2-Methylpyridin-3-ol

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  • Identifiers

    CAS number
    1121-25-1

    Molecular formula
    C6H7NO

    SMILES
    CC1=C(C=CC=N1)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 56.2%
    Phenolic 55.21%
    Roasted 52.99%
    Burnt 52.68%
    Nutty 47.99%
    Smoky 45.28%
    Caramellic 42.04%
    Vanilla 41.13%
    Musty 39.56%
    Coffee 37.17%

     

    Flavor
    Nutty 47.47%
    Phenolic 45.1%
    Coffee 39.02%
    Musty 38.75%
    Bitter 34.91%
    Roasted 32.46%
    Meaty 31.92%
    Medicinal 30.36%
    Sweet 30.27%
    Almond 30.12%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    8.0 (weak base)

    Molecular weight
    109.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    230°C

    Flash point

    • 93.17 ˚C est.

  • Synonyms

    • 3-Hydroxy-2-methylpyridine
    • 1121-25-1
    • 2-Methylpyridin-3-ol
    • 3-Pyridinol, 2-methyl-
    • 365FJ23A8Z
    • EINECS 214-327-3
    • NSC-27506
    • DTXSID40149907
    • NSC 27506
    • RefChem:476225
    • DTXCID6072398
    • 214-327-3
    • 3-Hydroxy-2-picoline
    • 2-Methyl-3-pyridinol
    • 2-Methyl-3-hydroxypyridine
    • MFCD00082538
    • 55780-69-3
    • 3-Hydroxy-2-methylpyridine-d3
    • 2-Methyl-pyridin-3-ol
    • 3-hydroxyl-2-methylpyridine
    • 3-Pyridinol, methyl-
    • UNII-365FJ23A8Z
    • 2-Methyl-3-pyridinol; 2-Methyl-3-hydroxypyridine; NSC 27506;
    • NSC27506
    • 2methylpyridin-3-ol
    • 2-methyl-3-pyridol
    • 2-methylpyridine-3-ol
    • 2-methyl-pyridine-3-ol
    • 2-methyl 3-hydroxy pyridine
    • 2-methyl-3-hydroxy-pyridine
    • 3-hydroxy-2-methyl pyridine
    • SCHEMBL118678
    • SCHEMBL323906
    • SCHEMBL693562
    • CHEMBL134348
    • orb1301402
    • SCHEMBL2068597
    • SCHEMBL3518716
    • SCHEMBL29776703
    • CHEBI:211253
    • 3-Hydroxy-2-methylpyridine, 99%
    • STR06099
    • CL0055
    • MSK165122
    • AKOS005145808
    • AC-5084
    • CS-W002339
    • EBC-617467
    • FH10720
    • HY-W002339
    • PB18442
    • PS-9276
    • SB10555
    • BP-12767
    • PD158232
    • SY007645
    • DB-009071
    • H1365
    • NS00015314
    • EN300-55470
    • 121H251
    • AQ-344/40575762
    • F044756
    • Q27256528
    • F0001-0267
    • 1121-25-1

  • Applications

    2-Methylpyridin-3-ol (CAS 1121-25-1) is commonly used as a building block and intermediate in the synthesis of heterocyclic compounds for pharmaceuticals and agrochemicals, and it can serve as a precursor to ligands for industrial catalysis and coordination chemistry. It may also find utility in fragrance and flavor applications as a specialty odorant or precursor for aroma compounds, and in dye and pigment chemistry as a starting point for heterocyclic dye systems. In addition, it is used in materials-related work as a functionalized pyridine building block for polymer, coating, or ink formulations where ring substitutions enable tailored properties.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 134.44
    methanol 275.28
    isopropanol 87.3
    water 21.35
    ethyl acetate 36.27
    n-propanol 111.3
    acetone 20.97
    n-butanol 101.42
    acetonitrile 53.16
    DMF 111.72
    toluene 17.47
    isobutanol 83.43
    1,4-dioxane 100.69
    methyl acetate 44.06
    THF 150.7
    2-butanone 42.0
    n-pentanol 84.19
    sec-butanol 76.35
    n-hexane 5.88
    ethylene glycol 34.23
    NMP 89.06
    cyclohexane 3.65
    DMSO 143.4
    n-butyl acetate 49.62
    n-octanol 23.16
    chloroform 96.94
    n-propyl acetate 28.13
    acetic acid 119.64
    dichloromethane 105.28
    cyclohexanone 61.93
    propylene glycol 27.49
    isopropyl acetate 21.53
    DMAc 118.75
    2-ethoxyethanol 105.97
    isopentanol 85.07
    n-heptane 6.64
    ethyl formate 60.15
    1,2-dichloroethane 61.6
    n-hexanol 62.64
    2-methoxyethanol 147.6
    isobutyl acetate 18.04
    tetrachloromethane 26.38
    n-pentyl acetate 37.1
    transcutol 253.19
    n-heptanol 33.71
    ethylbenzene 8.41
    MIBK 29.63
    2-propoxyethanol 88.05
    tert-butanol 107.26
    MTBE 61.89
    2-butoxyethanol 62.42
    propionic acid 79.23
    o-xylene 18.79
    formic acid 170.28
    diethyl ether 51.95
    m-xylene 14.7
    p-xylene 13.19
    chlorobenzene 28.32
    dimethyl carbonate 13.71
    n-octane 2.74
    formamide 206.72
    cyclopentanone 75.57
    2-pentanone 35.48
    anisole 28.55
    cyclopentyl methyl ether 54.54
    gamma-butyrolactone 104.78
    1-methoxy-2-propanol 75.08
    pyridine 72.51
    3-pentanone 27.49
    furfural 128.38
    n-dodecane 1.93
    diethylene glycol 71.99
    diisopropyl ether 14.76
    tert-amyl alcohol 98.27
    acetylacetone 24.82
    n-hexadecane 2.07
    acetophenone 27.49
    methyl propionate 31.0
    isopentyl acetate 40.92
    trichloroethylene 91.95
    n-nonanol 21.11
    cyclohexanol 48.36
    benzyl alcohol 33.99
    2-ethylhexanol 33.45
    isooctanol 28.81
    dipropyl ether 31.72
    1,2-dichlorobenzene 27.75
    ethyl lactate 18.22
    propylene carbonate 54.84
    n-methylformamide 120.05
    2-pentanol 54.2
    n-pentane 6.9
    1-propoxy-2-propanol 57.76
    1-methoxy-2-propyl acetate 37.79
    2-(2-methoxypropoxy) propanol 54.98
    mesitylene 10.93
    ε-caprolactone 65.55
    p-cymene 12.66
    epichlorohydrin 118.7
    1,1,1-trichloroethane 44.89
    2-aminoethanol 80.89
    morpholine-4-carbaldehyde 114.92
    sulfolane 114.08
    2,2,4-trimethylpentane 5.66
    2-methyltetrahydrofuran 87.66
    n-hexyl acetate 35.16
    isooctane 3.99
    2-(2-butoxyethoxy)ethanol 81.06
    sec-butyl acetate 17.98
    tert-butyl acetate 30.95
    decalin 3.24
    glycerin 52.45
    diglyme 136.21
    acrylic acid 64.49
    isopropyl myristate 15.51
    n-butyric acid 102.55
    acetyl acetate 19.88
    di(2-ethylhexyl) phthalate 19.26
    ethyl propionate 19.44
    nitromethane 131.17
    1,2-diethoxyethane 73.15
    benzonitrile 43.31
    trioctyl phosphate 15.08
    1-bromopropane 39.06
    gamma-valerolactone 114.89
    n-decanol 15.63
    triethyl phosphate 19.21
    4-methyl-2-pentanol 34.15
    propionitrile 59.24
    vinylene carbonate 55.45
    1,1,2-trichlorotrifluoroethane 80.47
    DMS 24.59
    cumene 9.83
    2-octanol 22.2
    2-hexanone 34.07
    octyl acetate 19.21
    limonene 17.59
    1,2-dimethoxyethane 113.55
    ethyl orthosilicate 21.08
    tributyl phosphate 20.17
    diacetone alcohol 45.65
    N,N-dimethylaniline 25.77
    acrylonitrile 69.78
    aniline 45.41
    1,3-propanediol 102.73
    bromobenzene 22.02
    dibromomethane 68.37
    1,1,2,2-tetrachloroethane 69.85
    2-methyl-cyclohexyl acetate 26.1
    tetrabutyl urea 23.91
    diisobutyl methanol 21.41
    2-phenylethanol 35.52
    styrene 10.75
    dioctyl adipate 21.88
    dimethyl sulfate 29.42
    ethyl butyrate 32.19
    methyl lactate 23.22
    butyl lactate 31.79
    diethyl carbonate 21.97
    propanediol butyl ether 43.84
    triethyl orthoformate 29.79
    p-tert-butyltoluene 12.09
    methyl 4-tert-butylbenzoate 35.34
    morpholine 124.0
    tert-butylamine 66.51
    n-dodecanol 12.09
    dimethoxymethane 67.72
    ethylene carbonate 45.41
    cyrene 44.68
    2-ethoxyethyl acetate 52.22
    2-ethylhexyl acetate 31.91
    1,2,4-trichlorobenzene 33.61
    4-methylpyridine 67.52
    dibutyl ether 26.59
    2,6-dimethyl-4-heptanol 21.41
    DEF 57.39
    dimethyl isosorbide 83.13
    tetrachloroethylene 65.62
    eugenol 42.35
    triacetin 32.36
    span 80 39.73
    1,4-butanediol 51.09
    1,1-dichloroethane 47.2
    2-methyl-1-pentanol 70.52
    methyl formate 67.83
    2-methyl-1-butanol 80.86
    n-decane 3.14
    butyronitrile 66.25
    3,7-dimethyl-1-octanol 24.44
    1-chlorooctane 10.88
    1-chlorotetradecane 4.94
    n-nonane 2.92
    undecane 2.37
    tert-butylcyclohexane 4.38
    cyclooctane 1.96
    cyclopentanol 63.36
    tetrahydropyran 73.21
    tert-amyl methyl ether 50.4
    2,5,8-trioxanonane 99.85
    1-hexene 20.37
    2-isopropoxyethanol 59.38
    2,2,2-trifluoroethanol 51.99
    methyl butyrate 33.95

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction