol 456.84
    bromobenzene 160.12
    dibromomethane 326.03
    1,1,2,2-tetrachloroethane 526.92
    2-methyl-cyclohexyl acetate 100.96
    tetrabutyl urea 85.12
    diisobutyl methanol 59.79
    2-phenylethanol 184.16
    styrene 40.68
    dioctyl adipate 81.55
    dimethyl sulfate 205.73
    ethyl butyrate 167.43
    methyl lactate 216.26
    butyl lactate 146.27
    diethyl carbonate 100.21
    propanediol butyl ether 247.07
    triethyl orthoformate 120.48
    p-tert-butyltoluene 46.18
    methyl 4-tert-butylbenzoate 128.46
    morpholine 563.51
    tert-butylamine 118.76
    n-dodecanol 57.45
    dimethoxymethane 304.29
    ethylene carbonate 305.12
    cyrene 163.36
    2-ethoxyethyl acetate 229.83
    2-ethylhexyl acetate 138.89
    1,2,4-trichlorobenzene 222.01
    4-methylpyridine 315.6
    dibutyl ether 87.17
    2,6-dimethyl-4-heptanol 59.79
    DEF 301.89
    dimethyl isosorbide 240.31
    tetrachloroethylene 402.43
    eugenol 146.53
    triacetin 170.14
    span 80 180.05
    1,4-butanediol 189.71
    1,1-dichloroethane 330.08
    2-methyl-1-pentanol 113.81
    methyl formate 390.23
    2-methyl-1-butanol 194.15
    n-decane 11.95
    butyronitrile 273.89
    3,7-dimethyl-1-octanol 91.78
    1-chlorooctane 51.35
    1-chlorotetradecane 19.1
    n-nonane 10.98
    undecane 8.8
    tert-butylcyclohexane 7.99
    cyclooctane 9.99
    cyclopentanol 321.46
    tetrahydropyran 357.79
    tert-amyl methyl ether 103.94
    2,5,8-trioxanonane 315.6
    1-hexene 30.22
    2-isopropoxyethanol 192.89
    2,2,2-trifluoroethanol 434.99
    methyl butyrate 171.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction