2-Methylpropanal oxime

Overview IFRA Request a quote

  • Identifiers

    CAS number
    151-00-8

    Molecular formula
    C4H9NO

    SMILES
    CC(C)/C=N/O

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 72.45%
    Pungent 47.86%
    Fruity 42.2%
    Ethereal 37.94%
    Vegetable 36.71%
    Fermented 35.82%
    Cocoa 35.21%
    Fresh 31.67%
    Alcoholic 29.71%
    Sharp 29.71%

     

    Flavor
    Green 36.41%
    Pungent 33.79%
    Cheese 25.4%
    Mustard 23.31%
    Oily 22.8%
    Ethereal 22.24%
    Sharp 21.26%
    Tomato 21.06%
    Tropical 20.96%
    Onion 20.87%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    8.68 (weak base)

    Molecular weight
    87.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    152°C

    Flash point

    • 41.2 ˚C est.

  • Synonyms

    • Isobutyraldehyde oxime
    • 151-00-8
    • 2-Methylpropanal oxime
    • Isobutylaldoxime
    • Isobutyraldeoxime
    • Isobutanal oxime
    • 2-Methyl-1-propanal oxime
    • Isobutyraldoxime
    • (NE)-N-(2-methylpropylidene)hydroxylamine
    • NSC 8425
    • EINECS 205-779-2
    • USAF AM-8
    • 5EW54CL2K7
    • AI3-07277
    • N-hydroxy-2-methylpropanimine
    • CHEBI:17502
    • 1-(hydroxyimino)-2-methylpropane
    • NSC-8425
    • RefChem:476177
    • 205-779-2
    • (E)-2-methylpropanal oxime
    • (E)-isobutyraldehyde oxime
    • (E)-isobutyraldoxime
    • MFCD00013940
    • (1E)-2-Methylpropanal oxime
    • 2-methyl-propionaldehyde oxime
    • isobutyraldehyde (E)-oxime
    • (E)-2-methylpropionaldoxime
    • (E)-2-methylpropionaldehyde oxime
    • 5775-73-5
    • ISOBUTYRALDEHYDE, OXIME
    • Isobutyraldoxim
    • Isobutyraldehydeoxime
    • (E)-Isobutanal oxime
    • (E)-N-(2-methylpropylidene)hydroxylamine
    • (E)-2-methylpropanal-oxime
    • UNII-5EW54CL2K7
    • (1E)-2-methylpropionaldoxime
    • orb1302441
    • SCHEMBL1234657
    • SCHEMBL7296055
    • SCHEMBL7350892
    • CHEBI:61143
    • (1E)-2-Methylpropanal oxime #
    • Propyl aldoxime, 2-methyl-, anti-
    • Propanal, 2-methyl-, oxime, (E)-
    • AKOS009143906
    • AKOS025310547
    • AS-6280
    • CS-W000111
    • propanal, 2-methyl-, oxime, (1E)-
    • (1E)-N-hydroxy-2-methylpropan-1-imine
    • SY318972
    • NS00024930
    • C03219
    • D77551
    • EN300-206306
    • F986266
    • Q27102429
    • Q27130845
    • 151-00-8

  • Applications

    2-Methylpropanal oxime (CAS 151-00-8) is primarily used as an organic synthesis intermediate. It serves as a versatile building block for oxime chemistry and can be transformed into other functional groups, such as by reduction to amines or dehydration to nitriles, enabling access to isobutyl-containing compounds. In research and development, it is encountered as a precursor in pharmaceutical and agrochemical syntheses and as a basis for developing functionalized monomers for coatings, adhesives, and plastics through subsequent functionalization. Depending on formulation and regulatory context, it may be considered as a reactive intermediate in synthesis workflows or in processing sequences involving oxime chemistry.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 59.04
    methanol 128.36
    isopropanol 22.01
    water 10.81
    ethyl acetate 11.75
    n-propanol 37.55
    acetone 20.16
    n-butanol 30.48
    acetonitrile 14.77
    DMF 23.17
    toluene 2.5
    isobutanol 24.8
    1,4-dioxane 22.44
    methyl acetate 14.91
    THF 54.07
    2-butanone 16.59
    n-pentanol 17.77
    sec-butanol 21.63
    n-hexane 3.2
    ethylene glycol 52.3
    NMP 104.24
    cyclohexane 2.68
    DMSO 51.6
    n-butyl acetate 36.2
    n-octanol 23.91
    chloroform 44.65
    n-propyl acetate 14.56
    acetic acid 230.67
    dichloromethane 32.16
    cyclohexanone 49.14
    propylene glycol 49.53
    isopropyl acetate 7.79
    DMAc 26.69
    2-ethoxyethanol 31.39
    isopentanol 21.97
    n-heptane 4.97
    ethyl formate 20.32
    1,2-dichloroethane 18.69
    n-hexanol 51.29
    2-methoxyethanol 58.34
    isobutyl acetate 12.12
    tetrachloromethane 10.07
    n-pentyl acetate 19.77
    transcutol 144.62
    n-heptanol 24.8
    ethylbenzene 3.36
    MIBK 11.91
    2-propoxyethanol 72.93
    tert-butanol 30.41
    MTBE 8.75
    2-butoxyethanol 43.85
    propionic acid 82.95
    o-xylene 4.35
    formic acid 125.57
    diethyl ether 5.82
    m-xylene 4.09
    p-xylene 5.24
    chlorobenzene 12.33
    dimethyl carbonate 6.38
    n-octane 1.82
    formamide 58.35
    cyclopentanone 62.49
    2-pentanone 13.4
    anisole 10.04
    cyclopentyl methyl ether 20.43
    gamma-butyrolactone 94.85
    1-methoxy-2-propanol 33.92
    pyridine 17.88
    3-pentanone 10.48
    furfural 80.92
    n-dodecane 1.71
    diethylene glycol 74.04
    diisopropyl ether 2.86
    tert-amyl alcohol 30.14
    acetylacetone 17.5
    n-hexadecane 1.77
    acetophenone 18.23
    methyl propionate 13.11
    isopentyl acetate 35.2
    trichloroethylene 48.9
    n-nonanol 21.22
    cyclohexanol 31.38
    benzyl alcohol 16.57
    2-ethylhexanol 33.0
    isooctanol 19.98
    dipropyl ether 15.13
    1,2-dichlorobenzene 19.33
    ethyl lactate 20.77
    propylene carbonate 59.71
    n-methylformamide 32.83
    2-pentanol 14.47
    n-pentane 2.14
    1-propoxy-2-propanol 59.81
    1-methoxy-2-propyl acetate 34.41
    2-(2-methoxypropoxy) propanol 61.91
    mesitylene 4.05
    ε-caprolactone 53.76
    p-cymene 10.02
    epichlorohydrin 49.61
    1,1,1-trichloroethane 20.21
    2-aminoethanol 65.18
    morpholine-4-carbaldehyde 62.31
    sulfolane 154.93
    2,2,4-trimethylpentane 2.67
    2-methyltetrahydrofuran 36.03
    n-hexyl acetate 34.8
    isooctane 2.03
    2-(2-butoxyethoxy)ethanol 72.8
    sec-butyl acetate 9.34
    tert-butyl acetate 15.72
    decalin 2.94
    glycerin 77.2
    diglyme 72.54
    acrylic acid 92.88
    isopropyl myristate 16.45
    n-butyric acid 69.01
    acetyl acetate 14.12
    di(2-ethylhexyl) phthalate 29.05
    ethyl propionate 11.91
    nitromethane 94.49
    1,2-diethoxyethane 19.41
    benzonitrile 19.59
    trioctyl phosphate 22.43
    1-bromopropane 8.91
    gamma-valerolactone 78.86
    n-decanol 16.96
    triethyl phosphate 17.45
    4-methyl-2-pentanol 11.78
    propionitrile 13.26
    vinylene carbonate 48.54
    1,1,2-trichlorotrifluoroethane 85.4
    DMS 25.45
    cumene 5.11
    2-octanol 15.21
    2-hexanone 15.05
    octyl acetate 23.51
    limonene 15.33
    1,2-dimethoxyethane 25.23
    ethyl orthosilicate 16.27
    tributyl phosphate 27.51
    diacetone alcohol 36.14
    N,N-dimethylaniline 9.77
    acrylonitrile 20.19
    aniline 11.26
    1,3-propanediol 58.13
    bromobenzene 8.82
    dibromomethane 21.56
    1,1,2,2-tetrachloroethane 43.68
    2-methyl-cyclohexyl acetate 34.3
    tetrabutyl urea 31.49
    diisobutyl methanol 18.52
    2-phenylethanol 30.07
    styrene 3.42
    dioctyl adipate 29.71
    dimethyl sulfate 18.23
    ethyl butyrate 21.77
    methyl lactate 23.21
    butyl lactate 37.79
    diethyl carbonate 16.17
    propanediol butyl ether 59.65
    triethyl orthoformate 19.41
    p-tert-butyltoluene 10.21
    methyl 4-tert-butylbenzoate 38.66
    morpholine 31.0
    tert-butylamine 18.2
    n-dodecanol 13.9
    dimethoxymethane 12.57
    ethylene carbonate 32.99
    cyrene 55.68
    2-ethoxyethyl acetate 24.73
    2-ethylhexyl acetate 27.15
    1,2,4-trichlorobenzene 28.35
    4-methylpyridine 13.46
    dibutyl ether 12.68
    2,6-dimethyl-4-heptanol 18.52
    DEF 15.51
    dimethyl isosorbide 88.63
    tetrachloroethylene 37.49
    eugenol 43.12
    triacetin 44.33
    span 80 68.88
    1,4-butanediol 25.08
    1,1-dichloroethane 12.96
    2-methyl-1-pentanol 17.25
    methyl formate 25.85
    2-methyl-1-butanol 23.24
    n-decane 2.44
    butyronitrile 12.99
    3,7-dimethyl-1-octanol 25.59
    1-chlorooctane 10.51
    1-chlorotetradecane 5.14
    n-nonane 2.37
    undecane 1.96
    tert-butylcyclohexane 3.62
    cyclooctane 1.22
    cyclopentanol 41.54
    tetrahydropyran 18.7
    tert-amyl methyl ether 10.07
    2,5,8-trioxanonane 67.59
    1-hexene 6.36
    2-isopropoxyethanol 21.84
    2,2,2-trifluoroethanol 73.85
    methyl butyrate 17.35

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction