2-Methyl-6-(methylthio)pyrazine

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  • Identifiers

    CAS number
    2884-13-1

    Molecular formula
    C6H8N2S

    SMILES
    CC1=CN=CC(=N1)SC

  • Odor profile

    Fragrance
    Roasted 83.37%
    Nutty 79.47%
    Meaty 73.89%
    Coffee 56.85%
    Hazelnut 53.08%
    Burnt 49.95%
    Sulfurous 47.69%
    Cocoa 47.08%
    Beefy 44.38%
    Earthy 42.96%

     

    Flavor
    Roasted 60.05%
    Nutty 51.98%
    Coffee 48.81%
    Meaty 43.56%
    Roast 41.2%
    Cocoa 39.2%
    Potato 36.03%
    Sulfury 34.88%
    Vegetable 34.23%
    Hazelnut 32.15%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    2.95 (strong acid)

    Molecular weight
    140.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    219°C

    Flash point

    • 93.99 ˚C est.

  • Synonyms

    • 2-Methyl-6-(methylthio)pyrazine
    • 2884-13-1
    • 2-Methylthio-6-methylpyrazine
    • Pyrazine, 2-methyl-6-(methylthio)-
    • 2-methyl-6-methylsulfanylpyrazine
    • 2-Methyl-6-(methylsulfanyl)pyrazine
    • 2-Methyl-6-methylsulfanyl-pyrazine
    • UNII-9821YQG3NE
    • FEMA no. 3208, 6-(methylthio)-
    • 9821YQG3NE
    • DTXSID60183040
    • CHEMBL327251
    • SCHEMBL23882612
    • DTXCID70105531
    • AKOS006271813
    • 2-Methyl-6-(methylsulfanyl)pyrazine #
    • NS00125844
    • Q27272067

  • Applications

    2-Methyl-6-(methylthio)pyrazine (CAS 2884-13-1) is primarily used as an aroma and flavor compound, contributing savory, roasted, and nutty notes with a sulfur-containing character in specialized formulations. In perfumery, it serves as a note to add roasted-meat facets to fragrance blends; in the flavor and beverage sector, it may be used to enhance savory or umami profiles in processed foods, seasonings, or savory snacks. The compound can also function as an intermediate in organic synthesis for specialty chemicals and may appear in cosmetic and household formulations as a fragrance ingredient or odorant. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 236.39
    methanol 338.73
    isopropanol 184.72
    water 6.16
    ethyl acetate 332.78
    n-propanol 219.23
    acetone 580.25
    n-butanol 205.36
    acetonitrile 356.56
    DMF 673.7
    toluene 235.13
    isobutanol 190.65
    1,4-dioxane 581.44
    methyl acetate 297.42
    THF 813.75
    2-butanone 415.93
    n-pentanol 181.04
    sec-butanol 199.99
    n-hexane 44.95
    ethylene glycol 116.47
    NMP 713.49
    cyclohexane 72.38
    DMSO 853.31
    n-butyl acetate 286.59
    n-octanol 135.7
    chloroform 966.0
    n-propyl acetate 221.35
    acetic acid 359.57
    dichloromethane 987.71
    cyclohexanone 631.87
    propylene glycol 119.22
    isopropyl acetate 193.39
    DMAc 543.81
    2-ethoxyethanol 291.13
    isopentanol 172.64
    n-heptane 54.77
    ethyl formate 269.61
    1,2-dichloroethane 581.42
    n-hexanol 222.86
    2-methoxyethanol 402.5
    isobutyl acetate 159.64
    tetrachloromethane 215.08
    n-pentyl acetate 198.27
    transcutol 527.26
    n-heptanol 127.7
    ethylbenzene 119.57
    MIBK 200.73
    2-propoxyethanol 333.43
    tert-butanol 228.65
    MTBE 233.06
    2-butoxyethanol 220.02
    propionic acid 267.82
    o-xylene 164.71
    formic acid 146.55
    diethyl ether 275.12
    m-xylene 172.61
    p-xylene 164.76
    chlorobenzene 370.48
    dimethyl carbonate 162.08
    n-octane 27.04
    formamide 155.78
    cyclopentanone 829.34
    2-pentanone 326.65
    anisole 229.51
    cyclopentyl methyl ether 399.71
    gamma-butyrolactone 802.72
    1-methoxy-2-propanol 292.39
    pyridine 485.35
    3-pentanone 294.83
    furfural 765.9
    n-dodecane 22.81
    diethylene glycol 277.01
    diisopropyl ether 100.34
    tert-amyl alcohol 216.09
    acetylacetone 374.06
    n-hexadecane 25.94
    acetophenone 252.58
    methyl propionate 283.48
    isopentyl acetate 231.12
    trichloroethylene 1059.36
    n-nonanol 112.72
    cyclohexanol 249.14
    benzyl alcohol 213.53
    2-ethylhexanol 160.12
    isooctanol 112.08
    dipropyl ether 207.33
    1,2-dichlorobenzene 362.34
    ethyl lactate 124.46
    propylene carbonate 425.1
    n-methylformamide 323.05
    2-pentanol 151.28
    n-pentane 47.99
    1-propoxy-2-propanol 246.28
    1-methoxy-2-propyl acetate 227.68
    2-(2-methoxypropoxy) propanol 176.13
    mesitylene 114.13
    ε-caprolactone 493.81
    p-cymene 108.15
    epichlorohydrin 749.0
    1,1,1-trichloroethane 553.27
    2-aminoethanol 153.0
    morpholine-4-carbaldehyde 605.73
    sulfolane 1046.64
    2,2,4-trimethylpentane 35.62
    2-methyltetrahydrofuran 561.85
    n-hexyl acetate 240.65
    isooctane 24.53
    2-(2-butoxyethoxy)ethanol 228.04
    sec-butyl acetate 140.55
    tert-butyl acetate 206.01
    decalin 46.11
    glycerin 175.91
    diglyme 451.17
    acrylic acid 271.31
    isopropyl myristate 99.43
    n-butyric acid 309.81
    acetyl acetate 224.22
    di(2-ethylhexyl) phthalate 113.94
    ethyl propionate 193.99
    nitromethane 598.69
    1,2-diethoxyethane 253.4
    benzonitrile 337.17
    trioctyl phosphate 88.41
    1-bromopropane 331.73
    gamma-valerolactone 786.29
    n-decanol 89.5
    triethyl phosphate 112.9
    4-methyl-2-pentanol 98.97
    propionitrile 299.57
    vinylene carbonate 407.41
    1,1,2-trichlorotrifluoroethane 508.81
    DMS 198.23
    cumene 94.9
    2-octanol 104.28
    2-hexanone 254.64
    octyl acetate 132.04
    limonene 151.49
    1,2-dimethoxyethane 453.82
    ethyl orthosilicate 107.1
    tributyl phosphate 102.1
    diacetone alcohol 230.85
    N,N-dimethylaniline 174.71
    acrylonitrile 370.92
    aniline 254.49
    1,3-propanediol 195.2
    bromobenzene 401.23
    dibromomethane 661.51
    1,1,2,2-tetrachloroethane 800.99
    2-methyl-cyclohexyl acetate 168.99
    tetrabutyl urea 133.19
    diisobutyl methanol 101.18
    2-phenylethanol 217.5
    styrene 159.41
    dioctyl adipate 139.79
    dimethyl sulfate 287.38
    ethyl butyrate 208.95
    methyl lactate 168.44
    butyl lactate 154.91
    diethyl carbonate 145.28
    propanediol butyl ether 197.03
    triethyl orthoformate 143.77
    p-tert-butyltoluene 99.74
    methyl 4-tert-butylbenzoate 196.75
    morpholine 507.82
    tert-butylamine 152.19
    n-dodecanol 73.94
    dimethoxymethane 371.05
    ethylene carbonate 330.77
    cyrene 232.76
    2-ethoxyethyl acetate 235.75
    2-ethylhexyl acetate 200.6
    1,2,4-trichlorobenzene 416.49
    4-methylpyridine 500.05
    dibutyl ether 166.6
    2,6-dimethyl-4-heptanol 101.18
    DEF 370.51
    dimethyl isosorbide 312.74
    tetrachloroethylene 552.84
    eugenol 210.53
    triacetin 201.03
    span 80 173.16
    1,4-butanediol 127.03
    1,1-dichloroethane 537.72
    2-methyl-1-pentanol 167.07
    methyl formate 327.85
    2-methyl-1-butanol 187.2
    n-decane 34.96
    butyronitrile 313.8
    3,7-dimethyl-1-octanol 121.54
    1-chlorooctane 123.55
    1-chlorotetradecane 55.51
    n-nonane 36.36
    undecane 27.43
    tert-butylcyclohexane 44.21
    cyclooctane 33.31
    cyclopentanol 295.88
    tetrahydropyran 483.34
    tert-amyl methyl ether 208.75
    2,5,8-trioxanonane 283.67
    1-hexene 127.45
    2-isopropoxyethanol 215.1
    2,2,2-trifluoroethanol 164.42
    methyl butyrate 259.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction