2-Methyl-6-ethyl-3-hydroxypyridine

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  • Identifiers

    CAS number
    42451-07-0

    Molecular formula
    C8H11NO

    SMILES
    CCC1=NC(=C(C=C1)O)C

    Safety labels

  • Odor profile

    Fragrance
    Burnt 52.78%
    Roasted 52.57%
    Phenolic 48.12%
    Smoky 44.94%
    Nutty 41.82%
    Musty 40.66%
    Earthy 38.74%
    Sweet 35.09%
    Coffee 34.52%
    Meaty 32.3%

     

    Flavor
    Roasted 42.92%
    Meaty 39.8%
    Phenolic 36.36%
    Burnt 35.84%
    Nutty 35.58%
    Coffee 32.89%
    Musty 32.49%
    Smoky 29.73%
    Medicinal 29.16%
    Spicy 28.95%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    8.55 (weak base)

    Molecular weight
    137.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    230°C

    Flash point

    • 102.42 ˚C est.

  • Synonyms

    • 42451-07-0
    • 2-Methyl-6-ethyl-3-hydroxypyridine
    • 6-Ethyl-3-hydroxy-2-methylpyridine
    • 2-Me-6-Ehp
    • W522N65A4H
    • DTXSID50195233
    • RefChem:88207
    • DTXCID60117724
    • 6-ethyl-2-methylpyridin-3-ol
    • 6-Ethyl-2-methyl-3-pyridinol
    • UNII-W522N65A4H
    • 3-Pyridinol, 6-ethyl-2-methyl-
    • SCHEMBL1252630
    • ALBB-037955
    • SB54689
    • DB-207750
    • Q27292310
    • 42451-07-0

  • Applications

    2-Methyl-6-ethyl-3-hydroxypyridine (CAS 42451-07-0) is primarily used as a synthetic building block and intermediate in organic synthesis across pharmaceutical and agrochemical contexts; it may serve as a ligand for metal-centered catalytic systems and as a precursor to more complex heterocyclic and functionalized compounds; it has potential as a dye or pigment precursor for specialty coatings and inks; it can act as a functional building block in the development of specialty polymers and materials; and it is often evaluated for chelating applications and research use in coordination chemistry.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 425.6
    methanol 501.28
    isopropanol 315.77
    water 3.19
    ethyl acetate 235.94
    n-propanol 316.29
    acetone 413.31
    n-butanol 241.7
    acetonitrile 347.64
    DMF 609.2
    toluene 122.52
    isobutanol 237.64
    1,4-dioxane 567.53
    methyl acetate 297.74
    THF 661.3
    2-butanone 332.06
    n-pentanol 187.55
    sec-butanol 251.32
    n-hexane 17.74
    ethylene glycol 115.48
    NMP 391.0
    cyclohexane 23.92
    DMSO 750.36
    n-butyl acetate 311.09
    n-octanol 125.33
    chloroform 680.61
    n-propyl acetate 169.86
    acetic acid 272.15
    dichloromethane 1018.97
    cyclohexanone 392.86
    propylene glycol 116.54
    isopropyl acetate 125.53
    DMAc 373.04
    2-ethoxyethanol 274.12
    isopentanol 200.22
    n-heptane 26.88
    ethyl formate 313.15
    1,2-dichloroethane 512.14
    n-hexanol 249.35
    2-methoxyethanol 436.63
    isobutyl acetate 110.51
    tetrachloromethane 135.41
    n-pentyl acetate 168.46
    transcutol 523.32
    n-heptanol 137.59
    ethylbenzene 79.12
    MIBK 128.05
    2-propoxyethanol 346.46
    tert-butanol 349.19
    MTBE 266.32
    2-butoxyethanol 214.32
    propionic acid 228.77
    o-xylene 101.65
    formic acid 135.84
    diethyl ether 218.7
    m-xylene 99.95
    p-xylene 108.65
    chlorobenzene 211.6
    dimethyl carbonate 94.75
    n-octane 15.59
    formamide 218.41
    cyclopentanone 506.88
    2-pentanone 224.66
    anisole 161.34
    cyclopentyl methyl ether 215.74
    gamma-butyrolactone 598.13
    1-methoxy-2-propanol 268.44
    pyridine 339.78
    3-pentanone 168.07
    furfural 492.3
    n-dodecane 15.61
    diethylene glycol 243.8
    diisopropyl ether 63.89
    tert-amyl alcohol 269.11
    acetylacetone 219.33
    n-hexadecane 17.43
    acetophenone 147.43
    methyl propionate 194.32
    isopentyl acetate 251.05
    trichloroethylene 808.21
    n-nonanol 105.62
    cyclohexanol 161.75
    benzyl alcohol 145.22
    2-ethylhexanol 151.34
    isooctanol 108.21
    dipropyl ether 145.27
    1,2-dichlorobenzene 202.39
    ethyl lactate 84.79
    propylene carbonate 315.69
    n-methylformamide 385.88
    2-pentanol 143.16
    n-pentane 19.97
    1-propoxy-2-propanol 244.25
    1-methoxy-2-propyl acetate 208.91
    2-(2-methoxypropoxy) propanol 164.05
    mesitylene 66.8
    ε-caprolactone 317.69
    p-cymene 83.24
    epichlorohydrin 686.98
    1,1,1-trichloroethane 390.59
    2-aminoethanol 206.41
    morpholine-4-carbaldehyde 437.0
    sulfolane 637.0
    2,2,4-trimethylpentane 20.23
    2-methyltetrahydrofuran 435.66
    n-hexyl acetate 204.45
    isooctane 15.18
    2-(2-butoxyethoxy)ethanol 219.72
    sec-butyl acetate 99.66
    tert-butyl acetate 146.2
    decalin 20.52
    glycerin 143.78
    diglyme 395.07
    acrylic acid 185.29
    isopropyl myristate 83.98
    n-butyric acid 285.24
    acetyl acetate 126.91
    di(2-ethylhexyl) phthalate 87.64
    ethyl propionate 125.33
    nitromethane 450.63
    1,2-diethoxyethane 249.4
    benzonitrile 233.34
    trioctyl phosphate 72.78
    1-bromopropane 263.46
    gamma-valerolactone 560.06
    n-decanol 85.17
    triethyl phosphate 82.89
    4-methyl-2-pentanol 89.62
    propionitrile 277.81
    vinylene carbonate 297.42
    1,1,2-trichlorotrifluoroethane 292.69
    DMS 138.95
    cumene 66.45
    2-octanol 101.67
    2-hexanone 177.44
    octyl acetate 110.54
    limonene 105.31
    1,2-dimethoxyethane 427.55
    ethyl orthosilicate 81.73
    tributyl phosphate 84.92
    diacetone alcohol 168.5
    N,N-dimethylaniline 115.73
    acrylonitrile 349.91
    aniline 154.16
    1,3-propanediol 247.38
    bromobenzene 231.66
    dibromomethane 568.04
    1,1,2,2-tetrachloroethane 516.48
    2-methyl-cyclohexyl acetate 129.87
    tetrabutyl urea 106.46
    diisobutyl methanol 85.51
    2-phenylethanol 181.22
    styrene 92.34
    dioctyl adipate 106.1
    dimethyl sulfate 156.04
    ethyl butyrate 180.45
    methyl lactate 98.27
    butyl lactate 125.25
    diethyl carbonate 122.53
    propanediol butyl ether 175.1
    triethyl orthoformate 112.44
    p-tert-butyltoluene 77.12
    methyl 4-tert-butylbenzoate 149.8
    morpholine 532.25
    tert-butylamine 213.83
    n-dodecanol 69.06
    dimethoxymethane 337.22
    ethylene carbonate 251.91
    cyrene 153.42
    2-ethoxyethyl acetate 207.65
    2-ethylhexyl acetate 186.95
    1,2,4-trichlorobenzene 215.11
    4-methylpyridine 324.48
    dibutyl ether 130.89
    2,6-dimethyl-4-heptanol 85.51
    DEF 258.15
    dimethyl isosorbide 262.33
    tetrachloroethylene 342.67
    eugenol 153.9
    triacetin 153.63
    span 80 143.04
    1,4-butanediol 121.56
    1,1-dichloroethane 483.6
    2-methyl-1-pentanol 160.52
    methyl formate 327.36
    2-methyl-1-butanol 202.02
    n-decane 23.14
    butyronitrile 303.24
    3,7-dimethyl-1-octanol 112.88
    1-chlorooctane 89.55
    1-chlorotetradecane 39.49
    n-nonane 22.27
    undecane 18.59
    tert-butylcyclohexane 24.11
    cyclooctane 10.76
    cyclopentanol 241.07
    tetrahydropyran 383.63
    tert-amyl methyl ether 167.41
    2,5,8-trioxanonane 260.98
    1-hexene 74.08
    2-isopropoxyethanol 178.62
    2,2,2-trifluoroethanol 107.81
    methyl butyrate 191.97

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction