2-Methyltetrahydrofuran

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  • Identifiers

    CAS number
    96-47-9

    Molecular formula
    C5H10O

    SMILES
    CC1CCCO1

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 87.56%
    Ethereal 71.47%
    Solvent 67.62%
    Mint 53.86%
    Musty 36.83%
    Camphoreous 33.26%
    Pungent 29.32%
    Rummy 28.94%
    Alcoholic 28.48%
    Fermented 27.79%

     

    Flavor
    Vegetable 31.09%
    Green 30.26%
    Caramel 29.93%
    Earthy 25.98%
    Sweet 24.78%
    Herbal 22.82%
    Cauliflower 21.44%
    Minty 21.01%
    Camphor 20.88%
    Musty 20.74%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    7.8 (neutral)

    Molecular weight
    86.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    82°C

    Flash point

    • -12.98 ˚C est.

  • Synonyms

    • 2-METHYLTETRAHYDROFURAN
    • 96-47-9
    • 2-Methyloxolane
    • Methyltetrahydrofuran
    • Tetrahydro-2-methylfuran
    • Tetrahydrosylvan
    • Furan, tetrahydro-2-methyl-
    • Furan, 2-methyl-tetrahydro-
    • Furan, tetrahydromethyl-
    • 25265-68-3
    • methyl tetrahydrofuran
    • 2-MeTHF
    • Tetrahydrosilvan
    • FCD0VD8ALF
    • UNII-FCD0VD8ALF
    • NSC 2115
    • 2-Methylfuranidine
    • EINECS 202-507-4
    • BRN 0102448
    • CCRIS 8717
    • DTXSID9030258
    • AI3-25425
    • NSC-2115
    • EINECS 246-769-8
    • MFCD00005367
    • UN2536
    • Tetrahydrofuran, 2-methyl-
    • DTXCID7010258
    • EC 202-507-4
    • 5-17-01-00078 (Beilstein Handbook Reference)
    • 2-METHYLTETRAHYDROFURAN [MI]
    • (+/-)-2-METHYLTETRAHYDROFURAN
    • 2-methyl tetrahydrofuran
    • 2-methyl-tetrahydrofuran
    • 2-methyl-tetrahydro-furan
    • 2Methyloxolane
    • MeTHF
    • (+/-)-2-Methyltetrahydrofuran; MTHF; NSC 2115; Tetrahydro-2-methylfuran; Tetrahydrosylvan; 2-Me-THF
    • methyl-tetrahydrofuran
    • Tetrahydro2methylfuran
    • Me-THF
    • Methyl tetrahydrofurane
    • 2-methyltetrahyrdofuran
    • 2-methyltetrahydrofurane
    • Furan, 2methyltetrahydro
    • Furan, tetrahydro2methyl
    • 2-methyl tetrahydrofurane
    • 2-methyl-tetrahydrofurane
    • Tetrahydrosylvan;Methy THF
    • WLN: T5OTJ B1
    • (2S)-2-methyltetrahydrofuran
    • CHEMBL1580503
    • NSC2115
    • BCP16203
    • STR08776
    • Tox21_200383
    • AKOS009157664
    • FM14741
    • CAS-96-47-9
    • NCGC00090914-01
    • NCGC00090914-02
    • NCGC00257937-01
    • 2-Methyltetrahydrofuran, analytical standard
    • DB-015964
    • CS-0010107
    • M0437
    • NS00007944
    • 2-Methyltetrahydrofuran (stabilized with BHT)
    • 2-Methyltetrahydrofuran - Stabilized with BHT
    • EN300-60207
    • E80342
    • 2-Methyltetrahydrofuran, purum, >=97.0% (GC)
    • Q209444
    • Methyltetrahydrofuran [UN2536] [Flammable liquid]
    • 2-Methyltetrahydrofuran, 99+%, unstabilized, Extra Dry
    • 2-Methyltetrahydrofuran, anhydrous, >=99%, Inhibitor-free
    • 2-Methyltetrahydrofuran, absolute, stored over molecular sieve
    • 2-Methyltetrahydrofuran, stabilized, anhydrous, water Max 20ppm
    • 2-Methyltetrahydrofuran, anhydrous, >=99.0%, contains 250 ppm BHT as stabilizer
    • 2-Methyltetrahydrofuran, ReagentPlus(R), >=99.5%, contains 150-400 ppm BHT as stabilizer
    • 2-Methyltetrahydrofuran, anhydrous, contains 250 ppm BHT as stabilizer, ZerO2(TM), >=99.0%
    • 246-769-8

  • Applications

    2-Methyltetrahydrofuran (CAS 96-47-9) is a renewable ether solvent increasingly used as a greener alternative to THF in industrial processes. It serves as a processing solvent for polymers and resins in polymerization and formulation work, and is widely used in coatings, inks, and adhesive formulations to improve pigment dispersion and film formation. In pharmaceutical development and manufacturing, it is employed as an intermediate solvent for crystallization, extraction, and purification steps, offering lower peroxide propensity and easier recovery compared with traditional ethers. It can also be used in cleaning formulations and industrial cleaners as a high-boiling, water-immiscible solvent. Under local regulations and formulation limits, 2-MeTHF is chosen as a sustainable solvent option in production and processing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2343.4
    methanol 2232.64
    isopropanol 1673.07
    water 30.85
    ethyl acetate 1285.73
    n-propanol 1701.55
    acetone 1314.2
    n-butanol 1359.25
    acetonitrile 1713.87
    DMF 931.3
    toluene 444.83
    isobutanol 1017.39
    1,4-dioxane 2026.93
    methyl acetate 1170.99
    THF 1750.77
    2-butanone 1014.94
    n-pentanol 796.16
    sec-butanol 1297.51
    n-hexane 170.61
    ethylene glycol 718.75
    NMP 724.13
    cyclohexane 264.73
    DMSO 997.22
    n-butyl acetate 537.14
    n-octanol 375.64
    chloroform 4033.41
    n-propyl acetate 383.32
    acetic acid 2163.07
    dichloromethane 2709.65
    cyclohexanone 892.31
    propylene glycol 1117.37
    isopropyl acetate 567.56
    DMAc 822.93
    2-ethoxyethanol 1100.92
    isopentanol 857.89
    n-heptane 162.86
    ethyl formate 619.31
    1,2-dichloroethane 1123.95
    n-hexanol 872.42
    2-methoxyethanol 1815.78
    isobutyl acetate 220.17
    tetrachloromethane 798.04
    n-pentyl acetate 320.49
    transcutol 2490.57
    n-heptanol 362.74
    ethylbenzene 155.07
    MIBK 348.01
    2-propoxyethanol 1239.78
    tert-butanol 1330.34
    MTBE 786.77
    2-butoxyethanol 611.17
    propionic acid 1386.12
    o-xylene 243.81
    formic acid 747.34
    diethyl ether 1257.83
    m-xylene 257.36
    p-xylene 194.69
    chlorobenzene 579.41
    dimethyl carbonate 259.56
    n-octane 52.18
    formamide 826.21
    cyclopentanone 972.47
    2-pentanone 763.3
    anisole 411.15
    cyclopentyl methyl ether 738.99
    gamma-butyrolactone 1086.14
    1-methoxy-2-propanol 1321.38
    pyridine 1427.39
    3-pentanone 582.77
    furfural 1030.42
    n-dodecane 42.4
    diethylene glycol 1092.13
    diisopropyl ether 260.96
    tert-amyl alcohol 987.4
    acetylacetone 692.02
    n-hexadecane 45.2
    acetophenone 295.8
    methyl propionate 788.01
    isopentyl acetate 356.23
    trichloroethylene 2028.43
    n-nonanol 319.4
    cyclohexanol 865.9
    benzyl alcohol 459.75
    2-ethylhexanol 398.22
    isooctanol 248.16
    dipropyl ether 497.61
    1,2-dichlorobenzene 457.43
    ethyl lactate 240.55
    propylene carbonate 590.54
    n-methylformamide 830.7
    2-pentanol 839.2
    n-pentane 225.32
    1-propoxy-2-propanol 815.17
    1-methoxy-2-propyl acetate 521.19
    2-(2-methoxypropoxy) propanol 458.41
    mesitylene 139.69
    ε-caprolactone 842.97
    p-cymene 129.05
    epichlorohydrin 1297.05
    1,1,1-trichloroethane 1397.31
    2-aminoethanol 1302.43
    morpholine-4-carbaldehyde 1086.01
    sulfolane 755.86
    2,2,4-trimethylpentane 82.25
    2-methyltetrahydrofuran 1394.81
    n-hexyl acetate 458.45
    isooctane 54.31
    2-(2-butoxyethoxy)ethanol 717.23
    sec-butyl acetate 257.5
    tert-butyl acetate 424.32
    decalin 71.51
    glycerin 1036.9
    diglyme 1082.21
    acrylic acid 1140.11
    isopropyl myristate 155.19
    n-butyric acid 1514.62
    acetyl acetate 689.93
    di(2-ethylhexyl) phthalate 147.08
    ethyl propionate 396.23
    nitromethane 1838.79
    1,2-diethoxyethane 728.19
    benzonitrile 548.24
    trioctyl phosphate 106.07
    1-bromopropane 929.36
    gamma-valerolactone 1227.34
    n-decanol 228.76
    triethyl phosphate 136.85
    4-methyl-2-pentanol 359.96
    propionitrile 1107.27
    vinylene carbonate 560.67
    1,1,2-trichlorotrifluoroethane 1217.01
    DMS 301.68
    cumene 104.65
    2-octanol 221.51
    2-hexanone 366.81
    octyl acetate 220.9
    limonene 210.79
    1,2-dimethoxyethane 930.75
    ethyl orthosilicate 143.43
    tributyl phosphate 133.69
    diacetone alcohol 537.74
    N,N-dimethylaniline 223.96
    acrylonitrile 1175.23
    aniline 807.12
    1,3-propanediol 1295.98
    bromobenzene 558.89
    dibromomethane 1928.8
    1,1,2,2-tetrachloroethane 1594.49
    2-methyl-cyclohexyl acetate 207.58
    tetrabutyl urea 159.07
    diisobutyl methanol 184.94
    2-phenylethanol 438.71
    styrene 238.63
    dioctyl adipate 207.26
    dimethyl sulfate 299.03
    ethyl butyrate 353.91
    methyl lactate 426.89
    butyl lactate 271.14
    diethyl carbonate 216.25
    propanediol butyl ether 550.24
    triethyl orthoformate 249.13
    p-tert-butyltoluene 129.71
    methyl 4-tert-butylbenzoate 270.39
    morpholine 2271.33
    tert-butylamine 945.98
    n-dodecanol 170.38
    dimethoxymethane 710.87
    ethylene carbonate 493.45
    cyrene 272.93
    2-ethoxyethyl acetate 479.91
    2-ethylhexyl acetate 279.63
    1,2,4-trichlorobenzene 539.28
    4-methylpyridine 978.49
    dibutyl ether 380.6
    2,6-dimethyl-4-heptanol 184.94
    DEF 743.93
    dimethyl isosorbide 466.05
    tetrachloroethylene 1149.7
    eugenol 288.39
    triacetin 405.82
    span 80 470.91
    1,4-butanediol 508.61
    1,1-dichloroethane 1637.04
    2-methyl-1-pentanol 494.6
    methyl formate 465.74
    2-methyl-1-butanol 816.55
    n-decane 75.4
    butyronitrile 1028.45
    3,7-dimethyl-1-octanol 322.31
    1-chlorooctane 213.14
    1-chlorotetradecane 85.11
    n-nonane 77.67
    undecane 54.01
    tert-butylcyclohexane 66.95
    cyclooctane 79.25
    cyclopentanol 964.41
    tetrahydropyran 1636.79
    tert-amyl methyl ether 509.18
    2,5,8-trioxanonane 708.05
    1-hexene 409.63
    2-isopropoxyethanol 661.15
    2,2,2-trifluoroethanol 645.11
    methyl butyrate 430.32

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction